The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Arfaptin homology (AH) domain/BAR domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 4656: Metastasis suppressor 1, isoform CRA_e

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 18 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Phospholipid binding GO:0005543
Interacting selectively and non-covalently with phospholipids, a class of lipids containing phosphoric acid as a mono- or diester.
13 A0A0B4JCQ4 (/IDA) A0A0B4JCZ8 (/IDA) A0A0B4JD47 (/IDA) A0A0B4K7H4 (/IDA) A0A0B4K7T1 (/IDA) A0A0B4K822 (/IDA) A0A0B4KED3 (/IDA) A0A0B4KEE8 (/IDA) A0A0B4KEK0 (/IDA) A0A0B4KEU9 (/IDA)
(3 more)
SH3 domain binding GO:0017124
Interacting selectively and non-covalently with a SH3 domain (Src homology 3) of a protein, small protein modules containing approximately 50 amino acid residues found in a great variety of intracellular or membrane-associated proteins.
13 A0A0B4JCQ4 (/IDA) A0A0B4JCZ8 (/IDA) A0A0B4JD47 (/IDA) A0A0B4K7H4 (/IDA) A0A0B4K7T1 (/IDA) A0A0B4K822 (/IDA) A0A0B4KED3 (/IDA) A0A0B4KEE8 (/IDA) A0A0B4KEK0 (/IDA) A0A0B4KEU9 (/IDA)
(3 more)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
13 A0A0B4JCQ4 (/IPI) A0A0B4JCZ8 (/IPI) A0A0B4JD47 (/IPI) A0A0B4K7H4 (/IPI) A0A0B4K7T1 (/IPI) A0A0B4K822 (/IPI) A0A0B4KED3 (/IPI) A0A0B4KEE8 (/IPI) A0A0B4KEK0 (/IPI) A0A0B4KEU9 (/IPI)
(3 more)
Actin monomer binding GO:0003785
Interacting selectively and non-covalently with monomeric actin, also known as G-actin.
2 O43312 (/IDA) Q6P9S0 (/IDA)
Actin monomer binding GO:0003785
Interacting selectively and non-covalently with monomeric actin, also known as G-actin.
2 Q5ZMW2 (/ISS) Q8R1S4 (/ISS)
Receptor binding GO:0005102
Interacting selectively and non-covalently with one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.
2 Q5ZMW2 (/ISS) Q8R1S4 (/ISS)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
2 O43312 (/IPI) Q95Y95 (/IPI)
Actin binding GO:0003779
Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments.
1 Q8R1S4 (/IDA)
Actin monomer binding GO:0003785
Interacting selectively and non-covalently with monomeric actin, also known as G-actin.
1 Q8R1S4 (/ISO)
Receptor binding GO:0005102
Interacting selectively and non-covalently with one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.
1 O43312 (/IPI)
Receptor binding GO:0005102
Interacting selectively and non-covalently with one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.
1 Q8R1S4 (/ISO)
Phosphatidylinositol-4,5-bisphosphate binding GO:0005546
Interacting selectively and non-covalently with phosphatidylinositol-4,5-bisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 4' and 5' positions.
1 Q6P9S0 (/IDA)
Phosphatidylinositol binding GO:0035091
Interacting selectively and non-covalently with any inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives.
1 C7FZZ0 (/IDA)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
1 O43312 (/IPI)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
1 Q8R1S4 (/ISO)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
1 C7FZZ0 (/IDA)
Rac GTPase binding GO:0048365
Interacting selectively and non-covalently with Rac protein, any member of the Rac subfamily of the Ras superfamily of monomeric GTPases.
1 Q6P9S0 (/IDA)
Actin filament binding GO:0051015
Interacting selectively and non-covalently with an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits.
1 Q8R1S4 (/IDA)

There are 41 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Border follicle cell migration GO:0007298
The directed movement of a border cell through the nurse cells to reach the oocyte. An example of this is found in Drosophila melanogaster.
13 A0A0B4JCQ4 (/IMP) A0A0B4JCZ8 (/IMP) A0A0B4JD47 (/IMP) A0A0B4K7H4 (/IMP) A0A0B4K7T1 (/IMP) A0A0B4K822 (/IMP) A0A0B4KED3 (/IMP) A0A0B4KEE8 (/IMP) A0A0B4KEK0 (/IMP) A0A0B4KEU9 (/IMP)
(3 more)
Germ cell migration GO:0008354
The orderly movement of a cell specialized to produce haploid gametes through the embryo from its site of production to the place where the gonads will form.
