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CATH Superfamily 1.10.8.100

rRNA adenine dimethylase, C-terminal domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 2578: rRNA adenine N-6-methyltransferase

There are 5 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
23S rRNA (adenine(2085)-N(6))-dimethyltransferase. [EC: 2.1.1.184]
2 S-adenosyl-L-methionine + adenine(2085) in 23S rRNA = 2 S-adenosyl-L- homocysteine + N(6)-dimethyladenine(2085) in 23S rRNA.
  • ErmC is a methyltransferase that confers resistance to the macrolide- lincosamide-streptogramin B group of antibiotics by catalyzing the methylation of 23S rRNA at adenine(2085).
  • Formerly EC 2.1.1.48.
 301 A0A015X2Z5 A0A059N278 A0A095XF98 A0A095XZ10 A0A095ZRX2 A0A096BCL7 A0A0B4ZIG2 A0A0C4K3J6 A0A0C4M7A4 A0A0C5H0S4
(291 more...)
Transferred entry: 2.1.1.181, 2.1.1.182, 2.1.1.183 and 2.1.1.184. [EC: 2.1.1.48]
    		145 A0A059N278 A0A0C4M7A4 A0A0D1B322 A0A0E2HH62 A0A0H3MV49 A0A0I9W6R8 A0A0J9BRA0 A0A0K9JEG2 A0A0M1XVB9 A0A0M2A957
    (135 more...)
    23S rRNA (adenine(1618)-N(6))-methyltransferase. [EC: 2.1.1.181]
    S-adenosyl-L-methionine + adenine(1618) in 23S rRNA = S-adenosyl-L- homocysteine + rRNA containing N(6)-methyladenine(1618) in 23S rRNA.
    • The recombinant YbiN protein is able to methylate partially deproteinized 50 S ribosomal subunit, but neither the completely assembled 50 S subunits nor completely deproteinized 23 S rRNA.
    • Formerly EC 2.1.1.48.
    		 126 A0A059N278 A0A0D1B322 A0A0E2HH62 A0A0I9W6R8 A0A0J9BRA0 A0A0K9JEG2 A0A0M1XVB9 A0A0M2A957 A0A0M4JUA0 A0A0R1GRC1
    (116 more...)
    18S rRNA (adenine(1779)-N(6)/adenine(1780)-N(6))-dimethyltransferase. [EC: 2.1.1.183]
    4 S-adenosyl-L-methionine + adenine(1779)/adenine(1780) in 18S rRNA = 4 S-adenosyl-L-homocysteine + N(6)-dimethyladenine(1779)/N(6)- dimethyladenine(1780) in 18S rRNA.
    • DIM1 is involved in pre-rRNA processing.
    • Formerly EC 2.1.1.48.
    		 125 A0A059N278 A0A0D1B322 A0A0E2HH62 A0A0I9W6R8 A0A0J9BRA0 A0A0K9JEG2 A0A0M1XVB9 A0A0M2A957 A0A0M4JUA0 A0A0R1GRC1
    (115 more...)
    16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase. [EC: 2.1.1.182]
    4 S-adenosyl-L-methionine + adenine(1518)/adenine(1519) in 16S rRNA = 4 S-adenosyl-L-homocysteine + N(6)-dimethyladenine(1518)/N(6)- dimethyladenine(1519) in 16S rRNA.
    • KsgA introduces the most highly conserved ribosomal RNA modification, the dimethylation of adenine(1518) and adenine(1519) in 16S rRNA.
    • Strains lacking the methylase are resistant to kasugamycin.
    • Formerly EC 2.1.1.48.
    		 125 A0A059N278 A0A0D1B322 A0A0E2HH62 A0A0I9W6R8 A0A0J9BRA0 A0A0K9JEG2 A0A0M1XVB9 A0A0M2A957 A0A0M4JUA0 A0A0R1GRC1
    (115 more...)
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