The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:
"Cysteine Rich Protein
".
FunFam 6145: LIM domain-containing protein 1
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 42 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
34 |
A1ZA47 (/IPI)
A5H447 (/IPI)
A6NIX2 (/IPI)
F1QSX8 (/IPI)
G5EEL1 (/IPI)
G5EFL5 (/IPI)
H9XVP5 (/IPI)
O75112 (/IPI)
Q04584 (/IPI)
Q06BR1 (/IPI)
(24 more) |
Transcription corepressor activity GO:0003714
Interacting selectively and non-covalently with a repressing transcription factor and also with the basal transcription machinery in order to stop, prevent, or reduce the frequency, rate or extent of transcription. Cofactors generally do not bind the template nucleic acid, but rather mediate protein-protein interactions between repressive transcription factors and the basal transcription machinery.
|
7 | A8DZE6 (/ISS) B5DEH0 (/ISS) B7ZUL2 (/ISS) E1BKA3 (/ISS) G5E5X0 (/ISS) Q5U2Z2 (/ISS) Q9UGP4 (/ISS) |
Transcription corepressor activity GO:0003714
Interacting selectively and non-covalently with a repressing transcription factor and also with the basal transcription machinery in order to stop, prevent, or reduce the frequency, rate or extent of transcription. Cofactors generally do not bind the template nucleic acid, but rather mediate protein-protein interactions between repressive transcription factors and the basal transcription machinery.
|
4 | Q7TQJ8 (/IDA) Q91XC0 (/IDA) Q96IF1 (/IDA) Q9QXD8 (/IDA) |
Muscle alpha-actinin binding GO:0051371
Interacting selectively and non-covalently with muscle isoforms of actinin. Muscle alpha-actinin isoforms are found in skeletal and cardiac muscle and are localized to the Z-disc.
|
4 | B0WXP3 (/ISS) Q179D0 (/ISS) Q28WK7 (/ISS) Q7PTE3 (/ISS) |
Transcription corepressor activity GO:0003714
Interacting selectively and non-covalently with a repressing transcription factor and also with the basal transcription machinery in order to stop, prevent, or reduce the frequency, rate or extent of transcription. Cofactors generally do not bind the template nucleic acid, but rather mediate protein-protein interactions between repressive transcription factors and the basal transcription machinery.
|
3 | A9LS46 (/IMP) Q06BR1 (/IMP) Q91XC0 (/IMP) |
Transcription factor binding GO:0008134
Interacting selectively and non-covalently with a transcription factor, any protein required to initiate or regulate transcription.
|
3 | A5H447 (/IPI) Q679P3 (/IPI) R4GKC8 (/IPI) |
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
|
2 | Q15654 (/IDA) Q15942 (/IDA) |
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
|
2 | Q62523 (/ISO) Q9Z1Y4 (/ISO) |
Actin binding GO:0003779
Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments.
|
2 | Q96HC4 (/ISS) Q9VY77 (/ISS) |
Protein kinase C binding GO:0005080
Interacting selectively and non-covalently with protein kinase C.
|
2 | Q62920 (/IDA) Q9JKS4 (/IDA) |
Interleukin-1 receptor binding GO:0005149
Interacting selectively and non-covalently with the interleukin-1 receptor.
|
2 | Q3SX26 (/ISS) Q9Z1Y4 (/ISS) |
Kinase binding GO:0019900
Interacting selectively and non-covalently with a kinase, any enzyme that catalyzes the transfer of a phosphate group.
|
2 | Q3SX26 (/ISS) Q9Z1Y4 (/ISS) |
Activating transcription factor binding GO:0033613
Interacting selectively and non-covalently with an activating transcription factor, any protein whose activity is required to initiate or upregulate transcription.
|
2 | Q679P3 (/IPI) R4GKC8 (/IPI) |
Alpha-catenin binding GO:0045294
Interacting selectively and non-covalently with the alpha subunit of the catenin complex.
|
2 | Q91XC0 (/IDA) Q96IF1 (/IDA) |
Muscle alpha-actinin binding GO:0051371
Interacting selectively and non-covalently with muscle isoforms of actinin. Muscle alpha-actinin isoforms are found in skeletal and cardiac muscle and are localized to the Z-disc.
|
2 | A1ZA47 (/IPI) Q9JKS4 (/IPI) |
Chromatin binding GO:0003682
Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
|
1 | Q91XC0 (/IDA) |
Transcription corepressor activity GO:0003714
Interacting selectively and non-covalently with a repressing transcription factor and also with the basal transcription machinery in order to stop, prevent, or reduce the frequency, rate or extent of transcription. Cofactors generally do not bind the template nucleic acid, but rather mediate protein-protein interactions between repressive transcription factors and the basal transcription machinery.
|
1 | Q91XC0 (/ISO) |
Actin binding GO:0003779
Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments.
|
1 | Q62920 (/IDA) |
Actin binding GO:0003779
Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments.
|
1 | A1ZA47 (/IPI) |
Protein kinase C binding GO:0005080
Interacting selectively and non-covalently with protein kinase C.
|
1 | Q96HC4 (/ISS) |
Interleukin-1 receptor binding GO:0005149
Interacting selectively and non-covalently with the interleukin-1 receptor.
|
1 | Q15654 (/IDA) |
Interleukin-1 receptor binding GO:0005149
Interacting selectively and non-covalently with the interleukin-1 receptor.
|
1 | Q9Z1Y4 (/ISO) |
Cytoskeletal protein binding GO:0008092
Interacting selectively and non-covalently with any protein component of any cytoskeleton (actin, microtubule, or intermediate filament cytoskeleton).
|
1 | O75112 (/IPI) |
Cytoskeletal protein binding GO:0008092
Interacting selectively and non-covalently with any protein component of any cytoskeleton (actin, microtubule, or intermediate filament cytoskeleton).
|
1 | Q9JKS4 (/ISO) |
Transcription factor binding GO:0008134
Interacting selectively and non-covalently with a transcription factor, any protein required to initiate or regulate transcription.
|
1 | Q0VA45 (/ISS) |
Zinc ion binding GO:0008270
Interacting selectively and non-covalently with zinc (Zn) ions.
|
1 | Q9UGP4 (/TAS) |
DEAD/H-box RNA helicase binding GO:0017151
Interacting selectively and non-covalently with the enzyme DEAD/H-box RNA helicase.
|
1 | Q9U3F4 (/IPI) |
Kinase binding GO:0019900
Interacting selectively and non-covalently with a kinase, any enzyme that catalyzes the transfer of a phosphate group.
|
1 | Q15654 (/IPI) |
Kinase binding GO:0019900
Interacting selectively and non-covalently with a kinase, any enzyme that catalyzes the transfer of a phosphate group.
|
1 | Q9Z1Y4 (/ISO) |
Receptor signaling complex scaffold activity GO:0030159
Functions to provide a physical support for the assembly of a multiprotein receptor signaling complex.
