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CATH Superfamily 1.20.5.170

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 18348: Nucleotide sugar dehydrogenase

There are 5 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
UDP-glucose 6-dehydrogenase. [EC: 1.1.1.22]
UDP-glucose + 2 NAD(+) + H(2)O = UDP-glucuronate + 2 NADH.
  • Also acts on UDP-2-deoxyglucose.
 7 A0A174L8Z8 A0A174XF57 A0A1C6IYG1 B9THJ7 E7GH57 N1MNF0 R1CMP8
UDP-N-acetylglucosamine 6-dehydrogenase. [EC: 1.1.1.136]
UDP-N-acetyl-alpha-D-glucosamine + 2 NAD(+) + H(2)O = UDP-2-acetamido-2- deoxy-alpha-D-glucuronate + 2 NADH.
  • This enzyme participates in the biosynthetic pathway for UDP-alpha-D- ManNAc(3)NAcA (UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-mannuronic acid), an important precursor of B-band lipopolysaccharide.
 3 A0A128ETH0 A0A165ZUA4 A0A1E3AEE5
GDP-mannose 6-dehydrogenase. [EC: 1.1.1.132]
GDP-D-mannose + 2 NAD(+) + H(2)O = GDP-D-mannuronate + 2 NADH.
  • Also uses the corresponding deoxynucleoside diphosphate derivative as a substrate.
 1 A0A1C6KUH8
UDP-N-acetylglucosamine 2-epimerase (non-hydrolyzing). [EC: 5.1.3.14]
UDP-N-acetyl-alpha-D-glucosamine = UDP-N-acetyl-alpha-D-mannosamine.
  • This bacterial enzyme catalyzes the reversible interconversion of UDP-GlcNAc and UDP-ManNAc.
  • The latter is used in a variety of bacterial polysaccharide biosyntheses.
  • Cf. EC 3.2.1.183.
 1 A0A173KXG7
UDP-N-acetyl-D-mannosamine dehydrogenase. [EC: 1.1.1.336]
UDP-N-acetyl-alpha-D-mannosamine + 2 NAD(+) + H(2)O = UDP-N-acetyl-alpha- D-mannosaminuronate + 2 NADH.
  • Part of the pathway for acetamido sugar biosynthesis in bacteria and archaea.
  • The enzyme has no activity with NADP(+).
  • Formerly EC 1.1.1.n3.
 1 A0A1B1NKP3