The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Cysteine Rich Protein
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 6226: Four and a half LIM domains 1

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 12 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
8 O35115 (/IPI) O70433 (/IPI) Q13642 (/IPI) Q13643 (/IPI) Q14192 (/IPI) Q5TD97 (/IPI) Q9R059 (/IPI) Q9WTX7 (/IPI)
Transcription factor binding GO:0008134
Interacting selectively and non-covalently with a transcription factor, any protein required to initiate or regulate transcription.
3 O35115 (/ISS) O70433 (/ISS) Q2KI95 (/ISS)
Transcription coactivator activity GO:0003713
Interacting selectively and non-covalently with a activating transcription factor and also with the basal transcription machinery in order to increase the frequency, rate or extent of transcription. Cofactors generally do not bind the template nucleic acid, but rather mediate protein-protein interactions between activating transcription factors and the basal transcription machinery.
1 Q9WTX7 (/IDA)
Transcription coactivator activity GO:0003713
Interacting selectively and non-covalently with a activating transcription factor and also with the basal transcription machinery in order to increase the frequency, rate or extent of transcription. Cofactors generally do not bind the template nucleic acid, but rather mediate protein-protein interactions between activating transcription factors and the basal transcription machinery.
1 Q14192 (/NAS)
Actin binding GO:0003779
Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments.
1 Q9R059 (/IDA)
Transcription factor binding GO:0008134
Interacting selectively and non-covalently with a transcription factor, any protein required to initiate or regulate transcription.
1 Q14192 (/IPI)
Transcription factor binding GO:0008134
Interacting selectively and non-covalently with a transcription factor, any protein required to initiate or regulate transcription.
1 O70433 (/ISO)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
1 Q14192 (/IPI)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
1 O70433 (/ISO)
Ion channel binding GO:0044325
Interacting selectively and non-covalently with one or more specific sites on an ion channel, a protein complex that spans a membrane and forms a water-filled channel across the phospholipid bilayer allowing selective ion transport down its electrochemical gradient.
1 Q13642 (/IPI)
Ion channel binding GO:0044325
Interacting selectively and non-covalently with one or more specific sites on an ion channel, a protein complex that spans a membrane and forms a water-filled channel across the phospholipid bilayer allowing selective ion transport down its electrochemical gradient.
1 P97447 (/ISO)
Androgen receptor binding GO:0050681
Interacting selectively and non-covalently with an androgen receptor.
1 Q14192 (/NAS)