|
1 | Q62920 (/NAS) |
Actinin binding GO:0042805
Interacting selectively and non-covalently with actinin, any member of a family of proteins that crosslink F-actin.
|
1 | Q62920 (/IDA) |
Actinin binding GO:0042805
Interacting selectively and non-covalently with actinin, any member of a family of proteins that crosslink F-actin.
|
1 | A1ZA47 (/IPI) |
Actinin binding GO:0042805
Interacting selectively and non-covalently with actinin, any member of a family of proteins that crosslink F-actin.
|
1 | Q96HC4 (/ISS) |
Alpha-catenin binding GO:0045294
Interacting selectively and non-covalently with the alpha subunit of the catenin complex.
|
1 | Q91XC0 (/ISO) |
Thyroid hormone receptor binding GO:0046966
Interacting selectively and non-covalently with a thyroid hormone receptor.
|
1 | Q15654 (/NAS) |
Protein N-terminus binding GO:0047485
Interacting selectively and non-covalently with a protein N-terminus, the end of any peptide chain at which the 2-amino (or 2-imino) function of a constituent amino acid is not attached in peptide linkage to another amino-acid residue.
|
1 | Q62920 (/IMP) |
Actin filament binding GO:0051015
Interacting selectively and non-covalently with an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits.
|
1 | Q91XC0 (/IDA) |
Muscle alpha-actinin binding GO:0051371
Interacting selectively and non-covalently with muscle isoforms of actinin. Muscle alpha-actinin isoforms are found in skeletal and cardiac muscle and are localized to the Z-disc.
|
1 | Q9JKS4 (/IDA) |
Muscle alpha-actinin binding GO:0051371
Interacting selectively and non-covalently with muscle isoforms of actinin. Muscle alpha-actinin isoforms are found in skeletal and cardiac muscle and are localized to the Z-disc.
|
1 | A1ZA47 (/IMP) |
Alpha-actinin binding GO:0051393
Interacting selectively and non-covalently with alpha-actinin, one of a family of proteins that cross-link F-actin as antiparallel homodimers. Alpha-actinin has a molecular mass of 93-103 KDa; at the N-terminus there are two calponin homology domains, at the C-terminus there are two EF-hands. These two domains are connected by the rod domain. This domain is formed by triple-helical spectrin repeats.
|
1 | Q04584 (/IPI) |
Cadherin binding involved in cell-cell adhesion GO:0098641
Any cadherin binding that occurs as part of the process of cell-cell adhesion.
|
1 | Q96HC4 (/IDA) |
Cadherin binding involved in cell-cell adhesion GO:0098641
Any cadherin binding that occurs as part of the process of cell-cell adhesion.
|
1 | Q8CI51 (/ISO) |
There are 132 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Somitogenesis GO:0001756
The formation of mesodermal clusters that are arranged segmentally along the anterior posterior axis of an embryo.
|
10 | E7FCN3 (/IMP) F1Q8D1 (/IMP) F1QGX8 (/IMP) F1QN07 (/IMP) Q4ZGK7 (/IMP) Q4ZGL0 (/IMP) Q4ZGL1 (/IMP) Q4ZGL5 (/IMP) Q4ZGL7 (/IMP) Q6P7E4 (/IMP) |
Heart development GO:0007507
The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood.
|
10 | E7FCN3 (/IMP) E7FFI0 (/IMP) F1Q8D1 (/IMP) F1QGX8 (/IMP) F1QN07 (/IMP) Q4ZGK7 (/IMP) Q4ZGL0 (/IMP) Q4ZGL1 (/IMP) Q4ZGL5 (/IMP) Q4ZGL7 (/IMP) |
Skeletal muscle tissue development GO:0007519
The developmental sequence of events leading to the formation of adult skeletal muscle tissue. The main events are: the fusion of myoblasts to form myotubes that increase in size by further fusion to them of myoblasts, the formation of myofibrils within their cytoplasm and the establishment of functional neuromuscular junctions with motor neurons. At this stage they can be regarded as mature muscle fibers.
|
9 | E7FCN3 (/IMP) F1Q8D1 (/IMP) F1QGX8 (/IMP) F1QN07 (/IMP) Q4ZGK7 (/IMP) Q4ZGL0 (/IMP) Q4ZGL1 (/IMP) Q4ZGL5 (/IMP) Q4ZGL7 (/IMP) |
Locomotory behavior GO:0007626
The specific movement from place to place of an organism in response to external or internal stimuli. Locomotion of a whole organism in a manner dependent upon some combination of that organism's internal state and external conditions.
|
9 | E7FCN3 (/IMP) F1Q8D1 (/IMP) F1QGX8 (/IMP) F1QN07 (/IMP) Q4ZGK7 (/IMP) Q4ZGL0 (/IMP) Q4ZGL1 (/IMP) Q4ZGL5 (/IMP) Q4ZGL7 (/IMP) |
Negative regulation of hippo signaling GO:0035331
Any process that stops, prevents, or reduces the frequency, rate or extent of hippo signaling.
|
7 | B5DEH0 (/ISS) E1BKA3 (/ISS) G5E5X0 (/ISS) Q5U2Z2 (/ISS) Q7TQJ8 (/ISS) Q91XC0 (/ISS) Q9QXD8 (/ISS) |
Positive regulation of gene silencing by miRNA GO:2000637
Any process that activates or increases the frequency, rate or extent of gene silencing by miRNA.
|
7 | B5DEH0 (/ISS) E1BKA3 (/ISS) G5E5X0 (/ISS) Q5U2Z2 (/ISS) Q7TQJ8 (/ISS) Q91XC0 (/ISS) Q9QXD8 (/ISS) |
Hippo signaling GO:0035329
The series of molecular signals mediated by the serine/threonine kinase Hippo or one of its orthologs. In Drosophila, Hippo in complex with the scaffold protein Salvador (Sav), phosphorylates and activates Warts (Wts), which in turn phosphorylates and inactivates the Yorkie (Yki) transcriptional activator. The core fly components hippo, sav, wts and mats are conserved in mammals as STK4/3 (MST1/2), SAV1/WW45, LATS1/2 and MOB1.
|
5 | H9XVP5 (/IMP) Q8I0G8 (/IMP) Q8T0F5 (/IMP) Q9N675 (/IMP) Q9VY77 (/IMP) |
Positive regulation of imaginal disc growth GO:0045572
Any process that activates or increases the frequency, rate or extent of imaginal disc growth.
|
5 | H9XVP5 (/IMP) Q8I0G8 (/IMP) Q8T0F5 (/IMP) Q9N675 (/IMP) Q9VY77 (/IMP) |
Positive regulation of organ growth GO:0046622
Any process that activates or increases the frequency, rate or extent of growth of an organ of an organism.
