The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 5679: Synaptosomal-associated protein 23

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 29 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
10 A8K287 (/IPI) O00161 (/IPI) O09044 (/IPI) O70377 (/IPI) P36975 (/IPI) P60878 (/IPI) P60879 (/IPI) P60880 (/IPI) P60881 (/IPI) Q17QQ3 (/IPI)
SNARE binding GO:0000149
Interacting selectively and non-covalently with a SNARE (soluble N-ethylmaleimide-sensitive factor attached protein receptor) protein.
2 P60879 (/IDA) P60881 (/IDA)
SNARE binding GO:0000149
Interacting selectively and non-covalently with a SNARE (soluble N-ethylmaleimide-sensitive factor attached protein receptor) protein.
2 P36975 (/IPI) P60881 (/IPI)
SNAP receptor activity GO:0005484
Acting as a marker to identify a membrane and interacting selectively with one or more SNAREs on another membrane to mediate membrane fusion.
2 O70377 (/IDA) P36975 (/IDA)
SNAP receptor activity GO:0005484
Acting as a marker to identify a membrane and interacting selectively with one or more SNAREs on another membrane to mediate membrane fusion.
2 P36975 (/ISS) Q9VH76 (/ISS)
Syntaxin-1 binding GO:0017075
Interacting selectively and non-covalently with the SNAP receptor syntaxin-1.
2 P60879 (/IDA) P60881 (/IDA)
Syntaxin-1 binding GO:0017075
Interacting selectively and non-covalently with the SNAP receptor syntaxin-1.
2 P60880 (/IPI) P60881 (/IPI)
Syntaxin binding GO:0019905
Interacting selectively and non-covalently with a syntaxin, a SNAP receptor involved in the docking of synaptic vesicles at the presynaptic zone of a synapse.
2 O00161 (/IPI) O70377 (/IPI)
Calcium-dependent protein binding GO:0048306
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules), in the presence of calcium.
2 P60879 (/ISS) P60880 (/ISS)
SNARE binding GO:0000149
Interacting selectively and non-covalently with a SNARE (soluble N-ethylmaleimide-sensitive factor attached protein receptor) protein.
1 P60879 (/ISO)
Catalytic activity GO:0003824
Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.
1 G3H0X3 (/ISS)
Voltage-gated potassium channel activity GO:0005249
Enables the transmembrane transfer of a potassium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.
1 P60881 (/IDA)
SNAP receptor activity GO:0005484
Acting as a marker to identify a membrane and interacting selectively with one or more SNAREs on another membrane to mediate membrane fusion.
1 P36975 (/NAS)
SNAP receptor activity GO:0005484
Acting as a marker to identify a membrane and interacting selectively with one or more SNAREs on another membrane to mediate membrane fusion.
1 P60881 (/TAS)
Calcium ion binding GO:0005509
Interacting selectively and non-covalently with calcium ions (Ca2+).
1 G3H0X3 (/ISS)
Peptidase activity GO:0008233
Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid.
1 G3H0X3 (/ISS)
Structural constituent of muscle GO:0008307
The action of a molecule that contributes to the structural integrity of a muscle fiber.
1 G3H0X3 (/ISS)
Myosin binding GO:0017022
Interacting selectively and non-covalently with any part of a myosin complex; myosins are any of a superfamily of molecular motor proteins that bind to actin and use the energy of ATP hydrolysis to generate force and movement along actin filaments.
1 P60881 (/IPI)
Syntaxin-1 binding GO:0017075
Interacting selectively and non-covalently with the SNAP receptor syntaxin-1.
1 P60879 (/ISO)
Protein domain specific binding GO:0019904
Interacting selectively and non-covalently with a specific domain of a protein.
1 P60881 (/IPI)
Syntaxin binding GO:0019905
Interacting selectively and non-covalently with a syntaxin, a SNAP receptor involved in the docking of synaptic vesicles at the presynaptic zone of a synapse.
1 O09044 (/ISO)
Syntaxin binding GO:0019905
Interacting selectively and non-covalently with a syntaxin, a SNAP receptor involved in the docking of synaptic vesicles at the presynaptic zone of a synapse.
