The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:
"YVTN repeat-like/Quinoprotein amine dehydrogenase
".
FunFam 102433: General transcriptional corepressor TUP1
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 9 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
3 | P16649 (/IPI) Q09715 (/IPI) Q9UUG8 (/IPI) |
|
Histone binding GO:0042393
Interacting selectively and non-covalently with a histone, any of a group of water-soluble proteins found in association with the DNA of plant and animal chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in nonspecific suppression of gene activity.
|
3 | P16649 (/IDA) Q09715 (/IDA) Q9UUG8 (/IDA) |
|
Transcriptional repressor activity, RNA polymerase II transcription factor binding GO:0001191
Interacting selectively and non-covalently with an RNA polymerase II transcription factor, which may be a single protein or a complex, in order to stop, prevent, or reduce the frequency, rate or extent of transcription from an RNA polymerase II promoter. A protein binding transcription factor may or may not also interact with the template nucleic acid (either DNA or RNA) as well.
|
1 | P16649 (/IDA) |
|
Transcriptional repressor activity, RNA polymerase II transcription factor binding GO:0001191
Interacting selectively and non-covalently with an RNA polymerase II transcription factor, which may be a single protein or a complex, in order to stop, prevent, or reduce the frequency, rate or extent of transcription from an RNA polymerase II promoter. A protein binding transcription factor may or may not also interact with the template nucleic acid (either DNA or RNA) as well.
|
1 | P16649 (/IMP) |
|
Mediator complex binding GO:0036033
Interacting selectively and non-covalently with a mediator complex. The mediator complex is a protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins.
|
1 | P16649 (/IDA) |
|
Mediator complex binding GO:0036033
Interacting selectively and non-covalently with a mediator complex. The mediator complex is a protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins.
|
1 | P16649 (/IPI) |
|
Histone deacetylase binding GO:0042826
Interacting selectively and non-covalently with the enzyme histone deacetylase.
|
1 | P16649 (/IDA) |
|
Histone deacetylase binding GO:0042826
Interacting selectively and non-covalently with the enzyme histone deacetylase.
|
1 | P16649 (/IPI) |
|
Phosphatidylinositol-3,5-bisphosphate binding GO:0080025
Interacting selectively and non-covalently with phosphatidylinositol-3,5-bisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3' and 5' positions.
|
1 | P16649 (/IDA) |
There are 40 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Negative regulation of transcription from RNA polymerase II promoter GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter.
|
4 | P0CY34 (/IMP) P16649 (/IMP) Q09715 (/IMP) Q9UUG8 (/IMP) |
|
Negative regulation of transcription by glucose GO:0045014
Any process involving glucose that stops, prevents or reduces the rate of transcription. The presence of glucose in the growth medium inhibits the synthesis of certain enzymes in bacteria growing on the medium. For example, transcription of some catabolic operons is under negative control by specific repressors and glucose is an anti-inducer of xylose utilization and glycerol kinase.
|
2 | Q09715 (/IMP) Q9UUG8 (/IMP) |
|
Negative regulation of transcription from RNA polymerase II promoter by glucose GO:0000433
Any process involving glucose that stops, prevents or reduces the rate of transcription from an RNA polymerase II promoter.
|
1 | P16649 (/IMP) |
|
Negative regulation of mating-type specific transcription from RNA polymerase II promoter GO:0001198
Any mating-type specific process that stops, prevents or reduces the rate of transcription from an RNA polymerase II promoter.
|
1 | P16649 (/IMP) |
|
Chromatin silencing GO:0006342
Repression of transcription by altering the structure of chromatin, e.g. by conversion of large regions of DNA into an inaccessible state often called heterochromatin.
|
1 | Q9UUG8 (/IMP) |
|
Chromatin silencing GO:0006342
Repression of transcription by altering the structure of chromatin, e.g. by conversion of large regions of DNA into an inaccessible state often called heterochromatin.
|
1 | Q09715 (/TAS) |
|
Negative regulation of transcription from RNA polymerase II promoter during mitotic cell cycle GO:0007070
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter that occurs during the mitotic cell cycle.
|
1 | P16649 (/IMP) |
|
Cellular response to starvation GO:0009267
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of nourishment.
