The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
TolB, C-terminal domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 33168: Senescence marker protein-30 (SMP-30)

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 13 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Calcium ion binding GO:0005509
Interacting selectively and non-covalently with calcium ions (Ca2+).
13 H8F4T3 (/ISS) Q06AA3 (/ISS) Q15493 (/ISS) Q2PFX5 (/ISS) Q5R837 (/ISS) Q64374 (/ISS) Q6DF62 (/ISS) Q6TLF6 (/ISS) Q9I922 (/ISS) Q9I923 (/ISS)
(3 more)
Gluconolactonase activity GO:0004341
Catalysis of the reaction: D-glucono-1,5-lactone + H2O = D-gluconate.
11 Q03336 (/ISS) Q06AA3 (/ISS) Q2PFX5 (/ISS) Q5R837 (/ISS) Q64374 (/ISS) Q6DF62 (/ISS) Q6TLF6 (/ISS) Q9I922 (/ISS) Q9I923 (/ISS) Q9TTJ5 (/ISS)
(1 more)
Zinc ion binding GO:0008270
Interacting selectively and non-covalently with zinc (Zn) ions.
11 Q03336 (/ISS) Q06AA3 (/ISS) Q2PFX5 (/ISS) Q5R837 (/ISS) Q64374 (/ISS) Q6DF62 (/ISS) Q6TLF6 (/ISS) Q9I922 (/ISS) Q9I923 (/ISS) Q9TTJ5 (/ISS)
(1 more)
Gluconolactonase activity GO:0004341
Catalysis of the reaction: D-glucono-1,5-lactone + H2O = D-gluconate.
4 Q03336 (/IDA) Q15493 (/IDA) Q64374 (/IDA) Q8P3F8 (/IDA)
Calcium ion binding GO:0005509
Interacting selectively and non-covalently with calcium ions (Ca2+).
4 Q03336 (/IDA) Q15493 (/IDA) Q7SIG4 (/IDA) Q8P3F8 (/IDA)
Gluconolactonase activity GO:0004341
Catalysis of the reaction: D-glucono-1,5-lactone + H2O = D-gluconate.
1 Q64374 (/ISO)
Calcium ion binding GO:0005509
Interacting selectively and non-covalently with calcium ions (Ca2+).
1 Q64374 (/ISO)
Calcium ion binding GO:0005509
Interacting selectively and non-covalently with calcium ions (Ca2+).
1 Q15493 (/TAS)
Zinc ion binding GO:0008270
Interacting selectively and non-covalently with zinc (Zn) ions.
1 Q15493 (/IDA)
Zinc ion binding GO:0008270
Interacting selectively and non-covalently with zinc (Zn) ions.
1 Q64374 (/ISO)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
1 Q8P3F8 (/IPI)
Diisopropyl-fluorophosphatase activity GO:0047862
Catalysis of the reaction: diisopropyl fluorophosphate + H(2)O = diisopropyl phosphate + 2 H(+) + hydrogen fluoride.
1 Q7SIG4 (/IDA)
L-arabinonolactonase activity GO:0050021
Catalysis of the reaction: L-arabinono-1,4-lactone + H(2)O = L-arabinonate + H(+).
1 Q1JUP5 (/IDA)

There are 45 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cellular calcium ion homeostasis GO:0006874
Any process involved in the maintenance of an internal steady state of calcium ions at the level of a cell.
9 Q15493 (/ISS) Q2PFX5 (/ISS) Q5R837 (/ISS) Q64374 (/ISS) Q6DF62 (/ISS) Q6TLF6 (/ISS) Q9I922 (/ISS) Q9I923 (/ISS) Q9TTJ5 (/ISS)
Positive regulation of ATPase activity GO:0032781
Any process that activates or increases the rate of ATP hydrolysis by an ATPase.
9 Q15493 (/ISS) Q2PFX5 (/ISS) Q5R837 (/ISS) Q64374 (/ISS) Q6DF62 (/ISS) Q6TLF6 (/ISS) Q9I922 (/ISS) Q9I923 (/ISS) Q9TTJ5 (/ISS)
Regulation of calcium-mediated signaling GO:0050848
Any process that modulates the frequency, rate or extent of calcium-mediated signaling, the process in which a cell uses calcium ions to convert an extracellular signal into a response.
9 Q15493 (/ISS) Q2PFX5 (/ISS) Q5R837 (/ISS) Q64374 (/ISS) Q6DF62 (/ISS) Q6TLF6 (/ISS) Q9I922 (/ISS) Q9I923 (/ISS) Q9TTJ5 (/ISS)
L-ascorbic acid biosynthetic process GO:0019853
The chemical reactions and pathways resulting in the formation of L-ascorbic acid; L-ascorbic acid ionizes to give L-ascorbate, (2R)-2-
8 Q03336 (/ISS) Q06AA3 (/ISS) Q6DF62 (/ISS) Q6TLF6 (/ISS) Q9I922 (/ISS) Q9I923 (/ISS) Q9TTJ5 (/ISS) Q9TTJ6 (/ISS)
Cold acclimation GO:0009631
Any process that increases freezing tolerance of an organism in response to low, nonfreezing temperatures.
