The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Voltage-gated potassium channels. Chain C
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 4229: Cyclic nucleotide-gated cation channel

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 13 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Intracellular cGMP activated cation channel activity GO:0005223
Enables the transmembrane transfer of a cation by a channel that opens when intracellular cGMP has been bound by the channel complex or one of its constituent parts.
7 A0A0G2JVT7 (/IDA) A0A0G2K054 (/IDA) Q00195 (/IDA) Q62927 (/IDA) Q64359 (/IDA) Q9ER32 (/IDA) Q9ER33 (/IDA)
CGMP binding GO:0030553
Interacting selectively and non-covalently with cGMP, the nucleotide cyclic GMP (guanosine 3',5'-cyclophosphate).
7 A0A0G2JVT7 (/IDA) A0A0G2K054 (/IDA) Q00195 (/IDA) Q62927 (/IDA) Q64359 (/IDA) Q9ER32 (/IDA) Q9ER33 (/IDA)
Signal transducer activity GO:0004871
Conveys a signal across a cell to trigger a change in cell function or state. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response.
4 A0A0G2JVT7 (/NAS) A0A0G2K054 (/NAS) Q9ER32 (/NAS) Q9ER33 (/NAS)
Intracellular cGMP activated cation channel activity GO:0005223
Enables the transmembrane transfer of a cation by a channel that opens when intracellular cGMP has been bound by the channel complex or one of its constituent parts.
4 A0A0G2JVT7 (/NAS) A0A0G2K054 (/NAS) Q9ER32 (/NAS) Q9ER33 (/NAS)
Protein C-terminus binding GO:0008022
Interacting selectively and non-covalently with a protein C-terminus, the end of any peptide chain at which the 1-carboxy function of a constituent amino acid is not attached in peptide linkage to another amino-acid residue.
4 A0A0G2JVT7 (/IPI) A0A0G2K054 (/IPI) Q9ER32 (/IPI) Q9ER33 (/IPI)
CGMP binding GO:0030553
Interacting selectively and non-covalently with cGMP, the nucleotide cyclic GMP (guanosine 3',5'-cyclophosphate).
4 A0A0G2JVT7 (/NAS) A0A0G2K054 (/NAS) Q9ER32 (/NAS) Q9ER33 (/NAS)
Intracellular cAMP activated cation channel activity GO:0005222
Enables the transmembrane transfer of a cation by a channel that opens when intracellular cAMP has been bound by the channel complex or one of its constituent parts.
2 Q00195 (/IDA) Q64359 (/IDA)
Ion channel activity GO:0005216
Enables the facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. May be either selective (it enables passage of a specific ion only) or non-selective (it enables passage of two or more ions of same charge but different size).
1 Q0GFG2 (/IDA)
Ion channel activity GO:0005216
Enables the facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. May be either selective (it enables passage of a specific ion only) or non-selective (it enables passage of two or more ions of same charge but different size).
1 Q62398 (/IMP)
Ion channel activity GO:0005216
Enables the facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. May be either selective (it enables passage of a specific ion only) or non-selective (it enables passage of two or more ions of same charge but different size).
1 Q03041 (/ISS)
Ion channel activity GO:0005216
Enables the facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. May be either selective (it enables passage of a specific ion only) or non-selective (it enables passage of two or more ions of same charge but different size).
1 Q3UW12 (/TAS)
Intracellular cyclic nucleotide activated cation channel activity GO:0005221
Enables the transmembrane transfer of a cation by a channel that opens when intracellular cyclic nucleotide has been bound by the channel complex or one of its constituent parts.
1 Q64359 (/IDA)
Intracellular cyclic nucleotide activated cation channel activity GO:0005221
Enables the transmembrane transfer of a cation by a channel that opens when intracellular cyclic nucleotide has been bound by the channel complex or one of its constituent parts.
1 Q62927 (/TAS)