|
5 | H9XVP5 (/IMP) Q8I0G8 (/IMP) Q8T0F5 (/IMP) Q9N675 (/IMP) Q9VY77 (/IMP) |
Regulation of cell-matrix adhesion GO:0001952
Any process that modulates the frequency, rate or extent of attachment of a cell to the extracellular matrix.
|
4 | B0WXP3 (/ISS) Q179D0 (/ISS) Q28WK7 (/ISS) Q7PTE3 (/ISS) |
Cytoskeleton organization GO:0007010
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures.
|
4 | A8DZE6 (/ISS) A9LS46 (/ISS) Q7TQJ8 (/ISS) Q9QXD8 (/ISS) |
Cell adhesion GO:0007155
The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.
|
4 | H9XVP5 (/ISS) Q8I0G8 (/ISS) Q8T0F5 (/ISS) Q9N675 (/ISS) |
Terminal branching, open tracheal system GO:0007430
Formation of terminal branches in the open tracheal system. These are long cytoplasmic extensions that form fine tubules that transport oxygen directly to the tissues. An example of the process is found in Drosophila melanogaster.
|
4 | H9XVP5 (/IMP) Q8I0G8 (/IMP) Q8T0F5 (/IMP) Q9N675 (/IMP) |
Chitin-based cuticle sclerotization GO:0007593
The process of hardening of a chitin-based cuticle.
|
4 | H9XVP5 (/IMP) Q8I0G8 (/IMP) Q8T0F5 (/IMP) Q9N675 (/IMP) |
Determination of adult lifespan GO:0008340
The control of viability and duration in the adult phase of the life-cycle.
|
4 | G5EEF6 (/IMP) G5EEL1 (/IMP) G5EFG1 (/IMP) G5EFL5 (/IMP) |
Liquid clearance, open tracheal system GO:0035002
The clearance of liquid from the epithelial tubes of an open tracheal system, shortly before the emergence of the larva, to generate an air-filled tubule system.
|
4 | H9XVP5 (/IMP) Q8I0G8 (/IMP) Q8T0F5 (/IMP) Q9N675 (/IMP) |
Pharyngeal pumping GO:0043050
The contraction and relaxation movements of the pharyngeal muscle that mediate feeding in nematodes.
|
4 | G5EEF6 (/IMP) G5EEL1 (/IMP) G5EFG1 (/IMP) G5EFL5 (/IMP) |
Positive regulation of eclosion GO:0045805
Any process that activates or increases the frequency, rate or extent of eclosion.
|
4 | H9XVP5 (/IMP) Q8I0G8 (/IMP) Q8T0F5 (/IMP) Q9N675 (/IMP) |
Imaginal disc-derived wing expansion GO:0048526
The process of expanding or inflating the folded imaginal disc-derived pupal wing, and the adhering of the dorsal and ventral surfaces, to form the mature adult wing.
|
4 | H9XVP5 (/IMP) Q8I0G8 (/IMP) Q8T0F5 (/IMP) Q9N675 (/IMP) |
Response to hypoxia GO:0001666
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.
|
3 | A6NIX2 (/IDA) Q96IF1 (/IDA) Q9UGP4 (/IDA) |
Response to hypoxia GO:0001666
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.
|
3 | Q7TQJ8 (/ISO) Q91XC0 (/ISO) Q9QXD8 (/ISO) |
Response to hypoxia GO:0001666
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.
|
3 | B5DEH0 (/ISS) G5E5X0 (/ISS) Q9QXD8 (/ISS) |
Osteoblast development GO:0002076
The process whose specific outcome is the progression of an osteoblast over time, from its formation to the mature structure. Osteoblast development does not include the steps involved in committing a cranial neural crest cell or an osteoprogenitor cell to an osteoblast fate. An osteoblast is a cell that gives rise to bone.
|
3 | B5DEH0 (/ISS) G5E5X0 (/ISS) Q9UGP4 (/ISS) |
Phosphorylation GO:0016310
The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide.
|
3 | B5DEH0 (/ISS) G5E5X0 (/ISS) Q9QXD8 (/ISS) |
Regulation of cell morphogenesis GO:0022604
Any process that modulates the frequency, rate or extent of cell morphogenesis. Cell morphogenesis is the developmental process in which the shape of a cell is generated and organized.
|
3 | A8DZE6 (/ISS) A9LS46 (/ISS) Q7TQJ8 (/ISS) |
Gene silencing by miRNA GO:0035195
Downregulation of gene expression through the action of microRNAs (miRNAs), endogenous 21-24 nucleotide small RNAs processed from stem-loop RNA precursors (pre-miRNAs). Once incorporated into a RNA-induced silencing complex (RISC), miRNAs can downregulate gene expression by either of two posttranscriptional mechanisms: endolytic cleavage of mRNA cleavage or translational repression, usually accompanied by poly-A tail shortening and subsequent degradation of the mRNA.
|
3 | A6NIX2 (/IMP) Q96IF1 (/IMP) Q9UGP4 (/IMP) |
Gene silencing by miRNA GO:0035195
Downregulation of gene expression through the action of microRNAs (miRNAs), endogenous 21-24 nucleotide small RNAs processed from stem-loop RNA precursors (pre-miRNAs). Once incorporated into a RNA-induced silencing complex (RISC), miRNAs can downregulate gene expression by either of two posttranscriptional mechanisms: endolytic cleavage of mRNA cleavage or translational repression, usually accompanied by poly-A tail shortening and subsequent degradation of the mRNA.
|
3 | Q7TQJ8 (/ISO) Q91XC0 (/ISO) Q9QXD8 (/ISO) |
Negative regulation of hippo signaling GO:0035331
Any process that stops, prevents, or reduces the frequency, rate or extent of hippo signaling.
|
3 | A6NIX2 (/IDA) Q96IF1 (/IDA) Q9UGP4 (/IDA) |
Negative regulation of hippo signaling GO:0035331
Any process that stops, prevents, or reduces the frequency, rate or extent of hippo signaling.
|
3 | Q7TQJ8 (/ISO) Q91XC0 (/ISO) Q9QXD8 (/ISO) |
Negative regulation of osteoblast differentiation GO:0045668
Any process that stops, prevents, or reduces the frequency, rate or extent of osteoblast differentiation.
|
3 | B5DEH0 (/ISS) G5E5X0 (/ISS) Q9UGP4 (/ISS) |
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
|
3 | B5DEH0 (/ISS) G5E5X0 (/ISS) Q9QXD8 (/ISS) |
Negative regulation of canonical Wnt signaling pathway GO:0090090
Any process that decreases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes.
|
3 | B5DEH0 (/ISS) G5E5X0 (/ISS) Q9UGP4 (/ISS) |
Positive regulation of gene silencing by miRNA GO:2000637
Any process that activates or increases the frequency, rate or extent of gene silencing by miRNA.
|
3 | A6NIX2 (/IMP) Q96IF1 (/IMP) Q9UGP4 (/IMP) |
Positive regulation of gene silencing by miRNA GO:2000637
Any process that activates or increases the frequency, rate or extent of gene silencing by miRNA.
