The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 2971: Clathrin assembly protein AP180

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 20 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
6 O55012 (/IPI) O60641 (/IPI) Q05140 (/IPI) Q13492 (/IPI) Q61548 (/IPI) Q9XZI6 (/IPI)
Clathrin binding GO:0030276
Interacting selectively and non-covalently with a clathrin heavy or light chain, the main components of the coat of coated vesicles and coated pits, and which also occurs in synaptic vesicles.
6 O55012 (/ISS) Q13492 (/ISS) Q498N4 (/ISS) Q7M6Y3 (/ISS) Q9VI75 (/ISS) Q9XZI6 (/ISS)
1-phosphatidylinositol binding GO:0005545
Interacting selectively and non-covalently with phosphatidylinositol, any glycophospholipid with its sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol.
4 Q13492 (/ISS) Q7M6Y3 (/ISS) Q9VI75 (/ISS) Q9XZI6 (/ISS)
1-phosphatidylinositol binding GO:0005545
Interacting selectively and non-covalently with phosphatidylinositol, any glycophospholipid with its sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol.
2 O55012 (/IDA) Q61548 (/IDA)
Clathrin binding GO:0030276
Interacting selectively and non-covalently with a clathrin heavy or light chain, the main components of the coat of coated vesicles and coated pits, and which also occurs in synaptic vesicles.
2 O55012 (/IDA) Q13492 (/IDA)
Clathrin heavy chain binding GO:0032050
Interacting selectively and non-covalently with a clathrin heavy chain.
2 Q05140 (/IPI) Q61548 (/IPI)
Clathrin adaptor activity GO:0035615
The binding activity of a molecule that brings together clathrin and one or more other molecules, permitting them to function in a coordinated way.
2 Q05140 (/IMP) Q13492 (/IMP)
Clathrin adaptor activity GO:0035615
The binding activity of a molecule that brings together clathrin and one or more other molecules, permitting them to function in a coordinated way.
2 O55012 (/ISS) Q7M6Y3 (/ISS)
SH3 domain binding GO:0017124
Interacting selectively and non-covalently with a SH3 domain (Src homology 3) of a protein, small protein modules containing approximately 50 amino acid residues found in a great variety of intracellular or membrane-associated proteins.
1 O55012 (/IDA)
Protein kinase binding GO:0019901
Interacting selectively and non-covalently with a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.
1 Q61548 (/IPI)
Protein kinase binding GO:0019901
Interacting selectively and non-covalently with a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.
1 O60641 (/ISS)
Clathrin binding GO:0030276
Interacting selectively and non-covalently with a clathrin heavy or light chain, the main components of the coat of coated vesicles and coated pits, and which also occurs in synaptic vesicles.
1 Q13492 (/IPI)
Clathrin binding GO:0030276
Interacting selectively and non-covalently with a clathrin heavy or light chain, the main components of the coat of coated vesicles and coated pits, and which also occurs in synaptic vesicles.
1 Q7M6Y3 (/ISO)
Clathrin binding GO:0030276
Interacting selectively and non-covalently with a clathrin heavy or light chain, the main components of the coat of coated vesicles and coated pits, and which also occurs in synaptic vesicles.
1 Q9VI75 (/NAS)
Clathrin heavy chain binding GO:0032050
Interacting selectively and non-covalently with a clathrin heavy chain.
1 Q13492 (/IDA)
Clathrin heavy chain binding GO:0032050
Interacting selectively and non-covalently with a clathrin heavy chain.
1 Q7M6Y3 (/ISO)
Clathrin adaptor activity GO:0035615
The binding activity of a molecule that brings together clathrin and one or more other molecules, permitting them to function in a coordinated way.
1 Q7M6Y3 (/ISO)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
1 O55012 (/IPI)
Cadherin binding GO:0045296
Interacting selectively and non-covalently with cadherin, a type I membrane protein involved in cell adhesion.
1 Q13492 (/IDA)
Cadherin binding GO:0045296
Interacting selectively and non-covalently with cadherin, a type I membrane protein involved in cell adhesion.
