CATH Superfamily 1.20.1250.10
The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was: waiting to be named.
FunFam 8065: Prolactin, isoform CRA_b
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 5 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Cytokine activity GO:0005125
Functions to control the survival, growth, differentiation and effector function of tissues and cells.
|
2 | E5RWR3 (/TAS) P17572 (/TAS) |
|
Prolactin receptor binding GO:0005148
Interacting selectively and non-covalently with the prolactin receptor.
|
2 | P01236 (/TAS) P01237 (/TAS) |
|
Hormone activity GO:0005179
The action characteristic of a hormone, any substance formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells in the same organism, upon which it has a specific regulatory action. The term was originally applied to agents with a stimulatory physiological action in vertebrate animals (as opposed to a chalone, which has a depressant action). Usage is now extended to regulatory compounds in lower animals and plants, and to synthetic substances having comparable effects; all bind receptors and trigger some biological process.
|
2 | P01237 (/TAS) P06879 (/TAS) |
|
Prolactin receptor binding GO:0005148
Interacting selectively and non-covalently with the prolactin receptor.
|
1 | P06879 (/ISO) |
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
1 | P01236 (/IPI) |
There are 41 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Positive regulation of endothelial cell proliferation GO:0001938
Any process that activates or increases the rate or extent of endothelial cell proliferation.
|
2 | F1RUF8 (/IMP) P01238 (/IMP) |
|
Estrogen biosynthetic process GO:0006703
The chemical reactions and pathways resulting in the formation of estrogens, C18 steroid hormones that can stimulate the development of female sexual characteristics. Also found in plants.
|
2 | E5RWR3 (/TAS) P17572 (/TAS) |
|
Photoperiodism GO:0009648
Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, a period of light or dark of a given length, measured relative to a particular duration known as the 'critical day length'. The critical day length varies between species.
|
2 | E5RWR3 (/TAS) P17572 (/TAS) |
|
Positive regulation of vascular endothelial growth factor production GO:0010575
Any process that increases or activates the frequency, rate, or extent of production of vascular endothelial growth factor.
|
2 | F1RUF8 (/IMP) P01238 (/IMP) |
|
Negative regulation of hydrogen peroxide biosynthetic process GO:0010730
Any process that decreases the rate, frequency or extent of hydrogen peroxide biosynthesis. The chemical reactions and pathways resulting in the formation of hydrogen peroxide (H2O2), a potentially harmful byproduct of aerobic cellular respiration which can cause damage to DNA.
|
2 | F1RUF8 (/IMP) P01238 (/IMP) |
|
Negative regulation of nitric oxide biosynthetic process GO:0045019
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of nitric oxide.
|
2 | F1RUF8 (/IMP) P01238 (/IMP) |
|
Response to electrical stimulus GO:0051602
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electrical stimulus.
|
2 | E5RWR3 (/IMP) P17572 (/IMP) |
|
Prolactin secretion GO:0070459
The regulated release of prolactin, a peptide hormone that stimulates lactation, from secretory granules in the anterior pituitary.
|
2 | E5RWR3 (/TAS) P17572 (/TAS) |
|
Cellular response to hypoxia GO:0071456
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.
|
2 | F1RUF8 (/IMP) P01238 (/IMP) |
|
Negative regulation of estrogen biosynthetic process GO:1904077
Any process that stops, prevents or reduces the frequency, rate or extent of estrogen biosynthetic process.
|
2 | F1RUF8 (/IMP) P01238 (/IMP) |
|
Negative regulation of progesterone biosynthetic process GO:2000183
Any process that stops, prevents, or reduces the frequency, rate or extent of progesterone biosynthetic process.
|
2 | F1RUF8 (/IMP) P01238 (/IMP) |
|
Cell surface receptor signaling pathway GO:0007166
A series of molecular signals initiated by activation of a receptor on the surface of a cell. The pathway begins with binding of an extracellular ligand to a cell surface receptor, or for receptors that signal in the absence of a ligand, by ligand-withdrawal or the activity of a constitutively active receptor. The pathway ends with regulation of a downstream cellular process, e.g. transcription.
|
1 | P01236 (/TAS) |
|
STAT protein import into nucleus GO:0007262
The directed movement of dimerized STAT (Signal Transducers and Activators of Transcription) proteins into the nucleus following activation by members of the janus activated kinase (JAK) family of tyrosine kinases.
|
1 | P06879 (/IDA) |
|
Female pregnancy GO:0007565
The set of physiological processes that allow an embryo or foetus to develop within the body of a female animal. It covers the time from fertilization of a female ovum by a male spermatozoon until birth.
|
1 | P01236 (/NAS) |
|
Parturition GO:0007567
The reproductive process in which the parent is separated from its offspring either by giving birth to live young or by laying eggs.
|
1 | P01237 (/IEP) |
|
Response to nutrient GO:0007584
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nutrient stimulus.
|
1 | P01237 (/IEP) |
|
Lactation GO:0007595
The regulated release of milk from the mammary glands and the period of time that a mother lactates to feed her young.
|
1 | P01237 (/TAS) |
|
Circadian rhythm GO:0007623
Any biological process in an organism that recurs with a regularity of approximately 24 hours.
|
1 | P01237 (/IEP) |
|
Cell proliferation GO:0008283
The multiplication or reproduction of cells, resulting in the expansion of a cell population.
