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CATH Superfamily 1.50.10.130

Terpene synthase, N-terminal domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Terpene synthase, N-terminal domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 306: Terpene synthase 19

There are 4 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Beta-phellandrene synthase (neryl-diphosphate-cyclizing). [EC: 4.2.3.51]
Neryl diphosphate = beta-phellandrene + diphosphate.
  • The enzyme from Solanum lycopersicum has very poor affinity with geranyl diphosphate as substrate.
  • Catalyzes the formation of the acyclic myrcene and ocimene as major products in addition to beta-phellandrene.
 2 C1K5M3 R9R6F4
(+)-alpha-santalene synthase ((2Z,6Z)-farnesyl diphosphate cyclizing). [EC: 4.2.3.50]
(2Z,6Z)-farnesyl diphosphate = (+)-alpha-santalene.
  • The enzyme synthesizes a mixture of sesquiterpenoids from (2Z,6Z)- farnesyl diphosphate.
  • Following dephosphorylation of (2Z,6Z)-farnesyl diphosphate, the (2Z,6Z)-farnesyl carbocation is converted to either the (6R)- or the (6S)-bisabolyl cations depending on the stereochemistry of the 6,1 closure.
  • The (6R)-bisabolyl cation will then lead to the formation of (+)- alpha-santalene (EC 4.2.3.50), while the (6S)-bisabolyl cation will give rise to (+)-endo-beta-bergamotene (see EC 4.2.3.53) as well as (-)-endo-alpha-bergamotene (see EC 4.2.3.54).
  • Small amounts of (-)-epi-beta-santalene are also formed from the (6R)-bisabolyl cation and small amounts of (-)-exo-alpha-bergamotene are formed from the (6S)-bisabolyl cation.
 1 B8XA41
(+)-endo-beta-bergamotene synthase ((2Z,6Z)-farnesyl diphosphate cyclizing). [EC: 4.2.3.53]
(2Z,6Z)-farnesyl diphosphate = (+)-endo-beta-bergamotene.
  • The enzyme synthesizes a mixture of sesquiterpenoids from (2Z,6Z)- farnesyl diphosphate.
  • Following dephosphorylation of (2Z,6Z)-farnesyl diphosphate, the (2Z,6Z)-farnesyl carbocation is converted to either the (6R)- or the (6S)-bisabolyl cations depending on the stereochemistry of the 6,1 closure.
  • The (6R)-bisabolyl cation will then lead to the formation of (+)- alpha-santalene (see EC 4.2.3.50), while the (6S)-bisabolyl cation will give rise to (-)-endo-alpha-bergamotene (see EC 4.2.3.54), as well as (+)-endo-beta-bergamotene.
  • Small amounts of (-)-epi-beta-santalene are also formed from the (6R)-bisabolyl cation and small amounts of (-)-exo-alpha-bergamotene are formed from the (6S)-bisabolyl cation.
 1 B8XA41
(-)-endo-alpha-bergamotene synthase ((2Z,6Z)-farnesyl diphosphate cyclizing). [EC: 4.2.3.54]
(2Z,6Z)-farnesyl diphosphate = (-)-endo-alpha-bergamotene.
  • The enzyme synthesizes a mixture of sesquiterpenoids from (2Z,6Z)- farnesyl diphosphate.
  • Following dephosphorylation of (2Z,6Z)-farnesyl diphosphate, the (2Z,6Z)-farnesyl carbocation is converted to either the (6R)- or the (6S)-bisabolyl cations depending on the stereochemistry of the 6,1 closure.
  • The (6R)-bisabolyl cation will then lead to the formation of (+)- alpha-santalene (see EC 4.2.3.50), while the (6S)-bisabolyl cation will give rise to (+)-endo-beta-bergamotene (EC 4.2.3.53) as well as (-)-endo-alpha-bergamotene.
  • Small amounts of (-)-epi-beta-santalene are also formed from the (6R)-bisabolyl cation and small amounts of (-)-exo-alpha-bergamotene are formed from the (6S)-bisabolyl cation (1).
 1 B8XA41