The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 13900: Ferritin light chain 1

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 10 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Iron ion binding GO:0005506
Interacting selectively and non-covalently with iron (Fe) ions.
9 O46415 (/ISS) P02791 (/ISS) P02793 (/ISS) P09451 (/ISS) P29391 (/ISS) P49945 (/ISS) Q2MHN1 (/ISS) Q53VB8 (/ISS) Q5R538 (/ISS)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
7 O16453 (/IPI) P02792 (/IPI) P02794 (/IPI) P19132 (/IPI) P29391 (/IPI) Q6NZ44 (/IPI) Q9TYS3 (/IPI)
Iron ion binding GO:0005506
Interacting selectively and non-covalently with iron (Fe) ions.
4 P02792 (/TAS) P02794 (/TAS) Q39101 (/TAS) Q9D5H4 (/TAS)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
3 O16453 (/IPI) P02792 (/IPI) Q9TYS3 (/IPI)
Ferroxidase activity GO:0004322
Catalysis of the reaction: 4 Fe2+ + 4 H+ + O2 = 4 Fe3+ + 2 H2O.
2 Q8N4E7 (/TAS) Q9D5H4 (/TAS)
Iron ion binding GO:0005506
Interacting selectively and non-covalently with iron (Fe) ions.
2 P02792 (/IDA) P09528 (/IDA)
Iron ion binding GO:0005506
Interacting selectively and non-covalently with iron (Fe) ions.
1 P29391 (/ISO)
Kinase binding GO:0019900
Interacting selectively and non-covalently with a kinase, any enzyme that catalyzes the transfer of a phosphate group.
1 Q8TD27 (/NAS)
Protein domain specific binding GO:0019904
Interacting selectively and non-covalently with a specific domain of a protein.
1 Q39101 (/IPI)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
1 P29391 (/ISO)

There are 45 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Immune response GO:0006955
Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat.
11 O46414 (/ISS) P02794 (/ISS) P08267 (/ISS) P09528 (/ISS) P18685 (/ISS) P19132 (/ISS) P29389 (/ISS) Q8MIP0 (/ISS) Q920K4 (/ISS) Q95MP7 (/ISS)
(1 more)
Negative regulation of cell proliferation GO:0008285
Any process that stops, prevents or reduces the rate or extent of cell proliferation.
11 O46414 (/ISS) P02794 (/ISS) P08267 (/ISS) P09528 (/ISS) P18685 (/ISS) P19132 (/ISS) P29389 (/ISS) Q8MIP0 (/ISS) Q920K4 (/ISS) Q95MP7 (/ISS)
(1 more)
Cellular iron ion homeostasis GO:0006879
Any process involved in the maintenance of an internal steady state of iron ions at the level of a cell.
5 P02792 (/TAS) P02793 (/TAS) P02794 (/TAS) Q8N4E7 (/TAS) Q9D5H4 (/TAS)
Response to reactive oxygen species GO:0000302
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a reactive oxygen species stimulus. Reactive oxygen species include singlet oxygen, superoxide, and oxygen free radicals.
3 Q39101 (/IGI) Q9LYN2 (/IGI) Q9S756 (/IGI)
Iron ion transport GO:0006826
The directed movement of iron (Fe) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
3 Q39101 (/IGI) Q9LYN2 (/IGI) Q9S756 (/IGI)
Flower development GO:0009908
The process whose specific outcome is the progression of the flower over time, from its formation to the mature structure. The flower is the reproductive structure in a plant, and its development begins with the transition of the vegetative or inflorescence meristem into a floral meristem.
3 Q39101 (/IGI) Q9LYN2 (/IGI) Q9S756 (/IGI)
Response to iron ion GO:0010039
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an iron ion stimulus.
3 Q39101 (/IEP) Q9LYN2 (/IEP) Q9S756 (/IEP)
Photosynthesis GO:0015979
The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds.
3 Q39101 (/IGI) Q9LYN2 (/IGI) Q9S756 (/IGI)
Leaf development GO:0048366
The process whose specific outcome is the progression of the leaf over time, from its formation to the mature structure.
3 Q39101 (/IGI) Q9LYN2 (/IGI) Q9S756 (/IGI)
Iron ion homeostasis GO:0055072
Any process involved in the maintenance of an internal steady state of iron ions within an organism or cell.
3 Q39101 (/IGI) Q9LYN2 (/IGI) Q9S756 (/IGI)
Receptor-mediated endocytosis GO:0006898
An endocytosis process in which cell surface receptors ensure specificity of transport. A specific receptor on the cell surface binds tightly to the extracellular macromolecule (the ligand) that it recognizes; the plasma-membrane region containing the receptor-ligand complex then undergoes endocytosis, forming a transport vesicle containing the receptor-ligand complex and excluding most other plasma-membrane proteins. Receptor-mediated endocytosis generally occurs via clathrin-coated pits and vesicles.
2 P09528 (/TAS) P29391 (/TAS)
Neutrophil degranulation GO:0043312
The regulated exocytosis of secretory granules containing preformed mediators such as proteases, lipases, and inflammatory mediators by a neutrophil.