|
1 | P01236 (/TAS) |
|
Positive regulation of cell proliferation GO:0008284
Any process that activates or increases the rate or extent of cell proliferation.
|
1 | P06879 (/IGI) |
|
Positive regulation of cell proliferation GO:0008284
Any process that activates or increases the rate or extent of cell proliferation.
|
1 | P01237 (/IMP) |
|
Response to organic cyclic compound GO:0014070
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic cyclic compound stimulus.
|
1 | P01237 (/IEP) |
|
Regulation of ossification GO:0030278
Any process that modulates the frequency, rate or extent of bone formation.
|
1 | P01237 (/IMP) |
|
Mammary gland development GO:0030879
The process whose specific outcome is the progression of the mammary gland over time, from its formation to the mature structure. The mammary gland is a large compound sebaceous gland that in female mammals is modified to secrete milk. Its development starts with the formation of the mammary line and ends as the mature gland cycles between nursing and weaning stages.
|
1 | P06879 (/IGI) |
|
Response to estradiol GO:0032355
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by estradiol, a C18 steroid hormone hydroxylated at C3 and C17 that acts as a potent estrogen.
|
1 | P01237 (/IEP) |
|
Response to lipopolysaccharide GO:0032496
Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria.
|
1 | P01237 (/IEP) |
|
Cellular response to hormone stimulus GO:0032870
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus.
|
1 | P01237 (/IEP) |
|
Multicellular organismal response to stress GO:0033555
Any process that results in a change in state or activity of a multicellular organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).
|
1 | P01237 (/IEP) |
|
Negative regulation of luteinizing hormone secretion GO:0033685
Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of luteinizing hormone.
|
1 | P14676 (/TAS) |
|
Regulation of multicellular organism growth GO:0040014
Any process that modulates the frequency, rate or extent of growth of the body of an organism so that it reaches its usual body size.
|
1 | P01236 (/IEP) |
|
Response to drug GO:0042493
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease.
|
1 | P01237 (/IEP) |
|
Ovulation cycle GO:0042698
The type of sexual cycle seen in females, often with physiologic changes in the endometrium that recur at regular intervals during the reproductive years.
|
1 | P01237 (/IEP) |
|
Maternal behavior GO:0042711
Female behaviors associated with the care and rearing of offspring.
|
1 | P06879 (/IGI) |
|
Cellular protein metabolic process GO:0044267
The chemical reactions and pathways involving a specific protein, rather than of proteins in general, occurring at the level of an individual cell. Includes cellular protein modification.
|
1 | P01236 (/TAS) |
|
Response to ethanol GO:0045471
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ethanol stimulus.
|
1 | P01237 (/IEP) |
|
Regulation of JAK-STAT cascade GO:0046425
Any process that modulates the frequency, rate or extent of the JAK-STAT signaling pathway.
|
1 | P06879 (/IDA) |
|
Positive regulation of JAK-STAT cascade GO:0046427
Any process that activates or increases the frequency, rate or extent of the JAK-STAT signaling pathway activity.
|
1 | P01236 (/IDA) |
|
Positive regulation of JAK-STAT cascade GO:0046427
Any process that activates or increases the frequency, rate or extent of the JAK-STAT signaling pathway activity.
|
1 | P06879 (/IGI) |
|
Positive regulation of JAK-STAT cascade GO:0046427
Any process that activates or increases the frequency, rate or extent of the JAK-STAT signaling pathway activity.
|
1 | P06879 (/ISO) |
|
Positive regulation of epithelial cell proliferation GO:0050679
Any process that activates or increases the rate or extent of epithelial cell proliferation.
|
1 | P01237 (/IDA) |
|
JAK-STAT cascade involved in growth hormone signaling pathway GO:0060397
The process in which STAT proteins (Signal Transducers and Activators of Transcription) are activated by members of the JAK (janus activated kinase) family of tyrosine kinases, following the binding of physiological ligands to the growth hormone receptor. Once activated, STATs dimerize and translocate to the nucleus and modulate the expression of target genes.
|
1 | P01236 (/TAS) |
There are 8 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
|
41 |
A0A087RDC7 (/ISS)
A0A091EIW7 (/ISS)
A0A091HDM8 (/ISS)
A0A091J3G4 (/ISS)
A0A091KQA2 (/ISS)
A0A091P137 (/ISS)
A0A091R3S1 (/ISS)
A0A091SN26 (/ISS)
A0A091UR89 (/ISS)
A0A091W291 (/ISS)
(31 more) |
|
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
|
5 | E5RWR3 (/IDA) F1RUF8 (/IDA) P01238 (/IDA) P14676 (/IDA) P17572 (/IDA) |
|
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
|
3 | E5RWR3 (/TAS) P14676 (/TAS) P17572 (/TAS) |
|
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
|
2 | P01236 (/TAS) P01237 (/TAS) |
|
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
|
2 | E5RWR3 (/IMP) P17572 (/IMP) |
|
Secretory granule GO:0030141
A small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion. Secretory granules move towards the periphery of the cell and upon stimulation, their membranes fuse with the cell membrane, and their protein load is exteriorized. Processing of the contained protein may take place in secretory granules.
|
2 | P01237 (/IDA) P06879 (/IDA) |
|
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
|
1 | P01237 (/IDA) |
|
Endosome lumen GO:0031904
The volume enclosed by the membrane of an endosome.
|
1 | P01236 (/TAS) |
