The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:
"Protein prenylyltransferase
".
FunFam 11082: Protein farnesyltransferase/geranylgeranyltransfer...
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 21 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Protein geranylgeranyltransferase activity GO:0004661
Catalysis of the covalent addition of a geranylgeranyl (20-carbon isoprenoid) group via thioether linkages to a cysteine residue at or near the C terminus of a protein.
|
7 | O24304 (/ISS) P29702 (/ISS) P93227 (/ISS) Q04631 (/ISS) Q54RT9 (/ISS) Q61239 (/ISS) Q9LX33 (/ISS) |
|
Protein farnesyltransferase activity GO:0004660
Catalysis of the reaction: farnesyl diphosphate + protein-cysteine = S-farnesyl protein + diphosphate.
|
6 | O24304 (/ISS) O60052 (/ISS) P29702 (/ISS) P93227 (/ISS) Q54RT9 (/ISS) Q9LX33 (/ISS) |
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
6 | O60052 (/IPI) P29703 (/IPI) P49354 (/IPI) Q00618 (/IPI) Q04631 (/IPI) Q9LX33 (/IPI) |
|
Protein farnesyltransferase activity GO:0004660
Catalysis of the reaction: farnesyl diphosphate + protein-cysteine = S-farnesyl protein + diphosphate.
|
5 | O60052 (/IDA) P29703 (/IDA) P49354 (/IDA) Q04631 (/IDA) Q61239 (/IDA) |
|
Rab geranylgeranyltransferase activity GO:0004663
Catalysis of the reaction: 2 geranylgeranyl diphosphate + protein-cysteine = 2 S-geranylgeranyl-protein + 2 diphosphate. This reaction is the formation of two thioether linkages between the C-1 atom of the geranylgeranyl groups and two cysteine residues within the terminal sequence motifs XXCC, XCXC or CCXX. Known substrates include Ras-related GTPases of a single family and the Rab family.
|
3 | Q00618 (/IDA) Q61239 (/IDA) Q8VYB7 (/IDA) |
|
Protein geranylgeranyltransferase activity GO:0004661
Catalysis of the covalent addition of a geranylgeranyl (20-carbon isoprenoid) group via thioether linkages to a cysteine residue at or near the C terminus of a protein.
|
2 | P29703 (/IDA) P49354 (/IDA) |
|
Farnesyltranstransferase activity GO:0004311
Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate + isopentenyl diphosphate = diphosphate + geranylgeranyl diphosphate.
|
1 | Q9LX33 (/TAS) |
|
Protein farnesyltransferase activity GO:0004660
Catalysis of the reaction: farnesyl diphosphate + protein-cysteine = S-farnesyl protein + diphosphate.
|
1 | Q61239 (/ISO) |
|
Protein farnesyltransferase activity GO:0004660
Catalysis of the reaction: farnesyl diphosphate + protein-cysteine = S-farnesyl protein + diphosphate.
|
1 | P49354 (/TAS) |
|
Protein geranylgeranyltransferase activity GO:0004661
Catalysis of the covalent addition of a geranylgeranyl (20-carbon isoprenoid) group via thioether linkages to a cysteine residue at or near the C terminus of a protein.
|
1 | Q61239 (/ISO) |
|
Protein geranylgeranyltransferase activity GO:0004661
Catalysis of the covalent addition of a geranylgeranyl (20-carbon isoprenoid) group via thioether linkages to a cysteine residue at or near the C terminus of a protein.
|
1 | P49354 (/TAS) |
|
CAAX-protein geranylgeranyltransferase activity GO:0004662
Catalysis of the reaction: geranylgeranyl diphosphate + protein-cysteine = S-geranylgeranyl-protein + diphosphate. This reaction is the formation of a thioether linkage between the C-1 atom of the geranylgeranyl group and a cysteine residue fourth from the C-terminus of the protein. The protein substrates have the C-terminal sequence CA1A2X, where the terminal residue, X, is preferably leucine and A2 should not be aromatic. Known substrates include most g-subunits of heterotrimeric G proteins and Ras-related GTPases such as members of the Ras and Rac/Rho families.
