CATH Superfamily 1.20.1250.10
The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was: waiting to be named.
FunFam 7977: KIT ligand, isoform CRA_a
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 6 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
2 | P20826 (/IPI) P21583 (/IPI) |
Ras guanyl-nucleotide exchange factor activity GO:0005088
Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Ras superfamily. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase.
|
1 | P21583 (/TAS) |
Cytokine activity GO:0005125
Functions to control the survival, growth, differentiation and effector function of tissues and cells.
|
1 | P20826 (/IDA) |
Stem cell factor receptor binding GO:0005173
Interacting selectively and non-covalently with the stem cell factor receptor (SCFR), a type III transmembrane kinase receptor.
|
1 | P20826 (/IDA) |
Stem cell factor receptor binding GO:0005173
Interacting selectively and non-covalently with the stem cell factor receptor (SCFR), a type III transmembrane kinase receptor.
|
1 | P21583 (/TAS) |
Phosphatidylinositol-4,5-bisphosphate 3-kinase activity GO:0046934
Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + ATP = a 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate + ADP + 2 H(+).
|
1 | P21583 (/TAS) |
There are 27 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Positive regulation of cell proliferation GO:0008284
Any process that activates or increases the rate or extent of cell proliferation.
|
2 | P20826 (/IDA) P21581 (/IDA) |
MAPK cascade GO:0000165
An intracellular protein kinase cascade containing at least a MAPK, a MAPKK and a MAP3K. The cascade can also contain two additional tiers: the upstream MAP4K and the downstream MAP Kinase-activated kinase (MAPKAPK). The kinases in each tier phosphorylate and activate the kinases in the downstream tier to transmit a signal within a cell.
|
1 | P21583 (/TAS) |
Ovarian follicle development GO:0001541
The process whose specific outcome is the progression of the ovarian follicle over time, from its formation to the mature structure.
|
1 | P21581 (/IDA) |
Neural crest cell migration GO:0001755
The characteristic movement of cells from the dorsal ridge of the neural tube to a variety of locations in a vertebrate embryo.
|
1 | P20826 (/IDA) |
Positive regulation of leukocyte migration GO:0002687
Any process that activates or increases the frequency, rate, or extent of leukocyte migration.
|
1 | P20826 (/IDA) |
Positive regulation of myeloid leukocyte differentiation GO:0002763
Any process that activates or increases the frequency, rate, or extent of myeloid leukocyte differentiation.
|
1 | P20826 (/IGI) |
Signal transduction GO:0007165
The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
|
1 | P21583 (/TAS) |
Germ cell development GO:0007281
The process whose specific outcome is the progression of an immature germ cell over time, from its formation to the mature structure (gamete). A germ cell is any reproductive cell in a multicellular organism.
|
1 | P20826 (/TAS) |
Cell proliferation GO:0008283
The multiplication or reproduction of cells, resulting in the expansion of a cell population.
|
1 | P21583 (/TAS) |
Positive regulation of cell proliferation GO:0008284
Any process that activates or increases the rate or extent of cell proliferation.
|
1 | P20826 (/IGI) |
Male gonad development GO:0008584
The process whose specific outcome is the progression of the male gonad over time, from its formation to the mature structure.
|
1 | P21583 (/IEP) |
Regulation of phosphatidylinositol 3-kinase signaling GO:0014066
Any process that modulates the frequency, rate or extent of signal transduction mediated by the phosphatidylinositol 3-kinase cascade.
|
1 | P21583 (/TAS) |
Negative regulation of mast cell apoptotic process GO:0033026
Any process that stops, prevents, or reduces the frequency, rate, or extent of mast cell apoptotic process.
|
1 | P20826 (/IDA) |
Embryonic hemopoiesis GO:0035162
The stages of blood cell formation that take place within the embryo.
|
1 | P21583 (/IDA) |
Embryonic hemopoiesis GO:0035162
The stages of blood cell formation that take place within the embryo.
|
1 | P20826 (/ISO) |
Ectopic germ cell programmed cell death GO:0035234
Programmed cell death of an errant germ line cell that is outside the normal migratory path or ectopic to the gonad. This is an important mechanism of regulating germ cell survival within the embryo.
|
1 | P20826 (/IMP) |
Negative regulation of apoptotic process GO:0043066
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
|
1 | P20826 (/IGI) |
Positive regulation of MAP kinase activity GO:0043406
Any process that activates or increases the frequency, rate or extent of MAP kinase activity.
|
1 | P20826 (/IGI) |
Positive regulation of melanocyte differentiation GO:0045636
Any process that activates or increases the frequency, rate or extent of melanocyte differentiation.
