The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: Pre-mRNA-processing-splicing factor 8, U5-snRNA-binding domain

The active centre of the spliceosome consists of an intricate network formed by U5, U2 and U6 snRNAs, and a pre-mRNA substrate. Prp8 is a component of the U5 snRNP that extensively crosslinks with this RNA catalytic core PMID:23354046. Structural domains comprising this superfamily share the structure of the U5-snRNA-binding domain of the pre-mRNA-processing-splicing factor 8 (Prp8). The essential spliceosomal protein Prp8 interacts with U5 and U6 snRNAs and with specific pre-mRNA sequences that participate in catalysis PMID:16431982.Due to Prp8's close association with crucial RNA sequences, together with extensive genetic evidence, it is believed that this protein directly affects the function of the catalytic core, probably acting as a splicing cofactor PMID:16431982.

GO Diversity

Unique GO annotations
39 Unique GO terms

EC Diversity

Unique EC annotations
4 Unique EC terms

Species Diversity

Unique species annotations
1212 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Domains: 3
Domain clusters (>95% seq id): 1
Domain clusters (>35% seq id): 1
Unique PDBs: 2
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 0
Unique EC: 4
Unique GO: 39
Unique Species: 1212