2 H8F4T3 (/IEP) Q9VFG5 (/IEP)
Cold acclimation GO:0009631
Any process that increases freezing tolerance of an organism in response to low, nonfreezing temperatures.
2 H8F4T3 (/IMP) Q9VFG5 (/IMP)
Multicellular organism reproduction GO:0032504
The biological process in which new individuals are produced by one or two multicellular organisms. The new individuals inherit some proportion of their genetic material from the parent or parents.
2 Q76NR6 (/IEP) Q9VYR1 (/IEP)
Negative regulation of imaginal disc-derived wing size GO:0044720
Any process that reduces the size of an imaginal disc-derived wing.
2 H8F4T3 (/IMP) Q9VFG5 (/IMP)
Regulation of cell proliferation involved in imaginal disc-derived wing morphogenesis GO:0090256
Any process that modulates the frequency, rate, or extent of the multiplication or reproduction of cells, resulting in the expansion of a cell population that contributes to imaginal disc-derived wing morphogenesis.
2 H8F4T3 (/IMP) Q9VFG5 (/IMP)
Kidney development GO:0001822
The process whose specific outcome is the progression of the kidney over time, from its formation to the mature structure. The kidney is an organ that filters the blood and/or excretes the end products of body metabolism in the form of urine.
1 Q03336 (/IEP)
Liver development GO:0001889
The process whose specific outcome is the progression of the liver over time, from its formation to the mature structure. The liver is an exocrine gland which secretes bile and functions in metabolism of protein and carbohydrate and fat, synthesizes substances involved in the clotting of the blood, synthesizes vitamin A, detoxifies poisonous substances, stores glycogen, and breaks down worn-out erythrocytes.
1 Q03336 (/IEP)
Negative regulation of protein phosphorylation GO:0001933
Any process that stops, prevents or reduces the rate of addition of phosphate groups to amino acids within a protein.
1 Q03336 (/IMP)
Negative regulation of protein kinase activity GO:0006469
Any process that stops, prevents, or reduces the frequency, rate or extent of protein kinase activity.
1 Q03336 (/IMP)
Cellular calcium ion homeostasis GO:0006874
Any process involved in the maintenance of an internal steady state of calcium ions at the level of a cell.
1 Q03336 (/IDA)
Spermatogenesis GO:0007283
The process of formation of spermatozoa, including spermatocytogenesis and spermiogenesis.
1 Q03336 (/IDA)
Aging GO:0007568
A developmental process that is a deterioration and loss of function over time. Aging includes loss of functions such as resistance to disease, homeostasis, and fertility, as well as wear and tear. Aging includes cellular senescence, but is more inclusive. May precede death and may succeed developmental maturation (GO:0021700).
1 Q03336 (/IEP)
Positive regulation of triglyceride biosynthetic process GO:0010867
Any process that increases the rate, frequency, or extent of triglyceride biosynthesis. Triglyceride biosynthesis is the collection of chemical reactions and pathways resulting in the formation of triglyceride, any triester of glycerol.
1 Q03336 (/IDA)
Positive regulation of glucose metabolic process GO:0010907
Any process that increases the rate, frequency or extent of glucose metabolism. Glucose metabolic processes are the chemical reactions and pathways involving glucose, the aldohexose gluco-hexose.
1 Q03336 (/IDA)
Positive regulation of phosphatase activity GO:0010922
Any process that increases the rate or frequency of phosphatase activity. Phosphatases catalyze the hydrolysis of phosphoric monoesters, releasing inorganic phosphate.
1 Q03336 (/IMP)
L-arabinose catabolic process to 2-oxoglutarate GO:0019570
The chemical reactions and pathways resulting in the breakdown of L-arabinose into other compounds, including 2-oxoglutarate.
1 Q1JUP5 (/IDA)
L-ascorbic acid biosynthetic process GO:0019853
The chemical reactions and pathways resulting in the formation of L-ascorbic acid; L-ascorbic acid ionizes to give L-ascorbate, (2R)-2-
1 Q64374 (/IDA)
Negative regulation of cell growth GO:0030308
Any process that stops, prevents, or reduces the frequency, rate, extent or direction of cell growth.
1 P56553 (/IEP)
Negative regulation of phosphoprotein phosphatase activity GO:0032515
Any process that stops or reduces the activity of a phosphoprotein phosphatase.
