The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Ankyrin repeat-containing domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 23931: Histone-lysine N-methyltransferase EHMT1 isoform 4

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 17 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
2 Q5DW34 (/IPI) Q9H9B1 (/IPI)
P53 binding GO:0002039
Interacting selectively and non-covalently with one of the p53 family of proteins.
1 Q9H9B1 (/IPI)
P53 binding GO:0002039
Interacting selectively and non-covalently with one of the p53 family of proteins.
1 Q5DW34 (/ISO)
Methyltransferase activity GO:0008168
Catalysis of the transfer of a methyl group to an acceptor molecule.
1 Q9H9B1 (/IDA)
Methyltransferase activity GO:0008168
Catalysis of the transfer of a methyl group to an acceptor molecule.
1 Q5DW34 (/ISO)
Methyltransferase activity GO:0008168
Catalysis of the transfer of a methyl group to an acceptor molecule.
1 Q8BHB2 (/ISS)
Protein-lysine N-methyltransferase activity GO:0016279
Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to the epsilon-amino group of a lysine residue in a protein substrate.
1 Q9H9B1 (/IDA)
Protein-lysine N-methyltransferase activity GO:0016279
Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to the epsilon-amino group of a lysine residue in a protein substrate.
1 Q5DW34 (/ISO)
Histone-lysine N-methyltransferase activity GO:0018024
Catalysis of the reaction: S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N6-methyl-L-lysine. The methylation of peptidyl-lysine in histones forms N6-methyl-L-lysine, N6,N6-dimethyl-L-lysine and N6,N6,N6-trimethyl-L-lysine derivatives.
1 Q9H9B1 (/IDA)
Histone-lysine N-methyltransferase activity GO:0018024
Catalysis of the reaction: S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N6-methyl-L-lysine. The methylation of peptidyl-lysine in histones forms N6-methyl-L-lysine, N6,N6-dimethyl-L-lysine and N6,N6,N6-trimethyl-L-lysine derivatives.
1 Q5DW34 (/ISO)
Histone-lysine N-methyltransferase activity GO:0018024
Catalysis of the reaction: S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N6-methyl-L-lysine. The methylation of peptidyl-lysine in histones forms N6-methyl-L-lysine, N6,N6-dimethyl-L-lysine and N6,N6,N6-trimethyl-L-lysine derivatives.
1 Q8BHB2 (/ISS)
Histone methyltransferase activity (H3-K9 specific) GO:0046974
Catalysis of the reaction: S-adenosyl-L-methionine + histone H3 L-lysine (position 9) = S-adenosyl-L-homocysteine + histone H3 N6-methyl-L-lysine (position 9). This reaction is the addition of a methyl group onto lysine at position 9 of the histone H3 protein.
1 Q5DW34 (/IDA)
Histone methyltransferase activity (H3-K9 specific) GO:0046974
Catalysis of the reaction: S-adenosyl-L-methionine + histone H3 L-lysine (position 9) = S-adenosyl-L-homocysteine + histone H3 N6-methyl-L-lysine (position 9). This reaction is the addition of a methyl group onto lysine at position 9 of the histone H3 protein.
1 Q5DW34 (/IMP)
Histone methyltransferase activity (H3-K9 specific) GO:0046974
Catalysis of the reaction: S-adenosyl-L-methionine + histone H3 L-lysine (position 9) = S-adenosyl-L-homocysteine + histone H3 N6-methyl-L-lysine (position 9). This reaction is the addition of a methyl group onto lysine at position 9 of the histone H3 protein.
1 Q9H9B1 (/ISS)
Histone methyltransferase activity (H3-K27 specific) GO:0046976
Catalysis of the reaction: S-adenosyl-L-methionine + histone H3 L-lysine (position 27) = S-adenosyl-L-homocysteine + histone H3 N6-methyl-L-lysine (position 27). This reaction is the addition of a methyl group onto lysine at position 27 of the histone H3 protein.
1 Q5DW34 (/IDA)
Histone methyltransferase activity (H3-K27 specific) GO:0046976
Catalysis of the reaction: S-adenosyl-L-methionine + histone H3 L-lysine (position 27) = S-adenosyl-L-homocysteine + histone H3 N6-methyl-L-lysine (position 27). This reaction is the addition of a methyl group onto lysine at position 27 of the histone H3 protein.
1 Q9H9B1 (/ISS)
C2H2 zinc finger domain binding GO:0070742
Interacting selectively and non-covalently with a C2H2-type zinc finger domain of a protein. The C2H2 zinc finger is the classical zinc finger domain, in which two conserved cysteines and histidines co-ordinate a zinc ion.
1 Q5DW34 (/IPI)