2 P02792 (/TAS) P02794 (/TAS)
Negative regulation of fibroblast proliferation GO:0048147
Any process that stops, prevents, or reduces the frequency, rate or extent of multiplication or reproduction of fibroblast cells.
2 P02794 (/IDA) P19132 (/IDA)
Cellular iron ion homeostasis GO:0006879
Any process involved in the maintenance of an internal steady state of iron ions at the level of a cell.
1 Q8N4E7 (/IDA)
Cellular iron ion homeostasis GO:0006879
Any process involved in the maintenance of an internal steady state of iron ions at the level of a cell.
1 O16453 (/IMP)
Cellular iron ion homeostasis GO:0006879
Any process involved in the maintenance of an internal steady state of iron ions at the level of a cell.
1 Q9D5H4 (/ISO)
Intracellular sequestering of iron ion GO:0006880
The process of binding or confining iron ions in an intracellular area such that they are separated from other components of a biological system.
1 P02794 (/IDA)
Intracellular sequestering of iron ion GO:0006880
The process of binding or confining iron ions in an intracellular area such that they are separated from other components of a biological system.
1 P09528 (/ISO)
Immune response GO:0006955
Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat.
1 Q8TD27 (/IDA)
Response to oxidative stress GO:0006979
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.
1 Q9SRL5 (/IMP)
Positive regulation of cell proliferation GO:0008284
Any process that activates or increases the rate or extent of cell proliferation.
1 Q8N4E7 (/IDA)
Positive regulation of cell proliferation GO:0008284
Any process that activates or increases the rate or extent of cell proliferation.
1 Q9D5H4 (/ISO)
Negative regulation of cell proliferation GO:0008285
Any process that stops, prevents or reduces the rate or extent of cell proliferation.
1 Q8TD27 (/IDA)
Response to cold GO:0009409
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cold stimulus, a temperature stimulus below the optimal temperature for that organism.
1 Q39101 (/IEP)
Response to bacterium GO:0009617
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a bacterium.
1 Q39101 (/IEP)
Response to bacterium GO:0009617
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a bacterium.
1 Q39101 (/IMP)
Response to cytokinin GO:0009735
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytokinin stimulus.
1 Q39101 (/IDA)
Response to abscisic acid GO:0009737
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an abscisic acid stimulus.
1 Q9SRL5 (/IEP)
Response to zinc ion GO:0010043
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a zinc ion stimulus.
1 Q39101 (/IEP)
Cellular response to iron ion starvation GO:0010106
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of iron ions.
1 Q9VYH1 (/IMP)
Response to lead ion GO:0010288
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lead ion stimulus.
1 P02793 (/IEP)
Response to hydrogen peroxide GO:0042542
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrogen peroxide (H2O2) stimulus.
1 Q39101 (/IEP)
Positive regulation of JAK-STAT cascade GO:0046427
Any process that activates or increases the frequency, rate or extent of the JAK-STAT signaling pathway activity.
1 Q9VYH1 (/IMP)
Negative regulation of fibroblast proliferation GO:0048147
Any process that stops, prevents, or reduces the frequency, rate or extent of multiplication or reproduction of fibroblast cells.
1 P09528 (/ISO)
Defense response to Gram-negative bacterium GO:0050829
Reactions triggered in response to the presence of a Gram-negative bacterium that act to protect the cell or organism.
1 C1BEL9 (/IDA)
Defense response to Gram-positive bacterium GO:0050830
Reactions triggered in response to the presence of a Gram-positive bacterium that act to protect the cell or organism.
1 Q9TYS3 (/IEP)
Positive regulation of lyase activity GO:0051349
Any process that activates or increases the frequency, rate or extent of lyase activity, the catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond.
1 Q8N4E7 (/IDA)
Positive regulation of lyase activity GO:0051349
Any process that activates or increases the frequency, rate or extent of lyase activity, the catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond.
1 Q9D5H4 (/ISO)
Iron ion homeostasis GO:0055072
Any process involved in the maintenance of an internal steady state of iron ions within an organism or cell.
1 P02792 (/TAS)
Negative regulation of necrotic cell death GO:0060547
Any process that decreases the rate, frequency or extent of necrotic cell death. Necrotic cell death is a cell death process that is morphologically characterized by a gain in cell volume (oncosis), swelling of organelles, plasma membrane rupture and subsequent loss of intracellular contents.
1 P19132 (/IMP)
Iron ion import GO:0097286
The directed movement of iron ions into a cell or organelle.
1 P09528 (/IDA)
Positive regulation of succinate dehydrogenase activity GO:1904231
Any process that activates or increases the frequency, rate or extent of succinate dehydrogenase activity.
1 Q8N4E7 (/IGI)
Positive regulation of succinate dehydrogenase activity GO:1904231
Any process that activates or increases the frequency, rate or extent of succinate dehydrogenase activity.
1 Q9D5H4 (/ISO)
Positive regulation of aconitate hydratase activity GO:1904234
Any process that activates or increases the frequency, rate or extent of aconitate hydratase activity.