1 Q9VH76 (/ISS)
Sodium ion binding GO:0031402
Interacting selectively and non-covalently with sodium ions (Na+).
1 G3H0X3 (/ISS)
Titin binding GO:0031432
Interacting selectively and non-covalently with titin, any of a family of giant proteins found in striated and smooth muscle. In striated muscle, single titin molecules span half the sarcomere, with their N- and C-termini in the Z-disc and M-line, respectively.
1 G3H0X3 (/ISS)
Protein complex scaffold GO:0032947
A structural molecule activity that provides a physical support for the assembly of a multiprotein complex. The scaffold may or may not be part of the final complex.
1 G3H0X3 (/ISS)
Ion channel binding GO:0044325
Interacting selectively and non-covalently with one or more specific sites on an ion channel, a protein complex that spans a membrane and forms a water-filled channel across the phospholipid bilayer allowing selective ion transport down its electrochemical gradient.
1 P60881 (/IPI)
Protein N-terminus binding GO:0047485
Interacting selectively and non-covalently with a protein N-terminus, the end of any peptide chain at which the 2-amino (or 2-imino) function of a constituent amino acid is not attached in peptide linkage to another amino-acid residue.
1 P60881 (/IPI)
Calcium-dependent protein binding GO:0048306
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules), in the presence of calcium.
1 P60881 (/IPI)
Ligase regulator activity GO:0055103
Modulates the activity of a ligase.
1 G3H0X3 (/ISS)

There are 71 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Locomotory behavior GO:0007626
The specific movement from place to place of an organism in response to external or internal stimuli. Locomotion of a whole organism in a manner dependent upon some combination of that organism's internal state and external conditions.
3 P60879 (/IMP) Q5TZ66 (/IMP) Q6PC54 (/IMP)
Golgi to plasma membrane transport GO:0006893
The directed movement of substances from the Golgi to the plasma membrane in transport vesicles that move from the trans-Golgi network to the plasma membrane, where they fuse and release their contents by exocytosis.
2 P36975 (/ISS) Q9VH76 (/ISS)
Neurotransmitter secretion GO:0007269
The regulated release of neurotransmitter from the presynapse into the synaptic cleft via calcium regualated exocytosis during synaptic transmission.
2 P36975 (/NAS) Q9VH76 (/NAS)
Synaptic transmission, cholinergic GO:0007271
The process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse using the neurotransmitter acetylcholine.
2 A5PEW5 (/IMP) O62414 (/IMP)
Synaptic vesicle docking GO:0016081
The initial (indirect) attachment of a synaptic vesicle membrane to the presynaptic active zone membrane, mediated by proteins protruding from the membrane and proteins of the presynaptic active zone cytoplasmic component. Synaptic vesicle tethering is the first step in this process.
2 P36975 (/NAS) P60880 (/NAS)
Vesicle-mediated transport GO:0016192
A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane.
2 P36975 (/NAS) Q9VH76 (/NAS)
Neutrophil degranulation GO:0043312
The regulated exocytosis of secretory granules containing preformed mediators such as proteases, lipases, and inflammatory mediators by a neutrophil.
2 O00161 (/TAS) P60880 (/TAS)
Regulation of insulin secretion GO:0050796
Any process that modulates the frequency, rate or extent of the regulated release of insulin.
2 P60879 (/TAS) P60880 (/TAS)
Exocytic insertion of neurotransmitter receptor to postsynaptic membrane GO:0098967
The exocytic fusion of neurotransmitter receptor containing vesicles with a plasma-membrane resulting in the integration of NT receptors with the plasma-membrane enabling them to participate in neurotransmitter reception. This process includes tethering and docking steps that prepare vesicles for fusion.
2 O70377 (/IMP) P60879 (/IMP)
Mitotic cytokinesis GO:0000281
A cell cycle process that results in the division of the cytoplasm of a cell after mitosis, resulting in the separation of the original cell into two daughter cells.
