View in Gene3D

CATH Superfamily 2.102.10.10

Rieske [2Fe-2S] iron-sulphur domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Rieske [2Fe-2S] iron-sulphur domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
« Back to all FunFams

FunFam 8229: Aromatic-ring-hydroxylating dioxygenase, alpha sub...

There are 19 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
3-phenylpropanoate dioxygenase. [EC: 1.14.12.19]
(1) 3-phenylpropanoate + NADH + O(2) = 3-(cis-5,6-dihydroxycyclohexa-1,3- dien-1-yl)propanoate + NAD(+). (2) (2E)-3-phenylprop-2-enoate + NADH + O(2) = (2E)-3-(2,3- dihydroxyphenyl)prop-2-enoate + NAD(+).
  • This enzyme catalyzes a step in the pathway of phenylpropanoid compounds degradation.
  • It catalyzes the insertion of both atoms of molecular oxygen into positions 2 and 3 of the phenyl ring of 3-phenylpropanoate or (2E)-3- phenylprop-2-enoate.
 318 A0A022PNS5 A0A023VGT2 A0A023Z0X1 A0A024KXR4 A0A025CJ25 A0A026RY39 A0A026UK62 A0A027TYM0 A0A028ASE5 A0A028E2L6
(308 more...)
Benzoate 1,2-dioxygenase. [EC: 1.14.12.10]
Benzoate + NADH + O(2) = (1R,6S)-1,6-dihydroxycyclohexa-2,4-diene-1- carboxylate + NAD(+).
  • A system, containing a reductase which is an iron-sulfur flavoprotein (FAD), and an iron-sulfur oxygenase.
  • Formerly EC 1.13.99.2.
 297 A0A009EUV4 A0A009GDK5 A0A009GW66 A0A009I1G6 A0A009II34 A0A009JL91 A0A009K7I6 A0A009KTM6 A0A009NHM9 A0A009PAZ7
(287 more...)
Anthranilate 1,2-dioxygenase (deaminating, decarboxylating). [EC: 1.14.12.1]
Anthranilate + NAD(P)H + O(2) = catechol + CO(2) + NAD(P)(+) + NH(3).
    		 295 A0A009FZG6 A0A009G442 A0A009H5P1 A0A009IK12 A0A009IKQ7 A0A009JDA7 A0A009JKU4 A0A009KFM3 A0A009LVU7 A0A009NMT3
    (285 more...)
    Biphenyl 2,3-dioxygenase. [EC: 1.14.12.18]
    Biphenyl + NADH + O(2) = (1S,2R)-3-phenylcyclohexa-3,5-diene-1,2-diol + NAD(+).
    • The enzyme from Burkholderia fungorum strain LB400 (previously Pseudomonas sp.) is part of a multicomponent system composed of an NADH:ferredoxin oxidoreductase (FAD cofactor), a [2Fe-2S] Rieske-type ferredoxin, and a terminal oxygenase that contains a [2Fe-2S] Rieske- type iron-sulfur cluster and a catalytic mononuclear nonheme iron center.
    • Chlorine-substituted biphenyls can also act as substrates.
    • Similar to the three-component enzyme systems EC 1.14.12.3 and EC 1.14.12.11.
    		 198 A0A009FNX5 A0A009JR72 A0A021X4M4 A0A023Z0X1 A0A024HHN4 A0A024KXR4 A0A025CJ25 A0A026RY39 A0A026UK62 A0A027TYM0
    (188 more...)
    2-halobenzoate 1,2-dioxygenase. [EC: 1.14.12.13]
    A 2-halobenzoate + NADH + O(2) = catechol + a halide anion + NAD(+) + CO(2).
    • A multicomponent enzyme system composed of a dioxygenase component and an electron transfer component.
    • The latter contains FAD.
    • The enzyme, characterized from the bacterium Burkholderia cepacia 2CBS, has a broad substrate specificity.
    • Substrates include 2-fluorobenzoate, 2-chlorobenzoate, 2-bromobenzoate, and 2-iodobenzoate, which are processed in this order of preference.
    		 145 A0A009JL91 A0A021XA10 A0A058YGT4 A0A059MTT0 A0A060V0W4 A0A063B9X6 A0A069BF16 A0A081YFM4 A0A084YX99 A0A088TPE9
    (135 more...)
    Naphthalene 1,2-dioxygenase. [EC: 1.14.12.12]
    Naphthalene + NADH + O(2) = (1R,2S)-1,2-dihydronaphthalene-1,2-diol + NAD(+).
    • Comprises a multicomponent system, containing a reductase that is an iron-sulfur flavoprotein (FAD; EC 1.18.1.3), an iron-sulfur oxygenase, and ferredoxin.
    		 28 A0A031JIT4 A0A095LDN8 A0A098EUF0 A0A0D5V9W4 A0A0E9FYD7 A0A0F6G7P1 A0A0F6L2K4 A0A0H3HVL8 A0A1H8CCN5 B1HM25
    (18 more...)
    Choline monooxygenase. [EC: 1.14.15.7]
    Choline + O(2) + 2 reduced ferredoxin + 2 H(+) = betaine aldehyde hydrate + H(2)O + 2 oxidized ferredoxin.
    • Catalyzes the first step of glycine betaine synthesis.
    • In many bacteria, plants and animals, the osmoprotectant betaine is synthesized in two steps: (1) choline to betaine aldehyde and (2) betaine aldehyde to betaine.
    • Different enzymes are involved in the first reaction.
    • In plants, the reaction is catalyzed by this enzyme whereas in animals and many bacteria, it is catalyzed by either membrane-bound EC 1.1.99.1 or soluble EC 1.1.3.17.
