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CATH Superfamily 1.20.200.10

Fumarase/aspartase (Central domain)

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Fumarase/aspartase (Central domain)
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 7028: Phenylalanine ammonia-lyase, putative, expressed

There are 5 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Phenylalanine ammonia-lyase. [EC: 4.3.1.24]
L-phenylalanine = trans-cinnamate + ammonia.
  • Member of the aromatic amino acid lyase family, other members of which are EC 4.3.1.3 and EC 4.3.1.23 and EC 4.3.1.25.
  • The enzyme from some species is highly specific for phenylalanine.
  • Formerly EC 4.3.1.5.
 1067 A0A022R2M9 A0A022REC2 A0A022RIN5 A0A023GS67 A0A023SGT4 A0A024CA10 A0A024CBV4 A0A059ABW9 A0A059BGW1 A0A059BGW5
(1057 more...)
Hydroxymethylglutaryl-CoA synthase. [EC: 2.3.3.10]
Acetyl-CoA + H(2)O + acetoacetyl-CoA = (S)-3-hydroxy-3-methylglutaryl-CoA + CoA.
  • Formerly EC 4.1.3.5.
 2 A0A0R6HKZ0 A0A0R6IIB2
Phenylalanine aminomutase (L-beta-phenylalanine forming). [EC: 5.4.3.10]
L-phenylalanine = L-beta-phenylalanine.
  • Cf. EC 5.4.3.11.
 2 Q68G84 Q6GZ04
Transferred entry: 4.3.1.23, 4.3.1.24 and 4.3.1.25. [EC: 4.3.1.5]
    		2 O04869 O04875
    Phenylalanine/tyrosine ammonia-lyase. [EC: 4.3.1.25]
    (1) L-phenylalanine = trans-cinnamate + ammonia. (2) L-tyrosine = trans-p-hydroxycinnamate + ammonia.
    • Member of the aromatic amino acid lyase family, other members of which are EC 4.3.1.3, EC 4.3.1.23 and EC 4.3.1.24.
    • The enzyme from some monocots, including maize, and from the yeast Rhodosporidium toruloides, deaminate L-phenylalanine and L-tyrosine with similar catalytic efficiency.
    • Formerly EC 4.3.1.5.
    		 1 Q8VXG7