The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Cysteine Rich Protein
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 5794: cDNA FLJ53160, highly similar to Zyxin

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 6 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
4 A5H447 (/IPI) Q04584 (/IPI) Q15942 (/IPI) Q62523 (/IPI)
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
1 Q15942 (/IDA)
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
1 Q62523 (/ISO)
Transcription factor binding GO:0008134
Interacting selectively and non-covalently with a transcription factor, any protein required to initiate or regulate transcription.
1 A5H447 (/IPI)
Transcription factor binding GO:0008134
Interacting selectively and non-covalently with a transcription factor, any protein required to initiate or regulate transcription.
1 Q0VA45 (/ISS)
Alpha-actinin binding GO:0051393
Interacting selectively and non-covalently with alpha-actinin, one of a family of proteins that cross-link F-actin as antiparallel homodimers. Alpha-actinin has a molecular mass of 93-103 KDa; at the N-terminus there are two calponin homology domains, at the C-terminus there are two EF-hands. These two domains are connected by the rod domain. This domain is formed by triple-helical spectrin repeats.
1 Q04584 (/IPI)

There are 14 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Transforming growth factor beta receptor signaling pathway GO:0007179
A series of molecular signals initiated by the binding of an extracellular ligand to a transforming growth factor beta receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
2 Q15942 (/IMP) Q62523 (/IMP)
Integrin-mediated signaling pathway GO:0007229
A series of molecular signals initiated by the binding of extracellular ligand to an integrin on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
2 Q15942 (/IMP) Q62523 (/IMP)
Regulation of inflammatory response GO:0050727
Any process that modulates the frequency, rate or extent of the inflammatory response, the immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents.
2 D4A7U1 (/IEP) Q99MM3 (/IEP)
Regulation of transcription from RNA polymerase II promoter GO:0006357
Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter.
1 A5H447 (/IMP)
Regulation of transcription from RNA polymerase II promoter GO:0006357
Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter.
1 Q0VA45 (/ISS)
Cell adhesion GO:0007155
The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.
1 Q15942 (/TAS)
Cell-matrix adhesion GO:0007160
The binding of a cell to the extracellular matrix via adhesion molecules.
1 Q15942 (/IC)
Cell-matrix adhesion GO:0007160
The binding of a cell to the extracellular matrix via adhesion molecules.
1 Q62523 (/IMP)
Signal transduction GO:0007165
The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
1 Q15942 (/TAS)
Transforming growth factor beta receptor signaling pathway GO:0007179
A series of molecular signals initiated by the binding of an extracellular ligand to a transforming growth factor beta receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
1 Q62523 (/ISO)
Integrin-mediated signaling pathway GO:0007229
A series of molecular signals initiated by the binding of extracellular ligand to an integrin on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
1 Q62523 (/ISO)
Cell-cell signaling GO:0007267
Any process that mediates the transfer of information from one cell to another. This process includes signal transduction in the receiving cell and, where applicable, release of a ligand and any processes that actively facilitate its transport and presentation to the receiving cell. Examples include signaling via soluble ligands, via cell adhesion molecules and via gap junctions.
1 Q15942 (/TAS)
Stress fiber assembly GO:0043149
The aggregation, arrangement and bonding together of a set of components to form a stress fiber. A stress fiber is a contractile actin filament bundle that consists of short actin filaments with alternating polarity.
1 Q15942 (/IMP)
Stress fiber assembly GO:0043149
The aggregation, arrangement and bonding together of a set of components to form a stress fiber. A stress fiber is a contractile actin filament bundle that consists of short actin filaments with alternating polarity.
1 Q62523 (/ISO)

There are 18 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Stress fiber GO:0001725
A contractile actin filament bundle that consists of short actin filaments with alternating polarity, cross-linked by alpha-actinin and possibly other actin bundling proteins, and with myosin present in a periodic distribution along the fiber.
3 A5H447 (/ISS) G3USS0 (/ISS) Q0VA45 (/ISS)
Focal adhesion GO:0005925
Small region on the surface of a cell that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments.
3 H0Y2Y8 (/IDA) Q04584 (/IDA) Q15942 (/IDA)
Focal adhesion GO:0005925
Small region on the surface of a cell that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments.
3 A5H447 (/ISS) G3USS0 (/ISS) Q0VA45 (/ISS)
Stress fiber GO:0001725
A contractile actin filament bundle that consists of short actin filaments with alternating polarity, cross-linked by alpha-actinin and possibly other actin bundling proteins, and with myosin present in a periodic distribution along the fiber.
2 Q04584 (/IDA) Q15942 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
2 H0Y2Y8 (/IDA) Q15942 (/IDA)
Stress fiber GO:0001725
A contractile actin filament bundle that consists of short actin filaments with alternating polarity, cross-linked by alpha-actinin and possibly other actin bundling proteins, and with myosin present in a periodic distribution along the fiber.
1 Q62523 (/ISO)
Cell GO:0005623
The basic structural and functional unit of all organisms. Includes the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope.
1 Q04584 (/IDA)
Cell GO:0005623
The basic structural and functional unit of all organisms. Includes the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope.
1 G3USS0 (/ISS)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 Q15942 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 Q62523 (/ISO)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 Q04584 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 G3USS0 (/ISS)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 Q62523 (/ISO)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 Q15942 (/TAS)
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
1 Q15942 (/TAS)
Cell-cell adherens junction GO:0005913
An adherens junction which connects a cell to another cell.
1 Q15942 (/IDA)
Cell-cell adherens junction GO:0005913
An adherens junction which connects a cell to another cell.
1 Q62523 (/ISO)
Focal adhesion GO:0005925
Small region on the surface of a cell that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments.
1 Q62523 (/ISO)
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