The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Leucine-rich Repeat Variant
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 69236: E3 ubiquitin-protein ligase TRIP12

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 9 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Ubiquitin-protein transferase activity GO:0004842
Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages.
15 A0A0B4JCV6 (/ISS) A0A0B4JCW5 (/ISS) A0A0B4JD62 (/ISS) A0A0B4JDA1 (/ISS) A0A0B4JDB5 (/ISS) A0A0B4LGQ5 (/ISS) A0A0B4LGR2 (/ISS) A0A0B4LHQ4 (/ISS) B4F6W9 (/ISS) E1B7Q7 (/ISS)
(5 more)
Ubiquitin-protein transferase activity GO:0004842
Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages.
1 Q14669 (/EXP)
Ubiquitin-protein transferase activity GO:0004842
Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages.
1 Q14669 (/IDA)
Ubiquitin-protein transferase activity GO:0004842
Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages.
1 Q14669 (/IMP)
Ubiquitin-protein transferase activity GO:0004842
Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages.
1 G5E870 (/ISO)
Ubiquitin-protein transferase activity GO:0004842
Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages.
1 Q14669 (/TAS)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
1 Q14669 (/IPI)
Thyroid hormone receptor binding GO:0046966
Interacting selectively and non-covalently with a thyroid hormone receptor.
1 Q14669 (/IDA)
Thyroid hormone receptor binding GO:0046966
Interacting selectively and non-covalently with a thyroid hormone receptor.
1 G5E870 (/ISO)

