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CATH Superfamily 1.10.8.50

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 5691: 5-hydroxymethyluracil DNA glycosylase

There are 2 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
DNA-formamidopyrimidine glycosylase. [EC: 3.2.2.23]
Hydrolysis of DNA containing ring-opened 7-methylguanine residues, releasing 2,6-diamino-4-hydroxy-5-(N-methyl)formamidopyrimidine.
  • May play a significant role in processes leading to recovery from mutagenesis and/or cell death by alkylating agents.
  • Also involved in the GO system responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine) from DNA.
 129 A0A023CUP0 A0A062XB96 A0A081BG33 A0A084AAW3 A0A087EQA8 A0A089ZB95 A0A091BUG5 A0A098R802 A0A0A6NVT8 A0A0A7SXX0
(119 more...)
DNA-(apurinic or apyrimidinic site) lyase. [EC: 4.2.99.18]
The C-O-P bond 3' to the apurinic or apyrimidinic site in DNA is broken by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.
  • 'Nicking' of the phosphodiester bond is due to a lyase-type reaction, not hydrolysis.
  • This group of enzymes was previously listed as endonucleases, under the number EC 3.1.25.2.
 129 A0A023CUP0 A0A062XB96 A0A081BG33 A0A084AAW3 A0A087EQA8 A0A089ZB95 A0A091BUG5 A0A098R802 A0A0A6NVT8 A0A0A7SXX0
(119 more...)