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CATH Superfamily 1.50.10.20

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 6422: Terpentedienyl-diphosphate synthase

There are 2 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Halimadienyl-diphosphate synthase. [EC: 5.5.1.16]
Geranylgeranyl diphosphate = tuberculosinyl diphosphate.
  • Found in pathogenic prokaryotes such as Mycobacterium tuberculosis but not in non-pathogens such as Mycobacterium smegmatis so may play a role in pathogenicity.
  • The product of the reaction is subsequently dephosphorylated yielding tuberculosinol (halima-5,13-dien-15-ol).
 8 A0A045JBW1 A0A120IYJ1 A0A1N6MJA8 A5U851 I6XH12 M8CHW4 O50406 R4MIU6
Terpentedienyl-diphosphate synthase. [EC: 5.5.1.15]
Geranylgeranyl diphosphate = terpentedienyl diphosphate.
  • Contains a DXDD motif, which is a characteristic of diterpene cylases whose reactions are initiated by protonation at the 14,15-double bond of geranylgeranyl diphosphate (GGDP).
  • The triggering proton is lost at the end of the cyclization reaction.
  • The product of the reaction, terpentedienyl diphosphate, is the substrate for EC 4.2.3.36 and is a precursor of the diterpenoid antibiotic terpentecin.
 1 Q9AJE4