1 Q7M6Y3 (/ISO)

There are 81 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Receptor-mediated endocytosis GO:0006898
An endocytosis process in which cell surface receptors ensure specificity of transport. A specific receptor on the cell surface binds tightly to the extracellular macromolecule (the ligand) that it recognizes; the plasma-membrane region containing the receptor-ligand complex then undergoes endocytosis, forming a transport vesicle containing the receptor-ligand complex and excluding most other plasma-membrane proteins. Receptor-mediated endocytosis generally occurs via clathrin-coated pits and vesicles.
4 Q13492 (/IDA) Q7M6Y3 (/IDA) Q9VI75 (/IDA) Q9XZI6 (/IDA)
Receptor-mediated endocytosis GO:0006898
An endocytosis process in which cell surface receptors ensure specificity of transport. A specific receptor on the cell surface binds tightly to the extracellular macromolecule (the ligand) that it recognizes; the plasma-membrane region containing the receptor-ligand complex then undergoes endocytosis, forming a transport vesicle containing the receptor-ligand complex and excluding most other plasma-membrane proteins. Receptor-mediated endocytosis generally occurs via clathrin-coated pits and vesicles.
4 O55012 (/ISS) Q13492 (/ISS) Q498N4 (/ISS) Q7M6Y3 (/ISS)
Axonogenesis GO:0007409
De novo generation of a long process of a neuron, that carries efferent (outgoing) action potentials from the cell body towards target cells. Refers to the morphogenesis or creation of shape or form of the developing axon.
3 O55012 (/IMP) Q05140 (/IMP) Q7M6Y3 (/IMP)
Regulation of endocytosis GO:0030100
Any process that modulates the frequency, rate or extent of endocytosis.
3 O55012 (/IMP) Q05140 (/IMP) Q13492 (/IMP)
Clathrin coat assembly GO:0048268
The process that results in the assembly of clathrin triskelia into the ordered structure known as a clathrin cage.
3 O55012 (/IDA) Q61548 (/IDA) Q9U6M6 (/IDA)
Synaptic vesicle endocytosis GO:0048488
Clathrin-mediated endocytosis of presynaptic membrane that recycles synaptic vesicle membrane and its components following synaptic vesicle exocytosis. This process starts with coating of the membrane with adaptor proteins and clathrin prior to invagination and ends when uncoating has finished.
3 Q9U6M6 (/IMP) Q9VI75 (/IMP) Q9XZI6 (/IMP)
Chemical synaptic transmission GO:0007268
The vesicular release of classical neurotransmitter molecules from a neuron, across a chemical synapse, the subsequent activation of neurotransmitter receptors of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse.
2 Q61548 (/IMP) Q9VI75 (/IMP)
Neurotransmitter secretion GO:0007269
The regulated release of neurotransmitter from the presynapse into the synaptic cleft via calcium regualated exocytosis during synaptic transmission.
2 Q61548 (/IMP) Q9U6M6 (/IMP)
Cell proliferation GO:0008283
The multiplication or reproduction of cells, resulting in the expansion of a cell population.
2 O55012 (/ISS) Q7M6Y3 (/ISS)
Negative regulation of gene expression GO:0010629
Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
2 O55012 (/ISS) Q7M6Y3 (/ISS)
Synaptic vesicle maturation GO:0016188
Steps required to form an initiated synaptic vesicle into a fully formed and transmissible synaptic vesicle.
2 O55012 (/ISS) Q13492 (/ISS)
Cargo loading into vesicle GO:0035459
The formation of a macromolecular complex between the coat proteins and proteins and/or lipoproteins that are going to be transported by a vesicle.
2 Q13492 (/IMP) Q7M6Y3 (/IMP)
Clathrin coat assembly GO:0048268
The process that results in the assembly of clathrin triskelia into the ordered structure known as a clathrin cage.
2 Q13492 (/IMP) Q61548 (/IMP)
Dendrite morphogenesis GO:0048813
The process in which the anatomical structures of a dendrite are generated and organized. A dendrite is a freely branching protoplasmic process of a nerve cell.
