The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:
"Leucine-rich Repeat Variant
".
FunFam 69002: cDNA, FLJ79380, highly similar to Exportin-1
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 12 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
7 | O14980 (/IPI) P14068 (/IPI) P30822 (/IPI) Q6P5F9 (/IPI) Q80U96 (/IPI) Q9PW90 (/IPI) Q9TVM2 (/IPI) |
Protein transporter activity GO:0008565
Enables the directed movement of proteins into, out of or within a cell, or between cells.
|
3 | P30822 (/IDA) Q6P5F9 (/IDA) Q9TVM2 (/IDA) |
Nuclear export signal receptor activity GO:0005049
Combining with a nuclear export signal (NES) to mediate transport of the NES-containing protein through the nuclear pore to the cytoplasm.
|
2 | O14980 (/IMP) P14068 (/IMP) |
Nuclear export signal receptor activity GO:0005049
Combining with a nuclear export signal (NES) to mediate transport of the NES-containing protein through the nuclear pore to the cytoplasm.
|
1 | P14068 (/IDA) |
Nuclear export signal receptor activity GO:0005049
Combining with a nuclear export signal (NES) to mediate transport of the NES-containing protein through the nuclear pore to the cytoplasm.
|
1 | A0A1D8PRR9 (/IGI) |
Nuclear export signal receptor activity GO:0005049
Combining with a nuclear export signal (NES) to mediate transport of the NES-containing protein through the nuclear pore to the cytoplasm.
|
1 | Q6P5F9 (/ISO) |
Transporter activity GO:0005215
Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells.
|
1 | O14980 (/TAS) |
Nucleocytoplasmic transporter activity GO:0005487
Enables the directed movement of substances between the nucleus and the cytoplasm of a cell.
|
1 | O14980 (/IMP) |
Nucleocytoplasmic transporter activity GO:0005487
Enables the directed movement of substances between the nucleus and the cytoplasm of a cell.
|
1 | Q6P5F9 (/ISO) |
GTP binding GO:0005525
Interacting selectively and non-covalently with GTP, guanosine triphosphate.
|
1 | P14068 (/NAS) |
Protein transporter activity GO:0008565
Enables the directed movement of proteins into, out of or within a cell, or between cells.
|
1 | P30822 (/IMP) |
Protein domain specific binding GO:0019904
Interacting selectively and non-covalently with a specific domain of a protein.
|
1 | Q80U96 (/IPI) |
There are 30 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Protein export from nucleus GO:0006611
The directed movement of a protein from the nucleus into the cytoplasm.
|
5 | O14980 (/IMP) P14068 (/IMP) P30822 (/IMP) Q6P5F9 (/IMP) Q9TVM2 (/IMP) |
Protein export from nucleus GO:0006611
The directed movement of a protein from the nucleus into the cytoplasm.
|
3 | O14980 (/IDA) Q6P5F9 (/IDA) Q80U96 (/IDA) |
Ribosomal large subunit export from nucleus GO:0000055
The directed movement of a ribosomal large subunit from the nucleus into the cytoplasm.
|
2 | O14980 (/IMP) P30822 (/IMP) |
Ribosomal large subunit export from nucleus GO:0000055
The directed movement of a ribosomal large subunit from the nucleus into the cytoplasm.
|
2 | P14068 (/ISO) Q6P5F9 (/ISO) |
Ribosomal small subunit export from nucleus GO:0000056
The directed movement of a ribosomal small subunit from the nucleus into the cytoplasm.
|
2 | O14980 (/IMP) Q9TVM2 (/IMP) |
Protein export from nucleus GO:0006611
The directed movement of a protein from the nucleus into the cytoplasm.
|
2 | A0A1D8PRR9 (/IGI) P14068 (/IGI) |
Ribosomal subunit export from nucleus GO:0000054
The directed movement of a ribosomal subunit from the nucleus into the cytoplasm.
|
1 | O14980 (/IMP) |
Ribosomal subunit export from nucleus GO:0000054
The directed movement of a ribosomal subunit from the nucleus into the cytoplasm.
|
1 | Q6P5F9 (/ISO) |
Ribosomal small subunit export from nucleus GO:0000056
The directed movement of a ribosomal small subunit from the nucleus into the cytoplasm.
|
1 | Q6P5F9 (/ISO) |
Negative regulation of transcription from RNA polymerase II promoter GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter.
|
1 | Q80U96 (/IMP) |
Response to yeast GO:0001878
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a yeast species.
|
1 | E7FBU7 (/IDA) |
MRNA export from nucleus GO:0006406
The directed movement of mRNA from the nucleus to the cytoplasm.
|
1 | P30822 (/IMP) |
Protein export from nucleus GO:0006611
The directed movement of a protein from the nucleus into the cytoplasm.
|
1 | Q6P5F9 (/ISO) |
Sister chromatid cohesion GO:0007062
The cell cycle process in which the sister chromatids of a replicated chromosome become tethered to each other.
|
1 | O14980 (/TAS) |
Centriole replication GO:0007099
The cell cycle process in which a daughter centriole is formed perpendicular to an existing centriole. An immature centriole contains a ninefold radially symmetric array of single microtubules; mature centrioles consist of a radial array of nine microtubule triplets, doublets, or singlets depending upon the species and cell type. Duplicated centrioles also become the ciliary basal body in cells that form cilia during G0.
|
1 | Q9TVM2 (/IMP) |
Multicellular organism development GO:0007275
The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).
|
1 | Q9TVM2 (/IDA) |
Brain development GO:0007420
The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.).
