The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
YVTN repeat-like/Quinoprotein amine dehydrogenase
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 103908: Hepatocyte growth factor receptor

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 47 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
18 B2RXS4 (/IPI) H9XVP3 (/IPI) O15031 (/IPI) O43157 (/IPI) O75051 (/IPI) P08581 (/IPI) P16056 (/IPI) P51805 (/IPI) P70206 (/IPI) Q04912 (/IPI)
(8 more)
Semaphorin receptor activity GO:0017154
Combining with a semaphorin, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
6 D3ZLH5 (/ISS) O15031 (/ISS) O75051 (/ISS) Q3V5K0 (/ISS) Q8CJH3 (/ISS) Q9QY40 (/ISS)
Semaphorin receptor activity GO:0017154
Combining with a semaphorin, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
5 H9XVP3 (/TAS) O43157 (/TAS) Q86M56 (/TAS) Q9UIW2 (/TAS) Q9V491 (/TAS)
Semaphorin receptor activity GO:0017154
Combining with a semaphorin, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
4 B2RXS4 (/IMP) P70207 (/IMP) P70208 (/IMP) Q8CJH3 (/IMP)
GTPase activator activity GO:0005096
Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP.
3 H9XVP3 (/IDA) Q86M56 (/IDA) Q9V491 (/IDA)
Heparin binding GO:0008201
Interacting selectively and non-covalently with heparin, any member of a group of glycosaminoglycans found mainly as an intracellular component of mast cells and which consist predominantly of alternating alpha-(1->4)-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues.
3 H9XVP3 (/IDA) Q86M56 (/IDA) Q9V491 (/IDA)
Semaphorin receptor activity GO:0017154
Combining with a semaphorin, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
3 O43157 (/IDA) Q9ULL4 (/IDA) U4PRY7 (/IDA)
Guanylate cyclase activator activity GO:0030250
Binds to and increases the activity of guanylate cyclase.
3 H9XVP3 (/IDA) Q86M56 (/IDA) Q9V491 (/IDA)
14-3-3 protein binding GO:0071889
Interacting selectively and non-covalently with a 14-3-3 protein. A 14-3-3 protein is any of a large family of approximately 30kDa acidic proteins which exist primarily as homo- and heterodimers within all eukaryotic cells, and have been implicated in the modulation of distinct biological processes by binding to specific phosphorylated sites on diverse target proteins, thereby forcing conformational changes or influencing interactions between their targets and other molecules. Each 14-3-3 protein sequence can be roughly divided into three sections: a divergent amino terminus, the conserved core region and a divergent carboxyl terminus. The conserved middle core region of the 14-3-3s encodes an amphipathic groove that forms the main functional domain, a cradle for interacting with client proteins.
3 H9XVP3 (/IPI) Q86M56 (/IPI) Q9V491 (/IPI)
Receptor activity GO:0004872
Combining with an extracellular or intracellular messenger to initiate a change in cell activity.
2 O43157 (/TAS) Q9UIW2 (/TAS)
Transmembrane signaling receptor activity GO:0004888
Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity or state as part of signal transduction.
2 O43157 (/NAS) P51805 (/NAS)
Semaphorin receptor activity GO:0017154
Combining with a semaphorin, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
2 P70207 (/IGI) Q80UG2 (/IGI)
Semaphorin receptor activity GO:0017154
Combining with a semaphorin, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
2 P70206 (/IPI) P70207 (/IPI)
Semaphorin receptor activity GO:0017154
Combining with a semaphorin, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
2 Q8CJH3 (/ISO) Q9QY40 (/ISO)
Protein domain specific binding GO:0019904
Interacting selectively and non-covalently with a specific domain of a protein.
2 D3ZLH5 (/ISS) Q9QY40 (/ISS)
Protein kinase activity GO:0004672
Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.
1 P16056 (/IDA)
Protein tyrosine kinase activity GO:0004713
Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate.
1 P97523 (/IDA)
Protein tyrosine kinase activity GO:0004713
Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate.
1 P08581 (/NAS)
Protein tyrosine kinase activity GO:0004713
Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate.
1 P08581 (/TAS)
Hepatocyte growth factor-activated receptor activity GO:0005008
Combining with hepatocyte growth factor and transmitting the signal across the plasma membrane to initiate a change in cell activity.
1 P16056 (/IDA)
Hepatocyte growth factor-activated receptor activity GO:0005008
Combining with hepatocyte growth factor and transmitting the signal across the plasma membrane to initiate a change in cell activity.
1 P97523 (/IMP)
Hepatocyte growth factor-activated receptor activity GO:0005008
Combining with hepatocyte growth factor and transmitting the signal across the plasma membrane to initiate a change in cell activity.
1 P08581 (/TAS)
Macrophage colony-stimulating factor receptor activity GO:0005011
Combining with macrophage colony-stimulating factor (M-CSF) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate.
1 Q04912 (/TAS)
Ras guanyl-nucleotide exchange factor activity GO:0005088
Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Ras superfamily. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase.
1 P08581 (/TAS)
GTPase activator activity GO:0005096
Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP.
1 O43157 (/TAS)
Beta-catenin binding GO:0008013
Interacting selectively and non-covalently with the beta subunit of the catenin complex.
1 P97523 (/IPI)
Enzyme binding GO:0019899
Interacting selectively and non-covalently with any enzyme.
1 Q04912 (/IPI)
Enzyme binding GO:0019899
Interacting selectively and non-covalently with any enzyme.
1 Q62190 (/ISO)
Protein phosphatase binding GO:0019903
Interacting selectively and non-covalently with any protein phosphatase.
1 P08581 (/IPI)
Protein phosphatase binding GO:0019903
Interacting selectively and non-covalently with any protein phosphatase.
1 P16056 (/ISO)
Protein domain specific binding GO:0019904
Interacting selectively and non-covalently with a specific domain of a protein.
1 Q9ULL4 (/IPI)
Protein domain specific binding GO:0019904
Interacting selectively and non-covalently with a specific domain of a protein.
1 Q9QY40 (/ISO)
Semaphorin receptor binding GO:0030215
Interacting selectively and non-covalently with semaphorin receptors.
1 Q95XP4 (/IPI)
Semaphorin receptor binding GO:0030215
Interacting selectively and non-covalently with semaphorin receptors.
1 O43157 (/TAS)
Protein complex binding GO:0032403
Interacting selectively and non-covalently with any protein complex (a complex of two or more proteins that may include other nonprotein molecules).
1 P97523 (/IDA)
GTPase activating protein binding GO:0032794
Interacting selectively and non-covalently with a GTPase activating protein.
1 Q8CJH3 (/IPI)
GTPase activating protein binding GO:0032794
Interacting selectively and non-covalently with a GTPase activating protein.
1 O43157 (/ISS)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
1 B0S5N4 (/IDA)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
1 B0S5N4 (/IMP)
Phospholipase binding GO:0043274
Interacting selectively and non-covalently with any phospholipase, enzymes that catalyze of the hydrolysis of a glycerophospholipid.
1 P97523 (/IPI)
Phosphatidylinositol 3-kinase binding GO:0043548
Interacting selectively and non-covalently with a phosphatidylinositol 3-kinase, any enzyme that catalyzes the addition of a phosphate group to an inositol lipid at the 3' position of the inositol ring.
1 P97523 (/IDA)
Phosphatidylinositol-4,5-bisphosphate 3-kinase activity GO:0046934
Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + ATP = a 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate + ADP + 2 H(+).
1 P08581 (/TAS)
Protein heterodimerization activity GO:0046982
Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer.
1 P97523 (/IDA)
Rac GTPase binding GO:0048365
Interacting selectively and non-covalently with Rac protein, any member of the Rac subfamily of the Ras superfamily of monomeric GTPases.
1 Q3V5K0 (/ISS)
Rho GDP-dissociation inhibitor binding GO:0051022
Interacting selectively and non-covalently with a Rho GDP-dissociation inhibitor protein.
1 Q9QY40 (/IPI)
Protein binding involved in cell-cell adhesion GO:0098632
Any protein binding that is involved in cell-cell adhesion.
1 Q9ULL4 (/IPI)
Protein binding involved in cell-cell adhesion GO:0098632
Any protein binding that is involved in cell-cell adhesion.
1 Q9QY40 (/ISO)

There are 251 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Semaphorin-plexin signaling pathway GO:0071526
A series of molecular signals generated as a consequence of a semaphorin receptor (composed of a plexin and a neurophilin) binding to a semaphorin ligand.
36 A0M8R7 (/ISS) A0M8S8 (/ISS) A1X150 (/ISS) O15031 (/ISS) O75051 (/ISS) P97523 (/ISS) Q00PJ8 (/ISS) Q07DV8 (/ISS) Q07DY1 (/ISS) Q07DZ1 (/ISS)
(26 more)
Positive chemotaxis GO:0050918
The directed movement of a motile cell or organism towards a higher concentration of a chemical.
