CATH Superfamily 1.20.1250.10
The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was: waiting to be named.
FunFam 1581: Interleukin 4
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 1 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Cytokine activity GO:0005125
Functions to control the survival, growth, differentiation and effector function of tissues and cells.
|
1 | P07750 (/IDA) |
There are 45 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Positive regulation of protein phosphorylation GO:0001934
Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein.
|
1 | P07750 (/IDA) |
|
Innate immune response in mucosa GO:0002227
Any process of the innate immune response that takes place in the mucosal tissues.
|
1 | P07750 (/IDA) |
|
T-helper 1 cell lineage commitment GO:0002296
The process in which a CD4-positive, alpha-beta T cell becomes committed to becoming a T-helper 1 cell, a CD4-positive, alpha-beta T cell specialized to promote immunological processes often associated with resistance to intracellular bacteria, fungi, and protozoa, and pathological conditions such as arthritis.
|
1 | P07750 (/IGI) |
|
Positive regulation of immunoglobulin production GO:0002639
Any process that activates or increases the frequency, rate, or extent of immunoglobulin production.
|
1 | P07750 (/IGI) |
|
Positive regulation of immunoglobulin production GO:0002639
Any process that activates or increases the frequency, rate, or extent of immunoglobulin production.
|
1 | P07750 (/IMP) |
|
Cholesterol metabolic process GO:0008203
The chemical reactions and pathways involving cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones. It is a component of the plasma membrane lipid bilayer and of plasma lipoproteins and can be found in all animal tissues.
|
1 | P07750 (/IMP) |
|
Negative regulation of epithelial cell migration GO:0010633
Any process that stops, prevents, or reduces the frequency, rate or extent of epithelial cell migration.
|
1 | P07750 (/ISO) |
|
Positive regulation of B cell proliferation GO:0030890
Any process that activates or increases the rate or extent of B cell proliferation.
|
1 | P07750 (/IDA) |
|
B cell costimulation GO:0031296
The process of providing, via surface-bound receptor-ligand pairs, a second, antigen-independent, signal in addition to that provided by the B cell receptor to augment B cell activation.
|
1 | P07750 (/IDA) |
|
Positive regulation of interleukin-13 production GO:0032736
Any process that activates or increases the frequency, rate, or extent of interleukin-13 production.
|
1 | P07750 (/ISO) |
|
T-helper 2 cell cytokine production GO:0035745
Any process that contributes to cytokine production by a T-helper 2 cell.
|
1 | P07750 (/ISO) |
|
Positive regulation of T cell proliferation GO:0042102
Any process that activates or increases the rate or extent of T cell proliferation.
|
1 | P07750 (/IDA) |
|
Positive regulation of activated T cell proliferation GO:0042104
Any process that activates or increases the rate or extent of activated T cell proliferation.
|
1 | P07750 (/IDA) |
|
B cell activation GO:0042113
The change in morphology and behavior of a mature or immature B cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific.
|
1 | P07750 (/IDA) |
|
Positive regulation of tyrosine phosphorylation of STAT protein GO:0042531
Any process that activates or increases the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a STAT (Signal Transducer and Activator of Transcription) protein.
|
1 | P07750 (/IDA) |
|
Defense response to protozoan GO:0042832
Reactions triggered in response to the presence of a protozoan that act to protect the cell or organism.
|
1 | P07750 (/IMP) |
|
Myeloid dendritic cell differentiation GO:0043011
The process in which a monocyte acquires the specialized features of a dendritic cell, an immunocompetent cell of the lymphoid and hemopoietic systems and skin.
|
1 | P07750 (/ISO) |
|
Positive regulation of mast cell degranulation GO:0043306
Any process that activates or increases the frequency, rate or extent of mast cell degranulation.
|
1 | P07750 (/IGI) |
|
Positive regulation of mast cell degranulation GO:0043306
Any process that activates or increases the frequency, rate or extent of mast cell degranulation.
|
1 | P07750 (/IMP) |
|
T-helper 2 cell differentiation GO:0045064
The process in which a relatively unspecialized T cell acquires specialized features of a T-helper 2 (Th2) cell. A Th2 cell is a CD4-positive, alpha-beta T cell that has the phenotype GATA-3-positive and produces interleukin-4.
|
1 | P07750 (/IDA) |
|
Positive regulation of chemokine biosynthetic process GO:0045080
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of chemokines.
|
1 | P07750 (/IDA) |
|
Positive regulation of MHC class II biosynthetic process GO:0045348
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of MHC class II.
