The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 5568: Mitofusin-2

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 6 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
2 O95140 (/IPI) Q80U63 (/IPI)
GTPase activity GO:0003924
Catalysis of the reaction: GTP + H2O = GDP + phosphate.
1 Q8R500 (/IMP)
GTP binding GO:0005525
Interacting selectively and non-covalently with GTP, guanosine triphosphate.
1 Q8R500 (/IMP)
Ubiquitin protein ligase binding GO:0031625
Interacting selectively and non-covalently with a ubiquitin protein ligase enzyme, any of the E3 proteins.
1 O95140 (/IPI)
Ubiquitin protein ligase binding GO:0031625
Interacting selectively and non-covalently with a ubiquitin protein ligase enzyme, any of the E3 proteins.
1 Q80U63 (/ISO)
GTPase binding GO:0051020
Interacting selectively and non-covalently with a GTPase, any enzyme that catalyzes the hydrolysis of GTP.
1 Q8R500 (/IPI)

There are 41 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein targeting to mitochondrion GO:0006626
The process of directing proteins towards and into the mitochondrion, usually mediated by mitochondrial proteins that recognize signals contained within the imported protein.
4 Q4R5A0 (/ISS) Q5RAE9 (/ISS) Q80U63 (/ISS) Q8R500 (/ISS)
Mitochondrial membrane organization GO:0007006
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrial membrane, either of the lipid bilayer surrounding a mitochondrion.
4 Q4R5A0 (/ISS) Q5RAE9 (/ISS) Q80U63 (/ISS) Q8R500 (/ISS)
Negative regulation of smooth muscle cell proliferation GO:0048662
Any process that stops, prevents or reduces the rate or extent of smooth muscle cell proliferation.
4 O95140 (/ISS) Q4R5A0 (/ISS) Q5RAE9 (/ISS) Q80U63 (/ISS)
Mitochondrial fusion GO:0008053
Merging of two or more mitochondria within a cell to form a single compartment.
3 O95140 (/IMP) Q80U63 (/IMP) Q8R500 (/IMP)
Mitochondrion localization GO:0051646
Any process in which a mitochondrion or mitochondria are transported to, and/or maintained in, a specific location within the cell.
3 Q4R5A0 (/ISS) Q5RAE9 (/ISS) Q80U63 (/ISS)
Mitochondrial fusion GO:0008053
Merging of two or more mitochondria within a cell to form a single compartment.
2 O95140 (/ISS) Q8R500 (/ISS)
Blastocyst formation GO:0001825
The initial formation of a blastocyst from a solid ball of cells known as a morula.
1 Q80U63 (/IMP)
Protein targeting to mitochondrion GO:0006626
The process of directing proteins towards and into the mitochondrion, usually mediated by mitochondrial proteins that recognize signals contained within the imported protein.
1 O95140 (/IDA)
Protein targeting to mitochondrion GO:0006626
The process of directing proteins towards and into the mitochondrion, usually mediated by mitochondrial proteins that recognize signals contained within the imported protein.
1 Q80U63 (/ISO)
Mitochondrion organization GO:0007005
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrion; includes mitochondrial morphogenesis and distribution, and replication of the mitochondrial genome as well as synthesis of new mitochondrial components.
1 Q8R500 (/IMP)
Mitochondrial membrane organization GO:0007006
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrial membrane, either of the lipid bilayer surrounding a mitochondrion.
1 O95140 (/IDA)
Mitochondrial membrane organization GO:0007006
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrial membrane, either of the lipid bilayer surrounding a mitochondrion.
1 Q80U63 (/ISO)
Axonogenesis GO:0007409
De novo generation of a long process of a neuron, that carries efferent (outgoing) action potentials from the cell body towards target cells. Refers to the morphogenesis or creation of shape or form of the developing axon.
1 A8WIN6 (/IMP)
Neuromuscular junction development GO:0007528
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a neuromuscular junction.
1 A8WIN6 (/IMP)
Blood coagulation GO:0007596
The sequential process in which the multiple coagulation factors of the blood interact, ultimately resulting in the formation of an insoluble fibrin clot; it may be divided into three stages: stage 1, the formation of intrinsic and extrinsic prothrombin converting principle; stage 2, the formation of thrombin; stage 3, the formation of stable fibrin polymers.
1 O95140 (/TAS)
Mitochondrial fusion GO:0008053
Merging of two or more mitochondria within a cell to form a single compartment.
1 Q80U63 (/ISO)
Mitochondrial fusion GO:0008053
Merging of two or more mitochondria within a cell to form a single compartment.
1 O95140 (/NAS)
Negative regulation of cell proliferation GO:0008285
Any process that stops, prevents or reduces the rate or extent of cell proliferation.
1 Q8R500 (/IMP)
Response to muscle activity GO:0014850
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a muscle activity stimulus.
1 Q8R500 (/IEP)
Macroautophagy GO:0016236
The major inducible pathway for the general turnover of cytoplasmic constituents in eukaryotic cells, it is also responsible for the degradation of active cytoplasmic enzymes and organelles during nutrient starvation. Macroautophagy involves the formation of double-membrane-bounded autophagosomes which enclose the cytoplasmic constituent targeted for degradation in a membrane-bounded structure. Autophagosomes then fuse with a lysosome (or vacuole) releasing single-membrane-bounded autophagic bodies that are then degraded within the lysosome (or vacuole). Though once thought to be a purely non-selective process, it appears that some types of macroautophagy, e.g. macropexophagy, macromitophagy, may involve selective targeting of the targets to be degraded.
1 O95140 (/TAS)
Axonal transport of mitochondrion GO:0019896
The directed movement of mitochondria along microtubules in nerve cell axons.
