The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Laminin
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 45295: Kinase C-binding protein NELL2

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 4 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
3 Q92832 (/IPI) Q99435 (/IPI) Q99435 (/IPI)
Protein kinase C binding GO:0005080
Interacting selectively and non-covalently with protein kinase C.
2 Q62918 (/IDA) Q62919 (/IDA)
Heparin binding GO:0008201
Interacting selectively and non-covalently with heparin, any member of a group of glycosaminoglycans found mainly as an intracellular component of mast cells and which consist predominantly of alternating alpha-(1->4)-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues.
2 Q62918 (/IDA) Q62919 (/IDA)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
2 Q62918 (/IDA) Q62919 (/IDA)

There are 25 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Neuron cellular homeostasis GO:0070050
The cellular homeostatic process that preserves a neuron in a stable, differentiated functional and structural state.
3 Q61220 (/ISS) Q99435 (/ISS) Q99435 (/ISS)
Regulation of gene expression GO:0010468
Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
2 Q2VWQ2 (/ISS) Q62919 (/ISS)
Positive regulation of bone mineralization GO:0030501
Any process that activates or increases the frequency, rate or extent of bone mineralization.
2 Q2VWQ2 (/ISS) Q62919 (/ISS)
Negative regulation of osteoblast proliferation GO:0033689
Any process that stops, prevents or reduces the rate or extent of osteoblast proliferation.
2 Q2VWQ2 (/ISS) Q62919 (/ISS)
Positive regulation of osteoblast differentiation GO:0045669
Any process that activates or increases the frequency, rate or extent of osteoblast differentiation.
2 Q2VWQ2 (/ISS) Q62919 (/ISS)
Protein homotrimerization GO:0070207
The formation of a protein homotrimer, a macromolecular structure consisting of three noncovalently associated identical subunits.
2 Q62918 (/IDA) Q62919 (/IDA)
Negative regulation of cellular protein catabolic process GO:1903363
Any process that stops, prevents or reduces the frequency, rate or extent of cellular protein catabolic process.
2 Q2VWQ2 (/ISS) Q62919 (/ISS)
Nervous system development GO:0007399
The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state.
1 Q92832 (/TAS)
Regulation of gene expression GO:0010468
Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
1 Q92832 (/IDA)
Regulation of gene expression GO:0010468
Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
1 Q2VWQ2 (/ISO)
Positive regulation of bone mineralization GO:0030501
Any process that activates or increases the frequency, rate or extent of bone mineralization.
1 Q92832 (/IDA)
Positive regulation of bone mineralization GO:0030501
Any process that activates or increases the frequency, rate or extent of bone mineralization.
1 Q2VWQ2 (/ISO)
Negative regulation of osteoblast proliferation GO:0033689
Any process that stops, prevents or reduces the rate or extent of osteoblast proliferation.
1 Q92832 (/IDA)
Negative regulation of osteoblast proliferation GO:0033689
Any process that stops, prevents or reduces the rate or extent of osteoblast proliferation.
1 Q2VWQ2 (/ISO)
Regulation of growth GO:0040008
Any process that modulates the frequency, rate or extent of the growth of all or part of an organism so that it occurs at its proper speed, either globally or in a specific part of the organism's development.
1 Q62918 (/IDA)
Positive regulation of apoptotic process GO:0043065
Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process.
1 Q62919 (/IDA)
Regulation of osteoblast differentiation GO:0045667
Any process that modulates the frequency, rate or extent of osteoblast differentiation.
1 Q62919 (/IMP)
Positive regulation of osteoblast differentiation GO:0045669
Any process that activates or increases the frequency, rate or extent of osteoblast differentiation.
1 Q92832 (/IDA)
Positive regulation of osteoblast differentiation GO:0045669
Any process that activates or increases the frequency, rate or extent of osteoblast differentiation.
1 Q2VWQ2 (/ISO)
Positive regulation of ossification GO:0045778
Any process that activates or increases the frequency, rate or extent of bone formation.
1 Q62919 (/IMP)
Development of secondary female sexual characteristics GO:0046543
The process whose specific outcome is the progression of the secondary female sexual characteristics over time, from their formation to the mature structures. In female humans, these include growth of axillary and pubic hair, breast development and menstrual periods. Their development occurs in response to sex hormone secretion.
1 Q62918 (/IMP)
Positive regulation of hormone secretion GO:0046887
Any process that activates or increases the frequency, rate or extent of the regulated release of a hormone from a cell.
1 Q62918 (/IMP)
Neuron cellular homeostasis GO:0070050
The cellular homeostatic process that preserves a neuron in a stable, differentiated functional and structural state.
1 Q62918 (/IDA)
Negative regulation of cellular protein catabolic process GO:1903363
Any process that stops, prevents or reduces the frequency, rate or extent of cellular protein catabolic process.
1 Q92832 (/IDA)
Negative regulation of cellular protein catabolic process GO:1903363
Any process that stops, prevents or reduces the frequency, rate or extent of cellular protein catabolic process.
1 Q2VWQ2 (/ISO)

There are 14 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
3 Q62918 (/IDA) Q62919 (/IDA) Q92832 (/IDA)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
2 Q62918 (/IDA) Q62919 (/IDA)
Cell GO:0005623
The basic structural and functional unit of all organisms. Includes the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope.
2 F1NWY6 (/IDA) Q90827 (/IDA)
Nuclear envelope GO:0005635
The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space).
2 Q2VWQ2 (/ISS) Q62919 (/ISS)
Perinuclear region of cytoplasm GO:0048471
Cytoplasm situated near, or occurring around, the nucleus.
2 Q2VWQ2 (/ISS) Q62919 (/ISS)
Nuclear envelope GO:0005635
The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space).
1 Q92832 (/IDA)
Nuclear envelope GO:0005635
The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space).
1 Q2VWQ2 (/ISO)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 Q2VWQ2 (/ISO)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 Q2VWQ2 (/ISS)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
1 Q62918 (/IDA)
Dendrite GO:0030425
A neuron projection that has a short, tapering, often branched, morphology, receives and integrates signals from other neurons or from sensory stimuli, and conducts a nerve impulse towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.
1 Q62918 (/IDA)
Perikaryon GO:0043204
The portion of the cell soma (neuronal cell body) that excludes the nucleus.
1 Q62918 (/IDA)
Perinuclear region of cytoplasm GO:0048471
Cytoplasm situated near, or occurring around, the nucleus.
1 Q92832 (/IDA)
Perinuclear region of cytoplasm GO:0048471
Cytoplasm situated near, or occurring around, the nucleus.
1 Q2VWQ2 (/ISO)