34 A0M8R7 (/ISS) A0M8S8 (/ISS) A1X150 (/ISS) D3ZLH5 (/ISS) P97523 (/ISS) Q00PJ8 (/ISS) Q07DV8 (/ISS) Q07DY1 (/ISS) Q07DZ1 (/ISS) Q07E01 (/ISS)
(24 more)
Positive regulation of endothelial cell chemotaxis GO:2001028
Any process that activates or increases the frequency, rate or extent of endothelial cell chemotaxis.
33 A0M8R7 (/ISS) A0M8S8 (/ISS) A1X150 (/ISS) P16056 (/ISS) P97523 (/ISS) Q00PJ8 (/ISS) Q07DV8 (/ISS) Q07DY1 (/ISS) Q07DZ1 (/ISS) Q07E01 (/ISS)
(23 more)
Axon guidance GO:0007411
The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues.
7 H9XVP3 (/IMP) P70208 (/IMP) Q80UG2 (/IMP) Q86M56 (/IMP) Q95XP4 (/IMP) Q9V491 (/IMP) Q9V4A7 (/IMP)
Semaphorin-plexin signaling pathway GO:0071526
A series of molecular signals generated as a consequence of a semaphorin receptor (composed of a plexin and a neurophilin) binding to a semaphorin ligand.
6 B2RXS4 (/IMP) D3ZLH5 (/IMP) P16056 (/IMP) P70207 (/IMP) Q80UG2 (/IMP) Q8CJH3 (/IMP)
Neuron migration GO:0001764
The characteristic movement of an immature neuron from germinal zones to specific positions where they will reside as they mature.
4 A0A0B5JQ16 (/IMP) A0M8V8 (/IMP) F1QLR7 (/IMP) P97523 (/IMP)
Liver development GO:0001889
The process whose specific outcome is the progression of the liver over time, from its formation to the mature structure. The liver is an exocrine gland which secretes bile and functions in metabolism of protein and carbohydrate and fat, synthesizes substances involved in the clotting of the blood, synthesizes vitamin A, detoxifies poisonous substances, stores glycogen, and breaks down worn-out erythrocytes.
4 A0A0B5JQ16 (/IMP) A0M8V8 (/IMP) F1QLR7 (/IMP) P16056 (/IMP)
Motor neuron axon guidance GO:0008045
The process in which the migration of an axon growth cone of a motor neuron is directed to a specific target site in response to a combination of attractive and repulsive cues.
4 H9XVP3 (/NAS) Q86M56 (/NAS) Q9V491 (/NAS) Q9V4A7 (/NAS)
Sensory neuron axon guidance GO:0097374
The process in which the migration of an axon growth cone of a sensory neuron is directed to a specific target site in response to a combination of attractive and repulsive cues. A sensory neuron is an afferent neuron conveying sensory impulses.
4 H9XVP3 (/IGI) Q86M56 (/IGI) Q9V491 (/IGI) Q9V4A7 (/IGI)
Sensory neuron axon guidance GO:0097374
The process in which the migration of an axon growth cone of a sensory neuron is directed to a specific target site in response to a combination of attractive and repulsive cues. A sensory neuron is an afferent neuron conveying sensory impulses.
4 H9XVP3 (/IMP) Q86M56 (/IMP) Q9V491 (/IMP) Q9V4A7 (/IMP)
Liver development GO:0001889
The process whose specific outcome is the progression of the liver over time, from its formation to the mature structure. The liver is an exocrine gland which secretes bile and functions in metabolism of protein and carbohydrate and fat, synthesizes substances involved in the clotting of the blood, synthesizes vitamin A, detoxifies poisonous substances, stores glycogen, and breaks down worn-out erythrocytes.
3 A0A0B5JQ16 (/IGI) A0M8V8 (/IGI) F1QLR7 (/IGI)
Sprouting angiogenesis GO:0002040
The extension of new blood vessels from existing capillaries into avascular tissues resulting from the proliferation of blood vessel endothelial cells.
3 A0A0R4IB44 (/IGI) B0S6W7 (/IGI) F1QBC0 (/IGI)
Sprouting angiogenesis GO:0002040
The extension of new blood vessels from existing capillaries into avascular tissues resulting from the proliferation of blood vessel endothelial cells.
3 A0A0R4IB44 (/IMP) B0S6W7 (/IMP) F1QBC0 (/IMP)
Negative regulation of cell adhesion GO:0007162
Any process that stops, prevents, or reduces the frequency, rate or extent of cell adhesion.
3 D3ZLH5 (/ISS) Q8CJH3 (/ISS) Q9QY40 (/ISS)
Signal transduction GO:0007165
The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
3 O43157 (/TAS) P08581 (/TAS) Q04912 (/TAS)
Ras protein signal transduction GO:0007265
A series of molecular signals within the cell that are mediated by a member of the Ras superfamily of proteins switching to a GTP-bound active state.
3 H9XVP3 (/IDA) Q86M56 (/IDA) Q9V491 (/IDA)
Motor neuron axon guidance GO:0008045
The process in which the migration of an axon growth cone of a motor neuron is directed to a specific target site in response to a combination of attractive and repulsive cues.
3 B0S5N4 (/IMP) Q80UG2 (/IMP) Q9V4A7 (/IMP)
Axon midline choice point recognition GO:0016199
The recognition of molecules at the central nervous system midline choice point by an axon growth cone; this choice point determines whether the growth cone will cross the midline.
3 H9XVP3 (/IMP) Q86M56 (/IMP) Q9V491 (/IMP)
Cell migration GO:0016477
The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. Cell migration is a central process in the development and maintenance of multicellular organisms.
3 A0A0B5JQ16 (/IMP) A0M8V8 (/IMP) F1QLR7 (/IMP)
Spinal cord motor neuron differentiation GO:0021522
The process in which neuroepithelial cells in the ventral neural tube acquire specialized structural and/or functional features of motor neurons. Motor neurons innervate an effector (muscle or glandular) tissue and are responsible for transmission of motor impulses from the brain to the periphery. Differentiation includes the processes involved in commitment of a cell to a specific fate.
3 A0A0B5JQ16 (/IMP) A0M8V8 (/IMP) F1QLR7 (/IMP)
Cerebellum development GO:0021549
The process whose specific outcome is the progression of the cerebellum over time, from its formation to the mature structure. The cerebellum is the portion of the brain in the back of the head between the cerebrum and the pons. In mice, the cerebellum controls balance for walking and standing, modulates the force and range of movement and is involved in the learning of motor skills.
3 A0A0B5JQ16 (/IMP) A0M8V8 (/IMP) F1QLR7 (/IMP)
Cerebellum morphogenesis GO:0021587
The process in which the anatomical structure of the cerebellum is generated and organized. The cerebellum is the portion of the brain in the back of the head between the cerebrum and the pons. The cerebellum controls balance for walking and standing, modulates the force and range of movement and is involved in the learning of motor skills.
3 A0A0B5JQ16 (/IMP) A0M8V8 (/IMP) F1QLR7 (/IMP)
Cerebellar granule cell differentiation GO:0021707
The process in which neuroblasts acquire specialized structural and/or functional features that characterize the mature cerebellar granule cell. Differentiation includes the processes involved in commitment of a neuroblast to a granule cell fate. A granule cell is a glutamatergic interneuron found in the cerebellar cortex.
3 A0A0B5JQ16 (/IMP) A0M8V8 (/IMP) F1QLR7 (/IMP)
Central nervous system neuron differentiation GO:0021953
The process in which a relatively unspecialized cell acquires specialized features of a neuron whose cell body resides in the central nervous system.
3 A0A0B5JQ16 (/IMP) A0M8V8 (/IMP) F1QLR7 (/IMP)
Exocrine pancreas development GO:0031017
The process whose specific outcome is the progression of the exocrine pancreas over time, from its formation to the mature structure. The exocrine pancreas produces and store zymogens of digestive enzymes, such as chymotrypsinogen and trypsinogen in the acinar cells.
3 A0A0B5JQ16 (/IMP) A0M8V8 (/IMP) F1QLR7 (/IMP)
Positive regulation of guanylate cyclase activity GO:0031284
Any process that activates or increases the frequency, rate or extent of guanylate cyclase activity.
3 H9XVP3 (/IDA) Q86M56 (/IDA) Q9V491 (/IDA)
Pectoral fin development GO:0033339
The process whose specific outcome is the progression of the pectoral fin over time, from its formation to the mature structure.
3 A0A0B5JQ16 (/IMP) A0M8V8 (/IMP) F1QLR7 (/IMP)
Axon extension GO:0048675
Long distance growth of a single axon process involved in cellular development.
3 A0A0R4IRZ9 (/IMP) B0S5N4 (/IMP) F1Q7U0 (/IMP)
Semaphorin-plexin signaling pathway GO:0071526
A series of molecular signals generated as a consequence of a semaphorin receptor (composed of a plexin and a neurophilin) binding to a semaphorin ligand.
