The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Leucine-rich Repeat Variant
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 69113: Cohesin subunit SA-3

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 3 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
5 O70576 (/IPI) Q8N3U4 (/IPI) Q8WVM7 (/IPI) Q8WVM7 (/IPI) Q9DGN0 (/IPI)
Transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding GO:0001228
Interacting selectively and non-covalently with a sequence of DNA that is in the transcription regulatory region for RNA polymerase II (RNAP II) in order to activate or increase the frequency, rate or extent of transcription from the RNAP II promoter.
3 O35638 (/IDA) Q9D3E6 (/IDA) Q9D3E6 (/IDA)
Chromatin binding GO:0003682
Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
3 O35638 (/IDA) Q9D3E6 (/IDA) Q9D3E6 (/IDA)

There are 12 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Sister chromatid cohesion GO:0007062
The cell cycle process in which the sister chromatids of a replicated chromosome become tethered to each other.
3 Q8N3U4 (/TAS) Q8WVM7 (/TAS) Q8WVM7 (/TAS)
Sister chromatid cohesion GO:0007062
The cell cycle process in which the sister chromatids of a replicated chromosome become tethered to each other.
1 Q8N3U4 (/IMP)
Sister chromatid cohesion GO:0007062
The cell cycle process in which the sister chromatids of a replicated chromosome become tethered to each other.
1 O35638 (/ISO)
Male meiosis sister chromatid cohesion GO:0007065
The joining of the sister chromatids of a replicated chromosome along the entire length of the chromosome that occurs during meiosis in a male.
1 O70576 (/ISS)
Female meiosis sister chromatid cohesion GO:0007066
The joining of the sister chromatids of a replicated chromosome along the entire length of the chromosome that occurs during meiosis in a female.
1 O70576 (/ISS)
Synapsis GO:0007129
The meiotic cell cycle process where side by side pairing and physical juxtaposition of homologous chromosomes is created during meiotic prophase. Synapsis begins when the chromosome arms begin to pair from the clustered telomeres and ends when synaptonemal complex or linear element assembly is complete.
1 O70576 (/IMP)
Synaptonemal complex assembly GO:0007130
The cell cycle process in which the synaptonemal complex is formed. This is a structure that holds paired chromosomes together during prophase I of meiosis and that promotes genetic recombination.
1 Q9UJ98 (/TAS)
Stem cell population maintenance GO:0019827
The process by which an organism or tissue maintains a population of stem cells of a single type. This can be achieved by a number of mechanisms: stem cell asymmetric division maintains stem cell numbers; stem cell symmetric division increases them; maintenance of a stem cell niche maintains the conditions for commitment to the stem cell fate for some types of stem cell; stem cells may arise de novo from other cell types.
1 O35638 (/IMP)
Negative regulation of DNA endoreduplication GO:0032876
Any process that stops, prevents, or reduces the frequency, rate or extent of DNA endoreduplication.
1 Q8N3U4 (/IMP)
Negative regulation of DNA endoreduplication GO:0032876
Any process that stops, prevents, or reduces the frequency, rate or extent of DNA endoreduplication.
1 O35638 (/ISO)
Protein localization to chromosome GO:0034502
Any process in which a protein is transported to, or maintained at, a specific location on a chromosome.
1 O70576 (/IMP)
Meiotic cell cycle GO:0051321
Progression through the phases of the meiotic cell cycle, in which canonically a cell replicates to produce four offspring with half the chromosomal content of the progenitor cell via two nuclear divisions.
1 Q99M76 (/TAS)

There are 26 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
7 O35638 (/TAS) O70576 (/TAS) Q8N3U4 (/TAS) Q8WVM7 (/TAS) Q8WVM7 (/TAS) Q9D3E6 (/TAS) Q9D3E6 (/TAS)
Chromatin GO:0000785
The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome.
6 O35638 (/IDA) Q8N3U4 (/IDA) Q8WVM7 (/IDA) Q8WVM7 (/IDA) Q9D3E6 (/IDA) Q9D3E6 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
5 Q8N3U4 (/TAS) Q8WVM7 (/TAS) Q8WVM7 (/TAS) Q99M76 (/TAS) Q9UJ98 (/TAS)
Chromosome, centromeric region GO:0000775
The region of a chromosome that includes the centromeric DNA and associated proteins. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome.
3 Q8N3U4 (/TAS) Q8WVM7 (/TAS) Q8WVM7 (/TAS)
Chromatin GO:0000785
The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome.
3 O35638 (/ISO) Q9D3E6 (/ISO) Q9D3E6 (/ISO)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
3 Q68DW7 (/IDA) Q8WVM7 (/IDA) Q8WVM7 (/IDA)
Chromosome GO:0005694
A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information.
3 Q8N3U4 (/TAS) Q8WVM7 (/TAS) Q8WVM7 (/TAS)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
3 Q8N3U4 (/TAS) Q8WVM7 (/TAS) Q8WVM7 (/TAS)
Nuclear body GO:0016604
Extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins.
3 Q68DW7 (/IDA) Q8WVM7 (/IDA) Q8WVM7 (/IDA)
Synaptonemal complex GO:0000795
A proteinaceous scaffold found between homologous chromosomes during meiosis. It consists of 2 lateral elements and a central element, all running parallel to each other. Transverse filaments connect the lateral elements to the central element.
2 Q99M76 (/TAS) Q9UJ98 (/TAS)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
2 Q8WVM7 (/IDA) Q8WVM7 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
2 Q9D3E6 (/ISO) Q9D3E6 (/ISO)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
2 Q9D3E6 (/ISO) Q9D3E6 (/ISO)
Nuclear body GO:0016604
Extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins.
2 Q9D3E6 (/ISO) Q9D3E6 (/ISO)
Meiotic cohesin complex GO:0030893
A cohesin complex that mediates sister chromatid cohesion during meiosis; has a subunit composition distinct from that of the mitotic cohesin complex.
2 O70576 (/IDA) Q9UJ98 (/IDA)
Condensed nuclear chromosome GO:0000794
A highly compacted molecule of DNA and associated proteins resulting in a cytologically distinct nuclear chromosome.
1 O70576 (/IDA)
Synaptonemal complex GO:0000795
A proteinaceous scaffold found between homologous chromosomes during meiosis. It consists of 2 lateral elements and a central element, all running parallel to each other. Transverse filaments connect the lateral elements to the central element.
1 O70576 (/IDA)
Lateral element GO:0000800
A proteinaceous core found between sister chromatids during meiotic prophase.
1 O70576 (/IDA)
Transverse filament GO:0000802
A structural unit of the synaptonemal complex that spans the regions between the lateral elements and connects them.
1 O70576 (/IDA)
Male germ cell nucleus GO:0001673
The nucleus of a male germ cell, a reproductive cell in males.
1 O70576 (/IDA)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
1 Q9UJ98 (/IDA)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
1 O70576 (/ISO)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
1 Q8N3U4 (/IDA)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
1 O35638 (/ISO)
Meiotic cohesin complex GO:0030893
A cohesin complex that mediates sister chromatid cohesion during meiosis; has a subunit composition distinct from that of the mitotic cohesin complex.
1 O70576 (/ISO)
Nuclear meiotic cohesin complex GO:0034991
A cohesin complex that mediates sister chromatid cohesion in the nucleus during meiosis; has a subunit composition distinct from that of the mitotic cohesin complex.
1 O70576 (/IDA)
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