13 A0A0B4JCQ4 (/IMP) A0A0B4JCZ8 (/IMP) A0A0B4JD47 (/IMP) A0A0B4K7H4 (/IMP) A0A0B4K7T1 (/IMP) A0A0B4K822 (/IMP) A0A0B4KED3 (/IMP) A0A0B4KEE8 (/IMP) A0A0B4KEK0 (/IMP) A0A0B4KEU9 (/IMP)
(3 more)
Filopodium assembly GO:0046847
The assembly of a filopodium, a thin, stiff protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal growth cone.
13 A0A0B4JCQ4 (/IMP) A0A0B4JCZ8 (/IMP) A0A0B4JD47 (/IMP) A0A0B4K7H4 (/IMP) A0A0B4K7T1 (/IMP) A0A0B4K822 (/IMP) A0A0B4KED3 (/IMP) A0A0B4KEE8 (/IMP) A0A0B4KEK0 (/IMP) A0A0B4KEU9 (/IMP)
(3 more)
Negative regulation of receptor-mediated endocytosis GO:0048261
Any process that stops, prevents, or reduces the frequency, rate or extent of receptor mediated endocytosis, the uptake of external materials by cells, utilizing receptors to ensure specificity of transport.
13 A0A0B4JCQ4 (/IMP) A0A0B4JCZ8 (/IMP) A0A0B4JD47 (/IMP) A0A0B4K7H4 (/IMP) A0A0B4K7T1 (/IMP) A0A0B4K822 (/IMP) A0A0B4KED3 (/IMP) A0A0B4KEE8 (/IMP) A0A0B4KEK0 (/IMP) A0A0B4KEU9 (/IMP)
(3 more)
Negative regulation of epithelial cell proliferation GO:0050680
Any process that stops, prevents or reduces the rate or extent of epithelial cell proliferation.
10 D2I1Y7 (/ISS) D3ZYM5 (/ISS) E1BP52 (/ISS) F1PKA2 (/ISS) F1PKA4 (/ISS) F6SBT8 (/ISS) F6Y6H8 (/ISS) F7IKD9 (/ISS) O43312 (/ISS) Q5R402 (/ISS)
Renal tubule morphogenesis GO:0061333
The process in which the renal tubule is generated by specification of cell fate, through the maintenance of cell polarity, regulated cell proliferation and morphogenetic cell rearrangements, shape changes and growth. A renal tubule is a tube that filters, re-absorbs and secretes substances to rid an organism of waste and to play a role in fluid homeostasis.
10 D2I1Y7 (/ISS) D3ZYM5 (/ISS) E1BP52 (/ISS) F1PKA2 (/ISS) F1PKA4 (/ISS) F6SBT8 (/ISS) F6Y6H8 (/ISS) F7IKD9 (/ISS) O43312 (/ISS) Q5R402 (/ISS)
Cellular response to fluid shear stress GO:0071498
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fluid shear stress stimulus. Fluid shear stress is the force acting on an object in a system where the fluid is moving across a solid surface.
10 D2I1Y7 (/ISS) D3ZYM5 (/ISS) E1BP52 (/ISS) F1PKA2 (/ISS) F1PKA4 (/ISS) F6SBT8 (/ISS) F6Y6H8 (/ISS) F7IKD9 (/ISS) O43312 (/ISS) Q5R402 (/ISS)
Glomerulus morphogenesis GO:0072102
The process in which the anatomical structures of the glomerulus are generated and organized. The glomerulus is a capillary tuft surrounded by Bowman's capsule in nephrons of the vertebrate kidney.
10 D2I1Y7 (/ISS) D3ZYM5 (/ISS) E1BP52 (/ISS) F1PKA2 (/ISS) F1PKA4 (/ISS) F6SBT8 (/ISS) F6Y6H8 (/ISS) F7IKD9 (/ISS) O43312 (/ISS) Q5R402 (/ISS)
Nephron tubule epithelial cell differentiation GO:0072160
The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells of the nephron tubule as it progresses from its formation to the mature state.
10 D2I1Y7 (/ISS) D3ZYM5 (/ISS) E1BP52 (/ISS) F1PKA2 (/ISS) F1PKA4 (/ISS) F6SBT8 (/ISS) F6Y6H8 (/ISS) F7IKD9 (/ISS) O43312 (/ISS) Q5R402 (/ISS)
Epithelial cell proliferation involved in renal tubule morphogenesis GO:2001013
Any epithelial cell proliferation that is involved in renal tubule morphogenesis.
10 D2I1Y7 (/ISS) D3ZYM5 (/ISS) E1BP52 (/ISS) F1PKA2 (/ISS) F1PKA4 (/ISS) F6SBT8 (/ISS) F6Y6H8 (/ISS) F7IKD9 (/ISS) O43312 (/ISS) Q5R402 (/ISS)
Membrane organization GO:0061024
A process which results in the assembly, arrangement of constituent parts, or disassembly of a membrane. A membrane is a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.