1 Q5TZ66 (/IMP)
Neurotransmitter uptake GO:0001504
The directed movement of neurotransmitters into neurons or glial cells. This process leads to inactivation and recycling of neurotransmitters.
1 P60880 (/NAS)
Antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent GO:0002479
The process in which an antigen-presenting cell expresses a peptide antigen of exogenous origin on its cell surface in association with an MHC class I protein complex following intracellular transport via a TAP (transporter associated with antigen processing) pathway. The peptide is typically a fragment of a larger exogenous protein which has been degraded within the cell and is dependent on TAP transport from the cytosol to ER for association with the MHC class I molecule. Class I here refers to classical class I molecules.
1 O00161 (/TAS)
Histamine secretion by mast cell GO:0002553
The regulated release of histamine by a mast cell or group of mast cells.
1 O00161 (/IMP)
Histamine secretion by mast cell GO:0002553
The regulated release of histamine by a mast cell or group of mast cells.
1 O09044 (/ISO)
Protein complex assembly GO:0006461
The aggregation, arrangement and bonding together of a set of components to form a protein complex.
1 O70377 (/IDA)
Protein complex assembly GO:0006461
The aggregation, arrangement and bonding together of a set of components to form a protein complex.
1 G3H0X3 (/ISS)
Proteolysis GO:0006508
The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.
1 G3H0X3 (/ISS)
Exocytosis GO:0006887
A process of secretion by a cell that results in the release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle by fusion of the vesicle with the plasma membrane of a cell. This process begins with steps that prepare vesicles for fusion with the membrane (tethering and docking) and ends when vesicle fusion is complete. This is the process in which most molecules are secreted from eukaryotic cells.
1 O09044 (/IMP)
Exocytosis GO:0006887
A process of secretion by a cell that results in the release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle by fusion of the vesicle with the plasma membrane of a cell. This process begins with steps that prepare vesicles for fusion with the membrane (tethering and docking) and ends when vesicle fusion is complete. This is the process in which most molecules are secreted from eukaryotic cells.
1 P60881 (/TAS)
Post-Golgi vesicle-mediated transport GO:0006892
The directed movement of substances from the Golgi to other parts of the cell, including organelles and the plasma membrane, mediated by small transport vesicles.
1 O00161 (/TAS)
Vesicle targeting GO:0006903
The process in which vesicles are directed to specific destination membranes. Targeting involves coordinated interactions among cytoskeletal elements (microtubules or actin filaments), motor proteins, molecules at the vesicle membrane and target membrane surfaces, and vesicle cargo.
1 O00161 (/TAS)
Vesicle fusion GO:0006906
Fusion of the membrane of a transport vesicle with its target membrane.
1 P36975 (/IDA)
Chemical synaptic transmission GO:0007268
The vesicular release of classical neurotransmitter molecules from a neuron, across a chemical synapse, the subsequent activation of neurotransmitter receptors of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse.
1 P60880 (/NAS)
Neurotransmitter secretion GO:0007269
The regulated release of neurotransmitter from the presynapse into the synaptic cleft via calcium regualated exocytosis during synaptic transmission.
1 P60879 (/IMP)
Neurotransmitter secretion GO:0007269
The regulated release of neurotransmitter from the presynapse into the synaptic cleft via calcium regualated exocytosis during synaptic transmission.
1 P60880 (/TAS)
Neuromuscular synaptic transmission GO:0007274
The process of communication from a neuron to a muscle, across a synapse.
1 P36975 (/IEP)
Axonogenesis GO:0007409
De novo generation of a long process of a neuron, that carries efferent (outgoing) action potentials from the cell body towards target cells. Refers to the morphogenesis or creation of shape or form of the developing axon.
1 P60881 (/IEP)
Long-term memory GO:0007616
The memory process that deals with the storage, retrieval and modification of information a long time (typically weeks, months or years) after receiving that information. This type of memory is typically dependent on gene transcription regulated by second messenger activation.
1 P60881 (/IMP)
Associative learning GO:0008306
Learning by associating a stimulus (the cause) with a particular outcome (the effect).
