The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Kelch-type beta propeller
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 2825: Host cell factor 1

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 15 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Chromatin binding GO:0003682
Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
2 P51611 (/ISS) Q61191 (/ISS)
Transcription coactivator activity GO:0003713
Interacting selectively and non-covalently with a activating transcription factor and also with the basal transcription machinery in order to increase the frequency, rate or extent of transcription. Cofactors generally do not bind the template nucleic acid, but rather mediate protein-protein interactions between activating transcription factors and the basal transcription machinery.
2 P51610 (/IMP) P51611 (/IMP)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
2 P51610 (/IPI) Q61191 (/IPI)
Transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding GO:0001205
Interacting selectively and non-covalently with a sequence of DNA that is in a distal enhancer region for RNA polymerase II (RNAP II) in order to activate or increase the frequency, rate or extent of transcription from the RNAP II promoter.
1 Q61191 (/IDA)
Chromatin binding GO:0003682
Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
1 P51610 (/IDA)
Chromatin binding GO:0003682
Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
1 Q61191 (/ISO)
Transcription factor activity, sequence-specific DNA binding GO:0003700
Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex.
1 P51610 (/NAS)
Transcription coactivator activity GO:0003713
Interacting selectively and non-covalently with a activating transcription factor and also with the basal transcription machinery in order to increase the frequency, rate or extent of transcription. Cofactors generally do not bind the template nucleic acid, but rather mediate protein-protein interactions between activating transcription factors and the basal transcription machinery.
1 Q61191 (/ISO)
Transcription coactivator activity GO:0003713
Interacting selectively and non-covalently with a activating transcription factor and also with the basal transcription machinery in order to increase the frequency, rate or extent of transcription. Cofactors generally do not bind the template nucleic acid, but rather mediate protein-protein interactions between activating transcription factors and the basal transcription machinery.
1 Q61191 (/TAS)
Activating transcription factor binding GO:0033613
Interacting selectively and non-covalently with an activating transcription factor, any protein whose activity is required to initiate or upregulate transcription.
1 P51610 (/IPI)
Activating transcription factor binding GO:0033613
Interacting selectively and non-covalently with an activating transcription factor, any protein whose activity is required to initiate or upregulate transcription.
1 Q61191 (/ISO)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
1 P51610 (/IPI)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
1 Q61191 (/ISO)
Cadherin binding GO:0045296
Interacting selectively and non-covalently with cadherin, a type I membrane protein involved in cell adhesion.
1 P51610 (/IDA)
Cadherin binding GO:0045296
Interacting selectively and non-covalently with cadherin, a type I membrane protein involved in cell adhesion.
1 Q61191 (/ISO)

There are 28 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Negative regulation of transcription from RNA polymerase II promoter GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter.
3 P51610 (/ISS) P51611 (/ISS) Q61191 (/ISS)
Histone H4-K5 acetylation GO:0043981
The modification of histone H4 by the addition of an acetyl group to a lysine residue at position 5 of the histone.
2 P51611 (/ISS) Q61191 (/ISS)
Histone H4-K8 acetylation GO:0043982
The modification of histone H4 by the addition of an acetyl group to a lysine residue at position 8 of the histone.
2 P51611 (/ISS) Q61191 (/ISS)
Histone H4-K16 acetylation GO:0043984
The modification of histone H4 by the addition of an acetyl group to a lysine residue at position 16 of the histone.
2 P51611 (/ISS) Q61191 (/ISS)
Protein stabilization GO:0050821
Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation.
2 P51611 (/ISS) Q61191 (/ISS)
Negative regulation of transcription from RNA polymerase II promoter GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter.
1 D3ZN95 (/IMP)
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
1 P51610 (/IDA)
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
1 Q61191 (/ISO)
Transcription from RNA polymerase II promoter GO:0006366
The synthesis of RNA from a DNA template by RNA polymerase II, originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs).
1 P51610 (/TAS)
Mitochondrion organization GO:0007005
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrion; includes mitochondrial morphogenesis and distribution, and replication of the mitochondrial genome as well as synthesis of new mitochondrial components.
1 P51610 (/TAS)
Positive regulation of gene expression GO:0010628
Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
1 P51610 (/IDA)
Positive regulation of gene expression GO:0010628
Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
1 Q61191 (/ISO)
Protein deubiquitination GO:0016579
The removal of one or more ubiquitin groups from a protein.
1 P51610 (/TAS)
Release from viral latency GO:0019046
The process by which a virus begins to replicate following a latency replication decision (switch).
1 Q61191 (/IDA)
Release from viral latency GO:0019046
The process by which a virus begins to replicate following a latency replication decision (switch).
1 P51610 (/NAS)
Regulation of protein complex assembly GO:0043254
Any process that modulates the frequency, rate or extent of protein complex assembly.
1 P51610 (/IDA)
Regulation of protein complex assembly GO:0043254
Any process that modulates the frequency, rate or extent of protein complex assembly.
1 Q61191 (/ISO)
Histone H4-K5 acetylation GO:0043981
The modification of histone H4 by the addition of an acetyl group to a lysine residue at position 5 of the histone.
1 P51610 (/IDA)
Histone H4-K5 acetylation GO:0043981
The modification of histone H4 by the addition of an acetyl group to a lysine residue at position 5 of the histone.
1 Q61191 (/ISO)
Histone H4-K8 acetylation GO:0043982
The modification of histone H4 by the addition of an acetyl group to a lysine residue at position 8 of the histone.
1 P51610 (/IDA)
Histone H4-K8 acetylation GO:0043982
The modification of histone H4 by the addition of an acetyl group to a lysine residue at position 8 of the histone.
1 Q61191 (/ISO)
Histone H4-K16 acetylation GO:0043984
The modification of histone H4 by the addition of an acetyl group to a lysine residue at position 16 of the histone.
1 P51610 (/IDA)
Histone H4-K16 acetylation GO:0043984
The modification of histone H4 by the addition of an acetyl group to a lysine residue at position 16 of the histone.
1 Q61191 (/ISO)
Positive regulation of cell cycle GO:0045787
Any process that activates or increases the rate or extent of progression through the cell cycle.
1 P51610 (/TAS)
Positive regulation of mitotic cell cycle GO:0045931
Any process that activates or increases the rate or extent of progression through the mitotic cell cycle.
1 P51611 (/IMP)
Protein stabilization GO:0050821
Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation.
1 P51610 (/IDA)
Protein stabilization GO:0050821
Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation.
1 Q61191 (/ISO)
Cellular response to organic cyclic compound GO:0071407
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic cyclic compound stimulus.
1 D3ZN95 (/IEP)

