The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Cation efflux protein transmembrane domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 5879: Zinc transporter domain protein

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 13 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Zinc ion transmembrane transporter activity GO:0005385
Enables the transfer of zinc (Zn) ions from one side of a membrane to the other.
3 O13918 (/IMP) P20107 (/IMP) Q62720 (/IMP)
Zinc ion transmembrane transporter activity GO:0005385
Enables the transfer of zinc (Zn) ions from one side of a membrane to the other.
2 M9PEG6 (/IC) Q7K3K5 (/IC)
Zinc ion transmembrane transporter activity GO:0005385
Enables the transfer of zinc (Zn) ions from one side of a membrane to the other.
1 Q62720 (/IDA)
Zinc ion transmembrane transporter activity GO:0005385
Enables the transfer of zinc (Zn) ions from one side of a membrane to the other.
1 P32798 (/IGI)
Zinc ion transmembrane transporter activity GO:0005385
Enables the transfer of zinc (Zn) ions from one side of a membrane to the other.
1 Q60738 (/ISO)
Zinc ion transmembrane transporter activity GO:0005385
Enables the transfer of zinc (Zn) ions from one side of a membrane to the other.
1 Q6P3M0 (/ISS)
Zinc ion transmembrane transporter activity GO:0005385
Enables the transfer of zinc (Zn) ions from one side of a membrane to the other.
1 Q9Y6M5 (/TAS)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
1 Q9Y6M5 (/IPI)
Cobalt ion transmembrane transporter activity GO:0015087
Enables the transfer of cobalt (Co) ions from one side of a membrane to the other.
1 P32798 (/IMP)
Calcium channel inhibitor activity GO:0019855
Stops, prevents, or reduces the activity of a calcium channel.
1 Q60738 (/IDA)
Calcium channel inhibitor activity GO:0019855
Stops, prevents, or reduces the activity of a calcium channel.
1 Q62720 (/IMP)
Calcium channel inhibitor activity GO:0019855
Stops, prevents, or reduces the activity of a calcium channel.
1 Q9Y6M5 (/ISS)
Zinc efflux transmembrane transporter activity GO:0022883
Catalysis of the transfer of a zinc ion or zinc ions from the inside of the cell to the outside of the cell across a membrane.
1 M9PEG6 (/IGI)

There are 31 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cellular zinc ion homeostasis GO:0006882
Any process involved in the maintenance of an internal steady state of zinc ions at the level of a cell.
6 M9PEG6 (/IMP) O13918 (/IMP) P20107 (/IMP) P32798 (/IMP) Q60738 (/IMP) Q7K3K5 (/IMP)
Zinc II ion transport GO:0006829
The directed movement of zinc (Zn II) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
2 Q60738 (/IDA) Q62720 (/IDA)
Zinc II ion transport GO:0006829
The directed movement of zinc (Zn II) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
2 Q6P3M0 (/ISS) Q9Y6M5 (/ISS)
Detoxification of zinc ion GO:0010312
Any process that reduces or removes the toxicity of zinc ion. These include transport of zinc away from sensitive areas and to compartments or complexes whose purpose is sequestration of zinc ion.
2 M9PEG6 (/IMP) Q7K3K5 (/IMP)
Zinc ion homeostasis GO:0055069
Any process involved in the maintenance of an internal steady state of zinc ions within an organism or cell.
2 M9PEG6 (/IGI) Q7K3K5 (/IGI)
Zinc II ion transmembrane transport GO:0071577
A process in which a zinc II ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore.
2 M9PEG6 (/IGI) Q7K3K5 (/IGI)
In utero embryonic development GO:0001701
The process whose specific outcome is the progression of the embryo in the uterus over time, from formation of the zygote in the oviduct, to birth. An example of this process is found in Mus musculus.
1 Q60738 (/IMP)
Cobalt ion transport GO:0006824
The directed movement of cobalt (Co) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
1 P32798 (/IMP)
Zinc II ion transport GO:0006829
The directed movement of zinc (Zn II) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
1 P32798 (/IGI)
Zinc II ion transport GO:0006829
The directed movement of zinc (Zn II) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
1 Q62720 (/IMP)
Zinc II ion transport GO:0006829
The directed movement of zinc (Zn II) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
1 Q60738 (/ISO)
Cellular calcium ion homeostasis GO:0006874
Any process involved in the maintenance of an internal steady state of calcium ions at the level of a cell.
1 Q60738 (/IDA)
Cellular calcium ion homeostasis GO:0006874
Any process involved in the maintenance of an internal steady state of calcium ions at the level of a cell.
1 Q9Y6M5 (/ISS)
Cellular cobalt ion homeostasis GO:0006877
Any process involved in the maintenance of an internal steady state of cobalt ions at the level of a cell.
1 O13918 (/IMP)
Cellular zinc ion homeostasis GO:0006882
Any process involved in the maintenance of an internal steady state of zinc ions at the level of a cell.
1 Q60738 (/IDA)
Cellular zinc ion homeostasis GO:0006882
Any process involved in the maintenance of an internal steady state of zinc ions at the level of a cell.
1 Q9Y6M5 (/ISS)
Response to zinc ion GO:0010043
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a zinc ion stimulus.
1 Q6P3M0 (/IDA)
Filamentous growth GO:0030447
The process in which a multicellular organism, a unicellular organism or a group of unicellular organisms grow in a threadlike, filamentous shape.
1 A0A1D8PGL8 (/IMP)
Negative regulation of neurotransmitter secretion GO:0046929
Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of a neurotransmitter.
1 Q62720 (/IMP)
Negative regulation of neurotransmitter secretion GO:0046929
Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of a neurotransmitter.
1 Q9Y6M5 (/ISS)
Zinc ion homeostasis GO:0055069
Any process involved in the maintenance of an internal steady state of zinc ions within an organism or cell.
1 M9PEG6 (/IMP)
Calcium ion import GO:0070509
The directed movement of calcium ions into a cell or organelle.
1 Q62720 (/IMP)
Cadmium ion transmembrane transport GO:0070574
A process in which a cadmium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore.
1 Q62720 (/IMP)
Cadmium ion transmembrane transport GO:0070574
A process in which a cadmium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore.
1 Q9Y6M5 (/ISS)
Zinc II ion transmembrane transport GO:0071577
A process in which a zinc II ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore.
1 O13918 (/IMP)
Negative regulation of zinc ion transmembrane import GO:0071584
Any process that stops, prevents, or reduces the frequency, rate or extent of zinc ion import.
1 Q60738 (/IDA)
Negative regulation of zinc ion transmembrane import GO:0071584
Any process that stops, prevents, or reduces the frequency, rate or extent of zinc ion import.
1 Q9Y6M5 (/ISS)
Detoxification of cadmium ion GO:0071585
Any process that reduces or removes the toxicity of cadmium ion. These may include transport of cadmium away from sensitive areas and to compartments or complexes whose purpose is sequestration of cadmium ion.
1 Q62720 (/IMP)
Negative regulation of calcium ion import GO:0090281
Any process that decreases the rate, frequency, or extent of the directed movement of calcium ions into a cell or organelle.
1 Q60738 (/IDA)
Negative regulation of calcium ion import GO:0090281
Any process that decreases the rate, frequency, or extent of the directed movement of calcium ions into a cell or organelle.
1 Q9Y6M5 (/ISS)
Cellular detoxification of cadmium ion GO:0098849
Any process that reduces or removes the toxicity of cadmium cations in a cell. These include transport of cadmium cations away from sensitive areas and to compartments or complexes whose purpose is sequestration.
1 O13918 (/IMP)