1 P60879 (/IMP)
Regulation of neuron projection development GO:0010975
Any process that modulates the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).
1 P60879 (/IGI)
Regulation of neuron projection development GO:0010975
Any process that modulates the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).
1 P60881 (/IMP)
Glutamate secretion GO:0014047
The controlled release of glutamate by a cell. The glutamate is the most abundant excitatory neurotransmitter in the nervous system.
1 P60880 (/TAS)
Positive regulation of satellite cell activation involved in skeletal muscle regeneration GO:0014718
Any process that activates, maintains or increases the frequency, rate or extent of activation of satellite cell involved in skeletal muscle regeneration. The activation of satellite cell is the process that initiates satellite cell division by causing it to move from quiescence to the G1 stage of the cell cycle. The cell swells and there are a number of other small changes. The cells then start to divide. Following cell division the cells will differentiate.
1 G3H0X3 (/ISS)
Response to muscle activity GO:0014850
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a muscle activity stimulus.
1 G3H0X3 (/ISS)
Protein transport GO:0015031
The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
1 O70377 (/IMP)
Synaptic vesicle exocytosis GO:0016079
Fusion of intracellular membrane-bounded vesicles with the pre-synaptic membrane of the neuronal cell resulting in release of neurotransmitter into the synaptic cleft.
1 P60880 (/TAS)
Synaptic vesicle priming GO:0016082
A process that converts synaptic vesicles to a state of competence for calcium triggered fusion with the active zone membrane by bringing the two membranes into very close proximity. Priming typically (but not always) occurs after docking (Jahn and Fasshauer, 2012). Primed vesicles are also capable of spontaneously fusing with the active zone membrane.
1 P36975 (/IDA)
Vesicle-mediated transport GO:0016192
A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane.
1 O70377 (/IMP)
Vesicle-mediated transport GO:0016192
A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane.
1 Q9VH76 (/ISS)
Endosomal transport GO:0016197
The directed movement of substances into, out of, or mediated by an endosome, a membrane-bounded organelle that carries materials newly ingested by endocytosis. It passes many of the materials to lysosomes for degradation.
1 P60881 (/IDA)
Regulation of exocytosis GO:0017157
Any process that modulates the frequency, rate or extent of exocytosis.
1 O70377 (/IMP)
Neuron differentiation GO:0030182
The process in which a relatively unspecialized cell acquires specialized features of a neuron.
1 P60881 (/IEP)
Growth hormone secretion GO:0030252
The regulated release of growth hormone from secretory granules into the blood.
1 P60881 (/IEP)
Sleep GO:0030431
Any process in which an organism enters and maintains a periodic, readily reversible state of reduced awareness and metabolic activity. Usually accompanied by physical relaxation, the onset of sleep in humans and other mammals is marked by a change in the electrical activity of the brain.
1 P60881 (/IDA)
Synaptic vesicle fusion to presynaptic active zone membrane GO:0031629
Fusion of the membrane of a synaptic vesicle with the presynaptic active zone membrane, thereby releasing its cargo neurotransmitters into the synaptic cleft.
1 P36975 (/IDA)
Positive regulation of synaptic plasticity GO:0031915
A process that increases synaptic plasticity, the ability of synapses to change as circumstances require. They may alter function, such as increasing or decreasing their sensitivity, or they may increase or decrease in actual numbers.
1 P60879 (/IMP)
Positive regulation of insulin secretion GO:0032024
Any process that activates or increases the frequency, rate or extent of the regulated release of insulin.
1 P60881 (/IEP)
Negative regulation of protein sumoylation GO:0033234
Any process that stops, prevents, or reduces the frequency, rate or extent of the addition of SUMO groups to a protein.
1 G3H0X3 (/ISS)
SNARE complex assembly GO:0035493
The aggregation, arrangement and bonding together of a set of components to form a SNARE complex, a protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers.
