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CATH Superfamily 1.25.10.10

Leucine-rich Repeat Variant

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Leucine-rich Repeat Variant
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 69281: AP-3 complex subunit delta

There are 4 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Phosphogluconate dehydrogenase (NADP(+)-dependent, decarboxylating). [EC: 1.1.1.44]
6-phospho-D-gluconate + NADP(+) = D-ribulose 5-phosphate + CO(2) + NADPH.
  • The enzyme participates in the oxidative branch of the pentose phosphate pathway, whose main purpose is to produce NADPH and pentose for biosynthetic reactions.
  • Highly specific for NADP(+).
  • Cf. EC 1.1.1.343.
 4 G7E543 G7E543 G7E544 G7E544
IgA-specific metalloendopeptidase. [EC: 3.4.24.13]
Cleavage of Pro-|-Thr bond in the hinge region of the heavy chain of human IgA.
  • Found in several pathogenic species of Streptococcus such as S.sanguis and S.pneumoniae.
  • There is also an IgA-specific prolyl endopeptidase of serine-type (see EC 3.4.21.72).
  • Belongs to peptidase family M26.
 2 B0EMF2 B0EMF2
Cystathionine beta-synthase. [EC: 4.2.1.22]
L-serine + L-homocysteine = L-cystathionine + H(2)O.
  • A multifunctional enzyme: catalyzes beta-replacement reaction between L-serine, L-cysteine, cysteine thioethers or some other beta- substituted alpha-L-amino acids and a variety of mercaptans.
  • Formerly EC 4.2.1.21.
 2 A0A182GTM7 A0A182GTM7
Mannosyl-oligosaccharide 1,2-alpha-mannosidase. [EC: 3.2.1.113]
Hydrolysis of the terminal (1->2)-linked alpha-D-mannose residues in the oligo-mannose oligosaccharide Man(9)(GlcNAc)(2).
  • Involved in the synthesis of glycoproteins.
 2 A0A0P4UJK0 A0A0P4UJK0
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