The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 46: Prolactin

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 3 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Prolactin receptor binding GO:0005148
Interacting selectively and non-covalently with the prolactin receptor.
8 A0MYF0 (/ISS) B0FNE3 (/ISS) B0FWK8 (/ISS) B2LVA4 (/ISS) L8IPG1 (/ISS) P01239 (/ISS) Q28318 (/ISS) Q6UC74 (/ISS)
Prolactin receptor binding GO:0005148
Interacting selectively and non-covalently with the prolactin receptor.
3 P01240 (/IDA) R9WQI9 (/IDA) W5PH94 (/IDA)
Prolactin receptor binding GO:0005148
Interacting selectively and non-covalently with the prolactin receptor.
3 P01240 (/IMP) R9WQI9 (/IMP) W5PH94 (/IMP)

There are 32 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Positive regulation of gene expression GO:0010628
Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
8 A0MYF0 (/ISS) B0FNE3 (/ISS) B0FWK8 (/ISS) B2LVA4 (/ISS) L8IPG1 (/ISS) P01239 (/ISS) Q28318 (/ISS) Q6UC74 (/ISS)
Peptide hormone secretion GO:0030072
The regulated release of a peptide hormone from a cell.
8 A0MYF0 (/ISS) B0FNE3 (/ISS) B0FWK8 (/ISS) B2LVA4 (/ISS) L8IPG1 (/ISS) P01239 (/ISS) Q28318 (/ISS) Q6UC74 (/ISS)
Negative regulation of apoptotic process GO:0043066
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
8 A0MYF0 (/ISS) B0FNE3 (/ISS) B0FWK8 (/ISS) B2LVA4 (/ISS) L8IPG1 (/ISS) P01239 (/ISS) Q28318 (/ISS) Q6UC74 (/ISS)
Positive regulation of fatty acid biosynthetic process GO:0045723
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of fatty acids.
8 A0MYF0 (/ISS) B0FNE3 (/ISS) B0FWK8 (/ISS) B2LVA4 (/ISS) L8IPG1 (/ISS) P01239 (/ISS) Q28318 (/ISS) Q6UC74 (/ISS)
Blastocyst formation GO:0001825
The initial formation of a blastocyst from a solid ball of cells known as a morula.
3 P01240 (/ISS) R9WQI9 (/ISS) W5PH94 (/ISS)
Biosynthetic process GO:0009058
The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones.
3 P01240 (/ISS) R9WQI9 (/ISS) W5PH94 (/ISS)
Positive regulation of gene expression GO:0010628
Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
3 P01240 (/IDA) R9WQI9 (/IDA) W5PH94 (/IDA)
Negative regulation of nitric oxide mediated signal transduction GO:0010751
Any process that decreases the rate, frequency or extent of nitric oxide mediated signal transduction. Nitric oxide mediated signal transduction is a series of molecular signals mediated by the detection of nitric oxide (NO).
3 P01240 (/ISS) R9WQI9 (/ISS) W5PH94 (/ISS)
Peptide hormone secretion GO:0030072
The regulated release of a peptide hormone from a cell.
3 P01240 (/IDA) R9WQI9 (/IDA) W5PH94 (/IDA)
Negative regulation of apoptotic process GO:0043066
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
3 P01240 (/IMP) R9WQI9 (/IMP) W5PH94 (/IMP)
Positive regulation of fatty acid biosynthetic process GO:0045723
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of fatty acids.
3 P01240 (/IDA) R9WQI9 (/IDA) W5PH94 (/IDA)
Positive regulation of lactation GO:1903489
Any process that activates or increases the frequency, rate or extent of lactation.
3 P01240 (/ISS) R9WQI9 (/ISS) W5PH94 (/ISS)
Negative regulation of peptide hormone secretion GO:0090278
Any process that decreases the rate, frequency, or extent of the regulated release of a peptide hormone from secretory granules.
2 P01240 (/IDA) R9WQI9 (/IDA)
Blastocyst formation GO:0001825
The initial formation of a blastocyst from a solid ball of cells known as a morula.
1 P01239 (/IDA)
Biosynthetic process GO:0009058
The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones.
1 P01239 (/IDA)
Response to mechanical stimulus GO:0009612
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mechanical stimulus.
1 P01239 (/IDA)
Positive regulation of gene expression GO:0010628
Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
1 P01239 (/IMP)
Negative regulation of gene expression GO:0010629
Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
1 P01239 (/IMP)
Negative regulation of nitric oxide mediated signal transduction GO:0010751
Any process that decreases the rate, frequency or extent of nitric oxide mediated signal transduction. Nitric oxide mediated signal transduction is a series of molecular signals mediated by the detection of nitric oxide (NO).
1 P01239 (/IMP)
Signal transduction involved in regulation of gene expression GO:0023019
Any process that modulates the frequency, rate or extent of gene expression as a consequence of a process in which a signal is released and/or conveyed from one location to another.
1 P01239 (/IMP)
Response to food GO:0032094
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a food stimulus; food is anything which, when taken into the body, serves to nourish or build up the tissues or to supply body heat.
1 P01239 (/IDA)
Negative regulation of luteinizing hormone secretion GO:0033685
Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of luteinizing hormone.
1 R9WQI9 (/IDA)
Negative regulation of luteinizing hormone secretion GO:0033685
Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of luteinizing hormone.
1 P01240 (/IMP)
Positive regulation of NF-kappaB import into nucleus GO:0042346
Any process that activates or increases the frequency, rate or extent of transfer of NF-kappaB, a transcription factor for eukaryotic RNA polymerase II promoters, from the cytoplasm into the nucleus, across the nuclear membrane.
1 P01239 (/IMP)
Response to external biotic stimulus GO:0043207
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external biotic stimulus, an external stimulus caused by, or produced by living things.
1 P01239 (/IDA)
Positive regulation of nitric oxide biosynthetic process GO:0045429
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of nitric oxide.
1 P01239 (/IMP)
Positive regulation of endocytosis GO:0045807
Any process that activates or increases the frequency, rate or extent of endocytosis.
1 P01239 (/IMP)
Long-day photoperiodism GO:0048571
Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, a day length that exceeds a particular duration known as the 'critical day length'. The critical day length varies between species. Although the term long-day is used, most species actually respond to the duration of the night, so that the response will occur when a period of darkness falls short of the number of hours defined by 24 hours minus the critical day length.
1 P01239 (/IDA)
Positive regulation of NF-kappaB transcription factor activity GO:0051092
Any process that activates or increases the frequency, rate or extent of activity of the transcription factor NF-kappaB.
1 P01239 (/IMP)
Positive regulation of lactation GO:1903489
Any process that activates or increases the frequency, rate or extent of lactation.
1 P01239 (/IMP)
Regulation of meiotic cell cycle process involved in oocyte maturation GO:1903538
Any process that modulates the frequency, rate or extent of meiotic cell cycle process involved in oocyte maturation.
1 P01239 (/IDA)
Response to L-arginine GO:1903576
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a L-arginine stimulus.
1 P01239 (/IDA)

There are 5 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
3 P01240 (/ISS) R9WQI9 (/ISS) W5PH94 (/ISS)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
1 P01239 (/IDA)
Endoplasmic reticulum lumen GO:0005788
The volume enclosed by the membranes of the endoplasmic reticulum.
1 P01239 (/TAS)
Endoplasmic reticulum membrane GO:0005789
The lipid bilayer surrounding the endoplasmic reticulum.
1 P01239 (/TAS)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 P01239 (/TAS)
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