There are 20 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Response to fungicide GO:0060992
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fungicide stimulus. Fungicides are chemicals used to kill fungi.
2 A0A0G2K889 (/IEP) D4A005 (/IEP)
Negative regulation of transcription from RNA polymerase II promoter GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter.
1 Q5DW34 (/IMP)
DNA methylation GO:0006306
The covalent transfer of a methyl group to either N-6 of adenine or C-5 or N-4 of cytosine.
1 Q5DW34 (/IDA)
DNA methylation GO:0006306
The covalent transfer of a methyl group to either N-6 of adenine or C-5 or N-4 of cytosine.
1 Q9H9B1 (/ISS)
Chromatin organization GO:0006325
Any process that results in the specification, formation or maintenance of the physical structure of eukaryotic chromatin.
1 Q9H9B1 (/IDA)
Chromatin organization GO:0006325
Any process that results in the specification, formation or maintenance of the physical structure of eukaryotic chromatin.
1 Q5DW34 (/ISO)
Chromatin organization GO:0006325
Any process that results in the specification, formation or maintenance of the physical structure of eukaryotic chromatin.
1 Q8BHB2 (/ISS)
Embryo development GO:0009790
The process whose specific outcome is the progression of an embryo from its formation until the end of its embryonic life stage. The end of the embryonic stage is organism-specific. For example, for mammals, the process would begin with zygote formation and end with birth. For insects, the process would begin at zygote formation and end with larval hatching. For plant zygotic embryos, this would be from zygote formation to the end of seed dormancy. For plant vegetative embryos, this would be from the initial determination of the cell or group of cells to form an embryo until the point when the embryo becomes independent of the parent plant.
1 Q5DW34 (/IMP)
Embryo development GO:0009790
The process whose specific outcome is the progression of an embryo from its formation until the end of its embryonic life stage. The end of the embryonic stage is organism-specific. For example, for mammals, the process would begin with zygote formation and end with birth. For insects, the process would begin at zygote formation and end with larval hatching. For plant zygotic embryos, this would be from zygote formation to the end of seed dormancy. For plant vegetative embryos, this would be from the initial determination of the cell or group of cells to form an embryo until the point when the embryo becomes independent of the parent plant.
1 Q9H9B1 (/ISS)
Histone methylation GO:0016571
The modification of histones by addition of methyl groups.
1 Q9H9B1 (/IDA)
Histone methylation GO:0016571
The modification of histones by addition of methyl groups.
1 Q5DW34 (/ISO)
Histone methylation GO:0016571
The modification of histones by addition of methyl groups.
1 Q8BHB2 (/ISS)
Peptidyl-lysine monomethylation GO:0018026
The methylation of peptidyl-lysine to form peptidyl-N6-methyl-L-lysine.
1 Q5DW34 (/IMP)
Peptidyl-lysine monomethylation GO:0018026
The methylation of peptidyl-lysine to form peptidyl-N6-methyl-L-lysine.
1 Q9H9B1 (/ISS)
Peptidyl-lysine dimethylation GO:0018027
The methylation of peptidyl-lysine to form peptidyl-N6,N6-dimethyl-L-lysine.
1 Q9H9B1 (/IDA)
Peptidyl-lysine dimethylation GO:0018027
The methylation of peptidyl-lysine to form peptidyl-N6,N6-dimethyl-L-lysine.
1 Q5DW34 (/IMP)
Peptidyl-lysine dimethylation GO:0018027
The methylation of peptidyl-lysine to form peptidyl-N6,N6-dimethyl-L-lysine.
1 Q5DW34 (/ISO)
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
1 Q5DW34 (/IMP)
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
1 Q9H9B1 (/ISS)
Regulation of signal transduction by p53 class mediator GO:1901796
Any process that modulates the frequency, rate or extent of signal transduction by p53 class mediator.
1 Q9H9B1 (/TAS)

There are 9 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
2 Q5DW34 (/IDA) Q9H9B1 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 Q9H9B1 (/IC)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 Q5DW34 (/ISO)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 Q9H9B1 (/ISS)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
1 Q9H9B1 (/IDA)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
1 Q5DW34 (/ISO)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
1 Q9H9B1 (/TAS)
Nuclear body GO:0016604
Extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins.
1 Q9H9B1 (/IDA)
Nuclear body GO:0016604
Extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins.
1 Q5DW34 (/ISO)