3 O43157 (/IDA) P08581 (/IDA) Q9ULL4 (/IDA)
Semaphorin-plexin signaling pathway GO:0071526
A series of molecular signals generated as a consequence of a semaphorin receptor (composed of a plexin and a neurophilin) binding to a semaphorin ligand.
3 P16056 (/ISO) Q8CJH3 (/ISO) Q9QY40 (/ISO)
Nematode male tail mating organ morphogenesis GO:0090597
The process in which the anatomical structures of the nematode male tail mating organ are generated and organized. The male tail is a sensory organ required for mating and, in C. elegans, consists of ray sensilla, an acellular cuticular fan, a sensory hook, and protracting, copulatory spicules.
3 Q3V5K0 (/IMP) Q95XP4 (/IMP) U4PRY7 (/IMP)
Semaphorin-plexin signaling pathway involved in regulation of photoreceptor cell axon guidance GO:2000305
Any semaphorin-plexin signaling pathway that is involved in regulation of photoreceptor cell axon guidance.
3 H9XVP3 (/IGI) Q86M56 (/IGI) Q9V491 (/IGI)
Homophilic cell adhesion via plasma membrane adhesion molecules GO:0007156
The attachment of a plasma membrane adhesion molecule in one cell to an identical molecule in an adjacent cell.
2 O15031 (/IDA) Q9ULL4 (/IDA)
Homophilic cell adhesion via plasma membrane adhesion molecules GO:0007156
The attachment of a plasma membrane adhesion molecule in one cell to an identical molecule in an adjacent cell.
2 B2RXS4 (/ISO) Q9QY40 (/ISO)
Negative regulation of cell adhesion GO:0007162
Any process that stops, prevents, or reduces the frequency, rate or extent of cell adhesion.
2 O43157 (/IDA) Q9ULL4 (/IDA)
Negative regulation of cell adhesion GO:0007162
Any process that stops, prevents, or reduces the frequency, rate or extent of cell adhesion.
2 Q8CJH3 (/ISO) Q9QY40 (/ISO)
Multicellular organism development GO:0007275
The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).
2 P51805 (/TAS) Q9UIW2 (/TAS)
Axon guidance GO:0007411
The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues.
2 Q6BEA0 (/IGI) Q9V4A7 (/IGI)
Brain development GO:0007420
The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.).
2 B2RXS4 (/IMP) P16056 (/IMP)
Regulation of cell shape GO:0008360
Any process that modulates the surface configuration of a cell.
2 B2RXS4 (/IMP) Q8CJH3 (/IMP)
Regulation of cell shape GO:0008360
Any process that modulates the surface configuration of a cell.
2 O15031 (/ISS) Q8CJH3 (/ISS)
Negative regulation of lamellipodium assembly GO:0010593
Any process that decreases the rate, frequency or extent of the formation of a lamellipodium, a thin sheetlike extension of the surface of a migrating cell.
2 Q9QY40 (/ISS) Q9ULL4 (/ISS)
Positive regulation of neuron projection development GO:0010976
Any process that increases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).
2 O15031 (/IDA) Q9ULL4 (/IDA)
Positive regulation of neuron projection development GO:0010976
Any process that increases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).
2 B2RXS4 (/ISO) Q9QY40 (/ISO)
Facial nerve structural organization GO:0021612
The process that contributes to the act of creating the structural organization of the facial nerve. This process pertains to the physical shaping of a rudimentary structure. This sensory and motor nerve supplies the muscles of facial expression and the expression and taste at the anterior two-thirds of the tongue. The principal branches are the superficial opthalmic, buccal, palatine and hyomandibular. The main trunk synapses within pterygopalatine ganglion in the parotid gland and this ganglion then gives of nerve branches which supply the lacrimal gland and the mucous secreting glands of the nasal and oral cavities.
2 P70208 (/IMP) Q80UG2 (/IMP)
Trigeminal nerve structural organization GO:0021637
The process that contributes to the act of creating the structural organization of the oculomotor nerve. This process pertains to the physical shaping of a rudimentary structure. The trigeminal nerve is composed of three large branches. They are the ophthalmic (V1, sensory), maxillary (V2, sensory) and mandibular (V3, motor and sensory) branches. The sensory ophthalmic branch travels through the superior orbital fissure and passes through the orbit to reach the skin of the forehead and top of the head. The maxillary nerve contains sensory branches that reach the pterygopalatine fossa via the inferior orbital fissure (face, cheek and upper teeth) and pterygopalatine canal (soft and hard palate, nasal cavity and pharynx). The motor part of the mandibular branch is distributed to the muscles of mastication, the mylohyoid muscle and the anterior belly of the digastric. The mandibular nerve also innervates the tensor veli palatini and tensor tympani muscles. The sensory part of the mandibular nerve is composed of branches that carry general sensory information from the mucous membranes of the mouth and cheek, anterior two-thirds of the tongue, lower teeth, skin of the lower jaw, side of the head and scalp and meninges of the anterior and middle cranial fossae.
2 P70208 (/IMP) Q80UG2 (/IMP)
Branchiomotor neuron axon guidance GO:0021785
The process in which a branchiomotor neuron growth cone is directed to a specific target site. Branchiomotor neurons are located in the hindbrain and innervate branchial arch-derived muscles that control jaw movements, facial expression, the larynx, and the pharynx.
2 P70208 (/IMP) Q80UG2 (/IMP)
Bone mineralization GO:0030282
The deposition of hydroxyapatite, a form of calcium phosphate with the formula Ca10(PO4)6(OH)2, in bone tissue.
2 F1REV2 (/IMP) F8W2F8 (/IMP)
Regulation of cell migration GO:0030334
Any process that modulates the frequency, rate or extent of cell migration.
2 P70207 (/IMP) Q95XP4 (/IMP)
Negative regulation of cell migration GO:0030336
Any process that stops, prevents, or reduces the frequency, rate or extent of cell migration.
2 D3ZLH5 (/IMP) Q9ULL4 (/IMP)
Negative regulation of GTPase activity GO:0034260
Any process that stops or reduces the rate of GTP hydrolysis by a GTPase.
2 D3ZLH5 (/ISS) Q9QY40 (/ISS)
Nematode male tail tip morphogenesis GO:0045138
The process in which the anatomical structure of the adult male tail tip is generated and organized. In some species of rhabitid nematodes, the male tail tip undergoes a morphological change such that the most posterior hypodermal cells in the tail (hyp8-11 in C. elegans) fuse and retract anteriorly, changing the shape of the tail from a pointed, tapered cone, or spike, to a rounded, blunt dome.
2 Q95XP4 (/IMP) U4PRY7 (/IMP)
Protein autophosphorylation GO:0046777
The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation).
2 P16056 (/IDA) P97523 (/IDA)
Neuron projection morphogenesis GO:0048812
The process in which the anatomical structures of a neuron projection are generated and organized. A neuron projection is any process extending from a neural cell, such as axons or dendrites.
2 Q80UG2 (/IMP) Q8CJH3 (/IMP)
Positive regulation of axonogenesis GO:0050772
Any process that activates or increases the frequency, rate or extent of axonogenesis.
2 B2RXS4 (/IGI) Q8CJH3 (/IGI)
Positive chemotaxis GO:0050918
The directed movement of a motile cell or organism towards a higher concentration of a chemical.
2 P08581 (/IDA) Q9ULL4 (/IDA)
Positive chemotaxis GO:0050918
The directed movement of a motile cell or organism towards a higher concentration of a chemical.
2 P16056 (/ISO) Q9QY40 (/ISO)
Semaphorin-plexin signaling pathway GO:0071526
A series of molecular signals generated as a consequence of a semaphorin receptor (composed of a plexin and a neurophilin) binding to a semaphorin ligand.
2 P51805 (/NAS) Q9HCM2 (/NAS)
Neuron projection guidance GO:0097485
The process in which the migration of a neuron projection is directed to a specific target site in response to a combination of attractive and repulsive cues.
2 P70206 (/IMP) P70208 (/IMP)
Semaphorin-plexin signaling pathway involved in axon guidance GO:1902287
Any semaphorin-plexin signaling pathway that is involved in axon guidance.
2 P70208 (/IMP) Q80UG2 (/IMP)
Neuron projection extension GO:1990138
Long distance growth of a single neuron projection involved in cellular development. A neuron projection is a prolongation or process extending from a nerve cell, e.g. an axon or dendrite.
2 P70206 (/IGI) P70208 (/IGI)
Negative regulation of transcription from RNA polymerase II promoter GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter.
1 P97523 (/IMP)
MAPK cascade GO:0000165
An intracellular protein kinase cascade containing at least a MAPK, a MAPKK and a MAP3K. The cascade can also contain two additional tiers: the upstream MAP4K and the downstream MAP Kinase-activated kinase (MAPKAPK). The kinases in each tier phosphorylate and activate the kinases in the downstream tier to transmit a signal within a cell.