2 O55012 (/IMP) Q7M6Y3 (/IMP)
Regulation of protein transport GO:0051223
Any process that modulates the frequency, rate or extent of the directed movement of a protein into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
2 O55012 (/IMP) Q05140 (/IMP)
Iron ion homeostasis GO:0055072
Any process involved in the maintenance of an internal steady state of iron ions within an organism or cell.
2 O55012 (/ISS) Q7M6Y3 (/ISS)
Clathrin-dependent endocytosis GO:0072583
An endocytosis process that begins when material is taken up into clathrin-coated pits, which then pinch off to form clathrin-coated endocytic vesicles.
2 Q13492 (/IMP) Q7M6Y3 (/IMP)
Iron ion import across plasma membrane GO:0098711
The directed movement of iron ions from outside of a cell, across the plasma membrane and into the cytosol.
2 O55012 (/ISS) Q7M6Y3 (/ISS)
Positive regulation of neuron death GO:1901216
Any process that activates or increases the frequency, rate or extent of neuron death.
2 O55012 (/ISS) Q7M6Y3 (/ISS)
Positive regulation of beta-amyloid formation GO:1902004
Any process that activates or increases the frequency, rate or extent of beta-amyloid formation.
2 Q13492 (/IMP) Q7M6Y3 (/IMP)
Regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process GO:1902959
Any process that modulates the frequency, rate or extent of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process.
2 O55012 (/ISS) Q7M6Y3 (/ISS)
Positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process GO:1902961
Any process that activates or increases the frequency, rate or extent of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process.
2 O55012 (/ISS) Q13492 (/ISS)
Negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process GO:1902963
Any process that stops, prevents or reduces the frequency, rate or extent of metalloendopeptidase activity involved in amyloid precursor protein catabolic process.
2 O55012 (/ISS) Q13492 (/ISS)
Protein complex assembly GO:0006461
The aggregation, arrangement and bonding together of a set of components to form a protein complex.
1 Q13492 (/TAS)
Ubiquitin-dependent protein catabolic process GO:0006511
The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein.
1 Q9XZI6 (/IMP)
Receptor-mediated endocytosis GO:0006898
An endocytosis process in which cell surface receptors ensure specificity of transport. A specific receptor on the cell surface binds tightly to the extracellular macromolecule (the ligand) that it recognizes; the plasma-membrane region containing the receptor-ligand complex then undergoes endocytosis, forming a transport vesicle containing the receptor-ligand complex and excluding most other plasma-membrane proteins. Receptor-mediated endocytosis generally occurs via clathrin-coated pits and vesicles.
1 Q7M6Y3 (/ISO)
Establishment or maintenance of cell polarity GO:0007163
Any cellular process that results in the specification, formation or maintenance of anisotropic intracellular organization or cell growth patterns.
1 Q05140 (/IMP)
Neurotransmitter secretion GO:0007269
The regulated release of neurotransmitter from the presynapse into the synaptic cleft via calcium regualated exocytosis during synaptic transmission.
1 Q9VI75 (/NAS)
Neuron-neuron synaptic transmission GO:0007270
The process of communication from a neuron to another neuron across a synapse.
1 Q9VI75 (/IMP)
Cell proliferation GO:0008283
The multiplication or reproduction of cells, resulting in the expansion of a cell population.
1 Q13492 (/IMP)
Cell proliferation GO:0008283
The multiplication or reproduction of cells, resulting in the expansion of a cell population.
1 Q7M6Y3 (/ISO)
Post-embryonic development GO:0009791
The process whose specific outcome is the progression of the organism over time, from the completion of embryonic development to the mature structure. See embryonic development.
1 Q9XZI6 (/IMP)
Negative regulation of gene expression GO:0010629
Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
1 Q13492 (/IMP)
Negative regulation of gene expression GO:0010629
Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
1 Q7M6Y3 (/ISO)
Positive regulation of necrotic cell death GO:0010940
Any process that increases the rate, frequency or extent of necrotic cell death. Necrotic cell death is a cell death process that is morphologically characterized by a gain in cell volume (oncosis), swelling of organelles, plasma membrane rupture and subsequent loss of intracellular contents.
