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CATH Superfamily 1.20.970.10

Transferase, Pyrimidine Nucleoside Phosphorylase; Chain C

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Transferase, Pyrimidine Nucleoside Phosphorylase; Chain C
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 3051: Thymidine phosphorylase

There are 2 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Thymidine phosphorylase. [EC: 2.4.2.4]
Thymidine + phosphate = thymine + 2-deoxy-alpha-D-ribose 1-phosphate.
  • In some tissues also catalyzes deoxyribosyltransferase reactions of the type catalyzed by EC 2.4.2.6.
  • Formerly EC 2.4.2.23.
 1742 A0A014M8D1 A0A017IQC0 A0A021X6Z7 A0A023E6H9 A0A023RN11 A0A023V6N6 A0A023Z7T2 A0A024IS08 A0A024K8G9 A0A024KLQ9
(1732 more...)
Pyrimidine-nucleoside phosphorylase. [EC: 2.4.2.2]
(1) Uridine + phosphate = uracil + alpha-D-ribose 1-phosphate. (2) Thymidine + phosphate = thymine + 2-deoxy-alpha-D-ribose 1-phosphate. (3) 2'-deoxyuridine + phosphate = uracil + 2-deoxy-alpha-D-ribose 1-phosphate.
  • Unlike EC 2.4.2.3, and EC 2.4.2.4, this enzyme can accept both the ribonucleoside uridine and the 2'-deoxyribonucleosides 2'-deoxyuridine and thymidine.
  • The reaction is reversible, and the enzyme does not distinguish between alpha-D-ribose 1-phosphate and 2-deoxy-alpha-D-ribose 1-phosphate in the synthetic direction.
  • Formerly EC 2.4.2.23.
 1 A0A1L9F3N0