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CATH Superfamily 1.20.1110.10

Calcium-transporting ATPase, transmembrane domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Calcium-transporting ATPase, transmembrane domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 14781: Probable cation-transporting ATPase 13A4

There are 3 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Calcium-transporting ATPase. [EC: 3.6.3.8]
ATP + H(2)O + Ca(2+)(Side 1) = ADP + phosphate + Ca(2+)(Side 2).
  • P-type ATPase that undergoes covalent phosphorylation during the transport cycle.
  • This enzyme family comprises three types of Ca(2+)-transporting enzymes that are found in the plasma membrane, the sarcoplasmic reticulum and in Saccharomyces cerevisiae.
  • The first and third transport one ion per ATP hydrolyzed, whereas the second transports two ions.
  • Formerly EC 3.6.1.38.
 8 A0A074SQY3 A0A086K1N8 A0A086KTG2 A0A086L2R6 A0A086PXN3 A0A086QT05 A0A0F4YVI0 S8G8M6
Phospholipid-translocating ATPase. [EC: 3.6.3.1]
ATP + H(2)O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2).
  • P-type ATPase that undergoes covalent phosphorylation during the transport cycle.
  • The enzyme apparently has several activities, one of them being the movement of phospholipids from one membrane face to the other.
  • Formerly EC 3.6.3.13.
 7 A0A074SQY3 A0A086K1N8 A0A086KTG2 A0A086L2R6 A0A086PXN3 A0A086QT05 S8G8M6
Succinate dehydrogenase (quinone). [EC: 1.3.5.1]
Succinate + a quinone = fumarate + a quinol.
  • The enzyme is found in the inner mitochondrial membrane in eukaryotes and the plasma membrane of many aerobic or facultative bacteria.
  • It catalyzes succinate oxidation in the citric acid cycle and transfers the electrons to quinones in the membrane, thus constituting a part of the aerobic respiratory chain (known as complex II).
  • In vivo the enzyme uses the quinone found in the organism - eukaryotic enzymes utilize ubiquinone, bacterial enzymes utilize ubiquinone or menaquinone, and archaebacterial enzymes from the Sulfolobus genus use caldariellaquinone.
  • Cf. EC 1.3.5.4.
 1 A0A091CKG8