1 Q8N4E7 (/IGI)
Positive regulation of aconitate hydratase activity GO:1904234
Any process that activates or increases the frequency, rate or extent of aconitate hydratase activity.
1 Q9D5H4 (/ISO)

There are 29 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Intracellular ferritin complex GO:0008043
A ferritin complex located in the cell. Intracellular ferritin complexes contain 24 subunits, in a mixture of L (light) chains and H (heavy) chains.
9 O46415 (/ISS) P02791 (/ISS) P02793 (/ISS) P09451 (/ISS) P29391 (/ISS) P49945 (/ISS) Q2MHN1 (/ISS) Q53VB8 (/ISS) Q5R538 (/ISS)
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
4 P02792 (/TAS) P02794 (/TAS) P09528 (/TAS) P29391 (/TAS)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
4 P09528 (/IDA) Q39101 (/IDA) Q9D5H4 (/IDA) Q9S756 (/IDA)
Chloroplast GO:0009507
A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma.
4 Q39101 (/ISS) Q9LYN2 (/ISS) Q9S756 (/ISS) Q9SRL5 (/ISS)
Chloroplast GO:0009507
A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma.
3 Q39101 (/IDA) Q9LYN2 (/IDA) Q9S756 (/IDA)
Chloroplast stroma GO:0009570
The space enclosed by the double membrane of a chloroplast but excluding the thylakoid space. It contains DNA, ribosomes and some temporary products of photosynthesis.
3 Q39101 (/IDA) Q9LYN2 (/IDA) Q9S756 (/IDA)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
3 P02792 (/IDA) Q39101 (/IDA) Q9LYN2 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
2 P02794 (/IDA) Q8N4E7 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
2 P09528 (/ISO) Q9D5H4 (/ISO)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
2 P02792 (/TAS) P02794 (/TAS)
Intracellular ferritin complex GO:0008043
A ferritin complex located in the cell. Intracellular ferritin complexes contain 24 subunits, in a mixture of L (light) chains and H (heavy) chains.
2 P02792 (/TAS) P02794 (/TAS)
Chloroplast envelope GO:0009941
The double lipid bilayer enclosing the chloroplast and separating its contents from the rest of the cytoplasm; includes the intermembrane space.
2 Q9LYN2 (/IDA) Q9S756 (/IDA)
Autolysosome GO:0044754
A type of secondary lysosome in which a primary lysosome has fused with the outer membrane of an autophagosome. It is involved in the second step of autophagy in which it degrades contents with acidic lysosomal hydrolases.
2 P02792 (/IDA) P02794 (/IDA)
Autolysosome GO:0044754
A type of secondary lysosome in which a primary lysosome has fused with the outer membrane of an autophagosome. It is involved in the second step of autophagy in which it degrades contents with acidic lysosomal hydrolases.
2 P09528 (/ISO) P29391 (/ISO)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
2 P02792 (/IDA) P02794 (/IDA)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
2 P09528 (/ISO) P29391 (/ISO)
Endocytic vesicle lumen GO:0071682
The volume enclosed by the membrane of an endocytic vesicle.
2 P09528 (/TAS) P29391 (/TAS)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 P02793 (/IDA)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
1 Q9D5H4 (/TAS)
Mitochondrial matrix GO:0005759
The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation.
1 Q8N4E7 (/TAS)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 Q8TD27 (/NAS)
Intracellular ferritin complex GO:0008043
A ferritin complex located in the cell. Intracellular ferritin complexes contain 24 subunits, in a mixture of L (light) chains and H (heavy) chains.
1 P02792 (/IDA)
Intracellular ferritin complex GO:0008043
A ferritin complex located in the cell. Intracellular ferritin complexes contain 24 subunits, in a mixture of L (light) chains and H (heavy) chains.
1 P29391 (/ISO)
Chloroplast thylakoid membrane GO:0009535
The pigmented membrane of a chloroplast thylakoid. An example of this component is found in Arabidopsis thaliana.
1 Q39101 (/IDA)
Thylakoid GO:0009579
A membranous cellular structure that bears the photosynthetic pigments in plants, algae, and cyanobacteria. In cyanobacteria thylakoids are of various shapes and are attached to, or continuous with, the plasma membrane. In eukaryotes they are flattened, membrane-bounded disk-like structures located in the chloroplasts; in the chloroplasts of higher plants the thylakoids form dense stacks called grana. Isolated thylakoid preparations can carry out photosynthetic electron transport and the associated phosphorylation.
1 Q39101 (/IDA)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
1 P29391 (/ISO)
Azurophil granule lumen GO:0035578
The volume enclosed by the membrane of an azurophil granule, a primary lysosomal granule found in neutrophil granulocytes that contains a wide range of hydrolytic enzymes and is released into the extracellular fluid.
1 P02792 (/TAS)
Tertiary granule lumen GO:1904724
Any membrane-enclosed lumen that is part of a tertiary granule.
1 P02794 (/TAS)
Ficolin-1-rich granule lumen GO:1904813
Any membrane-enclosed lumen that is part of a ficolin-1-rich granule.
1 P02794 (/TAS)
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