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CATH Superfamily 1.25.40.10

Tetratricopeptide repeat domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 146491: Rhomboid protease GluP

There are 1 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Rhomboid protease. [EC: 3.4.21.105]
Cleaves type-1 transmembrane domains using a catalytic dyad composed of serine and histidine that are contributed by different transmembrane domains.
  • These endopeptidases are multi-spanning membrane proteins.
  • Their catalytic site is embedded within the membrane and they cleave type-1 transmembrane domains.
  • Important for embryo development in Drosophila melanogaster.
  • Rhomboid is a key regulator of EGF receptor signaling and is responsible for cleaving Spitz, the main ligand of the Drosophila EGF receptor pathway.
  • Parasite-encoded rhomboid enzymes are also important for invasion of host cells by Toxoplasma and the malaria parasite.
  • Belongs to peptidase family S54.
 15 A0A080UNB8 A0A0D7XKQ6 A0A0H3E1N6 A0A0K6KEK2 A0A0K6KQP8 A0A0K6L2X9 A0A0K6MZX4 A0A0T8Q2N8 A0A0W8K6Q9 A0A162T8T3
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