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CATH Superfamily 1.50.10.20

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 6397: Terpene cyclase/mutase family member

There are 30 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Cycloartenol synthase. [EC: 5.4.99.8]
(3S)-2,3-epoxy-2,3-dihydrosqualene = cycloartenol.
    		 50 A0A088S2C9 A0A088S2C9 A0A0A6ZA39 A0A0A6ZA39 A0A0B2RG96 A0A0B2RG96 A0A0D2M767 A0A0D2M767 A0A1L3HE28 A0A1L3HE28
    (40 more...)
    Lanosterol synthase. [EC: 5.4.99.7]
    (3S)-2,3-epoxy-2,3-dihydrosqualene = lanosterol.
    • Formerly EC 1.14.1.3 and EC 1.99.1.13.
    		 36 A0A0L1HPJ2 A0A0L1HPJ2 A0A1L5JY50 A0A1L5JY50 A6ZSX8 A6ZSX8 B2ZWF7 B2ZWF7 C7GWT3 C7GWT3
    (26 more...)
    Beta-amyrin synthase. [EC: 5.4.99.39]
    (3S)-2,3-epoxy-2,3-dihydrosqualene = beta-amyrin.
    • Some organism possess a monofunctional beta-amyrin synthase, other have a multifunctional enzyme that also catalyzes the synthesis of alpha-amyrin (EC 5.4.99.40) or lupeol (EC 5.4.99.41).
    • Formerly EC 5.4.99.n1.
    		 26 A0A0N7AWI6 A0A0N7AWI6 A0A178WBX1 A0A178WBX1 A8CDT2 A8CDT2 B6EXY6 B6EXY6 E7DN63 E7DN63
    (16 more...)
    Lupeol synthase. [EC: 5.4.99.41]
    (3S)-2,3-epoxy-2,3-dihydrosqualene = lupeol.
    • Also forms some beta-amyrin.
    • The recombinant enzyme from Arabidopsis thaliana gives a 1:1 mixture of lupeol and lupan-3-beta,20-diol with small amounts of beta-amyrin, germanicol, taraxasterol and psi-taraxasterol.
    • See EC 4.2.1.128.
    • Formerly EC 5.4.99.n2.
    		 14 A8CDT3 A8CDT3 E2IUA9 E2IUA9 Q2XPU7 Q2XPU7 Q764T8 Q764T8 Q8RWT0 Q8RWT0
    (4 more...)
    Protostadienol synthase. [EC: 5.4.99.32]
    (3S)-2,3-epoxy-2,3-dihydrosqualene = (17Z)-protosta-17(20),24-dien-3- beta-ol.
    • (17Z)-protosta-17(20),24-dien-3-beta-ol is a precursor of the steroidal antibiotic helvolic acid.
    		 8 A1CVK0 A1CVK0 B0Y5B4 B0Y5B4 E4V6I8 E4V6I8 Q4WR16 Q4WR16
    Alpha-amyrin synthase. [EC: 5.4.99.40]
    (3S)-2,3-epoxy-2,3-dihydrosqualene = alpha-amyrin.
    • A multifunctional enzyme which produces both alpha- and beta-amyrin (see EC 5.4.99.39).
    		 6 E7DN64 E7DN64 Q8RWT0 Q8RWT0 Q9LRH7 Q9LRH7
    Taraxerol synthase. [EC: 5.4.99.35]
    (3S)-2,3-epoxy-2,3-dihydrosqualene = taraxerol.
    • The enzyme gives taraxerol, beta-amyrin and lupeol in the ratio 70:17:13.
    		 4 A8C981 A8C981 E2IUA6 E2IUA6
    Friedelin synthase. [EC: 5.4.99.50]
    (3S)-2,3-epoxy-2,3-dihydrosqualene = friedelin.
    • The enzyme from Kalanchoe daigremontiana also gives traces of other triterpenoids.
    		 4 A0A1L3HE30 A0A1L3HE30 E2IUA8 E2IUA8
    Squalene--hopene cyclase. [EC: 5.4.99.17]
    Squalene = hop-22(29)-ene.
    • The enzyme also produces the cyclization product hopan-22-ol by addition of water (cf. EC 4.2.1.129).
    • Hopene and hopanol are formed at a constant ratio of 5:1.
    		 4 A0A0A8K7L7 A0A0A8K7L7 P33247 P33247
    Squalene--hopanol cyclase. [EC: 4.2.1.129]
    Hopan-22-ol = squalene + H(2)O.
    • The enzyme produces the cyclization products hopene (cf. EC 5.4.99.17) and hopanol from squalene at a constant ratio of 5:1.
    		 4 A0A142XJ16 A0A142XJ16 P33247 P33247
    Alpha-seco-amyrin synthase. [EC: 5.4.99.52]
    (3S)-2,3-epoxy-2,3-dihydrosqualene = alpha-seco-amyrin.
    • The enzyme from Arabidopsis thaliana is multifunctional and produces about equal amounts of alpha- and beta-seco-amyrin.
    • See EC 5.4.99.54.
    		 2 Q9SYN1 Q9SYN1
    Dammarenediol II synthase. [EC: 4.2.1.125]
    Dammarenediol II = (3S)-2,3-epoxy-2,3-dihydrosqualene + H(2)O.
    • The reaction occurs in the reverse direction.
    		 2 Q08IT1 Q08IT1
    Beta-seco-amyrin synthase. [EC: 5.4.99.54]
    (3S)-2,3-epoxy-2,3-dihydrosqualene = beta-seco-amyrin.