1 P08581 (/TAS)
Activation of MAPK activity GO:0000187
The initiation of the activity of the inactive enzyme MAP kinase (MAPK).
1 P16056 (/IPI)
Somitogenesis GO:0001756
The formation of mesodermal clusters that are arranged segmentally along the anterior posterior axis of an embryo.
1 P70207 (/IEP)
Morphogenesis of a branching structure GO:0001763
The process in which the anatomical structures of branches are generated and organized. A branch is a division or offshoot from a main stem. Examples in animals would include blood vessels, nerves, lymphatics and other endothelial or epithelial tubes.
1 Q6BEA0 (/IMP)
Neuron migration GO:0001764
The characteristic movement of an immature neuron from germinal zones to specific positions where they will reside as they mature.
1 P97523 (/IDA)
Neural tube closure GO:0001843
The last step in the formation of the neural tube, where the paired neural folds are brought together and fuse at the dorsal midline.
1 B2RXS4 (/IMP)
Neural tube closure GO:0001843
The last step in the formation of the neural tube, where the paired neural folds are brought together and fuse at the dorsal midline.
1 O15031 (/ISS)
Endothelial cell morphogenesis GO:0001886
The change in form (cell shape and size) that occurs during the differentiation of an endothelial cell.
1 P08581 (/IDA)
Endothelial cell morphogenesis GO:0001886
The change in form (cell shape and size) that occurs during the differentiation of an endothelial cell.
1 P16056 (/ISO)
Liver development GO:0001889
The process whose specific outcome is the progression of the liver over time, from its formation to the mature structure. The liver is an exocrine gland which secretes bile and functions in metabolism of protein and carbohydrate and fat, synthesizes substances involved in the clotting of the blood, synthesizes vitamin A, detoxifies poisonous substances, stores glycogen, and breaks down worn-out erythrocytes.
1 P97523 (/IEP)
Placenta development GO:0001890
The process whose specific outcome is the progression of the placenta over time, from its formation to the mature structure. The placenta is an organ of metabolic interchange between fetus and mother, partly of embryonic origin and partly of maternal origin.
1 P16056 (/IMP)
Regulation of protein phosphorylation GO:0001932
Any process that modulates the frequency, rate or extent of addition of phosphate groups into an amino acid in a protein.
1 B2RXS4 (/IMP)
Regulation of protein phosphorylation GO:0001932
Any process that modulates the frequency, rate or extent of addition of phosphate groups into an amino acid in a protein.
1 O15031 (/ISS)
Positive regulation of endothelial cell proliferation GO:0001938
Any process that activates or increases the rate or extent of endothelial cell proliferation.
1 Q9ULL4 (/IMP)
Positive regulation of endothelial cell proliferation GO:0001938
Any process that activates or increases the rate or extent of endothelial cell proliferation.
1 Q9QY40 (/ISO)
Optic vesicle formation GO:0003403
The developmental process pertaining to the initial formation of the optic vesicle from the lateral wall of the forebrain. This process begins with the specific processes that contribute to the appearance of the vesicle and ends when the vesicle has evaginated. The optic vesicle is the evagination of neurectoderm that precedes formation of the optic cup.
1 F1QCL2 (/IGI)
Optic vesicle formation GO:0003403
The developmental process pertaining to the initial formation of the optic vesicle from the lateral wall of the forebrain. This process begins with the specific processes that contribute to the appearance of the vesicle and ends when the vesicle has evaginated. The optic vesicle is the evagination of neurectoderm that precedes formation of the optic cup.
1 F1QCL2 (/IMP)
Movement of cell or subcellular component GO:0006928
The directed, self-propelled movement of a cell or subcellular component without the involvement of an external agent such as a transporter or a pore.
1 Q04912 (/TAS)
Defense response GO:0006952
Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack.
1 Q04912 (/TAS)
Cell surface receptor signaling pathway GO:0007166
A series of molecular signals initiated by activation of a receptor on the surface of a cell. The pathway begins with binding of an extracellular ligand to a cell surface receptor, or for receptors that signal in the absence of a ligand, by ligand-withdrawal or the activity of a constitutively active receptor. The pathway ends with regulation of a downstream cellular process, e.g. transcription.
1 P70207 (/IDA)
Cell surface receptor signaling pathway GO:0007166
A series of molecular signals initiated by activation of a receptor on the surface of a cell. The pathway begins with binding of an extracellular ligand to a cell surface receptor, or for receptors that signal in the absence of a ligand, by ligand-withdrawal or the activity of a constitutively active receptor. The pathway ends with regulation of a downstream cellular process, e.g. transcription.
1 P08581 (/NAS)
Small GTPase mediated signal transduction GO:0007264
Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals.
1 Q3V5K0 (/ISS)
Chemical synaptic transmission GO:0007268
The vesicular release of classical neurotransmitter molecules from a neuron, across a chemical synapse, the subsequent activation of neurotransmitter receptors of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse.
1 P16056 (/IMP)
Single fertilization GO:0007338
The union of male and female gametes to form a zygote.
1 Q04912 (/TAS)
Nervous system development GO:0007399
The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state.
1 Q80UG2 (/IGI)
Neuroblast proliferation GO:0007405
The expansion of a neuroblast population by cell division. A neuroblast is any cell that will divide and give rise to a neuron.
1 B2RXS4 (/IMP)
Neuroblast proliferation GO:0007405
The expansion of a neuroblast population by cell division. A neuroblast is any cell that will divide and give rise to a neuron.
1 O15031 (/ISS)
Axon guidance GO:0007411
The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues.
1 Q9V4A7 (/IDA)
Axonal fasciculation GO:0007413
The collection of axons into a bundle of rods, known as a fascicle.
1 Q95XP4 (/IMP)
Axonal defasciculation GO:0007414
Separation of axons away from a bundle of axons known as a fascicle.
1 Q6BEA0 (/IGI)
Brain development GO:0007420
The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.).
1 P97523 (/IEP)
Brain development GO:0007420
The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.).
1 O15031 (/ISS)
Muscle organ development GO:0007517
The process whose specific outcome is the progression of the muscle over time, from its formation to the mature structure. The muscle is an organ consisting of a tissue made up of various elongated cells that are specialized to contract and thus to produce movement and mechanical work.
1 P16056 (/IGI)
Muscle organ development GO:0007517
The process whose specific outcome is the progression of the muscle over time, from its formation to the mature structure. The muscle is an organ consisting of a tissue made up of various elongated cells that are specialized to contract and thus to produce movement and mechanical work.
1 P16056 (/IMP)
Skeletal muscle tissue development GO:0007519
The developmental sequence of events leading to the formation of adult skeletal muscle tissue. The main events are: the fusion of myoblasts to form myotubes that increase in size by further fusion to them of myoblasts, the formation of myofibrils within their cytoplasm and the establishment of functional neuromuscular junctions with motor neurons. At this stage they can be regarded as mature muscle fibers.
1 P16056 (/IMP)
Cell aging GO:0007569
An aging process that has as participant a cell after a cell has stopped dividing. Cell aging may occur when a cell has temporarily stopped dividing through cell cycle arrest (GO:0007050) or when a cell has permanently stopped dividing, in which case it is undergoing cellular senescence (GO:0090398). May precede cell death (GO:0008219) and succeed cell maturation (GO:0048469).
1 P97523 (/IEP)
Lactation GO:0007595
The regulated release of milk from the mammary glands and the period of time that a mother lactates to feed her young.
1 P97523 (/IEP)
Motor neuron axon guidance GO:0008045
The process in which the migration of an axon growth cone of a motor neuron is directed to a specific target site in response to a combination of attractive and repulsive cues.
1 B0S5N4 (/IGI)
Cell proliferation GO:0008283
The multiplication or reproduction of cells, resulting in the expansion of a cell population.
1 P08581 (/TAS)
Positive regulation of cell proliferation GO:0008284
Any process that activates or increases the rate or extent of cell proliferation.
1 Q04912 (/TAS)
Regulation of cell shape GO:0008360
Any process that modulates the surface configuration of a cell.
1 O43157 (/IDA)
Regulation of cell shape GO:0008360
Any process that modulates the surface configuration of a cell.
1 Q8CJH3 (/ISO)
Epidermis development GO:0008544
The process whose specific outcome is the progression of the epidermis over time, from its formation to the mature structure. The epidermis is the outer epithelial layer of an animal, it may be a single layer that produces an extracellular material (e.g. the cuticle of arthropods) or a complex stratified squamous epithelium, as in the case of many vertebrate species.
1 U4PRY7 (/IMP)
Male gonad development GO:0008584
The process whose specific outcome is the progression of the male gonad over time, from its formation to the mature structure.