1 Q03336 (/IMP)
Positive regulation of ATPase activity GO:0032781
Any process that activates or increases the rate of ATP hydrolysis by an ATPase.
1 Q03336 (/IDA)
Negative regulation of GTPase activity GO:0034260
Any process that stops or reduces the rate of GTP hydrolysis by a GTPase.
1 Q03336 (/IMP)
Negative regulation of apoptotic process GO:0043066
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
1 Q03336 (/IDA)
Positive regulation of GTPase activity GO:0043547
Any process that activates or increases the activity of a GTPase.
1 Q03336 (/IDA)
Negative regulation of nitric oxide biosynthetic process GO:0045019
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of nitric oxide.
1 Q03336 (/IMP)
Positive regulation of fatty acid biosynthetic process GO:0045723
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of fatty acids.
1 Q03336 (/IDA)
Negative regulation of epithelial cell proliferation GO:0050680
Any process that stops, prevents or reduces the rate or extent of epithelial cell proliferation.
1 Q03336 (/IDA)
Regulation of calcium-mediated signaling GO:0050848
Any process that modulates the frequency, rate or extent of calcium-mediated signaling, the process in which a cell uses calcium ions to convert an extracellular signal into a response.
1 Q03336 (/IDA)
Negative regulation of cyclic-nucleotide phosphodiesterase activity GO:0051344
Any process that stops or reduces the rate of cyclic nucleotide phosphodiesterase activity, the catalysis of the reaction: nucleotide 3',5'-cyclic phosphate + H2O = nucleotide 5'-phosphate.
1 Q03336 (/IDA)
Liver regeneration GO:0097421
The regrowth of lost or destroyed liver.
1 Q03336 (/IEP)
Negative regulation of flagellated sperm motility GO:1901318
Any process that stops, prevents or reduces the frequency, rate or extent of flagellated sperm motility.
1 Q03336 (/IDA)
Positive regulation of superoxide dismutase activity GO:1901671
Any process that activates or increases the frequency, rate or extent of superoxide dismutase activity.
1 Q03336 (/IDA)
Positive regulation of calcium-transporting ATPase activity GO:1901896
Any process that activates or increases the frequency, rate or extent of calcium-transporting ATPase activity.
1 Q03336 (/IDA)
Negative regulation of RNA biosynthetic process GO:1902679
Any process that stops, prevents or reduces the frequency, rate or extent of RNA biosynthetic process.
1 Q03336 (/IMP)
Negative regulation of bone development GO:1903011
Any process that stops, prevents or reduces the frequency, rate or extent of bone development.
1 Q03336 (/IDA)
Negative regulation of bone development GO:1903011
Any process that stops, prevents or reduces the frequency, rate or extent of bone development.
1 Q03336 (/IMP)
Positive regulation of proteolysis involved in cellular protein catabolic process GO:1903052
Any process that activates or increases the frequency, rate or extent of proteolysis involved in cellular protein catabolic process.
1 Q03336 (/IDA)
Negative regulation of calcium-dependent ATPase activity GO:1903611
Any process that stops, prevents or reduces the frequency, rate or extent of calcium-dependent ATPase activity.
1 Q03336 (/IMP)
Negative regulation of DNA catabolic process GO:1903625
Any process that stops, prevents or reduces the frequency, rate or extent of DNA catabolic process.
1 Q03336 (/IDA)
Positive regulation of dUTP diphosphatase activity GO:1903629
Any process that activates or increases the frequency, rate or extent of dUTP diphosphatase activity.
1 Q03336 (/IDA)
Negative regulation of leucine-tRNA ligase activity GO:1903634
Any process that stops, prevents or reduces the frequency, rate or extent of leucine-tRNA ligase activity.
1 Q03336 (/IDA)
Negative regulation of DNA biosynthetic process GO:2000279
Any process that stops, prevents or reduces the frequency, rate or extent of DNA biosynthetic process.
1 Q03336 (/IMP)

There are 8 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
9 Q03336 (/ISS) Q15493 (/ISS) Q2PFX5 (/ISS) Q5R837 (/ISS) Q6DF62 (/ISS) Q6TLF6 (/ISS) Q9I922 (/ISS) Q9I923 (/ISS) Q9TTJ5 (/ISS)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
9 Q03336 (/ISS) Q15493 (/ISS) Q2PFX5 (/ISS) Q5R837 (/ISS) Q6DF62 (/ISS) Q6TLF6 (/ISS) Q9I922 (/ISS) Q9I923 (/ISS) Q9TTJ5 (/ISS)
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
2 Q76NR6 (/IDA) Q9VYR1 (/IDA)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
2 Q76NR6 (/IDA) Q9VYR1 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
2 Q03336 (/IDA) Q64374 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
2 H8F4T3 (/ISM) Q9VFG5 (/ISM)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 Q64374 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 Q03336 (/IDA)