View in Gene3D

CATH Superfamily 1.10.840.10

Ras guanine-nucleotide exchange factors catalytic domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Ras guanine-nucleotide exchange factors catalytic domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
« Back to all FunFams

FunFam 1430: Ras guanine nucleotide exchange factor

There are 5 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Non-specific serine/threonine protein kinase. [EC: 2.7.11.1]
ATP + a protein = ADP + a phosphoprotein.
  • This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date.
  • Formerly EC 2.7.1.37 and EC 2.7.1.70.
 2 B7P719 B7P719
Glycine hydroxymethyltransferase. [EC: 2.1.2.1]
5,10-methylenetetrahydrofolate + glycine + H(2)O = tetrahydrofolate + L-serine.
  • Also catalyzes the reaction of glycine with acetaldehyde to form L-threonine, and with 4-trimethylammoniobutanal to form 3-hydroxy- N(6),N(6),N(6)-trimethyl-L-lysine.
 2 F4PYX8 F4PYX8
Penicillin amidase. [EC: 3.5.1.11]
Penicillin + H(2)O = a carboxylate + 6-aminopenicillanate.
    		 2 B0EBI5 B0EBI5
    N-acetylmuramoyl-L-alanine amidase. [EC: 3.5.1.28]
    Hydrolyzes the link between N-acetylmuramoyl residues and L-amino acid residues in certain cell-wall glycopeptides.
    • Formerly EC 3.4.12.5, EC 3.4.17.7 and EC 3.4.19.10.
    		 2 B0ECX5 B0ECX5
    Trichodiene synthase. [EC: 4.2.3.6]
    (2E,6E)-farnesyl diphosphate = trichodiene + diphosphate.
    • Formerly EC 4.1.99.6.
    		 2 B0EJK5 B0EJK5
    CATH-Gene3D is a Global Biodata Core Resource Learn more...