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CATH Superfamily 1.20.1290.20

F-actin capping protein, alpha subunit

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: F-actin capping protein, alpha subunit

The F-actin capping protein is a heterodimer composed of two unrelated alpha and beta subunits. Neither of the subunits shows sequence similarity to other filament-capping proteins PMID:2341404.

This superfamily represents the alpha subunit of the F-actin capping protein (CAPZA), a protein of about 280 amino acid residues whose sequence is well conserved in eukaryotic species PMID:1711931. In Drosophila mutations in the alpha and beta subunits cause actin accumulation and subsequent retinal degeneration PMID:16143599. In humans CAPZA is part of the WASH complex that controls the fission of endosomes PMID:19922875.

INTERPRO:IPR002189, PFAM:PF01267

GO Diversity

Unique GO annotations
52 Unique GO terms

EC Diversity

Unique EC annotations
2 Unique EC terms

Species Diversity

Unique species annotations
1098 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Structures
Domains: 33
Domain clusters (>95% seq id): 2
Domain clusters (>35% seq id): 1
Unique PDBs: 16
Alignments
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 0
Function
Unique EC: 2
Unique GO: 52
Taxonomy
Unique Species: 1098