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CATH Superfamily 1.10.800.10

Aromatic amino acid hydroxylase

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Aromatic amino acid hydroxylase
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 554: Putative phenylalanine-4-hydroxylase

There are 2 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Phenylalanine 4-monooxygenase. [EC: 1.14.16.1]
L-phenylalanine + tetrahydrobiopterin + O(2) = L-tyrosine + 4a-hydroxytetrahydrobiopterin.
  • The reaction involves an arene oxide which rearranges to give the phenolic hydroxy group.
  • This results in the hydrogen at C-4 migrating to C-3 and in part being retained, a process known as the NIH-shift.
  • The 4a-hydroxytetrahydrobiopterin formed can dehydrate to 6,7- dihydrobiopterin, both spontaneously and by the action of EC 4.2.1.96.
  • The 6,7-dihydrobiopterin can be enzymically reduced back to tetrahydrobiopterin, by EC 1.5.1.34, or slowly rearranges into the more stable compound 7,8-dihydrobiopterin.
  • Formerly EC 1.14.3.1 and EC 1.99.1.2.
 563 A0A010SSD6 A0A023CE79 A0A023WN61 A0A024HK84 A0A031G488 A0A031H3A2 A0A031I6D1 A0A031IVV8 A0A059L571 A0A059V1F9
(553 more...)
4a-hydroxytetrahydrobiopterin dehydratase. [EC: 4.2.1.96]
(6R)-6-(L-erythro-1,2-dihydroxypropyl)-5,6,7,8-tetrahydro- 4a-hydroxypterin = (6R)-6-(L-erythro-1,2-dihydroxypropyl)-7,8-dihydro- 6H-pterin + H(2)O.
  • Catalyzes the dehydration of 4a-hydroxytetrahydrobiopterins.
 2 A0A0H6LCH2 A0A0P9MXI2
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