|
1 | P29703 (/IDA) |
|
Rab geranylgeranyltransferase activity GO:0004663
Catalysis of the reaction: 2 geranylgeranyl diphosphate + protein-cysteine = 2 S-geranylgeranyl-protein + 2 diphosphate. This reaction is the formation of two thioether linkages between the C-1 atom of the geranylgeranyl groups and two cysteine residues within the terminal sequence motifs XXCC, XCXC or CCXX. Known substrates include Ras-related GTPases of a single family and the Rab family.
|
1 | O60052 (/ISM) |
|
Microtubule binding GO:0008017
Interacting selectively and non-covalently with microtubules, filaments composed of tubulin monomers.
|
1 | P49354 (/IDA) |
|
Microtubule binding GO:0008017
Interacting selectively and non-covalently with microtubules, filaments composed of tubulin monomers.
|
1 | Q61239 (/ISO) |
|
Protein prenyltransferase activity GO:0008318
Catalysis of the covalent addition of an isoprenoid group such as a farnesyl or geranylgeranyl group via thioether linkages to a cysteine residue in a protein.
|
1 | Q9LX33 (/IDA) |
|
Rab GTPase binding GO:0017137
Interacting selectively and non-covalently with Rab protein, any member of the Rab subfamily of the Ras superfamily of monomeric GTPases.
|
1 | Q00618 (/ISS) |
|
Acetylcholine receptor regulator activity GO:0030548
Interacting (directly or indirectly) with acetylcholine receptors such that the proportion of receptors in the active form is changed.
|
1 | Q61239 (/IMP) |
|
Receptor tyrosine kinase binding GO:0030971
Interacting selectively and non-covalently with a receptor that possesses protein tyrosine kinase activity.
|
1 | Q61239 (/IPI) |
|
Alpha-tubulin binding GO:0043014
Interacting selectively and non-covalently with the microtubule constituent protein alpha-tubulin.
|
1 | P49354 (/IDA) |
|
Alpha-tubulin binding GO:0043014
Interacting selectively and non-covalently with the microtubule constituent protein alpha-tubulin.
|
1 | Q61239 (/ISO) |
There are 41 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Protein farnesylation GO:0018343
The covalent attachment of a farnesyl group to a protein.
|
8 | O24304 (/ISS) O60052 (/ISS) P29702 (/ISS) P93227 (/ISS) Q04631 (/ISS) Q54RT9 (/ISS) Q61239 (/ISS) Q9LX33 (/ISS) |
|
Protein geranylgeranylation GO:0018344
The covalent attachment of a geranylgeranyl group to a protein.
|
7 | O24304 (/ISS) O60052 (/ISS) P29702 (/ISS) P93227 (/ISS) Q04631 (/ISS) Q54RT9 (/ISS) Q61239 (/ISS) |
|
Protein geranylgeranylation GO:0018344
The covalent attachment of a geranylgeranyl group to a protein.
|
6 | O60052 (/IDA) P29703 (/IDA) P49354 (/IDA) Q00618 (/IDA) Q8VYB7 (/IDA) Q9LX33 (/IDA) |
|
Protein farnesylation GO:0018343
The covalent attachment of a farnesyl group to a protein.
|
3 | O60052 (/IDA) P29703 (/IDA) P49354 (/IDA) |
|
Protein farnesylation GO:0018343
The covalent attachment of a farnesyl group to a protein.
|
2 | P49354 (/TAS) Q9LX33 (/TAS) |
|
Protein targeting to membrane GO:0006612
The process of directing proteins towards a membrane, usually using signals contained within the protein.
|
1 | Q00618 (/IMP) |
|
ER to Golgi vesicle-mediated transport GO:0006888
The directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles. Small COP II coated vesicles form from the ER and then fuse directly with the cis-Golgi. Larger structures are transported along microtubules to the cis-Golgi.
|
1 | Q00618 (/IMP) |
|
Transforming growth factor beta receptor signaling pathway GO:0007179
A series of molecular signals initiated by the binding of an extracellular ligand to a transforming growth factor beta receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
|
1 | P49354 (/TAS) |
|
Peptide pheromone maturation GO:0007323
The generation of a mature, active peptide pheromone via processes unique to its processing and modification. An example of this process is found in Saccharomyces cerevisiae.
|
1 | P29703 (/IDA) |
|
Neuromuscular junction development GO:0007528
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a neuromuscular junction.
|
1 | Q541Z2 (/IMP) |
|
Positive regulation of cell proliferation GO:0008284
Any process that activates or increases the rate or extent of cell proliferation.
