The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:
"Leucine-rich Repeat Variant
".
FunFam 69180: Importin beta-3 subunit, putative
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 7 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
4 | O60518 (/IPI) P40069 (/IPI) Q8TEX9 (/IPI) Q8VI75 (/IPI) |
|
Nuclear localization sequence binding GO:0008139
Interacting selectively and non-covalently with a nuclear localization sequence, a specific peptide sequence that acts as a signal to localize the protein within the nucleus.
|
2 | P32337 (/IDA) P40069 (/IDA) |
|
Protein transporter activity GO:0008565
Enables the directed movement of proteins into, out of or within a cell, or between cells.
|
2 | P32337 (/IMP) P40069 (/IMP) |
|
Protein transporter activity GO:0008565
Enables the directed movement of proteins into, out of or within a cell, or between cells.
|
2 | P32337 (/IPI) P40069 (/IPI) |
|
GTP binding GO:0005525
Interacting selectively and non-covalently with GTP, guanosine triphosphate.
|
1 | O74476 (/NAS) |
|
Protein transmembrane transporter activity GO:0008320
Enables the transfer of a protein from one side of a membrane to the other.
|
1 | Q9VN44 (/ISS) |
|
Nuclear import signal receptor activity GO:0061608
Combining with a nuclear import signal (NIS) to mediate transport of the NIS-containing protein through the nuclear pore to the nucleus.
|
1 | O74476 (/IMP) |
There are 20 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Protein import into nucleus GO:0006606
The directed movement of a protein from the cytoplasm to the nucleus.
|
3 | O74476 (/IMP) P32337 (/IMP) P40069 (/IMP) |
|
DNA replication-dependent nucleosome assembly GO:0006335
The formation of nucleosomes on newly replicated DNA, coupled to strand elongation.
|
1 | Q8TEX9 (/IDA) |
|
DNA replication-dependent nucleosome assembly GO:0006335
The formation of nucleosomes on newly replicated DNA, coupled to strand elongation.
|
1 | Q8VI75 (/ISO) |
|
DNA replication-independent nucleosome assembly GO:0006336
The formation of nucleosomes outside the context of DNA replication.
|
1 | Q8TEX9 (/IDA) |
|
DNA replication-independent nucleosome assembly GO:0006336
The formation of nucleosomes outside the context of DNA replication.
|
1 | Q8VI75 (/ISO) |
|
MRNA export from nucleus GO:0006406
The directed movement of mRNA from the nucleus to the cytoplasm.
|
1 | P32337 (/IGI) |
|
Protein targeting GO:0006605
The process of targeting specific proteins to particular regions of the cell, typically membrane-bounded subcellular organelles. Usually requires an organelle specific protein sequence motif.
|
1 | O60100 (/NAS) |
|
Protein import into nucleus GO:0006606
The directed movement of a protein from the cytoplasm to the nucleus.
|
1 | O74476 (/IC) |
|
Protein import into nucleus GO:0006606
The directed movement of a protein from the cytoplasm to the nucleus.
|
1 | Q9VN44 (/ISS) |
|
NLS-bearing protein import into nucleus GO:0006607
The directed movement of a protein bearing a nuclear localization signal (NLS) from the cytoplasm into the nucleus, across the nuclear membrane.
|
1 | P40069 (/IMP) |
|
Ribosomal protein import into nucleus GO:0006610
The directed movement of a ribosomal protein from the cytoplasm into the nucleus, across the nuclear membrane.
|
1 | P40069 (/IMP) |
|
Ribosomal protein import into nucleus GO:0006610
The directed movement of a ribosomal protein from the cytoplasm into the nucleus, across the nuclear membrane.
|
1 | Q8VI75 (/ISO) |
|
Nucleocytoplasmic transport GO:0006913
The directed movement of molecules between the nucleus and the cytoplasm.
|
1 | O60100 (/NAS) |
|
Regulation of mitotic nuclear division GO:0007088
Any process that modulates the frequency, rate or extent of mitosis.
|
1 | P32337 (/IMP) |
|
Regulation of G2/M transition of mitotic cell cycle GO:0010389
Any process that modulates the rate or extent of progression from G2 phase to M phase of the mitotic cell cycle.
