The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of a thrombocyte, a nucleated cell found in all vertebrates but mammals involved in hemostasis.

The removal of histones, including histone dimers, from nucleosomes within chromatin.

The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA.

Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter.

A cell cycle process by which the cell nucleus divides as part of a meiotic cell cycle in the male germline.

A cell cycle process comprising the steps by which a cell progresses through male meiosis I, the first meiotic division in the male germline.

The process of formation of spermatozoa, including spermatocytogenesis and spermiogenesis.

Any process that activates or increases the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides, catalyzed by RNA polymerase II.

Any process that activates or increases the frequency, rate or extent of I-kappaB kinase/NF-kappaB signaling.

Any process that modulates the frequency, rate or extent of RNA splicing, the process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA.

Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.

Any process that modulates the frequency, rate or extent of the inflammatory response, the immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents.

Any process that activates or increases the frequency, rate or extent of transcription as part of a meiotic cell cycle.

Any process that modulates the frequency, rate or extent of phosphorylation of RNA polymerase II C-terminal domain.

Dynamic structural changes to eukaryotic chromatin occurring throughout the cell division cycle. These changes range from the local changes necessary for transcriptional regulation to global changes necessary for chromosome segregation.

Dynamic structural changes to eukaryotic chromatin occurring throughout the cell division cycle. These changes range from the local changes necessary for transcriptional regulation to global changes necessary for chromosome segregation.

Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter.

Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter.

Any process that regulates transcription such that the target genes are involved in the transition between G1 and S phase of the mitotic cell cycle.

Any process that regulates transcription such that the target genes are involved in the transition between G1 and S phase of the mitotic cell cycle.

The removal of histones, including histone dimers, from nucleosomes within chromatin.

The proliferation of cells in the inner cell mass.

The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA.

The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA.

The process of introducing a phosphate group on to a protein.

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism.

The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. In eukaryotes, chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles.

A cell cycle process by which the cell nucleus divides as part of a meiotic cell cycle in the male germline.

A cell cycle process comprising the steps by which a cell progresses through male meiosis I, the first meiotic division in the male germline.

The process of formation of spermatozoa, including spermatocytogenesis and spermiogenesis.

The process of formation of spermatozoa, including spermatocytogenesis and spermiogenesis.

The process of formation of spermatozoa, including spermatocytogenesis and spermiogenesis.

Any process that increases the rate or extent of progression from G2 phase to M phase of the mitotic cell cycle.

Any process that increases the rate or extent of progression from G2 phase to M phase of the mitotic cell cycle.

Any process that activates or increases the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides, catalyzed by RNA polymerase II.

Any process that activates or increases the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides, catalyzed by RNA polymerase II.

Any process that activates or increases the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides, catalyzed by RNA polymerase II.

Any process that activates or increases the frequency, rate or extent of I-kappaB kinase/NF-kappaB signaling.

Any process that increases the frequency, rate or extent of DNA binding. DNA binding is any process in which a gene product interacts selectively with DNA (deoxyribonucleic acid).

Any process that modulates the frequency, rate or extent of RNA splicing, the process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA.

The modification of histone H4 by the addition of an acetyl group to a lysine residue at position 12 of the histone.

The modification of histone H3 by the addition of an acetyl group to a lysine residue at position 14 of the histone.

Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.

The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation).

Any process that modulates the frequency, rate or extent of the inflammatory response, the immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents.

Any process that activates or increases the frequency, rate or extent of transcription as part of a meiotic cell cycle.

Any process that modulates the frequency, rate or extent of phosphorylation of RNA polymerase II C-terminal domain.

Any process that stops, prevents, or reduces the frequency, rate or extent of a DNA damage checkpoint.

A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

A highly compacted molecule of DNA and associated proteins resulting in a cytologically distinct nuclear chromosome.

The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome in the nucleus.

A highly compacted molecule of DNA and associated proteins resulting in a cytologically distinct structure.

A highly compacted molecule of DNA and associated proteins resulting in a cytologically distinct nuclear chromosome.

That part of the nuclear content other than the chromosomes or the nucleolus.

That part of the nuclear content other than the chromosomes or the nucleolus.

RNA polymerase II, one of three nuclear DNA-directed RNA polymerases found in all eukaryotes, is a multisubunit complex; typically it produces mRNAs, snoRNAs, and some of the snRNAs. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The largest subunit of RNA polymerase II contains an essential carboxyl-terminal domain (CTD) composed of a variable number of heptapeptide repeats (YSPTSPS). The remainder of the complex is composed of smaller subunits (generally ten or more), some of which are also found in RNA polymerases I and III. Although the core is competent to mediate ribonucleic acid synthesis, it requires additional factors to select the appropriate template.

A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information.

All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

A transcription elongation factor complex that facilitates the transition from abortive to productive elongation by phosphorylating the CTD domain of the large subunit of DNA-directed RNA polymerase II, holoenzyme. Contains a cyclin and a cyclin-dependent protein kinase catalytic subunit.