1 Q9XZI6 (/IGI)
Synaptic vesicle coating GO:0016183
The formation of clathrin coated pits in the presynaptic membrane endocytic zone, triggered by the presence of high concentrations of synaptic vesicle components. This process leads to, but does not include budding of the membrane to form new vesicles.
1 Q9VI75 (/TAS)
Synaptic vesicle budding from presynaptic endocytic zone membrane GO:0016185
Evagination of the presynaptic membrane, resulting in the formation of a new synaptic vesicle.
1 Q61548 (/IMP)
Synaptic vesicle maturation GO:0016188
Steps required to form an initiated synaptic vesicle into a fully formed and transmissible synaptic vesicle.
1 Q7M6Y3 (/IMP)
Vesicle-mediated transport GO:0016192
A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane.
1 O55012 (/IMP)
Vesicle-mediated transport GO:0016192
A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane.
1 Q13492 (/TAS)
Endosomal transport GO:0016197
The directed movement of substances into, out of, or mediated by an endosome, a membrane-bounded organelle that carries materials newly ingested by endocytosis. It passes many of the materials to lysosomes for degradation.
1 Q13492 (/IMP)
Endosomal transport GO:0016197
The directed movement of substances into, out of, or mediated by an endosome, a membrane-bounded organelle that carries materials newly ingested by endocytosis. It passes many of the materials to lysosomes for degradation.
1 Q7M6Y3 (/ISO)
Hemopoiesis GO:0030097
The process whose specific outcome is the progression of the myeloid and lymphoid derived organ/tissue systems of the blood and other parts of the body over time, from formation to the mature structure. The site of hemopoiesis is variable during development, but occurs primarily in bone marrow or kidney in many adult vertebrates.
1 Q7M6Y3 (/IMP)
Regulation of endocytosis GO:0030100
Any process that modulates the frequency, rate or extent of endocytosis.
1 Q7M6Y3 (/ISO)
Receptor internalization GO:0031623
A receptor-mediated endocytosis process that results in the movement of receptors from the plasma membrane to the inside of the cell. The process begins when cell surface receptors are monoubiquitinated following ligand-induced activation. Receptors are subsequently taken up into endocytic vesicles from where they are either targeted to the lysosome or vacuole for degradation or recycled back to the plasma membrane.
1 Q13492 (/IMP)
Receptor internalization GO:0031623
A receptor-mediated endocytosis process that results in the movement of receptors from the plasma membrane to the inside of the cell. The process begins when cell surface receptors are monoubiquitinated following ligand-induced activation. Receptors are subsequently taken up into endocytic vesicles from where they are either targeted to the lysosome or vacuole for degradation or recycled back to the plasma membrane.
1 Q7M6Y3 (/ISO)
Regulation of protein localization GO:0032880
Any process that modulates the frequency, rate or extent of any process in which a protein is transported to, or maintained in, a specific location.
1 Q13492 (/IDA)
Regulation of protein localization GO:0032880
Any process that modulates the frequency, rate or extent of any process in which a protein is transported to, or maintained in, a specific location.
1 Q7M6Y3 (/ISO)
Cargo loading into vesicle GO:0035459
The formation of a macromolecular complex between the coat proteins and proteins and/or lipoproteins that are going to be transported by a vesicle.
1 Q7M6Y3 (/ISO)
Cargo loading into vesicle GO:0035459
The formation of a macromolecular complex between the coat proteins and proteins and/or lipoproteins that are going to be transported by a vesicle.
1 O55012 (/ISS)
Locomotion GO:0040011
Self-propelled movement of a cell or organism from one location to another.
1 Q9XZI6 (/IMP)
Phototaxis GO:0042331
The directed movement of a motile cell or organism in response to light.
1 Q9VI75 (/IMP)
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
1 Q13492 (/IDA)
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
1 Q7M6Y3 (/ISO)
Negative regulation of receptor-mediated endocytosis GO:0048261
Any process that stops, prevents, or reduces the frequency, rate or extent of receptor mediated endocytosis, the uptake of external materials by cells, utilizing receptors to ensure specificity of transport.
