The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 145091: Ubiquitously transcribed tetratricopeptide repeat ...

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 5 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Core promoter binding GO:0001047
Interacting selectively and non-covalently with the regulatory region composed of the transcription start site and binding sites for the basal transcription machinery. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors.
2 M9PCJ7 (/IDA) Q76NQ3 (/IDA)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
2 M9PCJ7 (/IPI) Q76NQ3 (/IPI)
Histone demethylase activity GO:0032452
Catalysis of the removal of a methyl group from a histone.
2 M9PCJ7 (/IDA) Q76NQ3 (/IDA)
Histone demethylase activity GO:0032452
Catalysis of the removal of a methyl group from a histone.
2 O14607 (/TAS) O15550 (/TAS)
Histone demethylase activity (H3-K27 specific) GO:0071558
Catalysis of the removal of a methyl group from lysine at position 27 of the histone H3 protein.
2 M9PCJ7 (/IDA) Q76NQ3 (/IDA)

There are 18 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Negative regulation of cell proliferation GO:0008285
Any process that stops, prevents or reduces the rate or extent of cell proliferation.
2 M9PCJ7 (/IMP) Q76NQ3 (/IMP)
Positive regulation of autophagy GO:0010508
Any process that activates, maintains or increases the rate of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm.
2 M9PCJ7 (/IMP) Q76NQ3 (/IMP)
Histone demethylation GO:0016577
The modification of histones by removal of methyl groups.
2 M9PCJ7 (/IDA) Q76NQ3 (/IDA)
Ecdysone-mediated induction of salivary gland cell autophagic cell death GO:0035072
Any process induced by ecdysone that directly activates salivary gland programmed cell death during salivary gland histolysis.
2 M9PCJ7 (/IMP) Q76NQ3 (/IMP)
Induction of programmed cell death by ecdysone GO:0035078
Any process induced by the steroid hormone 20-hydroxyecdysone (ecdysone) that directly activates any of the steps required for programmed cell death.
2 M9PCJ7 (/IMP) Q76NQ3 (/IMP)
Wound healing GO:0042060
The series of events that restore integrity to a damaged tissue, following an injury.
2 M9PCJ7 (/IMP) Q76NQ3 (/IMP)
Sex comb development GO:0045498
The process whose specific outcome is the progression of the sex comb over time, from its formation to the mature structure. The sex combs are the male specific chaetae located on the prothoracic tarsal segment of the prothoracic leg.
2 M9PCJ7 (/IMP) Q76NQ3 (/IMP)
Negative regulation of Notch signaling pathway GO:0045746
Any process that stops, prevents, or reduces the frequency, rate or extent of the Notch signaling pathway.
2 M9PCJ7 (/IGI) Q76NQ3 (/IGI)
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
2 M9PCJ7 (/IMP) Q76NQ3 (/IMP)
Histone H3-K4 methylation GO:0051568
The modification of histone H3 by addition of one or more methyl groups to lysine at position 4 of the histone.
2 M9PCJ7 (/IDA) Q76NQ3 (/IDA)
Histone H3-K4 methylation GO:0051568
The modification of histone H3 by addition of one or more methyl groups to lysine at position 4 of the histone.
2 M9PCJ7 (/IMP) Q76NQ3 (/IMP)
Negative regulation of histone H3-K27 methylation GO:0061086
Any process that decreases the rate, frequency, or extent of histone H3-K27 methylation. Histone H3-K27 methylation is the modification of histone H3 by addition of a methyl group to lysine at position 27 of the histone.
2 M9PCJ7 (/IMP) Q76NQ3 (/IMP)
Cellular response to ecdysone GO:0071390
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ecdysone stimulus.
2 M9PCJ7 (/IMP) Q76NQ3 (/IMP)
Cellular response to gamma radiation GO:0071480
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gamma radiation stimulus. Gamma radiation is a form of electromagnetic radiation (EMR) or light emission of a specific frequency produced from sub-atomic particle interaction, such as electron-positron annihilation and radioactive decay. Gamma rays are generally characterized as EMR having the highest frequency and energy, and also the shortest wavelength, within the electromagnetic radiation spectrum.
2 M9PCJ7 (/IMP) Q76NQ3 (/IMP)
Histone H3-K27 demethylation GO:0071557
The modification of histone H3 by the removal of a methyl group from lysine at position 27 of the histone.
2 M9PCJ7 (/IMP) Q76NQ3 (/IMP)
Negative regulation of histone H3-K27 trimethylation GO:1902465
Any process that stops, prevents or reduces the frequency, rate or extent of histone H3-K27 trimethylation.
2 M9PCJ7 (/IMP) Q76NQ3 (/IMP)
Regulation of transcription from RNA polymerase II promoter in response to DNA damage GO:1990248
Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of DNA damage.
2 M9PCJ7 (/IMP) Q76NQ3 (/IMP)
Histone H3-K4 methylation GO:0051568
The modification of histone H3 by addition of one or more methyl groups to lysine at position 4 of the histone.
1 O15550 (/ISS)

There are 6 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
3 M9PCJ7 (/IDA) O15550 (/IDA) Q76NQ3 (/IDA)
MLL3/4 complex GO:0044666
A protein complex that can methylate lysine-4 of histone H3, and which contains either of the protein subunits MLL3 or MLL4 in mammals, or equivalent in other species.
3 M9PCJ7 (/IDA) O15550 (/IDA) Q76NQ3 (/IDA)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
2 O14607 (/TAS) O15550 (/TAS)
Polytene chromosome GO:0005700
A type of chromosome in a polyploid cell, formed when multiple copies of homologous chromosomes are aligned side by side to give a giant chromosome in which distinct chromosome bands are readily visible.
2 M9PCJ7 (/IDA) Q76NQ3 (/IDA)
Polytene chromosome interband GO:0005705
A stretch of less tightly packed chromatin along the polytene chromosome, found between bands.
2 M9PCJ7 (/IDA) Q76NQ3 (/IDA)
Histone methyltransferase complex GO:0035097
A multimeric complex that is able to catalyze the addition of methyl groups to histone proteins.
1 O15550 (/IDA)