|
3 | Q7TQJ8 (/ISO) Q91XC0 (/ISO) Q9QXD8 (/ISO) |
Nucleocytoplasmic transport GO:0006913
The directed movement of molecules between the nucleus and the cytoplasm.
|
2 | Q679P3 (/IDA) R4GKC8 (/IDA) |
Cytoskeleton organization GO:0007010
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures.
|
2 | A6NIX2 (/IMP) Q9UGP4 (/IMP) |
Cytoskeleton organization GO:0007010
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures.
|
2 | Q7TQJ8 (/ISO) Q9QXD8 (/ISO) |
Signal transduction GO:0007165
The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
|
2 | Q15942 (/TAS) Q9UGP4 (/TAS) |
Transforming growth factor beta receptor signaling pathway GO:0007179
A series of molecular signals initiated by the binding of an extracellular ligand to a transforming growth factor beta receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
|
2 | Q15942 (/IMP) Q62523 (/IMP) |
Integrin-mediated signaling pathway GO:0007229
A series of molecular signals initiated by the binding of extracellular ligand to an integrin on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
|
2 | Q15942 (/IMP) Q62523 (/IMP) |
Release of cytoplasmic sequestered NF-kappaB GO:0008588
The release of NF-kappaB from specific molecules in the cytoplasm to which it was bound, thereby allowing its translocation into the nucleus.
|
2 | Q3SX26 (/ISS) Q9Z1Y4 (/ISS) |
Neural crest cell development GO:0014032
The process aimed at the progression of a neural crest cell over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell.
|
2 | A9LS46 (/IMP) Q06BR1 (/IMP) |
Neural crest cell development GO:0014032
The process aimed at the progression of a neural crest cell over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell.
|
2 | A8DZE6 (/ISS) B7ZUL2 (/ISS) |
Positive regulation of cell migration GO:0030335
Any process that activates or increases the frequency, rate or extent of cell migration.
|
2 | Q3SX26 (/ISS) Q9Z1Y4 (/ISS) |
Regulation of protein localization GO:0032880
Any process that modulates the frequency, rate or extent of any process in which a protein is transported to, or maintained in, a specific location.
|
2 | Q679P3 (/IDA) R4GKC8 (/IDA) |
Negative regulation of sequence-specific DNA binding transcription factor activity GO:0043433
Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription.
|
2 | Q679P3 (/IDA) R4GKC8 (/IDA) |
Regulation of synapse assembly GO:0051963
Any process that modulates the frequency, rate or extent of synapse assembly, the aggregation, arrangement and bonding together of a set of components to form a synapse.
|
2 | Q8CI51 (/ISS) Q96HC4 (/ISS) |
Regulation of dendritic spine morphogenesis GO:0061001
Any process that modulates the rate, frequency, or extent of dendritic spine morphogenesis, the process in which the anatomical structures of a dendritic spine are generated and organized. A dendritic spine is a protrusion from a dendrite and a specialized subcellular compartment involved in synaptic transmission.
|
2 | Q8CI51 (/ISS) Q96HC4 (/ISS) |
Reproduction GO:0000003
The production of new individuals that contain some portion of genetic material inherited from one or more parent organisms.
|
1 | Q9U3F4 (/IMP) |
G2/M transition of mitotic cell cycle GO:0000086
The mitotic cell cycle transition by which a cell in G2 commits to M phase. The process begins when the kinase activity of M cyclin/CDK complex reaches a threshold high enough for the cell cycle to proceed. This is accomplished by activating a positive feedback loop that results in the accumulation of unphosphorylated and active M cyclin/CDK complex.
|
1 | Q96IF1 (/TAS) |
Negative regulation of transcription from RNA polymerase II promoter GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter.
|
1 | Q91XC0 (/IMP) |
Mitotic cell cycle GO:0000278
Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent.
|
1 | Q9VY77 (/IMP) |
Heart looping GO:0001947
The tube morphogenesis process in which the primitive heart tube loops asymmetrically. This looping brings the primitive heart chambers into alignment preceding their future integration. Heart looping begins with dextral-looping and ends when the main regional divisions of the mature heart and primordium of the great arterial trunks become established preceeding septation.
|
1 | Q6P7E4 (/IGI) |
Heart looping GO:0001947
The tube morphogenesis process in which the primitive heart tube loops asymmetrically. This looping brings the primitive heart chambers into alignment preceding their future integration. Heart looping begins with dextral-looping and ends when the main regional divisions of the mature heart and primordium of the great arterial trunks become established preceeding septation.
|
1 | Q6P7E4 (/IMP) |
Regulation of cell-matrix adhesion GO:0001952
Any process that modulates the frequency, rate or extent of attachment of a cell to the extracellular matrix.
|
1 | A1ZA47 (/IMP) |
Osteoblast development GO:0002076
The process whose specific outcome is the progression of an osteoblast over time, from its formation to the mature structure. Osteoblast development does not include the steps involved in committing a cranial neural crest cell or an osteoprogenitor cell to an osteoblast fate. An osteoblast is a cell that gives rise to bone.
|
1 | Q9QXD8 (/IMP) |
Embryonic heart tube morphogenesis GO:0003143
The process in which the anatomical structures of the embryonic heart tube are generated and organized. The embryonic heart tube is an epithelial tube that will give rise to the mature heart.
|
1 | Q6P7E4 (/IGI) |
Atrioventricular valve formation GO:0003190
The developmental process pertaining to the initial formation of the atrioventricular valve from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable.
|
1 | Q6P7E4 (/IMP) |
Atrial ventricular junction remodeling GO:0003294
The reorganization or renovation of heart tissue that contributes to the maturation of the connection between an atrium and a ventricle.
|
1 | Q6P7E4 (/IMP) |
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
|
1 | Q9UGP4 (/TAS) |
Regulation of transcription from RNA polymerase II promoter GO:0006357
Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter.
|
1 | A5H447 (/IMP) |
Regulation of transcription from RNA polymerase II promoter GO:0006357
Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter.
|
1 | Q0VA45 (/ISS) |
Receptor-mediated endocytosis GO:0006898
An endocytosis process in which cell surface receptors ensure specificity of transport. A specific receptor on the cell surface binds tightly to the extracellular macromolecule (the ligand) that it recognizes; the plasma-membrane region containing the receptor-ligand complex then undergoes endocytosis, forming a transport vesicle containing the receptor-ligand complex and excluding most other plasma-membrane proteins. Receptor-mediated endocytosis generally occurs via clathrin-coated pits and vesicles.
|
1 | Q9NR12 (/TAS) |
Cell adhesion GO:0007155
The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.
|
1 | Q15942 (/TAS) |
Cell-matrix adhesion GO:0007160
The binding of a cell to the extracellular matrix via adhesion molecules.