There are 14 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Response to corticosteroid GO:0031960
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a corticosteroid hormone stimulus. A corticosteroid is a steroid hormone that is produced in the adrenal cortex. Corticosteroids are involved in a wide range of physiologic systems such as stress response, immune response and regulation of inflammation, carbohydrate metabolism, protein catabolism, blood electrolyte levels, and behavior. They include glucocorticoids and mineralocorticoids.
4 A0A0G2JVT7 (/IEP) A0A0G2K054 (/IEP) Q9ER32 (/IEP) Q9ER33 (/IEP)
Response to magnesium ion GO:0032026
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a magnesium ion stimulus.
4 A0A0G2JVT7 (/IDA) A0A0G2K054 (/IDA) Q9ER32 (/IDA) Q9ER33 (/IDA)
Ion transmembrane transport GO:0034220
A process in which an ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore.
4 A0A0G2JVT7 (/IDA) A0A0G2K054 (/IDA) Q9ER32 (/IDA) Q9ER33 (/IDA)
Response to cAMP GO:0051591
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate) stimulus.
4 A0A0G2JVT7 (/IDA) A0A0G2K054 (/IDA) Q9ER32 (/IDA) Q9ER33 (/IDA)
Sensory perception of smell GO:0007608
The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process.
2 Q3UW12 (/IMP) Q62398 (/IMP)
Protein heterotetramerization GO:0051290
The formation of a protein heterotetramer, a macromolecular structure consisting of four noncovalently associated subunits, of which not all are identical.
2 Q00195 (/IDA) Q64359 (/IDA)
Membrane depolarization GO:0051899
The process in which membrane potential decreases with respect to its steady-state potential, usually from negative potential to a more positive potential. For example, the initial depolarization during the rising phase of an action potential is in the direction from the negative steady-state resting potential towards the positive membrane potential that will be the peak of the action potential.
2 Q00195 (/IDA) Q62927 (/IDA)
Ion transport GO:0006811
The directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
1 Q0GFG2 (/IDA)
Spermatogenesis GO:0007283
The process of formation of spermatozoa, including spermatocytogenesis and spermiogenesis.
1 Q62927 (/IEP)
Sensory perception of smell GO:0007608
The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process.
1 Q00195 (/IEP)
Sensory perception of smell GO:0007608
The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process.
1 Q03041 (/ISS)
Protein homotetramerization GO:0051289
The formation of a protein homotetramer, a macromolecular structure consisting of four noncovalently associated identical subunits.
1 Q00195 (/IDA)
Regulation of cytosolic calcium ion concentration GO:0051480
Any process involved in the maintenance of an internal steady state of calcium ions within the cytosol of a cell or between the cytosol and its surroundings.
1 Q62927 (/IDA)
Cilium assembly GO:0060271
The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole.
1 Q0GFG2 (/IMP)

There are 13 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Perikaryon GO:0043204
The portion of the cell soma (neuronal cell body) that excludes the nucleus.
6 A0A0G2JVT7 (/IDA) A0A0G2K054 (/IDA) Q00195 (/IDA) Q64359 (/IDA) Q9ER32 (/IDA) Q9ER33 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
5 A0A0G2JVT7 (/IDA) A0A0G2K054 (/IDA) Q62927 (/IDA) Q9ER32 (/IDA) Q9ER33 (/IDA)
Intracellular cyclic nucleotide activated cation channel complex GO:0017071
A protein complex that forms a transmembrane channel through which cations ions may pass in response to an intracellular cyclic nucleotide binding to the channel complex or one of its constituent parts.
4 A0A0G2JVT7 (/IC) A0A0G2K054 (/IC) Q9ER32 (/IC) Q9ER33 (/IC)
Dendrite GO:0030425
A neuron projection that has a short, tapering, often branched, morphology, receives and integrates signals from other neurons or from sensory stimuli, and conducts a nerve impulse towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.
4 A0A0G2JVT7 (/IDA) A0A0G2K054 (/IDA) Q9ER32 (/IDA) Q9ER33 (/IDA)
Photoreceptor outer segment membrane GO:0042622
The membrane surrounding the outer segment of a vertebrate photoreceptor.
4 A0A0G2JVT7 (/IDA) A0A0G2K054 (/IDA) Q9ER32 (/IDA) Q9ER33 (/IDA)
Neuronal cell body GO:0043025
The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
4 A0A0G2JVT7 (/IDA) A0A0G2K054 (/IDA) Q9ER32 (/IDA) Q9ER33 (/IDA)
Intracellular cyclic nucleotide activated cation channel complex GO:0017071
A protein complex that forms a transmembrane channel through which cations ions may pass in response to an intracellular cyclic nucleotide binding to the channel complex or one of its constituent parts.
3 Q00195 (/IDA) Q62927 (/IDA) Q64359 (/IDA)
Golgi membrane GO:0000139
The lipid bilayer surrounding any of the compartments of the Golgi apparatus.
2 Q16280 (/TAS) Q8IV77 (/TAS)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
2 Q00195 (/IDA) Q64359 (/IDA)
Golgi-associated vesicle membrane GO:0030660
The lipid bilayer surrounding a vesicle associated with the Golgi apparatus.
2 Q16280 (/TAS) Q8IV77 (/TAS)
Ciliary membrane GO:0060170
The portion of the plasma membrane surrounding a cilium.
2 Q16280 (/TAS) Q8IV77 (/TAS)
Integral component of membrane GO:0016021
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
1 Q0GFG2 (/IDA)
Terminal bouton GO:0043195
Terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters. The axon terminus is considered to be the whole region of thickening and the terminal bouton is a specialized region of it.
1 Q62927 (/IDA)