1 P97523 (/IEP)
Response to wounding GO:0009611
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to the organism.
1 P97523 (/IEP)
Response to virus GO:0009615
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a virus.
1 Q04912 (/IDA)
Response to virus GO:0009615
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a virus.
1 Q62190 (/IMP)
Response to virus GO:0009615
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a virus.
1 Q62190 (/ISO)
Embryonic body morphogenesis GO:0010172
The process in which the anatomical structures of the embryonic soma are generated and organized.
1 Q95XP4 (/IMP)
Response to acidic pH GO:0010447
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pH stimulus with pH < 7. pH is a measure of the acidity or basicity of an aqueous solution.
1 P97523 (/IEP)
Negative regulation of autophagy GO:0010507
Any process that stops, prevents, or reduces the frequency, rate or extent of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm.
1 P08581 (/NAS)
Negative regulation of lamellipodium assembly GO:0010593
Any process that decreases the rate, frequency or extent of the formation of a lamellipodium, a thin sheetlike extension of the surface of a migrating cell.
1 D3ZLH5 (/IMP)
Positive regulation of gene expression GO:0010628
Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
1 P97523 (/IMP)
Negative regulation of gene expression GO:0010629
Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
1 P16056 (/IMP)
Positive regulation of peptidyl-threonine phosphorylation GO:0010800
Any process that increases the frequency, rate or extent of peptidyl-threonine phosphorylation. Peptidyl-threonine phosphorylation is the phosphorylation of peptidyl-threonine to form peptidyl-O-phospho-L-threonine.
1 P97523 (/IMP)
Negative regulation of peptidyl-threonine phosphorylation GO:0010801
Any process that decreases the frequency, rate or extent of peptidyl-threonine phosphorylation. Peptidyl-threonine phosphorylation is the phosphorylation of peptidyl-threonine to form peptidyl-O-phospho-L-threonine.
1 P97523 (/IMP)
Positive regulation of glucose transport GO:0010828
Any process that increases the frequency, rate or extent of glucose transport. Glucose transport is the directed movement of the hexose monosaccharide glucose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
1 P16056 (/IMP)
Positive regulation of neuron projection development GO:0010976
Any process that increases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).
1 P97523 (/IMP)
Oligodendrocyte development GO:0014003
The process aimed at the progression of an oligodendrocyte over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. An oligodendrocyte is a type of glial cell involved in myelinating the axons in the central nervous system.
1 P97523 (/IEP)
Regulation of phosphatidylinositol 3-kinase signaling GO:0014066
Any process that modulates the frequency, rate or extent of signal transduction mediated by the phosphatidylinositol 3-kinase cascade.
1 P08581 (/TAS)
Positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068
Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the phosphatidylinositol 3-kinase cascade.
1 Q8CJH3 (/IMP)
Positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068
Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the phosphatidylinositol 3-kinase cascade.
1 O43157 (/ISS)
Response to organic cyclic compound GO:0014070
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic cyclic compound stimulus.
1 P97523 (/IEP)
Muscle cell migration GO:0014812
The orderly movement of a muscle cell from one site to another, often during the development of a multicellular organism.
1 P16056 (/IMP)
Myotube differentiation GO:0014902
The process in which a relatively unspecialized cell acquires specialized features of a myotube cell. Myotube differentiation starts with myoblast fusion and the appearance of specific cell markers (this is the cell development step). Then individual myotubes can fuse to form bigger myotubes and start to contract. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse.
1 P16056 (/IMP)
Regulation of smooth muscle cell migration GO:0014910
Any process that modulates the frequency, rate or extent of smooth muscle cell migration.
1 P70206 (/IMP)
Morphogenesis of embryonic epithelium GO:0016331
The process in which the anatomical structures of embryonic epithelia are generated and organized.
1 Q95XP4 (/IMP)
Cell migration GO:0016477
The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. Cell migration is a central process in the development and maintenance of multicellular organisms.
1 O43157 (/NAS)
Cranial nerve morphogenesis GO:0021602
The process in which the anatomical structure of the cranial nerves are generated and organized. The cranial nerves are composed of twelve pairs of nerves that emanate from the nervous tissue of the hindbrain. These nerves are sensory, motor, or mixed in nature, and provide the motor and general sensory innervation of the head, neck and viscera. They mediate vision, hearing, olfaction and taste and carry the parasympathetic innervation of the autonomic ganglia that control visceral functions.
1 Q80UG2 (/IMP)
Facial nerve morphogenesis GO:0021610
The process in which the anatomical structure of the facial nerve is generated and organized. This sensory and motor nerve supplies the muscles of facial expression and the expression and taste at the anterior two-thirds of the tongue. The principal branches are the superficial opthalmic, buccal, palatine and hyomandibular. The main trunk synapses within pterygopalatine ganglion in the parotid gland and this ganglion then gives of nerve branches which supply the lacrimal gland and the mucous secreting glands of the nasal and oral cavities.
1 Q80UG2 (/IMP)
Glossopharyngeal nerve morphogenesis GO:0021615
The process in which the anatomical structure of the glossopharyngeal nerve is generated and organized. Various sensory and motor branches of the glossopharyngeal nerve supply nerve connections to the pharynx and back of the tongue. The branchial motor component contains motor fibers that innervate muscles that elevate the pharynx and larynx, and the tympanic branch supplies parasympathetic fibers to the otic ganglion.
1 Q80UG2 (/IMP)
Trigeminal nerve morphogenesis GO:0021636
The process in which the anatomical structure of the trigeminal nerve is generated and organized. The trigeminal nerve is composed of three large branches. They are the ophthalmic (V1, sensory), maxillary (V2, sensory) and mandibular (V3, motor and sensory) branches. The sensory ophthalmic branch travels through the superior orbital fissure and passes through the orbit to reach the skin of the forehead and top of the head. The maxillary nerve contains sensory branches that reach the pterygopalatine fossa via the inferior orbital fissure (face, cheek and upper teeth) and pterygopalatine canal (soft and hard palate, nasal cavity and pharynx). The motor part of the mandibular branch is distributed to the muscles of mastication, the mylohyoid muscle and the anterior belly of the digastric. The mandibular nerve also innervates the tensor veli palatini and tensor tympani muscles. The sensory part of the mandibular nerve is composed of branches that carry general sensory information from the mucous membranes of the mouth and cheek, anterior two-thirds of the tongue, lower teeth, skin of the lower jaw, side of the head and scalp and meninges of the anterior and middle cranial fossae.
1 Q80UG2 (/IMP)
Vagus nerve morphogenesis GO:0021644
The process in which the anatomical structure of the vagus nerve is generated and organized. This nerve is primarily sensory but also has visceromotor components. It originates in the brain stem and controls many autonomic functions of the heart, lungs, stomach, pharynx, larynx, trachea, esophagus and other gastrointestinal tract components. It controls some motor functions such as speech. The sensory branches mediate sensation from the pharynx, larynx, thorax and abdomen; it also innervates taste buds in the epiglottis.
1 Q80UG2 (/IMP)
Hippocampus development GO:0021766
The progression of the hippocampus over time from its initial formation until its mature state.
1 P70208 (/IMP)
Postganglionic parasympathetic fiber development GO:0021784
The process whose specific outcome is the progression of the postganglionic portion of the parasympathetic fiber over time, from its formation to the mature structure. The parasympathetic fiber is one of the two divisions of the vertebrate autonomic nervous system. Parasympathetic nerves emerge cranially as pre ganglionic fibers from oculomotor, facial, glossopharyngeal and vagus and from the sacral region of the spinal cord. Most neurons are cholinergic and responses are mediated by muscarinic receptors. The parasympathetic system innervates, for example: salivary glands, thoracic and abdominal viscera, bladder and genitalia.
1 Q80UG2 (/IMP)
Chemorepulsion of branchiomotor axon GO:0021793
The process in which a branchiomotor neuron growth cone is directed to a specific target site in response to a repulsive chemical cue. Branchiomotor neurons are located in the hindbrain and innervate branchial arch-derived muscles that control jaw movements, facial expression, the larynx, and the pharynx.
1 Q80UG2 (/IMP)
Pyramidal neuron development GO:0021860
The progression of a pyramidal neuron from its initial formation to its mature state.
1 P70208 (/IMP)
Neural tube development GO:0021915
The process whose specific outcome is the progression of the neural tube over time, from its formation to the mature structure. The mature structure of the neural tube exists when the tube has been segmented into the forebrain, midbrain, hindbrain and spinal cord regions. In addition neural crest has budded away from the epithelium.
1 P70207 (/IEP)
Cerebellar granule cell precursor tangential migration GO:0021935
The early migration of granule cell precursors in which cells move orthogonal to the direction of radial migration and ultimately cover the superficial zone of the cerebellar primordium.
1 P70207 (/IMP)
Central nervous system neuron differentiation GO:0021953
The process in which a relatively unspecialized cell acquires specialized features of a neuron whose cell body resides in the central nervous system.