1 P60881 (/IMP)
Negative regulation of apoptotic process GO:0043066
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
1 G3H0X3 (/ISS)
Regulation of I-kappaB kinase/NF-kappaB signaling GO:0043122
Any process that modulates I-kappaB kinase/NF-kappaB signaling.
1 G3H0X3 (/ISS)
Sarcomere organization GO:0045214
The myofibril assembly process that results in the organization of muscle actomyosin into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs.
1 G3H0X3 (/ISS)
Positive regulation of proteolysis GO:0045862
Any process that activates or increases the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein.
1 G3H0X3 (/ISS)
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
1 G3H0X3 (/ISS)
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
1 G3H0X3 (/ISS)
Positive regulation of hormone secretion GO:0046887
Any process that activates or increases the frequency, rate or extent of the regulated release of a hormone from a cell.
1 P60881 (/IMP)
Regulation of short-term neuronal synaptic plasticity GO:0048172
A process that modulates short-term neuronal synaptic plasticity, the ability of neuronal synapses to change in the short-term as circumstances require. Short-term neuronal synaptic plasticity generally involves increasing or decreasing synaptic sensitivity.
1 P36975 (/IDA)
Synaptic vesicle transport GO:0048489
The directed movement of synaptic vesicles.
1 P36975 (/IDA)
Calcium ion-regulated exocytosis of neurotransmitter GO:0048791
The release of a neurotransmitter into the synaptic cleft by exocytosis of synaptic vesicles, where the release step is dependent on a rise in cytosolic calcium ion levels.
1 P60881 (/IDA)
Regulation of catalytic activity GO:0050790
Any process that modulates the activity of an enzyme.
1 G3H0X3 (/ISS)
Positive regulation of NF-kappaB transcription factor activity GO:0051092
Any process that activates or increases the frequency, rate or extent of activity of the transcription factor NF-kappaB.
1 G3H0X3 (/ISS)
Regulation of synapse assembly GO:0051963
Any process that modulates the frequency, rate or extent of synapse assembly, the aggregation, arrangement and bonding together of a set of components to form a synapse.
1 P60881 (/IEP)
Long-term synaptic potentiation GO:0060291
A process that modulates synaptic plasticity such that synapses are changed resulting in the increase in the rate, or frequency of synaptic transmission at the synapse.
1 P60879 (/IMP)
Membrane organization GO:0061024
A process which results in the assembly, arrangement of constituent parts, or disassembly of a membrane. A membrane is a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.
1 O09044 (/TAS)
Membrane fusion GO:0061025
The membrane organization process that joins two lipid bilayers to form a single membrane.
1 O70377 (/IDA)
Membrane fusion GO:0061025
The membrane organization process that joins two lipid bilayers to form a single membrane.
1 Q9VH76 (/ISS)
Membrane fusion GO:0061025
The membrane organization process that joins two lipid bilayers to form a single membrane.
1 O00161 (/TAS)
Regulation of establishment of protein localization GO:0070201
Any process that modulates the frequency, rate or extent of the directed movement of a protein to a specific location.
1 P60879 (/IMP)
Self proteolysis GO:0097264
The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their own peptide bonds.
1 G3H0X3 (/ISS)
Neurotransmitter receptor internalization GO:0099590
A receptor-mediated endocytosis process that results in the internalization of a neurotransmitter receptor.
1 P60879 (/IMP)
Short-term synaptic potentiation GO:1990926
The process by which synaptic transmission, induced by the arrival of a spike (action potential) at a synapse, acts to increase the amount of neurotransmitter released in response to the arrival of subsequent spikes. This effect is seen when a train of closely space spikes arrives at a synapse with a low initial release probability. It occurs in a timeframe of tens to hundreds of milliseconds.
1 P60879 (/IMP)

There are 72 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
SNARE complex GO:0031201
A protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers. One well-characterized example is the neuronal SNARE complex formed of synaptobrevin 2, syntaxin 1a, and SNAP-25.
