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CATH Superfamily 1.20.1560.10

ABC transporter type 1, transmembrane domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
ABC transporter type 1, transmembrane domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 26723: ABC multidrug transporter (Eurofung)

There are 11 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Xenobiotic-transporting ATPase. [EC: 3.6.3.44]
ATP + H(2)O + xenobiotic(In) = ADP + phosphate + xenobiotic(Out).
  • Enzymes of Gram-positive bacteria and eukaryotic cells that export a number of drugs, with unusual specificity, covering various groups of unrelated substances, while ignoring some that are closely related structurally.
  • Several distinct enzymes may be present in a single eukaryotic cell.
  • Many of them transport glutathione conjugates with drugs.
  • Some also show some 'flippase' (EC 3.6.3.1) activity.
  • Formerly EC 3.6.3.45.
 37 A0A074SVV3 A0A074T890 A0A086JPU0 A0A086K4C3 A0A086K5V4 A0A086KUL4 A0A086LSK6 A0A086PUW5 A0A086QDS5 A0A086QRK8
(27 more...)
Alpha-factor-transporting ATPase. [EC: 3.6.3.48]
ATP + H(2)O + alpha-factor(In) = ADP + phosphate + alpha-factor(Out).
  • A Saccharomyces cerevisiae enzyme that exports the alpha-factor sex pheromone.
 9 A0A074T890 A0A086JPU0 A0A086QDS5 A0A086QRK8 A0A0F7V2P0 A0A125YSH6 A0A125YUY7 A8WAD2 Q4FCM2
Beta-glucan-transporting ATPase. [EC: 3.6.3.42]
ATP + H(2)O + beta-glucan(In) = ADP + phosphate + beta-glucan(Out).
  • An enzyme found in Gram-negative bacteria that exports beta-glucan.
 8 A0A084FYJ9 A0A086K4C3 A0A086K5V4 A0A086KUL4 A0A086LSK6 A0A086PUW5 A0A125YHW5 A3RJI7
Adenosinetriphosphatase. [EC: 3.6.1.3]
ATP + H(2)O = ADP + phosphate.
  • Many enzymes previously listed under this number are now listed separately as EC 3.6.1.32 to EC 3.6.1.39.
  • The remaining enzymes, not separately listed on the basis of some function coupled with hydrolyzes of ATP, include enzymes dependent on Ca(2+), Mg(2+), anions, H(+) or DNA.
  • Formerly EC 3.6.1.4.
 3 A0A060SYY2 A0A0L1I249 A0A0P4U9S2
Peptide-transporting ATPase. [EC: 3.6.3.43]
ATP + H(2)O + peptide(In) = ADP + phosphate + peptide(Out).
  • A family of enzymes that exports alpha-hemolysin, cyclolysin, colicin V and siderophores from Gram-negative bacteria, and bacteriocin, subtilin, competence factor and pediocin from Gram-positive bacteria.
 3 A0A084FXR1 A0A084GB85 B0ET85
Phosphate-transporting ATPase. [EC: 3.6.3.27]
ATP + H(2)O + phosphate(Out) = ADP + phosphate + phosphate(In).
  • A bacterial enzyme that imports phosphate anions.
 3 A0A0A1TYW4 A0A0B7G4E8 L7FN93
Lipopolysaccharide-transporting ATPase. [EC: 3.6.3.39]
ATP + H(2)O + lipopolysaccharide(In) = ADP + phosphate + lipopolysaccharide(Out).
  • Enzymes of Gram-negative bacteria that export lipo-oligosaccharides and lipopolysaccharides.
 1 A0A084GB85
Fe(3+)-transporting ATPase. [EC: 3.6.3.30]
ATP + H(2)O + Fe(3+)(Out) = ADP + phosphate + Fe(3+)(In).
  • A bacterial enzyme that imports ferric cations.
 1 B7PG12
H(+)-transporting two-sector ATPase. [EC: 3.6.3.14]
ATP + H(2)O + H(+)(In) = ADP + phosphate + H(+)(Out).
  • A multisubunit non-phosphorylated ATPase that is involved in the transport of ions.
  • Large enzymes of mitochondria, chloroplasts and bacteria with a membrane sector (F(o), V(o), A(o)) and a cytoplasmic-compartment sector (F(1), V(1), A(1)).
  • The F-type enzymes of the inner mitochondrial and thylakoid membranes act as ATP synthases.
  • All of the enzymes included here operate in a rotational mode, where the extramembrane sector (containing 3 alpha- and 3 beta-subunits) is connected via the delta-subunit to the membrane sector by several smaller subunits.
  • Within this complex, the gamma- and epsilon-subunits, as well as the 9-12 c subunits rotate by consecutive 120 degree angles and perform parts of ATP synthesis.
  • This movement is driven by the H(+) electrochemical potential gradient.
  • The V-type (in vacuoles and clathrin-coated vesicles) and A-type (archaeal) enzymes have a similar structure but, under physiological conditions, they pump H(+) rather than synthesize ATP.
  • Formerly EC 3.6.1.34.
 1 B0ENW0
Nucleoside-triphosphate phosphatase. [EC: 3.6.1.15]
NTP + H(2)O = NDP + phosphate.
  • The enzyme is found in eukaryotes and thermophilic bacteria, but appears to be absent from mesophilic bacteria.
  • Also hydrolyzes nucleoside diphosphates, thiamine diphosphate and FAD.
  • The enzyme from the plant Pisum sativum (garden pea) is regulated by calmodulin.
 1 A0A0P4UK30
Sulfate-transporting ATPase. [EC: 3.6.3.25]
ATP + H(2)O + sulfate(Out) = ADP + phosphate + sulfate(In).
  • A bacterial enzyme that imports sulfate and thiosulfate anions.
 1 A0A084GB85
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