There are 39 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Negative regulation of transcription from RNA polymerase II promoter GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter.
3 O35115 (/ISS) O70433 (/ISS) Q2KI95 (/ISS)
Cardiac chamber morphogenesis GO:0003206
The process in which a cardiac chamber is generated and organized. A cardiac chamber is an enclosed cavity within the heart.
3 A0A140LFQ9 (/IMP) Q6GQL7 (/IMP) Q9W6K4 (/IMP)
Cardiac ventricle morphogenesis GO:0003208
The process in which the cardiac ventricle is generated and organized. A cardiac ventricle receives blood from a cardiac atrium and pumps it out of the heart.
3 A0A140LFQ9 (/IMP) Q6GQL7 (/IMP) Q9W6K4 (/IMP)
Cardiac atrium morphogenesis GO:0003209
The process in which the cardiac atrium is generated and organized. A cardiac atrium receives blood from a vein and pumps it to a cardiac ventricle.
3 A0A140LFQ9 (/IMP) Q6GQL7 (/IMP) Q9W6K4 (/IMP)
Locomotory behavior GO:0007626
The specific movement from place to place of an organism in response to external or internal stimuli. Locomotion of a whole organism in a manner dependent upon some combination of that organism's internal state and external conditions.
3 A0A140LFQ9 (/IMP) Q6GQL7 (/IMP) Q9W6K4 (/IMP)
Negative regulation of apoptotic process GO:0043066
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
3 O35115 (/ISS) O70433 (/ISS) Q2KI95 (/ISS)
Negative regulation of transcription from RNA polymerase II promoter GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter.
1 Q14192 (/IDA)
Negative regulation of transcription from RNA polymerase II promoter GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter.
1 O70433 (/ISO)
Osteoblast differentiation GO:0001649
The process whereby a relatively unspecialized cell acquires the specialized features of an osteoblast, a mesodermal or neural crest cell that gives rise to bone.
1 O70433 (/IEP)
Regulation of membrane depolarization GO:0003254
Any process that modulates the rate, frequency or extent of membrane depolarization. Membrane depolarization is the process in which membrane potential changes in the depolarizing direction from the resting potential, usually from negative to positive.
1 Q13642 (/IDA)
Regulation of membrane depolarization GO:0003254
Any process that modulates the rate, frequency or extent of membrane depolarization. Membrane depolarization is the process in which membrane potential changes in the depolarizing direction from the resting potential, usually from negative to positive.
1 P97447 (/ISO)
Transcription, DNA-templated GO:0006351
The cellular synthesis of RNA on a template of DNA.
1 Q9WTX7 (/TAS)
Regulation of transcription from RNA polymerase II promoter GO:0006357
Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter.
1 O70433 (/IDA)
Muscle organ development GO:0007517
The process whose specific outcome is the progression of the muscle over time, from its formation to the mature structure. The muscle is an organ consisting of a tissue made up of various elongated cells that are specialized to contract and thus to produce movement and mechanical work.
1 Q13642 (/NAS)
Muscle organ development GO:0007517
The process whose specific outcome is the progression of the muscle over time, from its formation to the mature structure. The muscle is an organ consisting of a tissue made up of various elongated cells that are specialized to contract and thus to produce movement and mechanical work.
1 Q13643 (/TAS)
Response to hormone GO:0009725
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus.
1 Q14192 (/IMP)
Response to hormone GO:0009725
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus.
1 O70433 (/ISO)
Animal organ morphogenesis GO:0009887
Morphogenesis of an animal organ. An organ is defined as a tissue or set of tissues that work together to perform a specific function or functions. Morphogenesis is the process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.
1 Q13642 (/NAS)
Negative regulation of G2/M transition of mitotic cell cycle GO:0010972
Any cell cycle regulatory process that decreases the rate or extent of progression of a cell from G2 to M phase of the mitotic cell cycle.
1 Q13642 (/IDA)
Negative regulation of G2/M transition of mitotic cell cycle GO:0010972
Any cell cycle regulatory process that decreases the rate or extent of progression of a cell from G2 to M phase of the mitotic cell cycle.
1 P97447 (/ISO)
Regulation of lipid metabolic process GO:0019216
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving lipids.
1 Q14192 (/TAS)
Actin cytoskeleton organization GO:0030036
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins.
1 Q9R059 (/IDA)
Negative regulation of cell growth GO:0030308
Any process that stops, prevents, or reduces the frequency, rate, extent or direction of cell growth.
1 Q13642 (/IDA)
Negative regulation of cell growth GO:0030308
Any process that stops, prevents, or reduces the frequency, rate, extent or direction of cell growth.
1 P97447 (/ISO)
Androgen receptor signaling pathway GO:0030521
Any series of molecular signals generated as a consequence of an androgen binding to its receptor.
1 Q14192 (/NAS)
Negative regulation of apoptotic process GO:0043066
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
1 Q14192 (/IDA)
Negative regulation of apoptotic process GO:0043066
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
1 O70433 (/ISO)
Positive regulation of potassium ion transport GO:0043268
Any process that activates or increases the frequency, rate or extent of the directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
1 Q13642 (/IDA)
Positive regulation of potassium ion transport GO:0043268
Any process that activates or increases the frequency, rate or extent of the directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
1 P97447 (/ISO)
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
1 O70433 (/IDA)
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
1 Q14192 (/NAS)
Positive regulation of transcription from RNA polymerase II promoter GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
1 Q9WTX7 (/IGI)
Atrial cardiac muscle cell development GO:0055014
The process whose specific outcome is the progression of an atrial cardiac muscle cell over time, from its formation to the mature state. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction. The atrium is the part of the heart that receives blood into the organ.
1 O70433 (/IEP)
Ventricular cardiac muscle cell development GO:0055015
The process whose specific outcome is the progression of a ventricular cardiac muscle cell over time, from its formation to the mature state. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction. The ventricle is the part of the heart that pumps blood out of the organ.
1 O70433 (/IEP)
Heart trabecula formation GO:0060347
The process of creating a trabecula in the heart. A trabecula is a tissue element in the form of a small beam, strut or rod.
1 O70433 (/IEP)
Regulation of potassium ion transmembrane transporter activity GO:1901016
Any process that modulates the frequency, rate or extent of potassium ion transmembrane transporter activity.
1 Q13642 (/IDA)
Regulation of potassium ion transmembrane transporter activity GO:1901016
Any process that modulates the frequency, rate or extent of potassium ion transmembrane transporter activity.
1 P97447 (/ISO)
Negative regulation of G1/S transition of mitotic cell cycle GO:2000134
Any cell cycle regulatory process that prevents the commitment of a cell from G1 to S phase of the mitotic cell cycle.
1 Q13642 (/IDA)
Negative regulation of G1/S transition of mitotic cell cycle GO:2000134
Any cell cycle regulatory process that prevents the commitment of a cell from G1 to S phase of the mitotic cell cycle.
1 P97447 (/ISO)

There are 15 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
13 A0A0D9SFB0 (/IDA) A0A0D9SFI6 (/IDA) A0A0D9SFZ9 (/IDA) A0A0D9SG53 (/IDA) A0A0D9SGB2 (/IDA) Q13642 (/IDA) Q5JXH7 (/IDA) Q5JXH8 (/IDA) Q5JXH9 (/IDA) Q5JXI0 (/IDA)
(3 more)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
13 A0A0D9SFB0 (/IDA) A0A0D9SFI6 (/IDA) A0A0D9SFZ9 (/IDA) A0A0D9SG53 (/IDA) A0A0D9SGB2 (/IDA) Q13642 (/IDA) Q5JXH7 (/IDA) Q5JXH8 (/IDA) Q5JXH9 (/IDA) Q5JXI0 (/IDA)
(3 more)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
3 O70433 (/IDA) Q13642 (/IDA) Q9R059 (/IDA)
Focal adhesion GO:0005925
Small region on the surface of a cell that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments.
3 Q13642 (/IDA) Q13643 (/IDA) Q14192 (/IDA)
Focal adhesion GO:0005925
Small region on the surface of a cell that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments.
3 O70433 (/ISO) P97447 (/ISO) Q9R059 (/ISO)
Z disc GO:0030018
Platelike region of a muscle sarcomere to which the plus ends of actin filaments are attached.
2 O35115 (/IDA) Q9R059 (/IDA)
Stress fiber GO:0001725
A contractile actin filament bundle that consists of short actin filaments with alternating polarity, cross-linked by alpha-actinin and possibly other actin bundling proteins, and with myosin present in a periodic distribution along the fiber.
1 Q9R059 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 P97447 (/ISO)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 Q14192 (/TAS)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
1 Q14192 (/TAS)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 Q13642 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 P97447 (/ISO)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 P97447 (/ISO)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 P97447 (/ISO)
M band GO:0031430
The midline of aligned thick filaments in a sarcomere; location of specific proteins that link thick filaments. Depending on muscle type the M band consists of different numbers of M lines.
1 O35115 (/IDA)
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