|
1 | P20826 (/IDA) |
Positive regulation of DNA replication GO:0045740
Any process that activates or increases the frequency, rate or extent of DNA replication.
|
1 | P21583 (/IDA) |
Positive regulation of DNA replication GO:0045740
Any process that activates or increases the frequency, rate or extent of DNA replication.
|
1 | P20826 (/ISO) |
Positive regulation of Ras protein signal transduction GO:0046579
Any process that activates or increases the frequency, rate or extent of Ras protein signal transduction.
|
1 | P20826 (/IDA) |
Phosphatidylinositol-mediated signaling GO:0048015
A series of molecular signals in which a cell uses a phosphatidylinositol-mediated signaling to convert a signal into a response. Phosphatidylinositols include phosphatidylinositol (PtdIns) and its phosphorylated derivatives.
|
1 | P21583 (/TAS) |
Positive regulation of peptidyl-tyrosine phosphorylation GO:0050731
Any process that activates or increases the frequency, rate or extent of the phosphorylation of peptidyl-tyrosine.
|
1 | P20826 (/IDA) |
Positive regulation of mast cell proliferation GO:0070668
Any process that activates or increases the rate or extent of mast cell proliferation.
|
1 | P20826 (/IDA) |
Extrinsic apoptotic signaling pathway in absence of ligand GO:0097192
A series of molecular signals in which a signal is conveyed from the cell surface to trigger the apoptotic death of a cell. The pathway starts with withdrawal of a ligand from a cell surface receptor, and ends when the execution phase of apoptosis is triggered.
|
1 | P20826 (/IDA) |
Positive regulation of hematopoietic stem cell proliferation GO:1902035
Any process that activates or increases the frequency, rate or extent of hematopoietic stem cell proliferation.
|
1 | P20826 (/IDA) |
There are 17 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
10 | P20826 (/ISS) P21581 (/ISS) P79169 (/ISS) P79368 (/ISS) Q06220 (/ISS) Q28132 (/ISS) Q29030 (/ISS) Q95M19 (/ISS) Q95MD2 (/ISS) Q95N18 (/ISS) |
Lamellipodium GO:0030027
A thin sheetlike process extended by the leading edge of a migrating cell or extending cell process; contains a dense meshwork of actin filaments.
|
10 | P20826 (/ISS) P21581 (/ISS) P79169 (/ISS) P79368 (/ISS) Q06220 (/ISS) Q28132 (/ISS) Q29030 (/ISS) Q95M19 (/ISS) Q95MD2 (/ISS) Q95N18 (/ISS) |
Filopodium GO:0030175
Thin, stiff, actin-based protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal or dendritic growth cone, or a dendritic shaft.
|
10 | P20826 (/ISS) P21581 (/ISS) P79169 (/ISS) P79368 (/ISS) Q06220 (/ISS) Q28132 (/ISS) Q29030 (/ISS) Q95M19 (/ISS) Q95MD2 (/ISS) Q95N18 (/ISS) |
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
9 | P21581 (/ISS) P79169 (/ISS) P79368 (/ISS) Q06220 (/ISS) Q28132 (/ISS) Q29030 (/ISS) Q95M19 (/ISS) Q95MD2 (/ISS) Q95N18 (/ISS) |
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
|
2 | P20826 (/TAS) P21583 (/TAS) |
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
2 | P20826 (/IDA) P21583 (/IDA) |
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
|
1 | P20826 (/IDA) |
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
1 | P21583 (/IDA) |
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
1 | P20826 (/ISO) |
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
1 | P20826 (/ISO) |
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
1 | P21583 (/NAS) |
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
1 | P21583 (/TAS) |
Integral component of membrane GO:0016021
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
|
1 | P20826 (/IDA) |
Lamellipodium GO:0030027
A thin sheetlike process extended by the leading edge of a migrating cell or extending cell process; contains a dense meshwork of actin filaments.
|
1 | P21583 (/IDA) |
Lamellipodium GO:0030027
A thin sheetlike process extended by the leading edge of a migrating cell or extending cell process; contains a dense meshwork of actin filaments.
|
1 | P20826 (/ISO) |
Filopodium GO:0030175
Thin, stiff, actin-based protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal or dendritic growth cone, or a dendritic shaft.
|
1 | P21583 (/IDA) |
Filopodium GO:0030175
Thin, stiff, actin-based protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal or dendritic growth cone, or a dendritic shaft.
|
1 | P20826 (/ISO) |