    • The enzyme involved in the second step, EC 1.2.1.8, appears to be the same in plants, animals and bacteria.
    • In some bacteria, betaine is synthesized from glycine through the actions of EC 2.1.1.156 and EC 2.1.1.157.
    • Formerly EC 1.14.14.4.
    		 23 A0A023J7R7 A0A023J7X1 A0A069Q635 A0A0H3QNH3 A0A0J8EX35 A0A0K9QHB2 A0A0P1DIG8 A0A1D5BPE1 A0A1E9BZP3 A0A1F0IGC1
    (13 more...)
    Salicylate 5-hydroxylase. [EC: 1.14.13.172]
    Salicylate + NADH + O(2) = 2,5-dihydroxybenzoate + NAD(+) + H(2)O.
    • This enzyme, which was characterized from the bacterium Ralstonia sp. U2, comprises a multicomponent system, containing a reductase that is an iron-sulfur flavoprotein (FAD; EC 1.18.1.7), an iron-sulfur oxygenase, and ferredoxin.
    		 16 A0A0G4JAY7 A0A0H2M2V4 A0A0H2M5X9 A0A0K1ZLS8 A0A0P0LHE4 A0A0P0MGR6 A0A0S4TRW2 A0A142XIH9 A0A1J0IGJ5 A0A1K0IH49
    (6 more...)
    Toluene dioxygenase. [EC: 1.14.12.11]
    Toluene + NADH + O(2) = (1S,2R)-3-methylcyclohexa-3,5-diene-1,2-diol + NAD(+).
    • A system, containing a reductase which is an iron-sulfur flavoprotein (FAD), an iron-sulfur oxygenase, and a ferredoxin.
    • Some other aromatic compounds, including ethylbenzene, 4-xylene and some halogenated toluenes, are converted into the corresponding cis- dihydrodiols.
    		 8 A0A1H0T4T6 C8TAG9 F2KHH4 I4K219 I4KKF1 J2YH32 Q3LUX4 Q4K9X5
    Terephthalate 1,2-dioxygenase. [EC: 1.14.12.15]
    Terephthalate + NADH + O(2) = (1R,6S)-dihydroxycyclohexa-2,4-diene-1,4- dicarboxylate + NAD(+).
    • In Comamonas testoteroni, contains a Rieske [2Fe-2S] center.
    		 8 A0A096FF41 A0A0M2DH63 A0A0M2DI65 A0A1B1KG81 D4X7Y8 Q0RWE4 Q3C1D5 Q3C1E3
    Formyltetrahydrofolate deformylase. [EC: 3.5.1.10]
    10-formyltetrahydrofolate + H(2)O = formate + tetrahydrofolate.
      		 4 A0A1H0WRH5 F2K5X2 G8Q2E2 I4JYX2
      Benzene 1,2-dioxygenase. [EC: 1.14.12.3]
      Benzene + NADH + O(2) = cis-cyclohexa-3,5-diene-1,2-diol + NAD(+).
      • A system, containing a reductase which is an iron-sulfur flavoprotein (FAD), an iron-sulfur oxygenase and ferredoxin.
      		 3 A0A0D8HYQ2 A0A0P1EGV8 A0A120LU49
      Phosphogluconate dehydrogenase (NADP(+)-dependent, decarboxylating). [EC: 1.1.1.44]
      6-phospho-D-gluconate + NADP(+) = D-ribulose 5-phosphate + CO(2) + NADPH.
      • The enzyme participates in the oxidative branch of the pentose phosphate pathway, whose main purpose is to produce NADPH and pentose for biosynthetic reactions.
      • Highly specific for NADP(+).
      • Cf. EC 1.1.1.343.
      		 1 G8Q212
      Aminomethyltransferase. [EC: 2.1.2.10]
      [Protein]-S(8)-aminomethyldihydrolipoyllysine + tetrahydrofolate = [protein]-dihydrolipoyllysine + 5,10-methylenetetrahydrofolate + NH(3).
      • A component, with EC 1.4.4.2 and EC 1.8.1.4, of the glycine cleavage system, formerly known as glycine synthase.
      • The glycine cleavage system is composed of four components that only loosely associate: the P protein (EC 1.4.4.2), the T protein (EC 2.1.2.10), the L protein (EC 1.8.1.4) and the lipoyl-bearing H protein.
      		 1 G8Q212
      2-aminobenzenesulfonate 2,3-dioxygenase. [EC: 1.14.12.14]
      2-aminobenzenesulfonate + NADH + O(2) = 2,3-dihydroxybenzenesulfonate + NH(3) + NAD(+).
        		 1 Q9RBG5
        Salicylate 1-monooxygenase. [EC: 1.14.13.1]
        Salicylate + NADH + O(2) = catechol + NAD(+) + H(2)O + CO(2).
          		 1 I3QHK8
          2-hydroxy-3-oxopropionate reductase. [EC: 1.1.1.60]
          D-glycerate + NAD(P)(+) = 2-hydroxy-3-oxopropanoate + NAD(P)H.
            		 1 G8Q212
            Ferredoxin--NAD(+) reductase. [EC: 1.18.1.3]
            Reduced ferredoxin + NAD(+) = oxidized ferredoxin + NADH.
            • The reaction is written for a [2Fe-2S] ferredoxin, which is characteristic of some mono- and dioxygenase systems.
            • some anaerobic bacteria have a 2[4Fe-4S] ferredoxin, which transfers two electrons.
            		 1 D5BNF2
            3-hydroxyisobutyrate dehydrogenase. [EC: 1.1.1.31]
            3-hydroxy-2-methylpropanoate + NAD(+) = 2-methyl-3-oxopropanoate + NADH.
              		 1 G8Q212
              CATH-Gene3D is a Global Biodata Core Resource Learn more...