2 Q6P9S0 (/IDA) Q95Y95 (/IDA)
Mitotic cytokinesis GO:0000281
A cell cycle process that results in the division of the cytoplasm of a cell after mitosis, resulting in the separation of the original cell into two daughter cells.
1 C7FZZ0 (/IMP)
In utero embryonic development GO:0001701
The process whose specific outcome is the progression of the embryo in the uterus over time, from formation of the zygote in the oviduct, to birth. An example of this process is found in Mus musculus.
1 Q8R1S4 (/IGI)
Phagocytosis GO:0006909
An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles.
1 C7FZZ0 (/IEP)
Movement of cell or subcellular component GO:0006928
The directed, self-propelled movement of a cell or subcellular component without the involvement of an external agent such as a transporter or a pore.
1 O43312 (/NAS)
Actin filament organization GO:0007015
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking.
1 Q8R1S4 (/IDA)
Cell adhesion GO:0007155
The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.
1 O43312 (/NAS)
Transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169
A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell where the receptor possesses tyrosine kinase activity, and ending with regulation of a downstream cellular process, e.g. transcription.
1 O43312 (/TAS)
Nervous system development GO:0007399
The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state.
1 Q8R1S4 (/NAS)
Muscle organ development GO:0007517
The process whose specific outcome is the progression of the muscle over time, from its formation to the mature structure. The muscle is an organ consisting of a tissue made up of various elongated cells that are specialized to contract and thus to produce movement and mechanical work.
1 Q8R1S4 (/NAS)
Cellular water homeostasis GO:0009992
Any process involved in the maintenance of an internal steady state of water within a cell.
1 C7FZZ0 (/IMP)
Membrane invagination GO:0010324
The infolding of a membrane.
1 C7FZZ0 (/IDA)
Magnesium ion homeostasis GO:0010960
Any process involved in the maintenance of an internal steady state of magnesium ions within an organism or cell.
1 Q8R1S4 (/IMP)
Cell projection assembly GO:0030031
Formation of a prolongation or process extending from a cell, e.g. a flagellum or axon.
1 Q95Y95 (/IDA)
Microspike assembly GO:0030035
Formation of a microspike, a dynamic, actin-rich projection extending from the surface of a migrating animal cell.
1 O43312 (/NAS)
Actin cytoskeleton organization GO:0030036
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins.
1 O43312 (/TAS)
Actin filament polymerization GO:0030041
Assembly of actin filaments by the addition of actin monomers to a filament.
1 Q8R1S4 (/IDA)
Bone mineralization GO:0030282
The deposition of hydroxyapatite, a form of calcium phosphate with the formula Ca10(PO4)6(OH)2, in bone tissue.
1 Q8R1S4 (/IMP)
Sorocarp stalk development GO:0031150
The process whose specific outcome is the progression of the sorocarp stalk over time, from its formation to the mature structure. The sorocarp stalk is a tubular structure that consists of cellulose-covered cells stacked on top of each other and surrounded by an acellular stalk tube composed of cellulose and glycoprotein. An example of this process is found in Dictyostelium discoideum.
1 C7FZZ0 (/IMP)
Positive regulation of actin filament bundle assembly GO:0032233
Any process that activates or increases the frequency, rate or extent of the assembly of actin filament bundles.
1 Q8R1S4 (/IMP)
Adherens junction maintenance GO:0034334
The maintenance of an adherens junction. An adherens junction is a cell junction at which the cytoplasmic face of the plasma membrane is attached to actin filaments.
1 Q8R1S4 (/IMP)
Negative regulation of epithelial cell proliferation GO:0050680
Any process that stops, prevents or reduces the rate or extent of epithelial cell proliferation.
1 Q8R1S4 (/IMP)
Renal tubule morphogenesis GO:0061333
The process in which the renal tubule is generated by specification of cell fate, through the maintenance of cell polarity, regulated cell proliferation and morphogenetic cell rearrangements, shape changes and growth. A renal tubule is a tube that filters, re-absorbs and secretes substances to rid an organism of waste and to play a role in fluid homeostasis.
1 Q8R1S4 (/IMP)
Cellular hypotonic response GO:0071476
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, a hypotonic environment, i.e. an environment with a lower concentration of solutes than the organism or cell.
1 C7FZZ0 (/IMP)
Cellular response to fluid shear stress GO:0071498
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fluid shear stress stimulus. Fluid shear stress is the force acting on an object in a system where the fluid is moving across a solid surface.