|
1 | Q15942 (/IC) |
Cell-matrix adhesion GO:0007160
The binding of a cell to the extracellular matrix via adhesion molecules.
|
1 | Q62523 (/IMP) |
Transforming growth factor beta receptor signaling pathway GO:0007179
A series of molecular signals initiated by the binding of an extracellular ligand to a transforming growth factor beta receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
|
1 | Q62523 (/ISO) |
Integrin-mediated signaling pathway GO:0007229
A series of molecular signals initiated by the binding of extracellular ligand to an integrin on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
|
1 | Q62523 (/ISO) |
Cell-cell signaling GO:0007267
Any process that mediates the transfer of information from one cell to another. This process includes signal transduction in the receiving cell and, where applicable, release of a ligand and any processes that actively facilitate its transport and presentation to the receiving cell. Examples include signaling via soluble ligands, via cell adhesion molecules and via gap junctions.
|
1 | Q15942 (/TAS) |
Multicellular organism development GO:0007275
The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).
|
1 | Q9UGP4 (/TAS) |
Axon guidance GO:0007411
The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues.
|
1 | Q9NR12 (/TAS) |
Heart development GO:0007507
The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood.
|
1 | Q62920 (/NAS) |
Regulation of cell shape GO:0008360
Any process that modulates the surface configuration of a cell.
|
1 | Q9UGP4 (/IMP) |
Regulation of cell shape GO:0008360
Any process that modulates the surface configuration of a cell.
|
1 | Q9QXD8 (/ISO) |
Regulation of cell shape GO:0008360
Any process that modulates the surface configuration of a cell.
|
1 | Q9QXD8 (/ISS) |
Release of cytoplasmic sequestered NF-kappaB GO:0008588
The release of NF-kappaB from specific molecules in the cytoplasm to which it was bound, thereby allowing its translocation into the nucleus.
|
1 | Q15654 (/IDA) |
Release of cytoplasmic sequestered NF-kappaB GO:0008588
The release of NF-kappaB from specific molecules in the cytoplasm to which it was bound, thereby allowing its translocation into the nucleus.
|
1 | Q9Z1Y4 (/ISO) |
Phosphorylation GO:0016310
The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide.
|
1 | Q9UGP4 (/IDA) |
Phosphorylation GO:0016310
The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide.
|
1 | Q9QXD8 (/ISO) |
Calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules GO:0016339
The attachment of one cell to another cell via adhesion molecules that require the presence of calcium for the interaction.
|
1 | Q91XC0 (/IMP) |
Cell migration GO:0016477
The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. Cell migration is a central process in the development and maintenance of multicellular organisms.
|
1 | Q9UGP4 (/IMP) |
Cell migration GO:0016477
The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. Cell migration is a central process in the development and maintenance of multicellular organisms.
|
1 | Q9QXD8 (/ISO) |
Cell migration GO:0016477
The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. Cell migration is a central process in the development and maintenance of multicellular organisms.
|
1 | Q9QXD8 (/ISS) |
Regulation of cell morphogenesis GO:0022604
Any process that modulates the frequency, rate or extent of cell morphogenesis. Cell morphogenesis is the developmental process in which the shape of a cell is generated and organized.
|
1 | A6NIX2 (/IMP) |
Regulation of cell morphogenesis GO:0022604
Any process that modulates the frequency, rate or extent of cell morphogenesis. Cell morphogenesis is the developmental process in which the shape of a cell is generated and organized.
|
1 | Q7TQJ8 (/ISO) |
Lamellipodium assembly GO:0030032
Formation of a lamellipodium, a thin sheetlike extension of the surface of a migrating cell.
|
1 | Q91XC0 (/IMP) |
Actin cytoskeleton organization GO:0030036
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins.
|
1 | Q3TJD7 (/IPI) |
Myofibril assembly GO:0030239
Formation of myofibrils, the repeating units of striated muscle.
|
1 | A1ZA47 (/IMP) |
Regulation of cell migration GO:0030334
Any process that modulates the frequency, rate or extent of cell migration.
|
1 | Q91XC0 (/IDA) |
Regulation of cell migration GO:0030334
Any process that modulates the frequency, rate or extent of cell migration.
|
1 | Q91XC0 (/IMP) |
Positive regulation of cell migration GO:0030335
Any process that activates or increases the frequency, rate or extent of cell migration.
|
1 | Q15654 (/IMP) |
Positive regulation of cell migration GO:0030335
Any process that activates or increases the frequency, rate or extent of cell migration.
|
1 | Q9Z1Y4 (/ISO) |
Ovarian follicle cell development GO:0030707
The process that occurs during oogenesis involving the ovarian follicle cells, somatic cells which surround the germ cells of an ovary. An example of this is found in Drosophila melanogaster.
|
1 | Q9VY77 (/IMP) |
Positive regulation of cellular biosynthetic process GO:0031328
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances, carried out by individual cells.
|
1 | Q91XC0 (/IMP) |
Positive regulation of protein complex assembly GO:0031334
Any process that activates or increases the frequency, rate or extent of protein complex assembly.
|
1 | Q96IF1 (/IDA) |
Positive regulation of protein complex assembly GO:0031334
Any process that activates or increases the frequency, rate or extent of protein complex assembly.
|
1 | Q91XC0 (/ISO) |
Pectoral fin development GO:0033339
The process whose specific outcome is the progression of the pectoral fin over time, from its formation to the mature structure.
|
1 | Q6P7E4 (/IMP) |
Negative regulation of kinase activity GO:0033673
Any process that stops, prevents, or reduces the frequency, rate or extent of kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule.
|
1 | Q91XC0 (/IDA) |
Positive regulation of kinase activity GO:0033674
Any process that activates or increases the frequency, rate or extent of kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule.
|
1 | Q91XC0 (/IDA) |
Cytoplasmic mRNA processing body assembly GO:0033962
The aggregation, arrangement and bonding together of proteins and RNA molecules to form a cytoplasmic mRNA processing body.
|
1 | Q9UGP4 (/IMP) |
Cytoplasmic mRNA processing body assembly GO:0033962
The aggregation, arrangement and bonding together of proteins and RNA molecules to form a cytoplasmic mRNA processing body.
|
1 | Q9QXD8 (/ISO) |
Cellular protein localization GO:0034613
Any process in which a protein is transported to, and/or maintained in, a specific location at the level of a cell. Localization at the cellular level encompasses movement within the cell, from within the cell to the cell surface, or from one location to another at the surface of a cell.
|
1 | Q91XC0 (/IMP) |
Wound healing, spreading of epidermal cells GO:0035313
The migration of an epidermal cell along or through a wound gap that contributes to the reestablishment of a continuous epidermis.
|
1 | Q91XC0 (/IMP) |
Regulation of GTPase activity GO:0043087
Any process that modulates the rate of GTP hydrolysis by a GTPase.
