The process in which a CD4-positive, alpha-beta T cell becomes committed to becoming a T-helper 17 cell, a CD4-positive, alpha-beta T cell with the phenotype RORgamma-t-positive that produces IL-17.

Any process that activates or increases the frequency, rate or extent of T cell activation.

Any process that activates or increases the frequency, rate or extent of B cell activation.

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-6 stimulus.

Any apoptotic process in a neutrophil, any of the immature or mature forms of a granular leukocyte that in its mature form has a nucleus with three to five lobes connected by slender threads of chromatin, and cytoplasm containing fine inconspicuous granules and stainable by neutral dyes.

An immune response taking place in the liver.

An immune response taking place in the liver.

Any process involved in the carrying out of an immune response by a neutrophil.

The movement of a monocyte in response to an external stimulus.

Any process that activates or increases the frequency, rate, or extent of an acute inflammatory response.

Any process that activates or increases the frequency, rate, or extent of leukocyte chemotaxis.

An acute inflammatory response that involves non-antibody proteins whose concentrations in the plasma increase in response to infection or injury of homeothermic animals.

The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages.

An immune response mediated through a body fluid.

Any process that activates or increases the rate or extent of cell proliferation.

Any process that activates or increases the rate or extent of cell proliferation.

Any process that stops, prevents or reduces the rate or extent of cell proliferation.

Any process that modulates the frequency, rate, or extent of production of vascular endothelial growth factor.

Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.

Any process that decreases the rate, frequency or extent of lipid storage. Lipid storage is the accumulation and maintenance in cells or tissues of lipids, compounds soluble in organic solvents but insoluble or sparingly soluble in aqueous solvents. Lipid reserves can be accumulated during early developmental stages for mobilization and utilization at later stages of development.

A series of molecular signals initiated by the binding of a cytokine to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.

A series of progressive, overlapping events triggered by exposure of the platelets to subendothelial tissue. These events include shape change, adhesiveness, aggregation, and release reactions. When carried through to completion, these events lead to the formation of a stable hemostatic plug.

The process whose specific outcome is the progression of the endocrine pancreas over time, from its formation to the mature structure. The endocrine pancreas is made up of islet cells that produce insulin, glucagon and somatostatin.

The process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).

Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptidoglycan stimulus. Peptidoglycan is a bacterial cell wall macromolecule.

Any process that activates or increases the frequency, rate, or extent of chemokine production.

Any process that activates or increases the frequency, rate, or extent of chemokine production.

Any process that activates or increases the frequency, rate, or extent of interleukin-6 production.

Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals.

Any process that activates or increases the frequency, rate or extent of the phosphorylation of peptidyl-serine.

Any process that activates or increases the rate or extent of T cell proliferation.

Any process that activates or increases the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a STAT (Signal Transducer and Activator of Transcription) protein.

Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process.

Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.

Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the MAPK cascade.

The process of covalently altering one or more amino acids in a protein after the protein has been completely translated and released from the ribosome.

The chemical reactions and pathways involving a specific protein, rather than of proteins in general, occurring at the level of an individual cell. Includes cellular protein modification.

Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of chemokines.

Any process that stops, prevents, or reduces the frequency, rate or extent of adipocyte differentiation.

Any process that activates or increases the frequency, rate or extent of osteoblast differentiation.

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA.

Any process that modulates the frequency, rate or extent of angiogenesis.

Any process that stops, prevents, or reduces the frequency, rate or extent of bone resorption.

Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.

Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.

Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.

Any process that activates or increases the frequency, rate or extent of the JAK-STAT signaling pathway activity.

Any process that activates or increases the rate or extent of smooth muscle cell proliferation.

Any process that activates or increases the frequency, rate or extent of the phosphorylation of peptidyl-tyrosine.

Reactions triggered in response to the presence of a Gram-negative bacterium that act to protect the cell or organism.

Reactions triggered in response to the presence of a Gram-positive bacterium that act to protect the cell or organism.

Any process that activates or increases the frequency, rate or extent of B cell activation.

Any process that activates or increases the frequency, rate or extent of the regulated release of immunoglobulins from a cell.

Any process that activates or increases the frequency, rate or extent of activity of a transcription factor, any factor involved in the initiation or regulation of transcription.

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucocorticoid stimulus. Glucocorticoids are hormonal C21 corticosteroids synthesized from cholesterol with the ability to bind with the cortisol receptor and trigger similar effects. Glucocorticoids act primarily on carbohydrate and protein metabolism, and have anti-inflammatory effects.

Reactions triggered in response to the presence of a virus that act to protect the cell or organism.

The regulated release of glucagon from secretory granules in the A (alpha) cells of the pancreas (islets of Langerhans).

A series of molecular signals initiated by the binding of interleukin-6 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrogen peroxide (H2O2) stimulus.

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria.

Any process that activates or increases the frequency, rate or extent of STAT protein import into nucleus.

Any process that activates or increases the frequency, rate or extent of T-helper 2 cell cytokine production.

Any process that stops, prevents or reduces the frequency, rate or extent of interleukin-1-mediated signaling pathway.

Any process that activates or increases the frequency, rate or extent of type B pancreatic cell apoptotic process.

Any process that activates or increases the frequency, rate or extent of estradiol secretion.

That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.

The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.

That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.

The volume enclosed by the membranes of the endoplasmic reticulum.

A hexameric protein complex consisting of two molecules each of interleukin-6, interleukin-6 receptor alpha chain, and gp-130.