There are 23 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
3 D3ZN95 (/IDA) P51610 (/IDA) Q61191 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
3 D3ZN95 (/IDA) P51610 (/IDA) Q61191 (/IDA)
Histone acetyltransferase complex GO:0000123
A protein complex that possesses histone acetyltransferase activity.
2 P51611 (/ISS) Q61191 (/ISS)
Neuronal cell body GO:0043025
The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
2 P51611 (/ISS) Q61191 (/ISS)
Set1C/COMPASS complex GO:0048188
A conserved protein complex that catalyzes methylation of histone H3. In Saccharomyces the complex contains Shg1p, Sdc1p, Swd1p, Swd2p, Swd3p, Spp1p, Bre2p, and the trithorax-related Set1p; in mammals it contains the catalytic subunit (SETD1A or SETD1B), WDR5, WDR82, RBBP5, ASH2L/ASH2, CXXC1/CFP1, HCFC1 and DPY30.
2 P51611 (/ISS) Q61191 (/ISS)
MLL1 complex GO:0071339
A protein complex that can methylate lysine-4 of histone H3. MLL1/MLL is the catalytic methyltransferase subunit, and the complex also contains the core components ASH2L, HCFC1/HCF1 WDR5 and RBBP5.
2 P51611 (/ISS) Q61191 (/ISS)
Histone acetyltransferase complex GO:0000123
A protein complex that possesses histone acetyltransferase activity.
1 P51610 (/IDA)
Histone acetyltransferase complex GO:0000123
A protein complex that possesses histone acetyltransferase activity.
1 Q61191 (/ISO)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 Q61191 (/ISO)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 P51611 (/ISS)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
1 P51610 (/TAS)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 Q61191 (/ISO)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 P51611 (/ISS)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
1 P51610 (/IDA)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
1 Q61191 (/ISO)
Axon GO:0030424
The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter.
1 D3ZN95 (/IDA)
Dendrite GO:0030425
A neuron projection that has a short, tapering, often branched, morphology, receives and integrates signals from other neurons or from sensory stimuli, and conducts a nerve impulse towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.
1 D3ZN95 (/IDA)
Neuronal cell body GO:0043025
The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
1 P51610 (/IDA)
Neuronal cell body GO:0043025
The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
1 Q61191 (/ISO)
Set1C/COMPASS complex GO:0048188
A conserved protein complex that catalyzes methylation of histone H3. In Saccharomyces the complex contains Shg1p, Sdc1p, Swd1p, Swd2p, Swd3p, Spp1p, Bre2p, and the trithorax-related Set1p; in mammals it contains the catalytic subunit (SETD1A or SETD1B), WDR5, WDR82, RBBP5, ASH2L/ASH2, CXXC1/CFP1, HCFC1 and DPY30.
1 P51610 (/IDA)
Set1C/COMPASS complex GO:0048188
A conserved protein complex that catalyzes methylation of histone H3. In Saccharomyces the complex contains Shg1p, Sdc1p, Swd1p, Swd2p, Swd3p, Spp1p, Bre2p, and the trithorax-related Set1p; in mammals it contains the catalytic subunit (SETD1A or SETD1B), WDR5, WDR82, RBBP5, ASH2L/ASH2, CXXC1/CFP1, HCFC1 and DPY30.
1 Q61191 (/ISO)
MLL1 complex GO:0071339
A protein complex that can methylate lysine-4 of histone H3. MLL1/MLL is the catalytic methyltransferase subunit, and the complex also contains the core components ASH2L, HCFC1/HCF1 WDR5 and RBBP5.
1 P51610 (/IDA)
MLL1 complex GO:0071339
A protein complex that can methylate lysine-4 of histone H3. MLL1/MLL is the catalytic methyltransferase subunit, and the complex also contains the core components ASH2L, HCFC1/HCF1 WDR5 and RBBP5.
1 Q61191 (/ISO)