15 P36975 (/ISS) P36976 (/ISS) P36977 (/ISS) P36978 (/ISS) P55820 (/ISS) P60877 (/ISS) P60878 (/ISS) P60879 (/ISS) P60880 (/ISS) Q17QQ3 (/ISS)
(5 more)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
14 G3H0X3 (/ISS) P36975 (/ISS) P36976 (/ISS) P36977 (/ISS) P36978 (/ISS) P55820 (/ISS) P60877 (/ISS) P60878 (/ISS) P60880 (/ISS) Q17QQ3 (/ISS)
(4 more)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
14 P36975 (/ISS) P36976 (/ISS) P36977 (/ISS) P36978 (/ISS) P55820 (/ISS) P60877 (/ISS) P60878 (/ISS) P60880 (/ISS) P60881 (/ISS) Q17QQ3 (/ISS)
(4 more)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
12 A5PEW5 (/IDA) A8K287 (/IDA) H3BV99 (/IDA) O00161 (/IDA) O09044 (/IDA) O62414 (/IDA) O70377 (/IDA) P36975 (/IDA) P60881 (/IDA) Q17QQ3 (/IDA)
(2 more)
SNARE complex GO:0031201
A protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers. One well-characterized example is the neuronal SNARE complex formed of synaptobrevin 2, syntaxin 1a, and SNAP-25.
6 O00161 (/IDA) O09044 (/IDA) O70377 (/IDA) P36975 (/IDA) P60880 (/IDA) P60881 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
4 O00161 (/TAS) O09044 (/TAS) P60879 (/TAS) P60880 (/TAS)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
3 A8K287 (/IDA) H3BV99 (/IDA) O00161 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
3 O00161 (/IDA) P60879 (/IDA) P60881 (/IDA)
Terminal bouton GO:0043195
Terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters. The axon terminus is considered to be the whole region of thickening and the terminal bouton is a specialized region of it.
3 O70377 (/IDA) P36975 (/IDA) P60881 (/IDA)
Synapse GO:0045202
The junction between a nerve fiber of one neuron and another neuron, muscle fiber or glial cell. As the nerve fiber approaches the synapse it enlarges into a specialized structure, the presynaptic nerve ending, which contains mitochondria and synaptic vesicles. At the tip of the nerve ending is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic nerve ending secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane.
3 A5PEW5 (/IDA) O62414 (/IDA) P60879 (/IDA)
Axon GO:0030424
The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter.
2 P60879 (/IDA) P60881 (/IDA)
Growth cone GO:0030426
The migrating motile tip of a growing nerve cell axon or dendrite.
2 P60881 (/IDA) Q17QQ3 (/IDA)
SNARE complex GO:0031201
A protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers. One well-characterized example is the neuronal SNARE complex formed of synaptobrevin 2, syntaxin 1a, and SNAP-25.
2 O09044 (/ISO) P60879 (/ISO)
Specific granule membrane GO:0035579
The lipid bilayer surrounding a specific granule, a granule with a membranous, tubular internal structure, found primarily in mature neutrophil cells. Most are released into the extracellular fluid. Specific granules contain lactoferrin, lysozyme, vitamin B12 binding protein and elastase.
2 O00161 (/TAS) P60880 (/TAS)
Neuron projection GO:0043005
A prolongation or process extending from a nerve cell, e.g. an axon or dendrite.
2 P60879 (/IDA) P60881 (/IDA)
Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex GO:0070032
A SNARE complex that contains synaptobrevin 2 (VAMP2), SNAP-25, syntaxin 1a, and complexin I (or orthologs thereof).
2 P60879 (/IDA) P60881 (/IDA)
Tertiary granule membrane GO:0070821
The lipid bilayer surrounding a tertiary granule.
2 O00161 (/TAS) P60880 (/TAS)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 G3H0X3 (/ISS)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
1 O09044 (/ISO)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 O09044 (/ISO)
Endosome GO:0005768
A vacuole to which materials ingested by endocytosis are delivered.
1 P60881 (/IDA)
Trans-Golgi network GO:0005802
The network of interconnected tubular and cisternal structures located within the Golgi apparatus on the side distal to the endoplasmic reticulum, from which secretory vesicles emerge. The trans-Golgi network is important in the later stages of protein secretion where it is thought to play a key role in the sorting and targeting of secreted proteins to the correct destination.