|
1 | P07750 (/IDA) |
|
Positive regulation of T cell differentiation GO:0045582
Any process that activates or increases the frequency, rate or extent of T cell differentiation.
|
1 | P07750 (/ISO) |
|
Negative regulation of osteoclast differentiation GO:0045671
Any process that stops, prevents, or reduces the frequency, rate or extent of osteoclast differentiation.
|
1 | P07750 (/IDA) |
|
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
|
1 | P07750 (/ISO) |
|
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
|
1 | P07750 (/IDA) |
|
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
|
1 | P07750 (/ISO) |
|
Positive regulation of transcription from RNA polymerase II promoter GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
|
1 | P07750 (/IDA) |
|
Positive regulation of transcription from RNA polymerase II promoter GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
|
1 | P07750 (/IGI) |
|
Positive regulation of isotype switching to IgE isotypes GO:0048295
Any process that activates or increases the frequency, rate or extent of isotype switching to IgE isotypes.
|
1 | P07750 (/IDA) |
|
Positive regulation of isotype switching to IgG isotypes GO:0048304
Any process that activates or increases the frequency, rate or extent of isotype switching to IgG isotypes.
|
1 | P07750 (/IDA) |
|
Positive regulation of peptidyl-tyrosine phosphorylation GO:0050731
Any process that activates or increases the frequency, rate or extent of the phosphorylation of peptidyl-tyrosine.
|
1 | P07750 (/IDA) |
|
Regulation of immune response GO:0050776
Any process that modulates the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus.
|
1 | P07750 (/IDA) |
|
Negative regulation of T cell activation GO:0050868
Any process that stops, prevents, or reduces the frequency, rate or extent of T cell activation.
|
1 | P07750 (/IDA) |
|
Positive regulation of B cell activation GO:0050871
Any process that activates or increases the frequency, rate or extent of B cell activation.
|
1 | P07750 (/IDA) |
|
Positive regulation of sequence-specific DNA binding transcription factor activity GO:0051091
Any process that activates or increases the frequency, rate or extent of activity of a transcription factor, any factor involved in the initiation or regulation of transcription.
|
1 | P07750 (/IDA) |
|
Negative regulation of white fat cell proliferation GO:0070351
Any process that stops or decreases the rate or extent of white fat cell proliferation.
|
1 | P07750 (/IDA) |
|
Dendritic cell differentiation GO:0097028
The process in which a precursor cell type acquires the specialized features of a dendritic cell. A dendritic cell is a leukocyte of dendritic lineage specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation.
|
1 | P07750 (/ISO) |
|
Extrinsic apoptotic signaling pathway in absence of ligand GO:0097192
A series of molecular signals in which a signal is conveyed from the cell surface to trigger the apoptotic death of a cell. The pathway starts with withdrawal of a ligand from a cell surface receptor, and ends when the execution phase of apoptosis is triggered.
|
1 | P07750 (/IDA) |
|
Positive regulation of myoblast fusion GO:1901741
Any process that activates or increases the frequency, rate or extent of myoblast fusion.
|
1 | P07750 (/IDA) |
|
Positive regulation of myoblast fusion GO:1901741
Any process that activates or increases the frequency, rate or extent of myoblast fusion.
|
1 | P07750 (/IMP) |
|
Negative regulation of complement-dependent cytotoxicity GO:1903660
Any process that stops, prevents or reduces the frequency, rate or extent of complement-dependent cytotoxicity.
|
1 | P07750 (/ISO) |
|
Negative regulation of T-helper 17 cell differentiation GO:2000320
Any process that stops, prevents or reduces the frequency, rate or extent of T-helper 17 cell differentiation.
|
1 | P07750 (/IDA) |
|
Negative regulation of endothelial cell apoptotic process GO:2000352
Any process that stops, prevents or reduces the frequency, rate or extent of endothelial cell apoptotic process.
|
1 | P07750 (/ISO) |
|
Negative regulation of extrinsic apoptotic signaling pathway GO:2001237
Any process that stops, prevents or reduces the frequency, rate or extent of extrinsic apoptotic signaling pathway.
|
1 | P07750 (/IDA) |
There are 2 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
|
1 | P07750 (/IDA) |
|
External side of plasma membrane GO:0009897
The leaflet of the plasma membrane that faces away from the cytoplasm and any proteins embedded or anchored in it or attached to its surface.
|
1 | P07750 (/IDA) |