1 Q13492 (/IDA)
Negative regulation of receptor-mediated endocytosis GO:0048261
Any process that stops, prevents, or reduces the frequency, rate or extent of receptor mediated endocytosis, the uptake of external materials by cells, utilizing receptors to ensure specificity of transport.
1 Q7M6Y3 (/ISO)
Clathrin coat assembly GO:0048268
The process that results in the assembly of clathrin triskelia into the ordered structure known as a clathrin cage.
1 Q7M6Y3 (/ISO)
Synaptic vesicle transport GO:0048489
The directed movement of synaptic vesicles.
1 Q9VI75 (/IMP)
Synaptic vesicle transport GO:0048489
The directed movement of synaptic vesicles.
1 Q9VI75 (/IPI)
Synaptic vesicle transport GO:0048489
The directed movement of synaptic vesicles.
1 Q9VI75 (/TAS)
Iron ion homeostasis GO:0055072
Any process involved in the maintenance of an internal steady state of iron ions within an organism or cell.
1 Q13492 (/IMP)
Iron ion homeostasis GO:0055072
Any process involved in the maintenance of an internal steady state of iron ions within an organism or cell.
1 Q7M6Y3 (/ISO)
Membrane organization GO:0061024
A process which results in the assembly, arrangement of constituent parts, or disassembly of a membrane. A membrane is a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.
1 Q13492 (/TAS)
Clathrin-dependent endocytosis GO:0072583
An endocytosis process that begins when material is taken up into clathrin-coated pits, which then pinch off to form clathrin-coated endocytic vesicles.
1 Q7M6Y3 (/ISO)
Clathrin-dependent endocytosis GO:0072583
An endocytosis process that begins when material is taken up into clathrin-coated pits, which then pinch off to form clathrin-coated endocytic vesicles.
1 O55012 (/ISS)
Iron ion import across plasma membrane GO:0098711
The directed movement of iron ions from outside of a cell, across the plasma membrane and into the cytosol.
1 Q13492 (/IMP)
Iron ion import across plasma membrane GO:0098711
The directed movement of iron ions from outside of a cell, across the plasma membrane and into the cytosol.
1 Q7M6Y3 (/ISO)
Positive regulation of neuron death GO:1901216
Any process that activates or increases the frequency, rate or extent of neuron death.
1 Q13492 (/IMP)
Positive regulation of neuron death GO:1901216
Any process that activates or increases the frequency, rate or extent of neuron death.
1 Q7M6Y3 (/ISO)
Positive regulation of beta-amyloid formation GO:1902004
Any process that activates or increases the frequency, rate or extent of beta-amyloid formation.
1 Q7M6Y3 (/ISO)
Positive regulation of beta-amyloid formation GO:1902004
Any process that activates or increases the frequency, rate or extent of beta-amyloid formation.
1 O55012 (/ISS)
Regulation of receptor localization to synapse GO:1902683
Any process that modulates the frequency, rate or extent of receptor localization to synapse.
1 Q9XZI6 (/IDA)
Regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process GO:1902959
Any process that modulates the frequency, rate or extent of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process.
1 Q13492 (/IMP)
Regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process GO:1902959
Any process that modulates the frequency, rate or extent of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process.
1 Q7M6Y3 (/ISO)
Positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process GO:1902961
Any process that activates or increases the frequency, rate or extent of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process.
1 Q7M6Y3 (/IMP)
Negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process GO:1902963
Any process that stops, prevents or reduces the frequency, rate or extent of metalloendopeptidase activity involved in amyloid precursor protein catabolic process.
1 Q7M6Y3 (/IMP)
Protein localization to postsynaptic membrane GO:1903539
A process in which a protein is transported to, or maintained in, a location within a postsynaptic membrane.
1 Q9XZI6 (/IMP)
Positive regulation of clathrin coat assembly GO:1905445
Any process that activates or increases the frequency, rate or extent of clathrin coat assembly.
1 Q05140 (/IMP)
Regulation of clathrin-dependent endocytosis GO:2000369
Any process that modulates the frequency, rate or extent of clathrin-mediated endocytosis.
