View in Gene3D

CATH Superfamily 2.110.10.10

Hemopexin-like domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Hemopexin-like domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
« Back to all FunFams

FunFam 1534: Matrix metalloproteinase 1 (Interstitial collagena...

There are 5 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Interstitial collagenase. [EC: 3.4.24.7]
Cleavage of the triple helix of collagen at about three-quarters of the length of the molecule from the N-terminus, at 775-Gly-|-Ile-776 in the alpha-1(I) chain. Cleaves synthetic substrates and alpha-macroglobulins at bonds where P1' is a hydrophobic residue.
  • The enzyme takes its name from substrates of the interstitial collagen group - types I, II and III, all of which are cleaved in the helical domain.
  • Alpha-macroglobulins are cleaved much more rapidly.
  • The enzyme is widely distributed in vertebrate animals.
  • Belongs to peptidase family M10B.
 11 A0A061I979 B7PMT8 B7QD68 C9VZX3 P03956 P13943 P21692 P28053 Q9EPL5 Q9EPL6
(1 more...)
Gelatinase B. [EC: 3.4.24.35]
Cleavage of gelatin types I and V and collagen types IV and V.
  • Belongs to peptidase family M10B.
 9 A0A059PAA7 O18733 P14780 P41245 P41246 P50282 P52176 Q5D713 Q98TC6
Macrophage elastase. [EC: 3.4.24.65]
Hydrolysis of soluble and insoluble elastin. Specific cleavages are also produced at 14-Ala-|-Leu-15 and 16-Tyr-|-Leu-17 in the B chain of insulin.
  • Belongs to peptidase family M10B.
 5 G3GUV3 P34960 P39900 P79227 Q63341
Neutrophil collagenase. [EC: 3.4.24.34]
Cleavage of interstitial collagens in the triple helical domain. Unlike EC 3.4.24.7, this enzyme cleaves type III collagen more slowly than type I.
  • Similar to interstitial collagenase in specificity.
  • Stored in the specific granules of neutrophil leukocytes.
  • Belongs to peptidase family M10B.
 3 O70138 O88766 P22894
Gelatinase A. [EC: 3.4.24.24]
Cleavage of gelatin type I and collagen types IV, V, VII, X. Cleaves the collagen-like sequence Pro-Gln-Gly-|-Ile-Ala-Gly-Gln.
  • Belongs to peptidase family M10B.
 3 A0A0S1LG91 A0A173GP40 Q90611