|
1 | O74476 (/IMP) |
|
Protein transport GO:0015031
The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
|
1 | Q8TEX9 (/NAS) |
|
Ribosome biogenesis GO:0042254
A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits; includes transport to the sites of protein synthesis.
|
1 | Q8VI75 (/ISO) |
|
Regulation of protein desumoylation GO:0060188
Any process that modulates the frequency, rate or extent of protein desumoylation. Protein desumoylation is the process in which a SUMO protein (small ubiquitin-related modifier) is cleaved from its target protein.
|
1 | P32337 (/IMP) |
|
Regulation of protein desumoylation GO:0060188
Any process that modulates the frequency, rate or extent of protein desumoylation. Protein desumoylation is the process in which a SUMO protein (small ubiquitin-related modifier) is cleaved from its target protein.
|
1 | P32337 (/IPI) |
|
Regulation of pseudohyphal growth GO:2000220
Any process that modulates the frequency, rate or extent of pseudohyphal growth.
|
1 | P40069 (/IMP) |
There are 19 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
5 | O60100 (/IDA) O74476 (/IDA) P32337 (/IDA) P40069 (/IDA) Q5B163 (/IDA) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
5 | O60100 (/IDA) O74476 (/IDA) Q8W498 (/IDA) Q93VS8 (/IDA) Q9VN44 (/IDA) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
3 | O74476 (/IDA) P32337 (/IDA) P40069 (/IDA) |
|
Nuclear envelope GO:0005635
The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space).
|
2 | O60100 (/IDA) O74476 (/IDA) |
|
Nuclear pore GO:0005643
Any of the numerous similar discrete openings in the nuclear envelope of a eukaryotic cell, where the inner and outer nuclear membranes are joined.
|
2 | O60100 (/NAS) O74476 (/NAS) |
|
Nuclear periphery GO:0034399
The portion of the nuclear lumen proximal to the inner nuclear membrane.
|
2 | O60100 (/IDA) O74476 (/IDA) |
|
Nuclear chromatin GO:0000790
The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome in the nucleus.
|
1 | Q8TEX9 (/IDA) |
|
Nuclear chromatin GO:0000790
The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome in the nucleus.
|
1 | Q8VI75 (/ISO) |
|
Cell wall GO:0005618
The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, most prokaryotic cells and some protozoan parasites, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan; in protozoan parasites such as Giardia species, it's made of carbohydrates and proteins.
|
1 | Q93VS8 (/IDA) |
|
Nuclear envelope GO:0005635
The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space).
|
1 | Q5B163 (/IMP) |
|
Nuclear pore GO:0005643
Any of the numerous similar discrete openings in the nuclear envelope of a eukaryotic cell, where the inner and outer nuclear membranes are joined.
|
1 | Q9VN44 (/ISS) |
|
Nucleolus GO:0005730
A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
|
1 | Q5B163 (/IDA) |
|
Cytoplasmic stress granule GO:0010494
A dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress.
|
1 | P40069 (/IDA) |
|
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
|
1 | Q8TEX9 (/IDA) |
|
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
|
1 | Q8VI75 (/ISO) |
|
Nuclear membrane GO:0031965
Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space.
|
1 | O74476 (/IDA) |
|
Protein complex GO:0043234
A stable macromolecular complex composed (only) of two or more polypeptide subunits along with any covalently attached molecules (such as lipid anchors or oligosaccharide) or non-protein prosthetic groups (such as nucleotides or metal ions). Prosthetic group in this context refers to a tightly bound cofactor. The component polypeptide subunits may be identical.
|
1 | Q8TEX9 (/IDA) |
|
Protein complex GO:0043234
A stable macromolecular complex composed (only) of two or more polypeptide subunits along with any covalently attached molecules (such as lipid anchors or oligosaccharide) or non-protein prosthetic groups (such as nucleotides or metal ions). Prosthetic group in this context refers to a tightly bound cofactor. The component polypeptide subunits may be identical.
|
1 | Q8VI75 (/ISO) |
|
Exocytic vesicle GO:0070382
A transport vesicle that mediates transport from an intracellular compartment to the plasma membrane, and fuses with the plasma membrane to release various cargo molecules, such as proteins or hormones, by exocytosis.
|
1 | E2RF06 (/IDA) |