1 P60879 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 P60881 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 G3H0X3 (/ISS)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 P60880 (/TAS)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 O09044 (/ISO)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 G3H0X3 (/ISS)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 P36975 (/NAS)
Cell-cell adherens junction GO:0005913
An adherens junction which connects a cell to another cell.
1 O00161 (/IDA)
Cell-cell adherens junction GO:0005913
An adherens junction which connects a cell to another cell.
1 O09044 (/ISO)
Focal adhesion GO:0005925
Small region on the surface of a cell that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments.
1 O00161 (/IDA)
Focal adhesion GO:0005925
Small region on the surface of a cell that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments.
1 O09044 (/ISO)
Synaptic vesicle GO:0008021
A secretory organelle, typically 50 nm in diameter, of presynaptic nerve terminals; accumulates in high concentrations of neurotransmitters and secretes these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane.
1 P60879 (/IDA)
Voltage-gated potassium channel complex GO:0008076
A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential.
1 P60881 (/IDA)
Actin cytoskeleton GO:0015629
The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes.
1 P60881 (/IDA)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
1 P60879 (/IDA)
Myofibril GO:0030016
The contractile element of skeletal and cardiac muscle; a long, highly organized bundle of actin, myosin, and other proteins that contracts by a sliding filament mechanism.
1 G3H0X3 (/ISS)
Z disc GO:0030018
Platelike region of a muscle sarcomere to which the plus ends of actin filaments are attached.
1 G3H0X3 (/ISS)
Lamellipodium GO:0030027
A thin sheetlike process extended by the leading edge of a migrating cell or extending cell process; contains a dense meshwork of actin filaments.
1 P60881 (/IDA)
Filopodium GO:0030175
Thin, stiff, actin-based protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal or dendritic growth cone, or a dendritic shaft.
1 P60881 (/IDA)
T-tubule GO:0030315
Invagination of the plasma membrane of a muscle cell that extends inward from the cell surface around each myofibril. The ends of T-tubules make contact with the sarcoplasmic reticulum membrane.
1 G3H0X3 (/ISS)
Axon GO:0030424
The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter.
1 P60879 (/ISO)
Growth cone GO:0030426
The migrating motile tip of a growing nerve cell axon or dendrite.
1 P60880 (/ISS)
Secretory granule membrane GO:0030667
The lipid bilayer surrounding a secretory granule.
1 Q9VH76 (/IDA)
Phagocytic vesicle membrane GO:0030670
The lipid bilayer surrounding a phagocytic vesicle.
1 O00161 (/TAS)
SNARE complex GO:0031201
A protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers. One well-characterized example is the neuronal SNARE complex formed of synaptobrevin 2, syntaxin 1a, and SNAP-25.
1 P60880 (/TAS)
Cytoplasmic vesicle GO:0031410
A vesicle found in the cytoplasm of a cell.
1 O09044 (/IDA)
Somatodendritic compartment GO:0036477
The region of a neuron that includes the cell body (cell soma) and the dendrite, but excludes the axon.
1 P60879 (/IDA)
Specific granule GO:0042581
Granule with a membranous, tubular internal structure, found primarily in mature neutrophil cells. Most are released into the extracellular fluid. Specific granules contain lactoferrin, lysozyme, vitamin B12 binding protein and elastase.
1 O00161 (/IDA)
Specific granule GO:0042581
Granule with a membranous, tubular internal structure, found primarily in mature neutrophil cells. Most are released into the extracellular fluid. Specific granules contain lactoferrin, lysozyme, vitamin B12 binding protein and elastase.
1 O09044 (/ISO)
Azurophil granule GO:0042582
Primary lysosomal granule found in neutrophil granulocytes. Contains a wide range of hydrolytic enzymes and is released into the extracellular fluid.