1 O60641 (/IMP)
Regulation of clathrin-dependent endocytosis GO:2000369
Any process that modulates the frequency, rate or extent of clathrin-mediated endocytosis.
1 Q61548 (/ISO)
Positive regulation of clathrin-dependent endocytosis GO:2000370
Any process that activates or increases the frequency, rate or extent of clathrin-mediated endocytosis.
1 Q9VI75 (/IMP)

There are 37 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Clathrin-coated pit GO:0005905
A part of the endomembrane system in the form of an invagination of a membrane upon which a clathrin coat forms, and that can be converted by vesicle budding into a clathrin-coated vesicle. Coated pits form on the plasma membrane, where they are involved in receptor-mediated selective transport of many proteins and other macromolecules across the cell membrane, in the trans-Golgi network, and on some endosomes.
4 Q13492 (/IDA) Q7M6Y3 (/IDA) Q9VI75 (/IDA) Q9XZI6 (/IDA)
Clathrin-coated pit GO:0005905
A part of the endomembrane system in the form of an invagination of a membrane upon which a clathrin coat forms, and that can be converted by vesicle budding into a clathrin-coated vesicle. Coated pits form on the plasma membrane, where they are involved in receptor-mediated selective transport of many proteins and other macromolecules across the cell membrane, in the trans-Golgi network, and on some endosomes.
4 O55012 (/ISS) Q13492 (/ISS) Q498N4 (/ISS) Q7M6Y3 (/ISS)
Presynaptic membrane GO:0042734
A specialized area of membrane of the axon terminal that faces the plasma membrane of the neuron or muscle fiber with which the axon terminal establishes a synaptic junction; many synaptic junctions exhibit structural presynaptic characteristics, such as conical, electron-dense internal protrusions, that distinguish it from the remainder of the axon plasma membrane.
3 O55012 (/IDA) Q05140 (/IDA) Q9XZI6 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
2 O55012 (/IDA) Q05140 (/IDA)
Synaptic vesicle GO:0008021
A secretory organelle, typically 50 nm in diameter, of presynaptic nerve terminals; accumulates in high concentrations of neurotransmitters and secretes these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane.
2 O55012 (/IDA) Q05140 (/IDA)
Postsynaptic density GO:0014069
An electron dense network of proteins within and adjacent to the postsynaptic membrane in asymetric synapses. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize them such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components.
2 O55012 (/IDA) Q05140 (/IDA)
Vesicle GO:0031982
Any small, fluid-filled, spherical organelle enclosed by membrane.
2 O55012 (/ISS) Q13492 (/ISS)
Neuronal cell body GO:0043025
The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
2 O55012 (/ISS) Q7M6Y3 (/ISS)
Intracellular membrane-bounded organelle GO:0043231
Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
2 A0A024R5P1 (/IDA) Q13492 (/IDA)
Postsynaptic membrane GO:0045211
A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane.
2 O55012 (/IDA) Q05140 (/IDA)
Neurofibrillary tangle GO:0097418
Intracellular mass of paired, helically wound protein filaments (also called PHF) lying in the cytoplasm of neuronal cell bodies and neuritic cell processes. Neurofibrillary tangles contain an abnormally phosphorylated form of a microtubule-associated protein, tau. The shape of these inclusions may resemble a flame or a star.
2 O55012 (/ISS) Q7M6Y3 (/ISS)
Intracellular GO:0005622
The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.
1 Q7M6Y3 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 Q13492 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 Q7M6Y3 (/ISO)
Endosome GO:0005768
A vacuole to which materials ingested by endocytosis are delivered.
1 O55012 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 Q05140 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 Q13492 (/TAS)
Clathrin-coated pit GO:0005905
A part of the endomembrane system in the form of an invagination of a membrane upon which a clathrin coat forms, and that can be converted by vesicle budding into a clathrin-coated vesicle. Coated pits form on the plasma membrane, where they are involved in receptor-mediated selective transport of many proteins and other macromolecules across the cell membrane, in the trans-Golgi network, and on some endosomes.