1 Q8R1S4 (/IDA)
Renal system development GO:0072001
The process whose specific outcome is the progression of the renal system over time, from its formation to the mature structure. The renal system maintains fluid balance and contributes to electrolyte balance, acid/base balance, and disposal of nitrogenous waste products. In humans, the renal system comprises a pair of kidneys, a pair of ureters, urinary bladder, urethra, sphincter muscle and associated blood vessels.
1 Q8R1S4 (/IMP)
Glomerulus morphogenesis GO:0072102
The process in which the anatomical structures of the glomerulus are generated and organized. The glomerulus is a capillary tuft surrounded by Bowman's capsule in nephrons of the vertebrate kidney.
1 Q8R1S4 (/IMP)
Nephron tubule epithelial cell differentiation GO:0072160
The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells of the nephron tubule as it progresses from its formation to the mature state.
1 Q8R1S4 (/IMP)
Clathrin-dependent endocytosis GO:0072583
An endocytosis process that begins when material is taken up into clathrin-coated pits, which then pinch off to form clathrin-coated endocytic vesicles.
1 C7FZZ0 (/IEP)
Lamellipodium organization GO:0097581
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a lamellipodium. A lamellipodium is a thin sheetlike process extended by the leading edge of a crawling fibroblast; contains a dense meshwork of actin filaments.
1 Q6P9S0 (/IMP)
Epithelial cell proliferation involved in renal tubule morphogenesis GO:2001013
Any epithelial cell proliferation that is involved in renal tubule morphogenesis.
1 Q8R1S4 (/IMP)

There are 17 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein complex GO:0043234
A stable macromolecular complex composed (only) of two or more polypeptide subunits along with any covalently attached molecules (such as lipid anchors or oligosaccharide) or non-protein prosthetic groups (such as nucleotides or metal ions). Prosthetic group in this context refers to a tightly bound cofactor. The component polypeptide subunits may be identical.
13 A0A0B4JCQ4 (/IPI) A0A0B4JCZ8 (/IPI) A0A0B4JD47 (/IPI) A0A0B4K7H4 (/IPI) A0A0B4K7T1 (/IPI) A0A0B4K822 (/IPI) A0A0B4KED3 (/IPI) A0A0B4KEE8 (/IPI) A0A0B4KEK0 (/IPI) A0A0B4KEU9 (/IPI)
(3 more)
Actin cytoskeleton GO:0015629
The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes.
2 Q5ZMW2 (/ISS) Q8R1S4 (/ISS)
Contractile vacuole GO:0000331
A specialized vacuole of eukaryotic cells, especially Protozoa, that fills with water from the cytoplasm and then discharges this externally by the opening of contractile vacuole pores. Its function is probably osmoregulatory.
1 C7FZZ0 (/IDA)
Ruffle GO:0001726
Projection at the leading edge of a crawling cell; the protrusions are supported by a microfilament meshwork.
1 Q6P9S0 (/IDA)
Ruffle GO:0001726
Projection at the leading edge of a crawling cell; the protrusions are supported by a microfilament meshwork.
1 O43312 (/NAS)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 Q8R1S4 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 O43312 (/TAS)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 Q6P9S0 (/IDA)
Adherens junction GO:0005912
A cell junction at which anchoring proteins (cadherins or integrins) extend through the plasma membrane and are attached to actin filaments.
1 Q8R1S4 (/IDA)
Actin cytoskeleton GO:0015629
The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes.
1 O43312 (/IDA)
Actin cytoskeleton GO:0015629
The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes.
1 Q8R1S4 (/ISO)
Lamellipodium GO:0030027
A thin sheetlike process extended by the leading edge of a migrating cell or extending cell process; contains a dense meshwork of actin filaments.
1 Q6P9S0 (/IDA)
Endocytic vesicle GO:0030139
A membrane-bounded intracellular vesicle formed by invagination of the plasma membrane around an extracellular substance. Endocytic vesicles fuse with early endosomes to deliver the cargo for further sorting.
1 O43312 (/TAS)
Filopodium GO:0030175
Thin, stiff, actin-based protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal or dendritic growth cone, or a dendritic shaft.
1 Q95Y95 (/IDA)
Cortical actin cytoskeleton GO:0030864
The portion of the actin cytoskeleton, comprising filamentous actin and associated proteins, that lies just beneath the plasma membrane.
1 Q6P9S0 (/IDA)
Intrinsic component of the cytoplasmic side of the plasma membrane GO:0031235
The component of a plasma membrane consisting of gene products and protein complexes that have some covalently attached part (e.g. peptide sequence or GPI anchor) which is embedded in the cytoplasmic side of the plasma membrane only.
1 Q95Y95 (/IDA)
Phagocytic vesicle GO:0045335
A membrane-bounded intracellular vesicle that arises from the ingestion of particulate material by phagocytosis.
1 C7FZZ0 (/IDA)