There are 20 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
4 M9PEG6 (/IDA) Q62720 (/IDA) Q7K3K5 (/IDA) Q9Y6M5 (/IDA)
Fungal-type vacuole GO:0000324
A vacuole that has both lytic and storage functions. The fungal vacuole is a large, membrane-bounded organelle that functions as a reservoir for the storage of small molecules (including polyphosphate, amino acids, several divalent cations (e.g. calcium), other ions, and other small molecules) as well as being the primary compartment for degradation. It is an acidic compartment, containing an ensemble of acid hydrolases. At least in S. cerevisiae, there are indications that the morphology of the vacuole is variable and correlated with the cell cycle, with logarithmically growing cells having a multilobed, reticulated vacuole, while stationary phase cells contain a single large structure.
2 P20107 (/IDA) P32798 (/IDA)
Golgi apparatus GO:0005794
A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions.
2 O13918 (/IDA) Q9Y6M5 (/IDA)
Basolateral plasma membrane GO:0016323
The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis.
2 M9PEG6 (/IDA) Q7K3K5 (/IDA)
Apical plasma membrane GO:0016324
The region of the plasma membrane located at the apical end of the cell.
2 M9PEG6 (/IDA) Q7K3K5 (/IDA)
Fungal-type vacuole membrane GO:0000329
The lipid bilayer surrounding a vacuole, the shape of which correlates with cell cycle phase. The membrane separates its contents from the cytoplasm of the cell. An example of this structure is found in Saccharomyces cerevisiae.
1 O13918 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 Q9Y6M5 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 Q60738 (/ISO)
Vacuolar membrane GO:0005774
The lipid bilayer surrounding the vacuole and separating its contents from the cytoplasm of the cell.
1 O13918 (/IDA)
Endoplasmic reticulum GO:0005783
The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
1 Q9Y6M5 (/IDA)
Endoplasmic reticulum GO:0005783
The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
1 Q60738 (/ISO)
Endoplasmic reticulum membrane GO:0005789
The lipid bilayer surrounding the endoplasmic reticulum.
1 O13918 (/IDA)
Golgi apparatus GO:0005794
A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions.
1 Q60738 (/ISO)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 Q60738 (/ISO)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 Q9Y6M5 (/TAS)
Integral component of membrane GO:0016021
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
1 Q62720 (/IDA)
T-tubule GO:0030315
Invagination of the plasma membrane of a muscle cell that extends inward from the cell surface around each myofibril. The ends of T-tubules make contact with the sarcoplasmic reticulum membrane.
1 Q62720 (/IDA)
T-tubule GO:0030315
Invagination of the plasma membrane of a muscle cell that extends inward from the cell surface around each myofibril. The ends of T-tubules make contact with the sarcoplasmic reticulum membrane.
1 Q9Y6M5 (/ISS)
Nuclear membrane GO:0031965
Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space.
1 Q9Y6M5 (/IDA)
Nuclear membrane GO:0031965
Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space.
1 Q60738 (/ISO)