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CATH Superfamily 1.20.140.20

Alpha-ketoacid/pyruvate dehydrogenase kinase, N-terminal domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Alpha-ketoacid/pyruvate dehydrogenase kinase, N-terminal domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 403: Pyruvate dehydrogenase kinase Pkp1

There are 3 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
[Pyruvate dehydrogenase (acetyl-transferring)] kinase. [EC: 2.7.11.2]
ATP + [pyruvate dehydrogenase (acetyl-transferring)] = ADP + [pyruvate dehydrogenase (acetyl-transferring)] phosphate.
  • Has no activating compound but is specific for its substrate.
  • A mitochondrial enzyme associated with the pyruvate dehydrogenase complex in mammals.
  • Phosphorylation inactivates EC 1.2.4.1.
  • Formerly EC 2.7.1.99.
 32 A0A061HV40 A0A0B4K7V5 A0A0B4KFG2 A0A0D9QYT8 A0A0J9R8W7 A0A0J9R914 A4D1H4 A8DY78 B7QK03 E0W1B8
(22 more...)
Transferred entry: 2.7.11.2. [EC: 2.7.1.99]
    		1 Q9JID3
    Histidine kinase. [EC: 2.7.13.3]
    ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.
    • This entry has been included to accommodate those protein-histidine kinases for which the phosphorylation site has not been established (i.e. either the pros- or tele-nitrogen of histidine).
    • A number of histones can act as acceptor.
    		 1 E3TC80