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CATH Superfamily 1.10.8.10

Ubiquitin-associated (UBA) domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
DNA helicase RuvA subunit, C-terminal domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 15612: Serine/threonine-protein kinase MARK2, putative

There are 3 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Non-specific serine/threonine protein kinase. [EC: 2.7.11.1]
ATP + a protein = ADP + a phosphoprotein.
  • This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date.
  • Formerly EC 2.7.1.37 and EC 2.7.1.70.
 1616 A0A024R5B2 A0A024R5B2 A0A026WQX3 A0A026WQX3 A0A034VK46 A0A034VK46 A0A034VME3 A0A034VME3 A0A034VMG6 A0A034VMG6
(1606 more...)
[Tau protein] kinase. [EC: 2.7.11.26]
ATP + [tau protein] = ADP + [tau protein] phosphate.
  • Activated by tubulin.
  • Involved in the formation of paired helical filaments, which are the main fibrous component of all fibrillary lesions in brain and are associated with Alzheimer's disease.
  • Formerly EC 2.7.1.135.
 24 A1ZBL7 A1ZBL7 E1JGM9 E1JGM9 O08678 O08678 O08679 O08679 Q05512 Q05512
(14 more...)
CAMP-dependent protein kinase. [EC: 2.7.11.11]
ATP + a protein = ADP + a phosphoprotein.
  • cAMP is required to activate this enzyme.
  • The inactive holoenzyme of cAMP-dependent protein kinase is a tetramer composed of two regulatory (R) and two catalytic (C) subunits.
  • cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP molecules and two free monomeric catalytic subunits (i.e. R(2)C(2) + 4 cAMP = R(2)(cAMP)(4) + 2 C).
  • Formerly EC 2.7.1.37.
 2 A0A0D2LMH0 A0A0D2LMH0
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