1 O00161 (/IDA)
Azurophil granule GO:0042582
Primary lysosomal granule found in neutrophil granulocytes. Contains a wide range of hydrolytic enzymes and is released into the extracellular fluid.
1 O09044 (/ISO)
Presynaptic membrane GO:0042734
A specialized area of membrane of the axon terminal that faces the plasma membrane of the neuron or muscle fiber with which the axon terminal establishes a synaptic junction; many synaptic junctions exhibit structural presynaptic characteristics, such as conical, electron-dense internal protrusions, that distinguish it from the remainder of the axon plasma membrane.
1 P60879 (/IDA)
Presynaptic membrane GO:0042734
A specialized area of membrane of the axon terminal that faces the plasma membrane of the neuron or muscle fiber with which the axon terminal establishes a synaptic junction; many synaptic junctions exhibit structural presynaptic characteristics, such as conical, electron-dense internal protrusions, that distinguish it from the remainder of the axon plasma membrane.
1 P60880 (/TAS)
Neuron projection GO:0043005
A prolongation or process extending from a nerve cell, e.g. an axon or dendrite.
1 P60880 (/ISS)
Neuronal cell body GO:0043025
The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
1 P60881 (/IDA)
Myelin sheath GO:0043209
An electrically insulating fatty layer that surrounds the axons of many neurons. It is an outgrowth of glial cells: Schwann cells supply the myelin for peripheral neurons while oligodendrocytes supply it to those of the central nervous system.
1 P60879 (/IDA)
Intracellular organelle GO:0043229
Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.
1 P60881 (/IDA)
Protein complex GO:0043234
A stable macromolecular complex composed (only) of two or more polypeptide subunits along with any covalently attached molecules (such as lipid anchors or oligosaccharide) or non-protein prosthetic groups (such as nucleotides or metal ions). Prosthetic group in this context refers to a tightly bound cofactor. The component polypeptide subunits may be identical.
1 G3H0X3 (/ISS)
Axonal growth cone GO:0044295
The migrating motile tip of a growing nerve cell axon.
1 P60881 (/IDA)
Axonal growth cone GO:0044295
The migrating motile tip of a growing nerve cell axon.
1 P60879 (/ISO)
Membrane raft GO:0045121
Any of the small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. Small rafts can sometimes be stabilized to form larger platforms through protein-protein and protein-lipid interactions.
1 P60881 (/IDA)
Perinuclear region of cytoplasm GO:0048471
Cytoplasm situated near, or occurring around, the nucleus.
1 P60879 (/IDA)
Presynaptic active zone membrane GO:0048787
The membrane portion of the presynaptic active zone; it is the site where docking and fusion of synaptic vesicles occurs for the release of neurotransmitters.
1 P60881 (/IDA)
Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex GO:0070032
A SNARE complex that contains synaptobrevin 2 (VAMP2), SNAP-25, syntaxin 1a, and complexin I (or orthologs thereof).
1 P60879 (/ISO)
Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex GO:0070033
A SNARE complex that contains synaptobrevin 2 (VAMP2), SNAP-25, syntaxin 1a, and complexin II (or orthologs thereof).
1 P60881 (/IDA)
Synaptobrevin 2-SNAP-25-syntaxin-1a complex GO:0070044
A SNARE complex that contains synaptobrevin 2 (VAMP2), SNAP-25, and syntaxin 1a (or orthologs thereof).
1 P60881 (/IDA)
Synaptobrevin 2-SNAP-25-syntaxin-1a complex GO:0070044
A SNARE complex that contains synaptobrevin 2 (VAMP2), SNAP-25, and syntaxin 1a (or orthologs thereof).
1 P60881 (/IMP)
Synaptobrevin 2-SNAP-25-syntaxin-1a complex GO:0070044
A SNARE complex that contains synaptobrevin 2 (VAMP2), SNAP-25, and syntaxin 1a (or orthologs thereof).
1 P60879 (/ISO)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
1 O00161 (/IDA)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
1 O09044 (/ISO)
Postsynapse GO:0098794
The part of a synapse that is part of the post-synaptic cell.
1 P60879 (/IDA)