1 P97523 (/IEP)
Anterior commissure morphogenesis GO:0021960
Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body in one half of the cerebral cortex towards target cells in the contralateral half. This axonal process is a member of those that make up the anterior commissure, a small midline fiber tract that lies at the anterior end of the corpus callosum.
1 Q80UG2 (/IMP)
Regulation of cell adhesion GO:0030155
Any process that modulates the frequency, rate or extent of attachment of a cell to another cell or to the extracellular matrix.
1 Q95XP4 (/IGI)
Regulation of cell adhesion GO:0030155
Any process that modulates the frequency, rate or extent of attachment of a cell to another cell or to the extracellular matrix.
1 Q95XP4 (/IMP)
Flagellated sperm motility GO:0030317
Any process involved in the controlled movement of a flagellated sperm cell.
1 P97523 (/IMP)
Regulation of cell migration GO:0030334
Any process that modulates the frequency, rate or extent of cell migration.
1 O75051 (/ISS)
Negative regulation of cell migration GO:0030336
Any process that stops, prevents, or reduces the frequency, rate or extent of cell migration.
1 Q9QY40 (/ISO)
Negative regulation of cell migration GO:0030336
Any process that stops, prevents, or reduces the frequency, rate or extent of cell migration.
1 Q9QY40 (/ISS)
Adult behavior GO:0030534
Behavior in a fully developed and mature organism.
1 P16056 (/IMP)
Pancreas development GO:0031016
The process whose specific outcome is the progression of the pancreas over time, from its formation to the mature structure. The pancreas is an endoderm derived structure that produces precursors of digestive enzymes and blood glucose regulating enzymes.
1 P97523 (/IEP)
Positive regulation of microtubule polymerization GO:0031116
Any process that activates or increases the frequency, rate or extent of microtubule polymerization.
1 P08581 (/IMP)
Positive regulation of microtubule polymerization GO:0031116
Any process that activates or increases the frequency, rate or extent of microtubule polymerization.
1 P16056 (/ISO)
Regulation of interleukin-6 production GO:0032675
Any process that modulates the frequency, rate, or extent of interleukin-6 production.
1 P16056 (/IMP)
Regulation of actin cytoskeleton organization GO:0032956
Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins.
1 Q95XP4 (/IMP)
Positive regulation of peptidyl-serine phosphorylation GO:0033138
Any process that activates or increases the frequency, rate or extent of the phosphorylation of peptidyl-serine.
1 P97523 (/IMP)
Negative regulation of osteoblast proliferation GO:0033689
Any process that stops, prevents or reduces the rate or extent of osteoblast proliferation.
1 Q8CJH3 (/IMP)
Negative regulation of osteoblast proliferation GO:0033689
Any process that stops, prevents or reduces the rate or extent of osteoblast proliferation.
1 O43157 (/ISS)
Negative regulation of GTPase activity GO:0034260
Any process that stops or reduces the rate of GTP hydrolysis by a GTPase.
1 Q9ULL4 (/IMP)
Negative regulation of GTPase activity GO:0034260
Any process that stops or reduces the rate of GTP hydrolysis by a GTPase.
1 Q9QY40 (/ISO)
Negative regulation of Rac protein signal transduction GO:0035021
Any process that stops, prevents, or reduces the frequency, rate or extent of Rac protein signal transduction.
1 Q9V4A7 (/NAS)
Negative regulation of Rho protein signal transduction GO:0035024
Any process that stops, prevents, or reduces the frequency, rate or extent of Rho protein signal transduction.
1 P08581 (/IDA)
Negative regulation of Rho protein signal transduction GO:0035024
Any process that stops, prevents, or reduces the frequency, rate or extent of Rho protein signal transduction.
1 P16056 (/ISO)
Positive regulation of Rho protein signal transduction GO:0035025
Any process that activates or increases the frequency, rate or extent of Rho protein signal transduction.
1 Q9V4A7 (/NAS)
Intracellular signal transduction GO:0035556
The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
1 O43157 (/NAS)
Entry of bacterium into host cell GO:0035635
The process in which a bacterium enters a host cell. The host is defined as the larger of the organisms involved in a symbiotic interaction.
1 P08581 (/TAS)
Response to drug GO:0042493
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease.
1 P97523 (/IEP)
Glucose homeostasis GO:0042593
Any process involved in the maintenance of an internal steady state of glucose within an organism or cell.
1 P16056 (/IMP)
Regulation of GTPase activity GO:0043087
Any process that modulates the rate of GTP hydrolysis by a GTPase.
1 B2RXS4 (/IMP)
Regulation of GTPase activity GO:0043087
Any process that modulates the rate of GTP hydrolysis by a GTPase.
1 O15031 (/ISS)
Positive regulation of MAP kinase activity GO:0043406
Any process that activates or increases the frequency, rate or extent of MAP kinase activity.
1 Q04912 (/IDA)
Positive regulation of MAP kinase activity GO:0043406
Any process that activates or increases the frequency, rate or extent of MAP kinase activity.
1 Q62190 (/ISO)
Response to peptide hormone GO:0043434
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide hormone stimulus. A peptide hormone is any of a class of peptides that are secreted into the blood stream and have endocrine functions in living animals.
1 P97523 (/IEP)
Positive regulation of GTPase activity GO:0043547
Any process that activates or increases the activity of a GTPase.
1 Q8CJH3 (/IMP)
Positive regulation of GTPase activity GO:0043547
Any process that activates or increases the activity of a GTPase.
1 O43157 (/ISS)
Ossification involved in bone maturation GO:0043931
The formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone, involved in the progression of the skeleton from its formation to its mature state.
1 Q8CJH3 (/IMP)
Ossification involved in bone maturation GO:0043931
The formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone, involved in the progression of the skeleton from its formation to its mature state.
1 O43157 (/ISS)
Nematode male tail tip morphogenesis GO:0045138
The process in which the anatomical structure of the adult male tail tip is generated and organized. In some species of rhabitid nematodes, the male tail tip undergoes a morphological change such that the most posterior hypodermal cells in the tail (hyp8-11 in C. elegans) fuse and retract anteriorly, changing the shape of the tail from a pointed, tapered cone, or spike, to a rounded, blunt dome.
1 Q95XP4 (/IGI)
Positive regulation of DNA replication GO:0045740
Any process that activates or increases the frequency, rate or extent of DNA replication.
1 P97523 (/IMP)
Positive regulation of mitotic nuclear division GO:0045840
Any process that activates or increases the frequency, rate or extent of mitosis.
1 P97523 (/IMP)
Positive regulation of transcription from RNA polymerase II promoter GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
1 P08581 (/IDA)
Positive regulation of transcription from RNA polymerase II promoter GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
1 P97523 (/IMP)
Positive regulation of transcription from RNA polymerase II promoter GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
1 P16056 (/ISO)
Hepatocyte growth factor receptor signaling pathway GO:0048012
The series of molecular signals generated as a consequence of the hepatocyte growth factor receptor binding to one of its physiological ligands.
1 P16056 (/IDA)
Hepatocyte growth factor receptor signaling pathway GO:0048012
The series of molecular signals generated as a consequence of the hepatocyte growth factor receptor binding to one of its physiological ligands.
1 Q04912 (/TAS)
Phosphatidylinositol-mediated signaling GO:0048015
A series of molecular signals in which a cell uses a phosphatidylinositol-mediated signaling to convert a signal into a response. Phosphatidylinositols include phosphatidylinositol (PtdIns) and its phosphorylated derivatives.
1 P08581 (/TAS)
Sympathetic nervous system development GO:0048485
The process whose specific outcome is the progression of the sympathetic nervous system over time, from its formation to the mature structure. The sympathetic nervous system is one of the two divisions of the vertebrate autonomic nervous system (the other being the parasympathetic nervous system). The sympathetic preganglionic neurons have their cell bodies in the thoracic and lumbar regions of the spinal cord and connect to the paravertebral chain of sympathetic ganglia. Innervate heart and blood vessels, sweat glands, viscera and the adrenal medulla. Most sympathetic neurons, but not all, use noradrenaline as a post-ganglionic neurotransmitter.
1 Q80UG2 (/IMP)
Axon extension GO:0048675
Long distance growth of a single axon process involved in cellular development.
1 B0S5N4 (/IGI)
Regulation of collateral sprouting in absence of injury GO:0048696
Any process that modulates the frequency, rate or extent of collateral sprouting in the absence of injury.
1 B0S5N4 (/IMP)
Branching morphogenesis of an epithelial tube GO:0048754
The process in which the anatomical structures of branches in an epithelial tube are generated and organized. A tube is a long hollow cylinder.
1 P08581 (/IMP)
Branching morphogenesis of an epithelial tube GO:0048754
The process in which the anatomical structures of branches in an epithelial tube are generated and organized. A tube is a long hollow cylinder.