1 Q7M6Y3 (/ISO)
Synaptic vesicle GO:0008021
A secretory organelle, typically 50 nm in diameter, of presynaptic nerve terminals; accumulates in high concentrations of neurotransmitters and secretes these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane.
1 Q9VI75 (/TAS)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
1 Q13492 (/IDA)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
1 Q7M6Y3 (/ISO)
AP-2 adaptor complex GO:0030122
A heterotetrameric AP-type membrane coat adaptor complex that consists of alpha, beta2, mu2 and sigma2 subunits, and links clathrin to the membrane surface of a vesicle, and the cargo receptors during receptor/clathrin mediated endocytosis. Vesicles with AP-2-containing coats are normally found primarily near the plasma membrane, on endocytic vesicles. In at least humans, the AP-2 complex can be heterogeneric due to the existence of multiple subunit isoforms encoded by different alpha genes (alphaA and alphaC).
1 Q61548 (/IC)
Clathrin-coated vesicle GO:0030136
A vesicle with a coat formed of clathrin connected to the membrane via one of the clathrin adaptor complexes.
1 O55012 (/IDA)
Extrinsic component of endosome membrane GO:0031313
The component of an endosome membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.
1 Q61548 (/IDA)
Vesicle GO:0031982
Any small, fluid-filled, spherical organelle enclosed by membrane.
1 Q7M6Y3 (/IDA)
Presynaptic membrane GO:0042734
A specialized area of membrane of the axon terminal that faces the plasma membrane of the neuron or muscle fiber with which the axon terminal establishes a synaptic junction; many synaptic junctions exhibit structural presynaptic characteristics, such as conical, electron-dense internal protrusions, that distinguish it from the remainder of the axon plasma membrane.
1 Q13492 (/ISS)
Neuronal cell body GO:0043025
The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
1 Q13492 (/IDA)
Neuronal cell body GO:0043025
The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
1 Q7M6Y3 (/ISO)
Terminal bouton GO:0043195
Terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters. The axon terminus is considered to be the whole region of thickening and the terminal bouton is a specialized region of it.
1 Q05140 (/IDA)
Intracellular membrane-bounded organelle GO:0043231
Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
1 Q7M6Y3 (/ISO)
Synapse GO:0045202
The junction between a nerve fiber of one neuron and another neuron, muscle fiber or glial cell. As the nerve fiber approaches the synapse it enlarges into a specialized structure, the presynaptic nerve ending, which contains mitochondria and synaptic vesicles. At the tip of the nerve ending is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic nerve ending secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane.
1 O55012 (/IDA)
Postsynaptic membrane GO:0045211
A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane.
1 Q13492 (/ISS)
Neurofibrillary tangle GO:0097418
Intracellular mass of paired, helically wound protein filaments (also called PHF) lying in the cytoplasm of neuronal cell bodies and neuritic cell processes. Neurofibrillary tangles contain an abnormally phosphorylated form of a microtubule-associated protein, tau. The shape of these inclusions may resemble a flame or a star.
1 Q13492 (/IMP)
Neurofibrillary tangle GO:0097418
Intracellular mass of paired, helically wound protein filaments (also called PHF) lying in the cytoplasm of neuronal cell bodies and neuritic cell processes. Neurofibrillary tangles contain an abnormally phosphorylated form of a microtubule-associated protein, tau. The shape of these inclusions may resemble a flame or a star.
1 Q7M6Y3 (/ISO)
Presynaptic endosome GO:0098830
An endosome present in the presynapse that fuses with endocytic vesicles arising in the presynaptic endocytic zone. This organelle is believed to be involved in regeneration of synaptic vesicles.
1 Q61548 (/IDA)
Presynaptic endocytic zone GO:0098833
A specialized region of the plasma membrane and underlying cytoplasm which surround the the active zone, into which synaptic vesicle membranes are recycled following exocytosis. It is especially enriched in endocytic proteins following intense activity.
1 Q61548 (/IDA)
Extrinsic component of presynaptic endocytic zone membrane GO:0098894
The component of the presynaptic endocytic zone membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.
1 Q61548 (/IDA)