|
1 | P0CY34 (/IMP) |
|
Quorum sensing GO:0009372
The process in which single-celled organisms monitor their population density by detecting the concentration of small, diffusible signal molecules produced by the cells themselves.
|
1 | P0CY34 (/IMP) |
|
Pathogenesis GO:0009405
The set of specific processes that generate the ability of an organism to induce an abnormal, generally detrimental state in another organism.
|
1 | P0CY34 (/IMP) |
|
Positive regulation of sterigmatocystin biosynthetic process GO:0010914
Any process that increases the rate, frequency, or extent of sterigmatocystin biosynthesis. Sterigmatocystin biosynthetic processes are the chemical reactions and pathways resulting in the formation of sterigmatocystin, a carcinogenic mycotoxin produced in high yields by strains of the common molds.
|
1 | C8V0I4 (/IMP) |
|
Single organismal cell-cell adhesion GO:0016337
The attachment of one cell to another cell via adhesion molecules, where both cells are part of the same organism.
|
1 | P0CY34 (/IMP) |
|
Nucleosome positioning GO:0016584
Ordering of successions of nucleosomes into regular arrays so that nucleosomes are positioned at defined distances from one another.
|
1 | P16649 (/IDA) |
|
Nucleosome positioning GO:0016584
Ordering of successions of nucleosomes into regular arrays so that nucleosomes are positioned at defined distances from one another.
|
1 | C8V0I4 (/IMP) |
|
Filamentous growth GO:0030447
The process in which a multicellular organism, a unicellular organism or a group of unicellular organisms grow in a threadlike, filamentous shape.
|
1 | P0CY34 (/IMP) |
|
Cellular response to drug GO:0035690
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease.
|
1 | P0CY34 (/IMP) |
|
Negative regulation of dipeptide transport by negative regulation of transcription from RNA polymerase II promoter GO:0035955
Any process that stops, prevents or reduces the frequency, rate or extent of dipeptide transport by stopping, preventing or reducing the frequency, rate or extent of transcription from an RNA polymerase II promoter.
|
1 | P16649 (/IMP) |
|
Phenotypic switching GO:0036166
A reversible switch of a cell from one cell type or form to another, at a frequency above the expected frequency for somatic mutations. Phenotypic switching involves changes in cell morphology and altered gene expression patterns. For example, Candida albicans switches from white cells to opaque cells for sexual mating. Phenotypic switching also occurs in multicellular organisms; smooth muscle cells (SMCs) exhibit phenotypic transitions to allow rapid adaption to fluctuating environmental cues.
|
1 | P0CY34 (/IMP) |
|
Filamentous growth of a population of unicellular organisms in response to starvation GO:0036170
The process in which a group of unicellular organisms grow in a threadlike, filamentous shape in response to deprivation of nourishment.
|
1 | P0CY34 (/IMP) |
|
Filamentous growth of a population of unicellular organisms in response to chemical stimulus GO:0036171
The process in which a group of unicellular organisms grow in a threadlike, filamentous shape in response to a chemical stimulus.
|
1 | P0CY34 (/IMP) |
|
Filamentous growth of a population of unicellular organisms in response to biotic stimulus GO:0036180
The process in which a group of unicellular organisms grow in a threadlike, filamentous shape in response to a biotic (living) stimulus.
|
1 | P0CY34 (/IMP) |
|
Chromatin remodeling in response to cation stress GO:0043156
Structural changes to eukaryotic chromatin occurring as a result of cation stress, an increase or decrease in the concentration of positively charged ions in the environment.
|
1 | Q9UUG8 (/IMP) |
|
Histone exchange GO:0043486
The replacement, within chromatin, of resident histones or histone subunits with alternative, sometimes variant, histones or subunits.
|
1 | P16649 (/IMP) |
|
Positive regulation of sexual sporulation resulting in formation of a cellular spore GO:0043941
Any process that activates, maintains or increases the frequency, rate or extent of the formation of cellular spores derived from the products of meiosis.
|
1 | C8V0I4 (/IMP) |
|
Development of symbiont in host GO:0044114
The progression of an organism from an initial condition to a later condition, occurring within the cells or tissues of the host organism. This may (but not necessarily) include a filamentous growth form, and also can include secretion of proteases and lipases to break down host tissue. The host is defined as the larger of the organisms involved in a symbiotic interaction.