|
1 | Q91XC0 (/IMP) |
Positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123
Any process that activates or increases the frequency, rate or extent of I-kappaB kinase/NF-kappaB signaling.
|
1 | Q91XC0 (/IMP) |
Stress fiber assembly GO:0043149
The aggregation, arrangement and bonding together of a set of components to form a stress fiber. A stress fiber is a contractile actin filament bundle that consists of short actin filaments with alternating polarity.
|
1 | Q15942 (/IMP) |
Stress fiber assembly GO:0043149
The aggregation, arrangement and bonding together of a set of components to form a stress fiber. A stress fiber is a contractile actin filament bundle that consists of short actin filaments with alternating polarity.
|
1 | Q62523 (/ISO) |
Positive regulation of MAP kinase activity GO:0043406
Any process that activates or increases the frequency, rate or extent of MAP kinase activity.
|
1 | Q91XC0 (/IDA) |
Sarcomere organization GO:0045214
The myofibril assembly process that results in the organization of muscle actomyosin into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs.
|
1 | Q9JKS4 (/IMP) |
Negative regulation of osteoblast differentiation GO:0045668
Any process that stops, prevents, or reduces the frequency, rate or extent of osteoblast differentiation.
|
1 | Q9QXD8 (/IMP) |
Positive regulation of osteoblast differentiation GO:0045669
Any process that activates or increases the frequency, rate or extent of osteoblast differentiation.
|
1 | Q9Z1Z9 (/IDA) |
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
|
1 | Q9UGP4 (/IDA) |
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
|
1 | Q9UGP4 (/IMP) |
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
|
1 | Q9QXD8 (/ISO) |
Glycerophospholipid biosynthetic process GO:0046474
The chemical reactions and pathways resulting in the formation of glycerophospholipids, any derivative of glycerophosphate that contains at least one O-acyl, O-alkyl, or O-alkenyl group attached to the glycerol residue.
|
1 | Q91XC0 (/IMP) |
Focal adhesion assembly GO:0048041
The aggregation and bonding together of a set of components to form a focal adhesion, a complex of intracellular signaling and structural proteins that provides a structural link between the internal actin cytoskeleton and the ECM, and also function as a locus of signal transduction activity.
|
1 | Q91XC0 (/IMP) |
Focal adhesion assembly GO:0048041
The aggregation and bonding together of a set of components to form a focal adhesion, a complex of intracellular signaling and structural proteins that provides a structural link between the internal actin cytoskeleton and the ECM, and also function as a locus of signal transduction activity.
|
1 | Q15654 (/NAS) |
Regulation of inflammatory response GO:0050727
Any process that modulates the frequency, rate or extent of the inflammatory response, the immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents.
|
1 | D4A7U1 (/IEP) |
Regulation of synapse assembly GO:0051963
Any process that modulates the frequency, rate or extent of synapse assembly, the aggregation, arrangement and bonding together of a set of components to form a synapse.
|
1 | Q62920 (/IDA) |
Convergent extension involved in gastrulation GO:0060027
The morphogenetic process in which an epithelium narrows along one axis and lengthens in a perpendicular axis usually resulting in the formation of the three primary germ layers, ectoderm, mesoderm and endoderm.
|
1 | F1QSX8 (/IGI) |
Convergent extension involved in gastrulation GO:0060027
The morphogenetic process in which an epithelium narrows along one axis and lengthens in a perpendicular axis usually resulting in the formation of the three primary germ layers, ectoderm, mesoderm and endoderm.
|
1 | F1QSX8 (/IMP) |
Dorsal convergence GO:0060030
The directed migration of individual cells and small groups of cells toward the dorsal midline during gastrulation. This process does not require cell rearrangement.
|
1 | F1QSX8 (/IMP) |
Regulation of dendritic spine morphogenesis GO:0061001
Any process that modulates the rate, frequency, or extent of dendritic spine morphogenesis, the process in which the anatomical structures of a dendritic spine are generated and organized. A dendritic spine is a protrusion from a dendrite and a specialized subcellular compartment involved in synaptic transmission.
|
1 | Q62920 (/IDA) |
Cell growth involved in cardiac muscle cell development GO:0061049
The growth of a cardiac muscle cell, where growth contributes to the progression of the cell over time from its initial formation to its mature state.
|
1 | Q62920 (/IGI) |
Cell growth involved in cardiac muscle cell development GO:0061049
The growth of a cardiac muscle cell, where growth contributes to the progression of the cell over time from its initial formation to its mature state.
|
1 | Q96HC4 (/ISS) |
Muscle structure development GO:0061061
The progression of a muscle structure over time, from its formation to its mature state. Muscle structures are contractile cells, tissues or organs that are found in multicellular organisms.
|
1 | A1ZA47 (/IMP) |
Regulation of transcription from RNA polymerase II promoter in response to hypoxia GO:0061418
Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a hypoxia stimulus.
|
1 | Q9UGP4 (/TAS) |
Protein localization to centrosome GO:0071539
A process in which a protein is transported to, or maintained at, the centrosome.
|
1 | Q9VY77 (/IMP) |
Negative regulation of canonical Wnt signaling pathway GO:0090090
Any process that decreases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes.
|
1 | Q9QXD8 (/IMP) |
Maintenance of synapse structure GO:0099558
A process that preserves the structural organistation and orientation of a synaptic cellular component such as the synaptic cytoskeleton and molecular scaffolds.
|
1 | Q9U3F4 (/IMP) |
Regulation of cellular response to hypoxia GO:1900037
Any process that modulates the frequency, rate or extent of cellular response to hypoxia.
|
1 | Q96IF1 (/IDA) |
Regulation of cellular response to hypoxia GO:1900037
Any process that modulates the frequency, rate or extent of cellular response to hypoxia.
|
1 | Q91XC0 (/ISO) |
There are 68 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Focal adhesion GO:0005925
Small region on the surface of a cell that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments.
|
13 |
A5H447 (/ISS)
B5DEH0 (/ISS)
G3USS0 (/ISS)
G5E5X0 (/ISS)
H9XVP5 (/ISS)
Q0VA45 (/ISS)
Q3SX26 (/ISS)
Q8I0G8 (/ISS)
Q8T0F5 (/ISS)
Q9N675 (/ISS)
(3 more) |
Focal adhesion GO:0005925
Small region on the surface of a cell that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments.
|
12 |
A0A087WZF1 (/IDA)
A0A0D9SFS2 (/IDA)
A1ZA47 (/IDA)
C9JRJ5 (/IDA)
H0Y2Y8 (/IDA)
Q04584 (/IDA)
Q15654 (/IDA)
Q15942 (/IDA)
Q91XC0 (/IDA)
Q93052 (/IDA)
(2 more) |
Stress fiber GO:0001725
A contractile actin filament bundle that consists of short actin filaments with alternating polarity, cross-linked by alpha-actinin and possibly other actin bundling proteins, and with myosin present in a periodic distribution along the fiber.