1 P16056 (/ISO)
Branching morphogenesis of a nerve GO:0048755
The process in which the anatomical structures of branches in a nerve are generated and organized. This term refers to an anatomical structure (nerve) not a cell (neuron).
1 B0S5N4 (/IGI)
Branching morphogenesis of a nerve GO:0048755
The process in which the anatomical structures of branches in a nerve are generated and organized. This term refers to an anatomical structure (nerve) not a cell (neuron).
1 B0S5N4 (/IMP)
Neuron projection morphogenesis GO:0048812
The process in which the anatomical structures of a neuron projection are generated and organized. A neuron projection is any process extending from a neural cell, such as axons or dendrites.
1 O43157 (/ISS)
Regulation of axon extension involved in axon guidance GO:0048841
Any process that modulates the frequency, rate or extent of axon extension involved in axon guidance.
1 Q80UG2 (/IMP)
Negative regulation of axon extension involved in axon guidance GO:0048843
Any process that stops, prevents, or reduces the frequency, rate or extent of axon extension involved in axon guidance.
1 P70208 (/IGI)
Positive regulation of dendrite morphogenesis GO:0050775
Any process that activates or increases the frequency, rate or extent of dendrite morphogenesis.
1 P97523 (/IMP)
Modulation of synaptic transmission GO:0050804
Any process that modulates the frequency or amplitude of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse. Amplitude, in this case, refers to the change in postsynaptic membrane potential due to a single instance of synaptic transmission.
1 P16056 (/IMP)
Positive chemotaxis GO:0050918
The directed movement of a motile cell or organism towards a higher concentration of a chemical.
1 P16056 (/IMP)
Negative chemotaxis GO:0050919
The directed movement of a motile cell or organism towards a lower concentration of a chemical.
1 P70208 (/IGI)
Regulation of negative chemotaxis GO:0050923
Any process that modulates the frequency, rate or extent of the directed movement of a motile cell or organism towards a lower concentration in a concentration gradient of a specific chemical.
1 Q80UG2 (/IMP)
Regulation of cellular component movement GO:0051270
Any process that modulates the frequency, rate or extent of the movement of a cellular component.
1 Q3V5K0 (/IMP)
Myoblast proliferation GO:0051450
The multiplication or reproduction of myoblasts, resulting in the expansion of a myoblast cell population. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers.
1 P16056 (/IMP)
Regulation of cytoskeleton organization GO:0051493
Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures.
1 O43157 (/IDA)
Regulation of cytoskeleton organization GO:0051493
Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures.
1 Q8CJH3 (/ISO)
Regulation of cytoskeleton organization GO:0051493
Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures.
1 Q8CJH3 (/ISS)
Positive regulation of cytoskeleton organization GO:0051495
Any process that activates or increases the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures.
1 P70208 (/IMP)
Negative regulation of stress fiber assembly GO:0051497
Any process that stops, prevents, or reduces the frequency, rate or extent of the assembly a stress fiber, a bundle of microfilaments and other proteins found in fibroblasts.
1 P08581 (/IDA)
Negative regulation of stress fiber assembly GO:0051497
Any process that stops, prevents, or reduces the frequency, rate or extent of the assembly a stress fiber, a bundle of microfilaments and other proteins found in fibroblasts.
1 P16056 (/ISO)
Centrosome localization GO:0051642
Any process in which a centrosome is transported to, and/or maintained in, a specific location within the cell.
1 P70207 (/IMP)
Positive regulation of protein kinase B signaling GO:0051897
Any process that activates or increases the frequency, rate or extent of protein kinase B signaling, a series of reactions mediated by the intracellular serine/threonine kinase protein kinase B.
1 Q04912 (/IDA)
Positive regulation of protein kinase B signaling GO:0051897
Any process that activates or increases the frequency, rate or extent of protein kinase B signaling, a series of reactions mediated by the intracellular serine/threonine kinase protein kinase B.
1 Q62190 (/ISO)
Cardiac muscle cell development GO:0055013
The process whose specific outcome is the progression of a cardiac muscle cell over time, from its formation to the mature state.
1 P16056 (/IMP)
Pharyngeal system development GO:0060037
The process whose specific outcome is the progression of the pharyngeal system over time, from its formation to the mature structure. The pharyngeal system is a transient embryonic complex that is specific to vertebrates. It comprises the pharyngeal arches, bulges of tissues of mesoderm and neural crest derivation through which pass nerves and pharyngeal arch arteries. The arches are separated internally by pharyngeal pouches, evaginations of foregut endoderm, and externally by pharyngeal clefts, invaginations of surface ectoderm. The development of the system ends when the stucture it contributes to are forming: the thymus, thyroid, parathyroids, maxilla, mandible, aortic arch, cardiac outflow tract, external and middle ear.
1 P70207 (/IEP)
Cardiac muscle contraction GO:0060048
Muscle contraction of cardiac muscle tissue.
1 P16056 (/IMP)
Excitatory postsynaptic potential GO:0060079
A process that leads to a temporary increase in postsynaptic potential due to the flow of positively charged ions into the postsynaptic cell. The flow of ions that causes an EPSP is an excitatory postsynaptic current (EPSC) and makes it easier for the neuron to fire an action potential.
1 P16056 (/IMP)
Limb bud formation GO:0060174
The process pertaining to the initial formation of a limb bud from unspecified parts. This process begins with the formation of a local condensation of mesenchyme cells within the prospective limb field, and ends when a limb bud is recognizable.
1 P70207 (/IEP)
Embryonic skeletal joint morphogenesis GO:0060272
The process in which the anatomical structures of skeletal joints are generated and organized during the embryonic phase. A skeletal joint is the connecting structure between the bones of the skeleton.
1 B0S5N4 (/IMP)
Cell chemotaxis GO:0060326
The directed movement of a motile cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis).
1 Q9ULL4 (/IDA)
Cell chemotaxis GO:0060326
The directed movement of a motile cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis).
1 Q9QY40 (/ISO)
Cell chemotaxis GO:0060326
The directed movement of a motile cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis).
1 Q9QY40 (/ISS)
Regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling GO:0060665
Any process that modulates the rate, frequency, or extent of branching involved in salivary gland morphogenesis as a result of signals being generated by the mesenchyme and received and interpreted by the salivary gland epithelium.
1 P16056 (/IMP)
Dichotomous subdivision of terminal units involved in salivary gland branching GO:0060666
The process in which a salivary epithelial cord bifurcates at its end.
1 P70206 (/IDA)
Establishment of skin barrier GO:0061436
Establishment of the epithelial barrier, the functional barrier in the skin that limits its permeability.
1 P08581 (/IMP)
Establishment of skin barrier GO:0061436
Establishment of the epithelial barrier, the functional barrier in the skin that limits its permeability.
1 P16056 (/ISO)
Negative regulation of thrombin-activated receptor signaling pathway GO:0070495
Any process that stops, prevents, or reduces the frequency, rate or extent of thrombin-activated receptor protein signaling pathway activity. A thrombin receptor signaling pathway is the series of molecular signals generated as a consequence of a thrombin-activated receptor binding to one of its physiological ligands.
1 P08581 (/IDA)
Negative regulation of thrombin-activated receptor signaling pathway GO:0070495
Any process that stops, prevents, or reduces the frequency, rate or extent of thrombin-activated receptor protein signaling pathway activity. A thrombin receptor signaling pathway is the series of molecular signals generated as a consequence of a thrombin-activated receptor binding to one of its physiological ligands.
1 P16056 (/ISO)
Dendrite self-avoidance GO:0070593
The process in which dendrites recognize and avoid contact with sister dendrites from the same cell.
1 Q9V4A7 (/IMP)
Cellular response to inorganic substance GO:0071241
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an inorganic substance stimulus.
1 P97523 (/IEP)
Cellular response to arsenic-containing substance GO:0071243
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an arsenic stimulus from compounds containing arsenic, including arsenates, arsenites, and arsenides.
1 P97523 (/IEP)
Cellular response to glucose stimulus GO:0071333
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucose stimulus.
1 P97523 (/IEP)
Cellular response to interleukin-6 GO:0071354
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-6 stimulus.
1 P97523 (/IEP)
Cellular response to growth factor stimulus GO:0071363
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth factor stimulus.
1 P97523 (/IEP)
Cellular response to peptide hormone stimulus GO:0071375
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide hormone stimulus. A peptide hormone is any of a class of peptides that are secreted into the blood stream and have endocrine functions in living animals.
1 P97523 (/IEP)
Semaphorin-plexin signaling pathway GO:0071526
A series of molecular signals generated as a consequence of a semaphorin receptor (composed of a plexin and a neurophilin) binding to a semaphorin ligand.
1 Q95XP4 (/IC)
Semaphorin-plexin signaling pathway GO:0071526
A series of molecular signals generated as a consequence of a semaphorin receptor (composed of a plexin and a neurophilin) binding to a semaphorin ligand.