1 A8WIN6 (/IMP)
Hemopoiesis GO:0030097
The process whose specific outcome is the progression of the myeloid and lymphoid derived organ/tissue systems of the blood and other parts of the body over time, from formation to the mature structure. The site of hemopoiesis is variable during development, but occurs primarily in bone marrow or kidney in many adult vertebrates.
1 A8WIN6 (/IMP)
Protein localization to pre-autophagosomal structure GO:0034497
Any process in which a protein is transported to, or maintained at, the pre-autophagosomal structure (PAS).
1 O95140 (/IDA)
Protein localization to pre-autophagosomal structure GO:0034497
Any process in which a protein is transported to, or maintained at, the pre-autophagosomal structure (PAS).
1 Q80U63 (/ISO)
Positive regulation of membrane potential GO:0045838
Any process that activates or increases the frequency, rate or extent of establishment or extent of a membrane potential, the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane.
1 Q8R500 (/IMP)
Negative regulation of Ras protein signal transduction GO:0046580
Any process that stops, prevents, or reduces the frequency, rate or extent of Ras protein signal transduction.
1 O95140 (/IDA)
Negative regulation of Ras protein signal transduction GO:0046580
Any process that stops, prevents, or reduces the frequency, rate or extent of Ras protein signal transduction.
1 Q80U63 (/ISO)
Intracellular distribution of mitochondria GO:0048312
Any process that establishes the spatial arrangement of mitochondria within the cell.
1 Q8R500 (/IMP)
Camera-type eye morphogenesis GO:0048593
The process in which the anatomical structures of the eye are generated and organized. The camera-type eye is an organ of sight that receives light through an aperture and focuses it through a lens, projecting it on a photoreceptor field.
1 Q80U63 (/IMP)
Negative regulation of smooth muscle cell proliferation GO:0048662
Any process that stops, prevents or reduces the rate or extent of smooth muscle cell proliferation.
1 Q8R500 (/IDA)
Response to axon injury GO:0048678
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an axon injury stimulus.
1 Q8R500 (/IEP)
Mitochondrion localization GO:0051646
Any process in which a mitochondrion or mitochondria are transported to, and/or maintained in, a specific location within the cell.
1 O95140 (/IDA)
Mitochondrion localization GO:0051646
Any process in which a mitochondrion or mitochondria are transported to, and/or maintained in, a specific location within the cell.
1 Q80U63 (/ISO)
Positive regulation of dendritic spine morphogenesis GO:0061003
Any process that increases the rate, frequency, or extent of dendritic spine morphogenesis, the process in which the anatomical structures of a dendritic spine are generated and organized. A dendritic spine is a protrusion from a dendrite and a specialized subcellular compartment involved in synaptic transmission.
1 Q8R500 (/IMP)
Parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization GO:0061734
A positive regulation of the macromitophagy pathway that is triggered by mitochondrial depolarization and requires the function of a parkin-family molecule.
1 Q80U63 (/IMP)
Parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization GO:0061734
A positive regulation of the macromitophagy pathway that is triggered by mitochondrial depolarization and requires the function of a parkin-family molecule.
1 O95140 (/ISS)
Mitochondrion morphogenesis GO:0070584
The process in which the anatomical structures of a mitochondrion are generated and organized.
1 Q8R500 (/IMP)
Negative regulation of release of cytochrome c from mitochondria GO:0090201
Any process that decreases the rate, frequency or extent of release of cytochrome c from mitochondria, the process in which cytochrome c is enabled to move from the mitochondrial intermembrane space into the cytosol, which is an early step in apoptosis and leads to caspase activation.
1 Q8R500 (/IMP)
Cellular response to oxygen-glucose deprivation GO:0090650
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of the deprivation of oxygen and glucose.
1 Q8R500 (/IEP)
Response to flavonoid GO:1905395
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a flavonoid stimulus.
1 Q8R500 (/IEP)
Response to hypobaric hypoxia GO:1990910
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension combined with low atmospheric pressure. Hypoxia is defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95% and hypobaric is defined as atmospheric pressure below 0.74 atm (greater than 2,500 m above sea level).
1 Q8R500 (/IEP)

There are 9 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
4 O95140 (/ISS) Q4R5A0 (/ISS) Q5RAE9 (/ISS) Q80U63 (/ISS)
Intrinsic component of mitochondrial outer membrane GO:0031306
The component of the mitochondrial outer membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane.
4 O95140 (/ISS) Q4R5A0 (/ISS) Q5RAE9 (/ISS) Q80U63 (/ISS)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
3 O95140 (/IDA) Q80U63 (/IDA) Q8R500 (/IDA)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
1 Q80U63 (/ISO)
Mitochondrial outer membrane GO:0005741
The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope.
1 Q8R500 (/IDA)
Mitochondrial outer membrane GO:0005741
The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope.
1 O95140 (/TAS)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 Q8R500 (/IDA)
Microtubule cytoskeleton GO:0015630
The part of the cytoskeleton (the internal framework of a cell) composed of microtubules and associated proteins.
1 Q80U63 (/IDA)
Intrinsic component of mitochondrial outer membrane GO:0031306
The component of the mitochondrial outer membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane.
1 Q8R500 (/IDA)