|
1 | E7F0E8 (/IMP) |
Regulation of centrosome duplication GO:0010824
Any process that modulates the frequency, rate or extent of centrosome duplication. Centrosome duplication is the replication of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized.
|
1 | Q6P5F9 (/IMP) |
Protein transport GO:0015031
The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
|
1 | Q9TVM2 (/IDA) |
Viral process GO:0016032
A multi-organism process in which a virus is a participant. The other participant is the host. Includes infection of a host cell, replication of the viral genome, and assembly of progeny virus particles. In some cases the viral genetic material may integrate into the host genome and only subsequently, under particular circumstances, 'complete' its life cycle.
|
1 | O14980 (/TAS) |
Protein localization to kinetochore GO:0034501
Any process in which a protein is transported to, or maintained at, the kinetochore.
|
1 | P30822 (/IGI) |
Protein localization to nucleus GO:0034504
A process in which a protein is transported to, or maintained in, a location within the nucleus.
|
1 | Q6P5F9 (/IMP) |
Cellular response to oxidative stress GO:0034599
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.
|
1 | P14068 (/IMP) |
Regulation of protein catabolic process GO:0042176
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds.
|
1 | Q6P5F9 (/IMP) |
Response to drug GO:0042493
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease.
|
1 | Q80U96 (/IEP) |
Regulation of mRNA stability GO:0043488
Any process that modulates the propensity of mRNA molecules to degradation. Includes processes that both stabilize and destabilize mRNAs.
|
1 | O14980 (/TAS) |
Regulation of protein export from nucleus GO:0046825
Any process that modulates the frequency, rate or extent of the directed movement of proteins from the nucleus to the cytoplasm.
|
1 | Q6P5F9 (/IMP) |
Nuclear export GO:0051168
The directed movement of substances out of the nucleus.
|
1 | Q9TVM2 (/IDA) |
Intracellular transport of virus GO:0075733
The directed movement of a virus, or part of a virus, within the host cell.
|
1 | O14980 (/TAS) |
Regulation of cellular response to hypoxia GO:1900037
Any process that modulates the frequency, rate or extent of cellular response to hypoxia.
|
1 | Q9TVM2 (/IMP) |
There are 30 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
5 | O14980 (/IDA) P14068 (/IDA) P30822 (/IDA) Q6P5F9 (/IDA) Q9TVM2 (/IDA) |
Kinetochore GO:0000776
A multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules.
|
2 | O14980 (/IDA) P30822 (/IDA) |
Kinetochore GO:0000776
A multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules.
|
2 | Q6P5F9 (/ISS) Q80U96 (/ISS) |
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
2 | O14980 (/IDA) P14068 (/IDA) |
Nuclear membrane GO:0031965
Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space.
|
2 | O14980 (/IDA) Q9TVM2 (/IDA) |
Kinetochore GO:0000776
A multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules.
|
1 | Q6P5F9 (/ISO) |
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
1 | Q6P5F9 (/ISO) |
Nuclear envelope GO:0005635
The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space).
|
1 | P14068 (/IDA) |
Nuclear envelope GO:0005635
The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space).
|
1 | O14980 (/TAS) |
Annulate lamellae GO:0005642
Stacks of endoplasmic reticulum (ER) membranes containing a high density of nuclear pores, thought to form from excess nuclear membrane components, that have been described in a number of different cells. Annulate lamellar membranes are continuous with and embedded within the ER.
|
1 | O14980 (/IDA) |
Annulate lamellae GO:0005642
Stacks of endoplasmic reticulum (ER) membranes containing a high density of nuclear pores, thought to form from excess nuclear membrane components, that have been described in a number of different cells. Annulate lamellar membranes are continuous with and embedded within the ER.
|
1 | Q6P5F9 (/ISO) |
Nuclear pore GO:0005643
Any of the numerous similar discrete openings in the nuclear envelope of a eukaryotic cell, where the inner and outer nuclear membranes are joined.
|
1 | Q9TVM2 (/IMP) |
Nuclear pore GO:0005643
Any of the numerous similar discrete openings in the nuclear envelope of a eukaryotic cell, where the inner and outer nuclear membranes are joined.
|
1 | P14068 (/NAS) |
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
1 | O14980 (/TAS) |
Nucleolus GO:0005730
A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
|
1 | O14980 (/IDA) |
Nucleolus GO:0005730
A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
|
1 | Q6P5F9 (/ISO) |
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
1 | O14980 (/IDA) |
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
1 | Q6P5F9 (/ISO) |
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
1 | O14980 (/TAS) |
Spindle pole body GO:0005816
The microtubule organizing center in fungi; functionally homologous to the animal cell centrosome.
|
1 | P30822 (/IDA) |
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
1 | Q6P5F9 (/ISO) |
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
1 | O14980 (/TAS) |
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
|
1 | O14980 (/IDA) |
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
|
1 | Q6P5F9 (/ISO) |
Intracellular ribonucleoprotein complex GO:0030529
An intracellular macromolecular complex containing both protein and RNA molecules.
|
1 | O14980 (/IDA) |
Intracellular ribonucleoprotein complex GO:0030529
An intracellular macromolecular complex containing both protein and RNA molecules.
|
1 | Q6P5F9 (/ISO) |
Nuclear membrane GO:0031965
Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space.
|
1 | Q6P5F9 (/ISO) |
Nuclear periphery GO:0034399
The portion of the nuclear lumen proximal to the inner nuclear membrane.
|
1 | P14068 (/IDA) |
Intracellular membrane-bounded organelle GO:0043231
Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
|
1 | O14980 (/IDA) |
Intracellular membrane-bounded organelle GO:0043231
Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
|
1 | Q6P5F9 (/ISO) |