|
1 | Q04631 (/IMP) |
|
Regulation of cell shape GO:0008360
Any process that modulates the surface configuration of a cell.
|
1 | Q9LX33 (/IMP) |
|
Pathogenesis GO:0009405
The set of specific processes that generate the ability of an organism to induce an abnormal, generally detrimental state in another organism.
|
1 | Q76KC1 (/IMP) |
|
Response to water deprivation GO:0009414
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a water deprivation stimulus, prolonged deprivation of water.
|
1 | Q9LX33 (/IMP) |
|
Negative regulation of abscisic acid-activated signaling pathway GO:0009788
Any process that stops, prevents, or reduces the frequency, rate or extent of abscisic acid (ABA) signaling.
|
1 | Q9LX33 (/IMP) |
|
Response to inorganic substance GO:0010035
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an inorganic substance stimulus.
|
1 | Q04631 (/IMP) |
|
Response to organic cyclic compound GO:0014070
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic cyclic compound stimulus.
|
1 | Q04631 (/IMP) |
|
Protein prenylation GO:0018342
The covalent attachment of a prenyl group to a protein; geranyl, farnesyl, or geranylgeranyl groups may be added.
|
1 | Q9LX33 (/IDA) |
|
Protein farnesylation GO:0018343
The covalent attachment of a farnesyl group to a protein.
|
1 | Q61239 (/ISO) |
|
Protein geranylgeranylation GO:0018344
The covalent attachment of a geranylgeranyl group to a protein.
|
1 | O60052 (/IC) |
|
Protein geranylgeranylation GO:0018344
The covalent attachment of a geranylgeranyl group to a protein.
|
1 | Q00618 (/IMP) |
|
Protein geranylgeranylation GO:0018344
The covalent attachment of a geranylgeranyl group to a protein.
|
1 | Q61239 (/ISO) |
|
Protein geranylgeranylation GO:0018344
The covalent attachment of a geranylgeranyl group to a protein.
|
1 | P49354 (/TAS) |
|
Regulation of rhodopsin mediated signaling pathway GO:0022400
Any process that modulates the frequency, rate or extent of rhodopsin-mediated signaling.
|
1 | P49354 (/TAS) |
|
Response to cytokine GO:0034097
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytokine stimulus.
|
1 | Q04631 (/IMP) |
|
Negative regulation of apoptotic process GO:0043066
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
|
1 | Q04631 (/IMP) |
|
Neurotransmitter receptor metabolic process GO:0045213
The chemical reactions and pathways involving neurotransmitter receptors.
|
1 | Q61239 (/IMP) |
|
Positive regulation of cell cycle GO:0045787
Any process that activates or increases the rate or extent of progression through the cell cycle.
|
1 | Q04631 (/IMP) |
|
Positive regulation of Ras protein signal transduction GO:0046579
Any process that activates or increases the frequency, rate or extent of Ras protein signal transduction.
|
1 | Q9VR31 (/IGI) |
|
Response to cadmium ion GO:0046686
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cadmium (Cd) ion stimulus.
|
1 | Q8VYB7 (/IEP) |
|
Regulation of meristem development GO:0048509
Any process that modulates the frequency, rate or extent of meristem development, the biological process whose specific outcome is the progression of the meristem over time, from its formation to the mature structure.
|
1 | Q9LX33 (/IMP) |
|
Positive regulation of nitric-oxide synthase biosynthetic process GO:0051770
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of a nitric oxide synthase enzyme.
|
1 | Q04631 (/IMP) |
|
Negative regulation of nitric-oxide synthase biosynthetic process GO:0051771
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of a nitric-oxide synthase enzyme.
|
1 | Q04631 (/IMP) |
|
Positive regulation of ERK1 and ERK2 cascade GO:0070374
Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.
|
1 | Q9VR31 (/IGI) |
|
Skeletal muscle acetylcholine-gated channel clustering GO:0071340
The accumulation of acetylcholine-gated cation channels in a narrow, central region of muscle fibers, in apposition to nerve terminals.
|
1 | Q541Z2 (/IDA) |
|
Protein targeting to plasma membrane GO:0072661
The process of directing proteins towards the plasma membrane; usually uses signals contained within the protein.