    • The enzyme from Arabidopsis thaliana is multifunctional and produces about equal amounts of alpha- and beta-seco-amyrin.
    • See EC 5.4.99.52.
    		 2 Q9SYN1 Q9SYN1
    Camelliol C synthase. [EC: 5.4.99.38]
    (3S)-2,3-epoxy-2,3-dihydrosqualene = camelliol C.
    • The product is 97% camelliol, 2% achilleol A and 0.2% beta-amyrin.
    • Achilleol is an isomer of camelliol C with a 4-methylenecyclohexanol ring system.
    • This enzyme probably evolved from EC 5.4.99.39.
    		 2 P0C8Y0 P0C8Y0
    Shionone synthase. [EC: 5.4.99.46]
    (3S)-2,3-epoxy-2,3-dihydrosqualene = shionone.
    • The enzyme gives traces of four other triterpenoids.
    		 2 F8WQD0 F8WQD0
    Glutinol synthase. [EC: 5.4.99.49]
    (3S)-2,3-epoxy-2,3-dihydrosqualene = glutinol.
    • The enzyme from Kalanchoe daigremontiana also gives traces of other triterpenoids.
    		 2 E2IUA7 E2IUA7
    Delta-amyrin synthase. [EC: 5.4.99.55]
    (3S)-2,3-epoxy-2,3-dihydrosqualene = delta-amyrin.
    • The enzyme from tomato (Solanum lycopersicum) gives 48% delta-amyrin, 18% alpha-amyrin, 13% beta-amyrin and traces of three or four other triterpenoid alcohols.
    • See also EC 5.4.99.40 and EC 5.4.99.39.
    		 2 E7DN64 E7DN64
    Isomultiflorenol synthase. [EC: 5.4.99.36]
    (3S)-2,3-epoxy-2,3-dihydrosqualene = isomultiflorenol.
      		 2 Q948R6 Q948R6
      Parkeol synthase. [EC: 5.4.99.47]
      (3S)-2,3-epoxy-2,3-dihydrosqualene = parkeol.
      • The enzyme from rice (Oryza sativa) produces parkeol as a single product.
      		 2 H2KWF1 H2KWF1
      Tirucalladienol synthase. [EC: 5.4.99.56]
      (3S)-2,3-epoxy-2,3-dihydrosqualene = tirucalla-7,24-dien-3-beta-ol.
      • The product from Arabidopsis thaliana is 85% tirucalla-7,24-dien-3- beta-ol with trace amounts of other triterpenoids.
      		 2 Q9LVY2 Q9LVY2
      Achilleol B synthase. [EC: 5.4.99.48]
      (3S)-2,3-epoxy-2,3-dihydrosqualene = achilleol B.
      • Achilleol B is probably formed by cleavage of the 8-14 and 9-10 bonds of (3S)-2,3-epoxy-2,3-dihydrosqualene as part of the cyclization reaction, after formation of the oleanane skeleton.
      		 2 Q2R712 Q2R712
      Lupan-3-beta,20-diol synthase. [EC: 4.2.1.128]
      Lupan-3-beta,20-diol = (3S)-2,3-epoxy-2,3-dihydrosqualene + H(2)O.
      • The reaction occurs in the reverse direction.
      • The recombinant enzyme from Arabidopsis thaliana gives a 1:1 mixture of lupeol and lupan-3-beta,20-diol with small amounts of beta-amyrin, germanicol, taraxasterol and psi-taraxasterol.
      • See EC 5.4.99.41.
      		 2 Q9C5M3 Q9C5M3
      Marneral synthase. [EC: 5.4.99.53]
      (3S)-2,3-epoxy-2,3-dihydrosqualene = marneral.
      • Marneral is a triterpenoid formed by Grob fragmentation of the A ring of 2,3-epoxy-2,3-dihydrosqualene during cyclization.
      		 2 Q9FJV8 Q9FJV8
      Baccharis oxide synthase. [EC: 5.4.99.51]
      (3S)-2,3-epoxy-2,3-dihydrosqualene = baccharis oxide.
      • The enzyme from Stevia rebaudiana also gives traces of other triterpenoids.
      		 2 B9X0J1 B9X0J1
      Dammaradiene synthase. [EC: 5.4.99.37]
      Squalene = dammara-20,24-diene.
        		 2 B3Y522 B3Y522
        Thalianol synthase. [EC: 5.4.99.31]
        (3S)-2,3-epoxy-2,3-dihydrosqualene = thalianol.
          		 2 Q9FI37 Q9FI37
          Baruol synthase. [EC: 5.4.99.57]
          (3S)-2,3-epoxy-2,3-dihydrosqualene = baruol.
          • The enzyme from Arabidopsis thaliana also produces traces of 22 other triterpenoids.
          		 2 O23390 O23390
          Arabidiol synthase. [EC: 4.2.1.124]
          Arabidiol = (3S)-2,3-epoxy-2,3-dihydrosqualene + H(2)O.
          • The reaction occurs in the reverse direction.
          		 2 Q9FR95 Q9FR95
          Cucurbitadienol synthase. [EC: 5.4.99.33]
          (3S)-2,3-epoxy-2,3-dihydrosqualene = cucurbitadienol.
            		 2 Q6BE24 Q6BE24
            Germanicol synthase. [EC: 5.4.99.34]
            (3S)-2,3-epoxy-2,3-dihydrosqualene = germanicol.
            • The enzyme produces germanicol, beta-amyrin and lupeol in the ratio 63:33:4.
            		 2 A8C980 A8C980
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