The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 4279: Eukaryotic translation initiation factor 4 gamma 2

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 12 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Translation initiation factor activity GO:0003743
Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide.
4 P79398 (/ISS) Q5R7J9 (/ISS) Q62448 (/ISS) Q95L46 (/ISS)
Translation factor activity, RNA binding GO:0008135
Functions during translation by interacting selectively and non-covalently with RNA during polypeptide synthesis at the ribosome.
4 P79398 (/ISS) Q5R7J9 (/ISS) Q62448 (/ISS) Q95L46 (/ISS)
Translation initiation factor activity GO:0003743
Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide.
3 P78344 (/IDA) P79398 (/IDA) Q62448 (/IDA)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
2 P78344 (/IPI) Q62448 (/IPI)
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
1 P78344 (/IDA)
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
1 Q62448 (/ISO)
Translation initiation factor activity GO:0003743
Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide.
1 Q62448 (/ISO)
Translation factor activity, RNA binding GO:0008135
Functions during translation by interacting selectively and non-covalently with RNA during polypeptide synthesis at the ribosome.
1 P78344 (/IDA)
Translation factor activity, RNA binding GO:0008135
Functions during translation by interacting selectively and non-covalently with RNA during polypeptide synthesis at the ribosome.
1 Q62448 (/ISO)
Translation factor activity, RNA binding GO:0008135
Functions during translation by interacting selectively and non-covalently with RNA during polypeptide synthesis at the ribosome.
1 P78344 (/TAS)
Cadherin binding GO:0045296
Interacting selectively and non-covalently with cadherin, a type I membrane protein involved in cell adhesion.
1 P78344 (/IDA)
Cadherin binding GO:0045296
Interacting selectively and non-covalently with cadherin, a type I membrane protein involved in cell adhesion.
1 Q62448 (/ISO)

There are 16 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Mesoderm development GO:0007498
The process whose specific outcome is the progression of the mesoderm over time, from its formation to the mature structure. The mesoderm is the middle germ layer that develops into muscle, bone, cartilage, blood and connective tissue.
5 A0A0R4IFW9 (/IGI) A3KQB2 (/IGI) F1R9I0 (/IGI) Q5KTT6 (/IGI) Q5KTT7 (/IGI)
Regulation of translational initiation GO:0006446
Any process that modulates the frequency, rate or extent of translational initiation.
4 P79398 (/ISS) Q5R7J9 (/ISS) Q62448 (/ISS) Q95L46 (/ISS)
Regulation of translational initiation GO:0006446
Any process that modulates the frequency, rate or extent of translational initiation.
3 P78344 (/IDA) P79398 (/IDA) Q62448 (/IDA)
Heart development GO:0007507
The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood.
2 F1LN59 (/IEP) Q1RP76 (/IEP)
Positive regulation of translation GO:0045727
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA.
2 F1LN59 (/IMP) Q1RP76 (/IMP)
Positive regulation of axon extension GO:0045773
Any process that activates or increases the frequency, rate or extent of axon extension.
2 F1LN59 (/IMP) Q1RP76 (/IMP)
Positive regulation of dendritic spine development GO:0060999
Any process that increases the rate, frequency, or extent of dendritic spine development, the process whose specific outcome is the progression of the dendritic spine over time, from its formation to the mature structure.
2 F1LN59 (/IMP) Q1RP76 (/IMP)
Regulation of translational initiation GO:0006446
Any process that modulates the frequency, rate or extent of translational initiation.
1 Q62448 (/ISO)
Cell cycle arrest GO:0007050
A regulatory process that halts progression through the cell cycle during one of the normal phases (G1, S, G2, M).
1 P78344 (/TAS)
Cell death GO:0008219
Any biological process that results in permanent cessation of all vital functions of a cell. A cell should be considered dead when any one of the following molecular or morphological criteria is met: (1) the cell has lost the integrity of its plasma membrane; (2) the cell, including its nucleus, has undergone complete fragmentation into discrete bodies (frequently referred to as apoptotic bodies). The cell corpse (or its fragments) may be engulfed by an adjacent cell in vivo, but engulfment of whole cells should not be considered a strict criteria to define cell death as, under some circumstances, live engulfed cells can be released from phagosomes (see PMID:18045538).
1 P78344 (/TAS)
Negative regulation of autophagy GO:0010507
Any process that stops, prevents, or reduces the frequency, rate or extent of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm.
1 P78344 (/IMP)
Negative regulation of autophagy GO:0010507
Any process that stops, prevents, or reduces the frequency, rate or extent of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm.
1 Q62448 (/ISO)
Positive regulation of cell growth GO:0030307
Any process that activates or increases the frequency, rate, extent or direction of cell growth.
1 P78344 (/IMP)
Positive regulation of cell growth GO:0030307
Any process that activates or increases the frequency, rate, extent or direction of cell growth.
1 Q62448 (/ISO)
Cellular macromolecule biosynthetic process GO:0034645
The chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass, carried out by individual cells.
1 P78344 (/IGI)
Cellular macromolecule biosynthetic process GO:0034645
The chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass, carried out by individual cells.
1 Q62448 (/ISO)

There are 10 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Eukaryotic translation initiation factor 4F complex GO:0016281
The eukaryotic translation initiation factor 4F complex is composed of eIF4E, eIF4A and eIF4G; it is involved in the recognition of the mRNA cap, ATP-dependent unwinding of the 5'-terminal secondary structure and recruitment of the mRNA to the ribosome.
4 P79398 (/ISS) Q5R7J9 (/ISS) Q62448 (/ISS) Q95L46 (/ISS)
Axon GO:0030424
The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter.
2 F1LN59 (/IDA) Q1RP76 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 Q62448 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 P78344 (/TAS)
Cell-cell adherens junction GO:0005913
An adherens junction which connects a cell to another cell.
1 P78344 (/IDA)
Cell-cell adherens junction GO:0005913
An adherens junction which connects a cell to another cell.
1 Q62448 (/ISO)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
1 P78344 (/IDA)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
1 Q62448 (/ISO)
Eukaryotic translation initiation factor 4F complex GO:0016281
The eukaryotic translation initiation factor 4F complex is composed of eIF4E, eIF4A and eIF4G; it is involved in the recognition of the mRNA cap, ATP-dependent unwinding of the 5'-terminal secondary structure and recruitment of the mRNA to the ribosome.
1 P78344 (/IDA)
Eukaryotic translation initiation factor 4F complex GO:0016281
The eukaryotic translation initiation factor 4F complex is composed of eIF4E, eIF4A and eIF4G; it is involved in the recognition of the mRNA cap, ATP-dependent unwinding of the 5'-terminal secondary structure and recruitment of the mRNA to the ribosome.
1 Q62448 (/ISO)