|
1 | P0CY34 (/IMP) |
|
Filamentous growth of a population of unicellular organisms GO:0044182
The process in which a group of unicellular organisms grow in a threadlike, filamentous shape.
|
1 | P0CY34 (/IMP) |
|
Entry into host GO:0044409
Penetration by an organism into the body, tissues, or cells of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction.
|
1 | P0CY34 (/IMP) |
|
Sterigmatocystin biosynthetic process GO:0045461
The chemical reactions and pathways resulting in the formation of sterigmatocystin, a carcinogenic mycotoxin produced in high yields by strains of the common molds.
|
1 | C8V0I4 (/IMP) |
|
Negative regulation of isoprenoid metabolic process GO:0045827
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving isoprenoid.
|
1 | P0CY34 (/IMP) |
|
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
|
1 | P0CY34 (/IGI) |
|
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
|
1 | P0CY34 (/IMP) |
|
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
|
1 | P0CY34 (/ISS) |
|
Evasion or tolerance of defenses of other organism involved in symbiotic interaction GO:0051834
Any process, either active or passive, by which an organism avoids or tolerates the effects of a second organism's defense(s), where the two organisms are in a symbiotic interaction. Defenses may be induced by the presence of the organism or may be preformed (e.g. physical barriers).
|
1 | P0CY34 (/IMP) |
|
Cleistothecium development GO:0070791
The process whose specific outcome is the progression of the cleistothecium over time, from its formation to the mature structure. The cleistothecium is a closed sexual fruiting body that contains ascospores in linear asci, characteristic of some filamentous Ascomycete fungi such as members of the genera Aspergillus and Emericella.
|
1 | C8V0I4 (/IMP) |
|
Cellular response to copper ion GO:0071280
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a copper ion stimulus.
|
1 | P0CY34 (/IMP) |
|
Cellular response to farnesol GO:0097308
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a farnesol stimulus.
|
1 | P0CY34 (/IMP) |
|
Negative regulation of filamentous growth of a population of unicellular organisms GO:1900429
Any process that stops, prevents or reduces the frequency, rate or extent of filamentous growth of a population of unicellular organisms.
|
1 | P0CY34 (/IMP) |
|
Regulation of invasive growth in response to glucose limitation GO:2000217
Any process that modulates the frequency, rate or extent of invasive growth in response to glucose limitation.
|
1 | P16649 (/IMP) |
|
Regulation of fatty acid biosynthetic process by regulation of transcription from RNA polymerase II promoter GO:2000531
Any process that modulates the frequency, rate or extent of the biosynthesis of fatty acids, by modulating the frequency, rate or extent of transcription from an RNA polymerase II promoter.
|
1 | P16649 (/IMP) |
|
Regulation of response to DNA damage stimulus GO:2001020
Any process that modulates the frequency, rate or extent of response to DNA damage stimulus.
|
1 | P16649 (/IMP) |
There are 8 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
3 | P16649 (/IDA) Q09715 (/IDA) Q9UUG8 (/IDA) |
|
Nuclear chromatin GO:0000790
The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome in the nucleus.
|
2 | Q09715 (/IC) Q9UUG8 (/IC) |
|
Nuclear chromatin GO:0000790
The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome in the nucleus.
|
2 | Q09715 (/IDA) Q9UUG8 (/IDA) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
2 | Q09715 (/IDA) Q9UUG8 (/IDA) |
|
Protein complex GO:0043234
A stable macromolecular complex composed (only) of two or more polypeptide subunits along with any covalently attached molecules (such as lipid anchors or oligosaccharide) or non-protein prosthetic groups (such as nucleotides or metal ions). Prosthetic group in this context refers to a tightly bound cofactor. The component polypeptide subunits may be identical.
|
2 | Q09715 (/NAS) Q9UUG8 (/NAS) |
|
Nuclear transcriptional repressor complex GO:0090568
A protein complex, located in the nucleus, that possesses activity that prevents or downregulates transcription.
|
2 | Q09715 (/EXP) Q9UUG8 (/EXP) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
1 | Q9UUG8 (/IDA) |
|
Transcriptional repressor complex GO:0017053
A protein complex that possesses activity that prevents or downregulates transcription.
|
1 | P16649 (/IPI) |