There are 20 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein ubiquitination involved in ubiquitin-dependent protein catabolic process GO:0042787
The process in which a ubiquitin group, or multiple groups, are covalently attached to the target protein, thereby initiating the degradation of that protein.
14 A0A0B4JCV6 (/ISS) A0A0B4JCW5 (/ISS) A0A0B4JD62 (/ISS) A0A0B4JDA1 (/ISS) A0A0B4JDB5 (/ISS) A0A0B4LGQ5 (/ISS) A0A0B4LGR2 (/ISS) A0A0B4LHQ4 (/ISS) B4F6W9 (/ISS) E1B7Q7 (/ISS)
(4 more)
Positive regulation of circadian rhythm GO:0042753
Any process that activates or increases the frequency, rate or extent of a circadian rhythm behavior.
9 A0A0B4JCV6 (/IMP) A0A0B4JCW5 (/IMP) A0A0B4JD62 (/IMP) A0A0B4JDA1 (/IMP) A0A0B4JDB5 (/IMP) A0A0B4LGQ5 (/IMP) A0A0B4LGR2 (/IMP) A0A0B4LHQ4 (/IMP) Q9VN58 (/IMP)
Positive regulation of protein catabolic process GO:0045732
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds.
9 A0A0B4JCV6 (/IMP) A0A0B4JCW5 (/IMP) A0A0B4JD62 (/IMP) A0A0B4JDA1 (/IMP) A0A0B4JDB5 (/IMP) A0A0B4LGQ5 (/IMP) A0A0B4LGR2 (/IMP) A0A0B4LHQ4 (/IMP) Q9VN58 (/IMP)
Cellular response to DNA damage stimulus GO:0006974
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism.
5 B4F6W9 (/ISS) E1B7Q7 (/ISS) F1LP64 (/ISS) F1RCR6 (/ISS) G5E870 (/ISS)
Embryo development GO:0009790
The process whose specific outcome is the progression of an embryo from its formation until the end of its embryonic life stage. The end of the embryonic stage is organism-specific. For example, for mammals, the process would begin with zygote formation and end with birth. For insects, the process would begin at zygote formation and end with larval hatching. For plant zygotic embryos, this would be from zygote formation to the end of seed dormancy. For plant vegetative embryos, this would be from the initial determination of the cell or group of cells to form an embryo until the point when the embryo becomes independent of the parent plant.
5 B4F6W9 (/ISS) E1B7Q7 (/ISS) F1LP64 (/ISS) F1RCR6 (/ISS) Q14669 (/ISS)
Negative regulation of histone H2A K63-linked ubiquitination GO:1901315
Any process that stops, prevents or reduces the frequency, rate or extent of histone H2A K63-linked ubiquitination.
5 B4F6W9 (/ISS) E1B7Q7 (/ISS) F1LP64 (/ISS) F1RCR6 (/ISS) G5E870 (/ISS)
Negative regulation of double-strand break repair GO:2000780
Any process that stops, prevents or reduces the frequency, rate or extent of double-strand break repair.
5 B4F6W9 (/ISS) E1B7Q7 (/ISS) F1LP64 (/ISS) F1RCR6 (/ISS) G5E870 (/ISS)
Protein polyubiquitination GO:0000209
Addition of multiple ubiquitin groups to a protein, forming a ubiquitin chain.
1 Q14669 (/TAS)
Cellular response to DNA damage stimulus GO:0006974
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism.
1 Q14669 (/IMP)
Cellular response to DNA damage stimulus GO:0006974
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism.
1 G5E870 (/ISO)
Embryo development GO:0009790
The process whose specific outcome is the progression of an embryo from its formation until the end of its embryonic life stage. The end of the embryonic stage is organism-specific. For example, for mammals, the process would begin with zygote formation and end with birth. For insects, the process would begin at zygote formation and end with larval hatching. For plant zygotic embryos, this would be from zygote formation to the end of seed dormancy. For plant vegetative embryos, this would be from the initial determination of the cell or group of cells to form an embryo until the point when the embryo becomes independent of the parent plant.
1 G5E870 (/IMP)
Trichome branching GO:0010091
Any process involved in the formation of branches in plant hair cells. An example of this process is found in Arabidopsis thaliana.
1 Q6WWW4 (/IMP)
DNA endoreduplication GO:0042023
Regulated re-replication of DNA within a single cell cycle, resulting in an increased cell ploidy. An example of this process occurs in the synthesis of Drosophila salivary gland cell polytene chromosomes.
1 Q6WWW4 (/IMP)
Protein ubiquitination involved in ubiquitin-dependent protein catabolic process GO:0042787
The process in which a ubiquitin group, or multiple groups, are covalently attached to the target protein, thereby initiating the degradation of that protein.
1 Q14669 (/IDA)
Protein ubiquitination involved in ubiquitin-dependent protein catabolic process GO:0042787
The process in which a ubiquitin group, or multiple groups, are covalently attached to the target protein, thereby initiating the degradation of that protein.
1 Q14669 (/IMP)
Protein ubiquitination involved in ubiquitin-dependent protein catabolic process GO:0042787
The process in which a ubiquitin group, or multiple groups, are covalently attached to the target protein, thereby initiating the degradation of that protein.
1 G5E870 (/ISO)
Negative regulation of histone H2A K63-linked ubiquitination GO:1901315
Any process that stops, prevents or reduces the frequency, rate or extent of histone H2A K63-linked ubiquitination.
1 Q14669 (/IMP)
Negative regulation of histone H2A K63-linked ubiquitination GO:1901315
Any process that stops, prevents or reduces the frequency, rate or extent of histone H2A K63-linked ubiquitination.
1 G5E870 (/ISO)
Negative regulation of double-strand break repair GO:2000780
Any process that stops, prevents or reduces the frequency, rate or extent of double-strand break repair.
1 Q14669 (/IMP)
Negative regulation of double-strand break repair GO:2000780
Any process that stops, prevents or reduces the frequency, rate or extent of double-strand break repair.
1 G5E870 (/ISO)

There are 10 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
9 A0A0B4JCV6 (/ISS) A0A0B4JCW5 (/ISS) A0A0B4JD62 (/ISS) A0A0B4JDA1 (/ISS) A0A0B4JDB5 (/ISS) A0A0B4LGQ5 (/ISS) A0A0B4LGR2 (/ISS) A0A0B4LHQ4 (/ISS) Q9VN58 (/ISS)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
5 B4F6W9 (/ISS) E1B7Q7 (/ISS) F1LP64 (/ISS) F1RCR6 (/ISS) G5E870 (/ISS)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 Q14669 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 G5E870 (/ISO)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
1 Q14669 (/IDA)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
1 G5E870 (/ISO)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 Q14669 (/TAS)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 Q6WWW4 (/IDA)
Nuclear speck GO:0016607
A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy.
1 Q14669 (/IDA)
Nuclear speck GO:0016607
A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy.
1 G5E870 (/ISO)
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