|
10 | A1ZA47 (/IDA) H9XVP5 (/IDA) Q04584 (/IDA) Q15942 (/IDA) Q3TJD7 (/IDA) Q679P3 (/IDA) Q8I0G8 (/IDA) Q8T0F5 (/IDA) Q9N675 (/IDA) R4GKC8 (/IDA) |
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
9 | A0A087WZF1 (/IDA) A0A0D9SFS2 (/IDA) H0Y2Y8 (/IDA) Q15654 (/IDA) Q15942 (/IDA) Q62920 (/IDA) Q91XC0 (/IDA) Q93052 (/IDA) Q96IF1 (/IDA) |
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
7 | C9JRJ5 (/IDA) Q15942 (/IDA) Q91XC0 (/IDA) Q96IF1 (/IDA) Q9NR12 (/IDA) Q9U3F4 (/IDA) Q9UGP4 (/IDA) |
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
7 | Q04584 (/IDA) Q3TJD7 (/IDA) Q679P3 (/IDA) Q6P7E4 (/IDA) Q9QXD8 (/IDA) Q9UGP4 (/IDA) R4GKC8 (/IDA) |
Z disc GO:0030018
Platelike region of a muscle sarcomere to which the plus ends of actin filaments are attached.
|
7 | A0A096MJ01 (/IDA) A0A096MKD4 (/IDA) A0A0G2JYM0 (/IDA) A1ZA47 (/IDA) O75112 (/IDA) Q8CI51 (/IDA) Q9JKS4 (/IDA) |
Cytoskeleton GO:0005856
Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles.
|
5 | H9XVP5 (/ISS) Q8I0G8 (/ISS) Q8T0F5 (/ISS) Q9JKS4 (/ISS) Q9N675 (/ISS) |
Focal adhesion GO:0005925
Small region on the surface of a cell that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments.
|
5 | Q3TJD7 (/ISO) Q62523 (/ISO) Q8BFW7 (/ISO) Q9QXD8 (/ISO) Q9Z1Y4 (/ISO) |
Actin cytoskeleton GO:0015629
The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes.
|
5 | A1ZA47 (/IDA) Q679P3 (/IDA) Q96HC4 (/IDA) Q9NR12 (/IDA) R4GKC8 (/IDA) |
Actin cytoskeleton GO:0015629
The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes.
|
5 | B0WXP3 (/ISS) Q179D0 (/ISS) Q28WK7 (/ISS) Q7PTE3 (/ISS) Q9U3F4 (/ISS) |
Striated muscle dense body GO:0055120
A vinculin-containing myofibril attachment structure of striated muscle that connects sarcomeres to the extracellular matrix. In nematode body wall muscle, the dense body performs the dual role of Z-disk and costamere.
|
5 | G5EEF6 (/IDA) G5EEL1 (/IDA) G5EFG1 (/IDA) G5EFL5 (/IDA) Q9U3F4 (/IDA) |
P-body GO:0000932
A focus in the cytoplasm where mRNAs may become inactivated by decapping or some other mechanism. Protein and RNA localized to these foci are involved in mRNA degradation, nonsense-mediated mRNA decay (NMD), translational repression, and RNA-mediated gene silencing.
|
4 | E1BKA3 (/ISS) Q5U2Z2 (/ISS) Q7TQJ8 (/ISS) Q91XC0 (/ISS) |
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
4 | Q3TJD7 (/ISO) Q62523 (/ISO) Q91XC0 (/ISO) Q9QXD8 (/ISO) |
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
4 | Q62523 (/ISO) Q8BFW7 (/ISO) Q91XC0 (/ISO) Q9Z1Y4 (/ISO) |
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
4 | Q62920 (/TAS) Q96IF1 (/TAS) Q9NR12 (/TAS) Q9UGP4 (/TAS) |
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
4 | A0A0D9SFS2 (/IDA) C9JRJ5 (/IDA) Q15654 (/IDA) Q9UGP4 (/IDA) |
Cell-cell junction GO:0005911
A cell junction that forms a connection between two or more cells in a multicellular organism; excludes direct cytoplasmic junctions such as ring canals.
|
4 | H9XVP5 (/ISS) Q8I0G8 (/ISS) Q8T0F5 (/ISS) Q9N675 (/ISS) |
Subapical complex GO:0035003
The most apical region of the lateral plasma membrane of an invertebrate epithelial cell. The subapical complex lies above the zonula adherens and the septate junction, and is comparable to the position of the tight junction of vertebrate cells.
|
4 | H9XVP5 (/IDA) Q8I0G8 (/IDA) Q8T0F5 (/IDA) Q9N675 (/IDA) |
P-body GO:0000932
A focus in the cytoplasm where mRNAs may become inactivated by decapping or some other mechanism. Protein and RNA localized to these foci are involved in mRNA degradation, nonsense-mediated mRNA decay (NMD), translational repression, and RNA-mediated gene silencing.
|
3 | A6NIX2 (/IDA) Q96IF1 (/IDA) Q9UGP4 (/IDA) |
P-body GO:0000932
A focus in the cytoplasm where mRNAs may become inactivated by decapping or some other mechanism. Protein and RNA localized to these foci are involved in mRNA degradation, nonsense-mediated mRNA decay (NMD), translational repression, and RNA-mediated gene silencing.
|
3 | Q7TQJ8 (/ISO) Q91XC0 (/ISO) Q9QXD8 (/ISO) |
Stress fiber GO:0001725
A contractile actin filament bundle that consists of short actin filaments with alternating polarity, cross-linked by alpha-actinin and possibly other actin bundling proteins, and with myosin present in a periodic distribution along the fiber.
|
3 | A5H447 (/ISS) G3USS0 (/ISS) Q0VA45 (/ISS) |
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
3 | B5DEH0 (/ISS) G5E5X0 (/ISS) Q9QXD8 (/ISS) |
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
3 | B5DEH0 (/ISS) G3USS0 (/ISS) G5E5X0 (/ISS) |
Cell-cell junction GO:0005911
A cell junction that forms a connection between two or more cells in a multicellular organism; excludes direct cytoplasmic junctions such as ring canals.
|
3 | Q5U2Z2 (/IDA) Q96IF1 (/IDA) Q9VY77 (/IDA) |
Adherens junction GO:0005912
A cell junction at which anchoring proteins (cadherins or integrins) extend through the plasma membrane and are attached to actin filaments.
|
3 | B5DEH0 (/ISS) G5E5X0 (/ISS) Q9QXD8 (/ISS) |
Cell-cell adherens junction GO:0005913
An adherens junction which connects a cell to another cell.
|
3 | Q15942 (/IDA) Q96HC4 (/IDA) Q9NR12 (/IDA) |
Cell-cell adherens junction GO:0005913
An adherens junction which connects a cell to another cell.
|
3 | Q3TJD7 (/ISO) Q62523 (/ISO) Q8CI51 (/ISO) |
Filamentous actin GO:0031941
A two-stranded helical polymer of the protein actin.
