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CATH Superfamily 1.20.1560.10

ABC transporter type 1, transmembrane domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
ABC transporter type 1, transmembrane domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 26664: ABC transporter, ATP-binding protein

There are 11 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Xenobiotic-transporting ATPase. [EC: 3.6.3.44]
ATP + H(2)O + xenobiotic(In) = ADP + phosphate + xenobiotic(Out).
  • Enzymes of Gram-positive bacteria and eukaryotic cells that export a number of drugs, with unusual specificity, covering various groups of unrelated substances, while ignoring some that are closely related structurally.
  • Several distinct enzymes may be present in a single eukaryotic cell.
  • Many of them transport glutathione conjugates with drugs.
  • Some also show some 'flippase' (EC 3.6.3.1) activity.
  • Formerly EC 3.6.3.45.
 182 A0A031IC74 A0A031IC74 A0A063BEZ6 A0A063BEZ6 A0A067AL41 A0A067AL41 A0A074T4D9 A0A074T4D9 A0A074T5E4 A0A074T5E4
(172 more...)
Adenosinetriphosphatase. [EC: 3.6.1.3]
ATP + H(2)O = ADP + phosphate.
  • Many enzymes previously listed under this number are now listed separately as EC 3.6.1.32 to EC 3.6.1.39.
  • The remaining enzymes, not separately listed on the basis of some function coupled with hydrolyzes of ATP, include enzymes dependent on Ca(2+), Mg(2+), anions, H(+) or DNA.
  • Formerly EC 3.6.1.4.
 42 A0A0J9RNA0 A0A0J9RNA0 A0A0J9UC83 A0A0J9UC83 A0A0P4U6K6 A0A0P4U6K6 A0A0P4UDX9 A0A0P4UDX9 A0A0P8YAJ7 A0A0P8YAJ7
(32 more...)
Phosphate-transporting ATPase. [EC: 3.6.3.27]
ATP + H(2)O + phosphate(Out) = ADP + phosphate + phosphate(In).
  • A bacterial enzyme that imports phosphate anions.
 36 A0A0E1NCE2 A0A0E1NCE2 A0A0T6Z3B3 A0A0T6Z3B3 A0A0U5F1S0 A0A0U5F1S0 A0A0U5FAX5 A0A0U5FAX5 A1JPD7 A1JPD7
(26 more...)
Heme-transporting ATPase. [EC: 3.6.3.41]
ATP + H(2)O + heme(In) = ADP + phosphate + heme(Out).
  • An enzyme found in Gram-negative bacteria that exports heme.
 4 A0A0E2PC94 A0A0E2PC94 D5AL45 D5AL45
Lipopolysaccharide-transporting ATPase. [EC: 3.6.3.39]
ATP + H(2)O + lipopolysaccharide(In) = ADP + phosphate + lipopolysaccharide(Out).
  • Enzymes of Gram-negative bacteria that export lipo-oligosaccharides and lipopolysaccharides.
 4 A0A084G702 A0A084G702 A0A0X8R6Y9 A0A0X8R6Y9
Histidine kinase. [EC: 2.7.13.3]
ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.
  • This entry has been included to accommodate those protein-histidine kinases for which the phosphorylation site has not been established (i.e. either the pros- or tele-nitrogen of histidine).
  • A number of histones can act as acceptor.
 4 A0A0C2CD11 A0A0C2CD11 A0A158G7Z3 A0A158G7Z3
Malate synthase. [EC: 2.3.3.9]
Acetyl-CoA + H(2)O + glyoxylate = (S)-malate + CoA.
  • The enzyme catalyzes the irreversible condensation of acetyl-CoA with glyoxylate to form (S)-malate.
  • Among other functions, the enzyme participates in the glyoxylate cycle, a modified version of the TCA cycle that bypasses steps that lead to a loss of CO(2).
  • Formerly EC 4.1.3.2.
 2 S9S5F9 S9S5F9
Guanylate cyclase. [EC: 4.6.1.2]
GTP = 3',5'-cyclic GMP + diphosphate.
  • Also acts on ITP and dGTP.
 2 A0A1A9YK51 A0A1A9YK51
Homoserine dehydrogenase. [EC: 1.1.1.3]
L-homoserine + NAD(P)(+) = L-aspartate 4-semialdehyde + NAD(P)H.
  • The enzyme from Saccharomyces cerevisiae acts most rapidly with NAD(+); the Neurospora enzyme with NADP(+).
  • The enzyme from Escherichia coli is a multifunctional protein, which also catalyzes the reaction of EC 2.7.2.4.
 2 R4XI45 R4XI45
Nucleoside-triphosphate phosphatase. [EC: 3.6.1.15]
NTP + H(2)O = NDP + phosphate.
  • The enzyme is found in eukaryotes and thermophilic bacteria, but appears to be absent from mesophilic bacteria.
  • Also hydrolyzes nucleoside diphosphates, thiamine diphosphate and FAD.
  • The enzyme from the plant Pisum sativum (garden pea) is regulated by calmodulin.
 2 A0A161MED8 A0A161MED8
Alkaline phosphatase. [EC: 3.1.3.1]
A phosphate monoester + H(2)O = an alcohol + phosphate.
  • Active at a high pH optimum.
  • Wide specificity.
  • Also catalyzes transphosphorylations.
  • Some enzymes hydrolyze diphosphate (cf. EC 3.6.1.1).
 2 A0A124BWF4 A0A124BWF4
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