1 Q80UG2 (/IGI)
Negative regulation of transforming growth factor beta production GO:0071635
Any process that stops, prevents, or reduces the frequency, rate, or extent of production of transforming growth factor-beta.
1 P16056 (/IMP)
Olfactory bulb axon guidance GO:0071678
The process in which the migration of an axon growth cone of a neuron in the olfactory bulb is directed to its target in the brain in response to a combination of attractive and repulsive cues.
1 Q9V4A7 (/IMP)
Reactive oxygen species metabolic process GO:0072593
The chemical reactions and pathways involving a reactive oxygen species, any molecules or ions formed by the incomplete one-electron reduction of oxygen. They contribute to the microbicidal activity of phagocytes, regulation of signal transduction and gene expression, and the oxidative damage to biopolymers.
1 P16056 (/IMP)
Semaphorin-plexin signaling pathway involved in bone trabecula morphogenesis GO:1900220
Any semaphorin-plexin signaling pathway that contributes to bone trabecula morphogenesis.
1 Q8CJH3 (/IMP)
Semaphorin-plexin signaling pathway involved in bone trabecula morphogenesis GO:1900220
Any semaphorin-plexin signaling pathway that contributes to bone trabecula morphogenesis.
1 O43157 (/ISS)
Regulation of cellular response to oxidative stress GO:1900407
Any process that modulates the frequency, rate or extent of cellular response to oxidative stress.
1 P16056 (/IMP)
Positive regulation of p38MAPK cascade GO:1900745
Any process that activates or increases the frequency, rate or extent of p38MAPK cascade.
1 P16056 (/IMP)
Negative regulation of hydrogen peroxide-mediated programmed cell death GO:1901299
Any process that stops, prevents or reduces the frequency, rate or extent of hydrogen peroxide-mediated programmed cell death.
1 P08581 (/IMP)
Negative regulation of hydrogen peroxide-mediated programmed cell death GO:1901299
Any process that stops, prevents or reduces the frequency, rate or extent of hydrogen peroxide-mediated programmed cell death.
1 P16056 (/ISO)
Negative regulation of guanyl-nucleotide exchange factor activity GO:1905098
Any process that stops, prevents or reduces the frequency, rate or extent of guanyl-nucleotide exchange factor activity.
1 P08581 (/IDA)
Negative regulation of guanyl-nucleotide exchange factor activity GO:1905098
Any process that stops, prevents or reduces the frequency, rate or extent of guanyl-nucleotide exchange factor activity.
1 P16056 (/ISO)
Positive regulation of endothelial cell chemotaxis GO:2001028
Any process that activates or increases the frequency, rate or extent of endothelial cell chemotaxis.
1 P08581 (/IMP)
Positive regulation of endothelial cell chemotaxis GO:2001028
Any process that activates or increases the frequency, rate or extent of endothelial cell chemotaxis.
1 P16056 (/ISO)
Regulation of neuron migration GO:2001222
Any process that modulates the frequency, rate or extent of neuron migration.
1 B2RXS4 (/IMP)
Regulation of neuron migration GO:2001222
Any process that modulates the frequency, rate or extent of neuron migration.
1 O15031 (/ISS)

There are 43 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
11 O43157 (/TAS) O75051 (/TAS) P08581 (/TAS) P51805 (/TAS) P70206 (/TAS) P70207 (/TAS) Q04912 (/TAS) Q80UG2 (/TAS) Q9HCM2 (/TAS) Q9UIW2 (/TAS)
(1 more)
Semaphorin receptor complex GO:0002116
A stable binary complex of a neurophilin and a plexin, together forming a functional semaphorin receptor.
5 O43157 (/TAS) O75051 (/TAS) P51805 (/TAS) Q9HCM2 (/TAS) Q9UIW2 (/TAS)
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
5 O15031 (/IDA) P08581 (/IDA) Q04912 (/IDA) Q95XP4 (/IDA) Q9ULL4 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
4 P51805 (/IDA) P97523 (/IDA) Q62190 (/IDA) Q9V4A7 (/IDA)
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
4 B2RXS4 (/ISO) P16056 (/ISO) Q62190 (/ISO) Q9QY40 (/ISO)
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
3 B2RXS4 (/IDA) O43157 (/IDA) P70207 (/IDA)
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
3 H9XVP3 (/ISM) Q86M56 (/ISM) Q9V491 (/ISM)
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
3 O15031 (/ISS) O75051 (/ISS) Q8CJH3 (/ISS)
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
3 O43157 (/TAS) P08581 (/TAS) Q04912 (/TAS)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
3 B0S5N4 (/IDA) P16056 (/IDA) P70206 (/IDA)
Integral component of membrane GO:0016021
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
2 P08581 (/NAS) P97523 (/NAS)
Dendrite GO:0030425
A neuron projection that has a short, tapering, often branched, morphology, receives and integrates signals from other neurons or from sensory stimuli, and conducts a nerve impulse towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.
2 P97523 (/IDA) Q9V4A7 (/IDA)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
2 O15031 (/IDA) Q9UIW2 (/IDA)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
2 B2RXS4 (/ISO) P70206 (/ISO)
Stress fiber GO:0001725
A contractile actin filament bundle that consists of short actin filaments with alternating polarity, cross-linked by alpha-actinin and possibly other actin bundling proteins, and with myosin present in a periodic distribution along the fiber.
1 Q62190 (/IDA)
Ruffle GO:0001726
Projection at the leading edge of a crawling cell; the protrusions are supported by a microfilament meshwork.
1 Q3V5K0 (/IDA)
Semaphorin receptor complex GO:0002116
A stable binary complex of a neurophilin and a plexin, together forming a functional semaphorin receptor.
1 O43157 (/IDA)
Semaphorin receptor complex GO:0002116
A stable binary complex of a neurophilin and a plexin, together forming a functional semaphorin receptor.
1 Q8CJH3 (/ISO)
Semaphorin receptor complex GO:0002116
A stable binary complex of a neurophilin and a plexin, together forming a functional semaphorin receptor.
1 Q8CJH3 (/ISS)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
1 P97523 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 P51805 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 P70208 (/ISO)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 P97523 (/IDA)
Vacuole GO:0005773
A closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material. Cells contain one or several vacuoles, that may have different functions from each other. Vacuoles have a diverse array of functions. They can act as a storage organelle for nutrients or waste products, as a degradative compartment, as a cost-effective way of increasing cell size, and as a homeostatic regulator controlling both turgor pressure and pH of the cytosol.
1 Q62190 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 P70208 (/ISO)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 Q80UG2 (/ISS)
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
1 Q8CJH3 (/ISO)
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
1 O43157 (/NAS)
Basal plasma membrane GO:0009925
The region of the plasma membrane located at the basal end of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis.
1 P08581 (/IDA)
Basal plasma membrane GO:0009925
The region of the plasma membrane located at the basal end of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis.
1 P16056 (/ISO)
Postsynaptic density GO:0014069
An electron dense network of proteins within and adjacent to the postsynaptic membrane in asymetric synapses. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize them such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components.
1 P97523 (/IDA)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
1 P51805 (/TAS)
Integral component of membrane GO:0016021
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
1 Q3V5K0 (/IDA)
Integral component of membrane GO:0016021
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
1 Q6BEA0 (/ISS)
Cell junction GO:0030054
A cellular component that forms a specialized region of connection between two or more cells or between a cell and the extracellular matrix. At a cell junction, anchoring proteins extend through the plasma membrane to link cytoskeletal proteins in one cell to cytoskeletal proteins in neighboring cells or to proteins in the extracellular matrix.
1 P51805 (/IDA)
Cell junction GO:0030054
A cellular component that forms a specialized region of connection between two or more cells or between a cell and the extracellular matrix. At a cell junction, anchoring proteins extend through the plasma membrane to link cytoskeletal proteins in one cell to cytoskeletal proteins in neighboring cells or to proteins in the extracellular matrix.
1 P70208 (/ISO)
Sperm flagellum GO:0036126
A microtubule-based flagellum (or cilium) that is part of a sperm, a mature male germ cell that develops from a spermatid.
1 P97523 (/IDA)
Neuron projection GO:0043005
A prolongation or process extending from a nerve cell, e.g. an axon or dendrite.
1 P97523 (/IDA)
Neuronal cell body GO:0043025
The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
1 P97523 (/IDA)
Intracellular membrane-bounded organelle GO:0043231
Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
1 P51805 (/IDA)
Intracellular membrane-bounded organelle GO:0043231
Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
1 P70208 (/ISO)
Postsynaptic membrane GO:0045211
A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane.
1 P97523 (/IDA)
Excitatory synapse GO:0060076
A synapse in which an action potential in the presynaptic cell increases the probability of an action potential occurring in the postsynaptic cell.
1 P97523 (/IDA)