|
3 | Q679P3 (/IDA) Q6P7E4 (/IDA) R4GKC8 (/IDA) |
Perinuclear region of cytoplasm GO:0048471
Cytoplasm situated near, or occurring around, the nucleus.
|
3 | Q679P3 (/IDA) Q6P7E4 (/IDA) R4GKC8 (/IDA) |
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
2 | Q8CI51 (/ISS) Q96HC4 (/ISS) |
Actin filament GO:0005884
A filamentous structure formed of a two-stranded helical polymer of the protein actin and associated proteins. Actin filaments are a major component of the contractile apparatus of skeletal muscle and the microfilaments of the cytoskeleton of eukaryotic cells. The filaments, comprising polymerized globular actin molecules, appear as flexible structures with a diameter of 5-9 nm. They are organized into a variety of linear bundles, two-dimensional networks, and three dimensional gels. In the cytoskeleton they are most highly concentrated in the cortex of the cell just beneath the plasma membrane.
|
2 | Q679P3 (/IDA) R4GKC8 (/IDA) |
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
2 | Q9QXD8 (/ISO) Q9Z1Y4 (/ISO) |
Adherens junction GO:0005912
A cell junction at which anchoring proteins (cadherins or integrins) extend through the plasma membrane and are attached to actin filaments.
|
2 | Q9UGP4 (/IDA) Q9VY77 (/IDA) |
Postsynaptic density GO:0014069
An electron dense network of proteins within and adjacent to the postsynaptic membrane in asymetric synapses. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize them such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components.
|
2 | Q8CI51 (/ISS) Q96HC4 (/ISS) |
Actin cytoskeleton GO:0015629
The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes.
|
2 | Q3TJD7 (/ISO) Q8CI51 (/ISO) |
Cortical actin cytoskeleton GO:0030864
The portion of the actin cytoskeleton, comprising filamentous actin and associated proteins, that lies just beneath the plasma membrane.
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2 | Q679P3 (/IDA) R4GKC8 (/IDA) |
Apical part of cell GO:0045177
The region of a polarized cell that forms a tip or is distal to a base. For example, in a polarized epithelial cell, the apical region has an exposed surface and lies opposite to the basal lamina that separates the epithelium from other tissue.
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2 | A1ZA47 (/IDA) Q9VY77 (/IDA) |
Stress fiber GO:0001725
A contractile actin filament bundle that consists of short actin filaments with alternating polarity, cross-linked by alpha-actinin and possibly other actin bundling proteins, and with myosin present in a periodic distribution along the fiber.
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1 | Q62523 (/ISO) |
Ruffle GO:0001726
Projection at the leading edge of a crawling cell; the protrusions are supported by a microfilament meshwork.
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1 | Q3TJD7 (/IDA) |
Cell GO:0005623
The basic structural and functional unit of all organisms. Includes the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope.
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1 | Q04584 (/IDA) |
Cell GO:0005623
The basic structural and functional unit of all organisms. Includes the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope.
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1 | G3USS0 (/ISS) |
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
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1 | Q91XC0 (/TAS) |
Transcription factor complex GO:0005667
A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription.
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1 | Q91XC0 (/IDA) |
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
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1 | Q9QXD8 (/ISO) |
Golgi apparatus GO:0005794
A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions.
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1 | Q96IF1 (/IDA) |
Golgi apparatus GO:0005794
A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions.
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1 | Q91XC0 (/ISO) |
Cytoskeleton GO:0005856
Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles.
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1 | O75112 (/IDA) |
Cytoskeleton GO:0005856
Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles.
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1 | Q9JKS4 (/ISO) |
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
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1 | Q15942 (/TAS) |
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
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1 | Q15942 (/TAS) |
Cell-cell junction GO:0005911
A cell junction that forms a connection between two or more cells in a multicellular organism; excludes direct cytoplasmic junctions such as ring canals.
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1 | Q91XC0 (/ISO) |
Adherens junction GO:0005912
A cell junction at which anchoring proteins (cadherins or integrins) extend through the plasma membrane and are attached to actin filaments.
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1 | Q9QXD8 (/ISO) |
Zonula adherens GO:0005915
A cell-cell adherens junction which forms a continuous belt near the apex of epithelial cells.
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1 | A1ZA47 (/IDA) |
Muscle tendon junction GO:0005927
A cell-substrate junction found at the terminal anchorage site of skeletal muscle cells to tendons.
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1 | A1ZA47 (/IDA) |
Postsynaptic density GO:0014069
An electron dense network of proteins within and adjacent to the postsynaptic membrane in asymetric synapses. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize them such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components.
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1 | Q62920 (/IDA) |
Actin cytoskeleton GO:0015629
The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes.
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1 | Q6P7E4 (/IPI) |
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
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1 | Q62920 (/IDA) |
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
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1 | Q96HC4 (/ISS) |
Basolateral plasma membrane GO:0016323
The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis.
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1 | A1ZA47 (/IDA) |
RISC complex GO:0016442
A ribonucleoprotein complex that contains members of the Argonaute family of proteins, small interfering RNAs (siRNAs) or microRNAs (miRNAs), and miRNA or siRNA-complementary mRNAs, in addition to a number of accessory factors. The RISC complex is involved in posttranscriptional repression of gene expression through downregulation of translation or induction of mRNA degradation.
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1 | Q9UGP4 (/IDA) |
RISC complex GO:0016442
A ribonucleoprotein complex that contains members of the Argonaute family of proteins, small interfering RNAs (siRNAs) or microRNAs (miRNAs), and miRNA or siRNA-complementary mRNAs, in addition to a number of accessory factors. The RISC complex is involved in posttranscriptional repression of gene expression through downregulation of translation or induction of mRNA degradation.
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1 | Q9QXD8 (/ISO) |
Z disc GO:0030018
Platelike region of a muscle sarcomere to which the plus ends of actin filaments are attached.
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1 | Q9JKS4 (/ISO) |
Lamellipodium GO:0030027
A thin sheetlike process extended by the leading edge of a migrating cell or extending cell process; contains a dense meshwork of actin filaments.
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1 | Q91XC0 (/IDA) |
Cell leading edge GO:0031252
The area of a motile cell closest to the direction of movement.
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1 | A1ZA47 (/IDA) |
M band GO:0031430
The midline of aligned thick filaments in a sarcomere; location of specific proteins that link thick filaments. Depending on muscle type the M band consists of different numbers of M lines.
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1 | Q9U3F4 (/IDA) |
Basal part of cell GO:0045178
The region of a cell situated near the base. For example, in a polarized epithelial cell, the basal surface rests on the basal lamina that separates the epithelium from other tissue.
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1 | A1ZA47 (/IDA) |
Apical cortex GO:0045179
The region that lies just beneath the plasma membrane on the apical edge of a cell.
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1 | Q9VY77 (/IDA) |