|
1 | O60052 (/IC) |
|
Positive regulation of tubulin deacetylation GO:0090044
Any process that increases the frequency, rate or extent of tubulin deacetylation. Tubulin deacetylation is the removal of an acetyl group from a protein amino acid.
|
1 | P49354 (/IDA) |
|
Positive regulation of tubulin deacetylation GO:0090044
Any process that increases the frequency, rate or extent of tubulin deacetylation. Tubulin deacetylation is the removal of an acetyl group from a protein amino acid.
|
1 | Q61239 (/ISO) |
|
Positive regulation of deacetylase activity GO:0090045
Any process that activates or increases the frequency, rate or extent of deacetylase activity, the catalysis of the hydrolysis of an acetyl group or groups from a substrate molecule.
|
1 | P49354 (/IDA) |
|
Positive regulation of deacetylase activity GO:0090045
Any process that activates or increases the frequency, rate or extent of deacetylase activity, the catalysis of the hydrolysis of an acetyl group or groups from a substrate molecule.
|
1 | Q61239 (/ISO) |
|
Execution phase of apoptosis GO:0097194
A stage of the apoptotic process that starts with the controlled breakdown of the cell through the action of effector caspases or other effector molecules (e.g. cathepsins, calpains etc.). Key steps of the execution phase are rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died.
|
1 | P49354 (/TAS) |
There are 15 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Protein farnesyltransferase complex GO:0005965
A protein complex that possesses protein farnesyltransferase activity.
|
7 | O24304 (/ISS) O60052 (/ISS) P29702 (/ISS) P93227 (/ISS) Q04631 (/ISS) Q54RT9 (/ISS) Q61239 (/ISS) |
|
CAAX-protein geranylgeranyltransferase complex GO:0005953
A heterodimeric enzyme, composed of an alpha and a beta subunit. Participates in the post-translational C-terminal modification of several small GTPases, allowing their targeting to the membrane.
|
6 | O24304 (/ISS) O60052 (/ISS) P29702 (/ISS) P93227 (/ISS) Q54RT9 (/ISS) Q61239 (/ISS) |
|
CAAX-protein geranylgeranyltransferase complex GO:0005953
A heterodimeric enzyme, composed of an alpha and a beta subunit. Participates in the post-translational C-terminal modification of several small GTPases, allowing their targeting to the membrane.
|
4 | O60052 (/IDA) P29703 (/IDA) P49354 (/IDA) Q04631 (/IDA) |
|
Protein farnesyltransferase complex GO:0005965
A protein complex that possesses protein farnesyltransferase activity.
|
2 | P29703 (/IDA) P49354 (/IDA) |
|
Rab-protein geranylgeranyltransferase complex GO:0005968
A heterodimeric enzyme complex, which in mammals is composed of an alpha and a beta subunit, and which associates with an accessory protein Rep (Rab escort protein). Catalyzes of the transfer of a geranyl-geranyl group from geranylgeranyl pyrophosphate to a Rab protein.
|
2 | Q00618 (/IDA) Q8VYB7 (/IDA) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
1 | O60052 (/IDA) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
1 | Q04631 (/IDA) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
1 | P49354 (/TAS) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
1 | Q8VYB7 (/IDA) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
1 | P49354 (/TAS) |
|
Microtubule associated complex GO:0005875
Any multimeric complex connected to a microtubule.
|
1 | P49354 (/IDA) |
|
Microtubule associated complex GO:0005875
Any multimeric complex connected to a microtubule.
|
1 | Q61239 (/ISO) |
|
CAAX-protein geranylgeranyltransferase complex GO:0005953
A heterodimeric enzyme, composed of an alpha and a beta subunit. Participates in the post-translational C-terminal modification of several small GTPases, allowing their targeting to the membrane.
|
1 | Q61239 (/ISO) |
|
Protein farnesyltransferase complex GO:0005965
A protein complex that possesses protein farnesyltransferase activity.
|
1 | Q61239 (/ISO) |
|
Rab-protein geranylgeranyltransferase complex GO:0005968
A heterodimeric enzyme complex, which in mammals is composed of an alpha and a beta subunit, and which associates with an accessory protein Rep (Rab escort protein). Catalyzes of the transfer of a geranyl-geranyl group from geranylgeranyl pyrophosphate to a Rab protein.
|
1 | Q00618 (/IPI) |